Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase subunit gamma-1

Gene

Polg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • base-excision repair, gap-filling Source: Ensembl
  • cellular response to glucose stimulus Source: RGD
  • mitochondrial DNA replication Source: GO_Central
  • response to gamma radiation Source: RGD
  • response to hyperoxia Source: RGD
  • response to light stimulus Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-1 (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
PolG-alpha
Gene namesi
Name:Polg
Synonyms:Mip1, Polg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620057. Polg.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • gamma DNA polymerase complex Source: RGD
  • mitochondrial nucleoid Source: UniProtKB
  • mitochondrion Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12161216DNA polymerase subunit gamma-1PRO_0000101272Add
BLAST

Proteomic databases

PaxDbiQ9QYV8.
PRIDEiQ9QYV8.

PTM databases

PhosphoSiteiQ9QYV8.

Expressioni

Gene expression databases

GenevisibleiQ9QYV8. RN.

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047900.

Structurei

3D structure databases

ProteinModelPortaliQ9QYV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiKOG3657. Eukaryota.
COG0749. LUCA.
GeneTreeiENSGT00390000000453.
HOGENOMiHOG000176668.
HOVERGENiHBG051400.
InParanoidiQ9QYV8.
KOiK02332.
OMAiDWSGQEI.
OrthoDBiEOG7T4MJC.
PhylomeDBiQ9QYV8.

Family and domain databases

InterProiIPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10267. PTHR10267. 2 hits.
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PIRSFiPIRSF000797. DNA_pol_mt. 1 hit.
PRINTSiPR00867. DNAPOLG.
SMARTiSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLWKKVA GAKVASGPVP ATGRWVSSSV LDPVPSDGQP QSQMPSSENG
60 70 80 90 100
QLRLNPLHIQ MLSRGLHEQI FGCGGDVPDE AAVQRSIEHL RKHGLWGQPT
110 120 130 140 150
TPLPDVQLRL PRLFGGNLDQ HFRLLAQKQS LPYLEAAASL SEAQLPPQPR
160 170 180 190 200
KWVWAEGWTR YGPEGEAEPV AIPEERALVF DVEVCLAEGT CPTLAVAISP
210 220 230 240 250
SAWYSWCSRR LVEERYSWTS QLSPADLIPL GVSASASSST QQDWQEQLVV
260 270 280 290 300
GHNVSFDRAH IREQYLIQGS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ
310 320 330 340 350
GKHKTQHPTK RGQKSQKNAN GPAISSWDWM DISSANNLAD VHNLYVGGPR
360 370 380 390 400
LAKEPRELFV KGSMRDIREN FQDLMEYCAR DVWATFEVFQ QQLPLFLERC
410 420 430 440 450
PHPVTLAGML EMGVSYLPVN QNWERYLTEA QSTYEELQRE MKKSLMELAN
460 470 480 490 500
DACQLLSGER YKEDPWLWDL EWDLQEFKQK KAKKVKKTAS ASKLPIEGAG
510 520 530 540 550
PFGDPMDQED PGPPSEEEEL QQNIMAHTRL QQLKSTTDLL PKRPQHLPGH
560 570 580 590 600
PGWYRKLCPR LDDPAWTPGP SLLSLQMRVT PKLMALTWDG FPLHYSDSHG
610 620 630 640 650
WGYLVPGRRD NLTELPVSPT EESAAVTCPY RAIESLYRRH CLDQGKQQLE
660 670 680 690 700
TQETDLAEEF LLTDSAMWQT VEELGCLDVE AEATVESSGL SQPLVPPTAC
710 720 730 740 750
APKTSQPTYH HGNGPYNDVD IPGCWFFKLP HKDGNNYNVG SPFAKDFLPK
760 770 780 790 800
MEDGTLQAGP GGARGPRALE INKMISFWRN AHKRISSQMV VWLPRSALPR
810 820 830 840 850
AVTRHPSFDE ESHYGAILPQ VVTAGTITRR AVEPTWLTAS NARPDRVGSE
860 870 880 890 900
LKAMVQAPPG YVLVGADVDS QELWIAAVLG DAHFAGMHGC TAFGWMTLQG
910 920 930 940 950
RKSRGTDLHS KTAATVGISR EHAKVFNYGR IYGAGQSFAE RLLMQFNHRL
960 970 980 990 1000
SRQEAADKAQ QMYAVTKGLR RYRLSDDGEW LVKQLNVPVD RTEDGWVSLQ
1010 1020 1030 1040 1050
DLRKIRREAS RKSRWKKWEV VTERAWTGGT ESEMFNKLES IAMSDTPRTP
1060 1070 1080 1090 1100
VLGCCISRAL EPSVVQGEFM TSRVNWVVQS SAVDYLHLML VAMKWLFEEF
1110 1120 1130 1140 1150
AIDGRFCISI HDEVRYLVRE EDRYRAALAL QITNLLTRCM FAYKLGLNDL
1160 1170 1180 1190 1200
PQSVAFFSAV DIDQCLRKEV TMDCKTPSNP TGMERKYGIP QGEALDIYQI
1210
IELTKGSLEK RSQPGP
Length:1,216
Mass (Da):136,856
Last modified:May 1, 2000 - v1
Checksum:iA74CD68B6BDB690C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti273 – 2731R → H in Novikoff hepatoma cells. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245646 mRNA. Translation: CAB56206.1.
AJ245647 mRNA. Translation: CAB56207.1.
RefSeqiNP_445980.1. NM_053528.1.
XP_006229472.1. XM_006229410.2.
UniGeneiRn.19327.

Genome annotation databases

EnsembliENSRNOT00000044567; ENSRNOP00000047900; ENSRNOG00000032293.
GeneIDi85472.
KEGGirno:85472.
UCSCiRGD:620057. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245646 mRNA. Translation: CAB56206.1.
AJ245647 mRNA. Translation: CAB56207.1.
RefSeqiNP_445980.1. NM_053528.1.
XP_006229472.1. XM_006229410.2.
UniGeneiRn.19327.

3D structure databases

ProteinModelPortaliQ9QYV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047900.

PTM databases

PhosphoSiteiQ9QYV8.

Proteomic databases

PaxDbiQ9QYV8.
PRIDEiQ9QYV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044567; ENSRNOP00000047900; ENSRNOG00000032293.
GeneIDi85472.
KEGGirno:85472.
UCSCiRGD:620057. rat.

Organism-specific databases

CTDi5428.
RGDi620057. Polg.

Phylogenomic databases

eggNOGiKOG3657. Eukaryota.
COG0749. LUCA.
GeneTreeiENSGT00390000000453.
HOGENOMiHOG000176668.
HOVERGENiHBG051400.
InParanoidiQ9QYV8.
KOiK02332.
OMAiDWSGQEI.
OrthoDBiEOG7T4MJC.
PhylomeDBiQ9QYV8.

Miscellaneous databases

PROiQ9QYV8.

Gene expression databases

GenevisibleiQ9QYV8. RN.

Family and domain databases

InterProiIPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10267. PTHR10267. 2 hits.
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PIRSFiPIRSF000797. DNA_pol_mt. 1 hit.
PRINTSiPR00867. DNAPOLG.
SMARTiSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mitochondrial DNA polymerase gamma from Novikoff hepatoma cells differs from that of normal rat liver in cDNA sequence and kinetic properties."
    Sun Q., Popanda O., Thielmann H.W.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-273.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiDPOG1_RAT
AccessioniPrimary (citable) accession number: Q9QYV8
Secondary accession number(s): Q9QYV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.