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Protein

Tomoregulin-1

Gene

Tmeff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May inhibit NODAL and BMP signaling during neural patterning.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Protein family/group databases

MEROPSiI01.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Tomoregulin-1
Short name:
TR-1
Alternative name(s):
Protein NC1
Transmembrane protein with EGF-like and one follistatin-like domain
Gene namesi
Name:Tmeff1
Synonyms:Nc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi62005. Tmeff1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 323ExtracellularSequence analysisAdd BLAST278
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 373CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000028605836 – 373Tomoregulin-1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi268 ↔ 281By similarity
Disulfide bondi276 ↔ 292By similarity
Disulfide bondi294 ↔ 303By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9QYV1.
PRIDEiQ9QYV1.

PTM databases

SwissPalmiQ9QYV1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008034.
GenevisibleiQ9QYV1. RN.

Interactioni

Subunit structurei

May interact with ST14.By similarity

Protein-protein interaction databases

BioGridi248901. 1 interactor.
STRINGi10116.ENSRNOP00000063443.

Structurei

3D structure databases

ProteinModelPortaliQ9QYV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 138Kazal-like 1Add BLAST53
Domaini177 – 230Kazal-like 2Add BLAST54
Domaini264 – 304EGF-likeAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 45Poly-Gly4

Sequence similaritiesi

Belongs to the tomoregulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCWX. Eukaryota.
ENOG410XQG4. LUCA.
GeneTreeiENSGT00730000110884.
HOGENOMiHOG000154541.
HOVERGENiHBG053816.
InParanoidiQ9QYV1.
OMAiCFVREAS.
OrthoDBiEOG091G0AKU.
PhylomeDBiQ9QYV1.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002350. Kazal_dom.
IPR036058. Kazal_dom_sf.
PfamiView protein in Pfam
PF07648. Kazal_2. 2 hits.
SMARTiView protein in SMART
SM00280. KAZAL. 2 hits.
SUPFAMiSSF100895. SSF100895. 2 hits.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS51465. KAZAL_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQAPLRLP AAPPLAVCGY TSVLLLFAFC LPGSGASNQP AGGGGDCPGG
60 70 80 90 100
RGKSINCSEL NLRESDIRAC DESSCKYGGV CKEDGDGLKC ACQFQCHTNY
110 120 130 140 150
IPVCGSNGDT YQNECFLRRA ACKHQKDITV VARGPCYSDN GSGSGEGEEE
160 170 180 190 200
GSGAGAHRKH SKCGPCKYKA ECDEDAENVG CVCNIDCSGY SFNPVCASDG
210 220 230 240 250
SSYNNPCFVR EASCIRQEQI DIRHLGHCTD TDDTSLLGKK DDGLQYRPDV
260 270 280 290 300
KDAGDQREDV YIGSHMPCPE NLNGYCIHGK CEFIYSTQKA SCRCESGYTG
310 320 330 340 350
QHCEKTDFSI LYVVPSRQKL THVLIAAIIG AVQIAIIVAI VMCITRKCPK
360 370
NNRGRRQKQN LGHFTSETSS RMV
Length:373
Mass (Da):40,143
Last modified:May 1, 2000 - v1
Checksum:iBDB8BC681B10280E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250730 mRNA. Translation: CAB60131.1.
BC129093 mRNA. Translation: AAI29094.1.
RefSeqiNP_075409.1. NM_023020.2.
UniGeneiRn.162809.

Genome annotation databases

EnsembliENSRNOT00000065775; ENSRNOP00000063443; ENSRNOG00000008034.
GeneIDi63845.
KEGGirno:63845.
UCSCiRGD:62005. rat.

Similar proteinsi

Entry informationi

Entry nameiTEFF1_RAT
AccessioniPrimary (citable) accession number: Q9QYV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families