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Protein

Tomoregulin-1

Gene

Tmeff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May inhibit NODAL and BMP signaling during neural patterning.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Protein family/group databases

MEROPSiI01.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Tomoregulin-1
Short name:
TR-1
Alternative name(s):
Protein NC1
Transmembrane protein with EGF-like and one follistatin-like domain
Gene namesi
Name:Tmeff1
Synonyms:Nc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi62005. Tmeff1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 323ExtracellularSequence analysisAdd BLAST278
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 373CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000028605836 – 373Tomoregulin-1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi268 ↔ 281By similarity
Disulfide bondi276 ↔ 292By similarity
Disulfide bondi294 ↔ 303By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9QYV1.
PRIDEiQ9QYV1.

PTM databases

SwissPalmiQ9QYV1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008034.
GenevisibleiQ9QYV1. RN.

Interactioni

Subunit structurei

May interact with ST14.By similarity

Protein-protein interaction databases

BioGridi248901. 1 interactor.
STRINGi10116.ENSRNOP00000063443.

Structurei

3D structure databases

ProteinModelPortaliQ9QYV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 138Kazal-like 1PROSITE-ProRule annotationAdd BLAST53
Domaini177 – 230Kazal-like 2PROSITE-ProRule annotationAdd BLAST54
Domaini264 – 304EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 45Poly-Gly4

Sequence similaritiesi

Belongs to the tomoregulin family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCWX. Eukaryota.
ENOG410XQG4. LUCA.
GeneTreeiENSGT00730000110884.
HOGENOMiHOG000154541.
HOVERGENiHBG053816.
InParanoidiQ9QYV1.
OMAiNIDCSGH.
OrthoDBiEOG091G0AKU.
PhylomeDBiQ9QYV1.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQAPLRLP AAPPLAVCGY TSVLLLFAFC LPGSGASNQP AGGGGDCPGG
60 70 80 90 100
RGKSINCSEL NLRESDIRAC DESSCKYGGV CKEDGDGLKC ACQFQCHTNY
110 120 130 140 150
IPVCGSNGDT YQNECFLRRA ACKHQKDITV VARGPCYSDN GSGSGEGEEE
160 170 180 190 200
GSGAGAHRKH SKCGPCKYKA ECDEDAENVG CVCNIDCSGY SFNPVCASDG
210 220 230 240 250
SSYNNPCFVR EASCIRQEQI DIRHLGHCTD TDDTSLLGKK DDGLQYRPDV
260 270 280 290 300
KDAGDQREDV YIGSHMPCPE NLNGYCIHGK CEFIYSTQKA SCRCESGYTG
310 320 330 340 350
QHCEKTDFSI LYVVPSRQKL THVLIAAIIG AVQIAIIVAI VMCITRKCPK
360 370
NNRGRRQKQN LGHFTSETSS RMV
Length:373
Mass (Da):40,143
Last modified:May 1, 2000 - v1
Checksum:iBDB8BC681B10280E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250730 mRNA. Translation: CAB60131.1.
BC129093 mRNA. Translation: AAI29094.1.
RefSeqiNP_075409.1. NM_023020.2.
UniGeneiRn.162809.

Genome annotation databases

EnsembliENSRNOT00000065775; ENSRNOP00000063443; ENSRNOG00000008034.
GeneIDi63845.
KEGGirno:63845.
UCSCiRGD:62005. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250730 mRNA. Translation: CAB60131.1.
BC129093 mRNA. Translation: AAI29094.1.
RefSeqiNP_075409.1. NM_023020.2.
UniGeneiRn.162809.

3D structure databases

ProteinModelPortaliQ9QYV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248901. 1 interactor.
STRINGi10116.ENSRNOP00000063443.

Protein family/group databases

MEROPSiI01.974.

PTM databases

SwissPalmiQ9QYV1.

Proteomic databases

PaxDbiQ9QYV1.
PRIDEiQ9QYV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065775; ENSRNOP00000063443; ENSRNOG00000008034.
GeneIDi63845.
KEGGirno:63845.
UCSCiRGD:62005. rat.

Organism-specific databases

CTDi8577.
RGDi62005. Tmeff1.

Phylogenomic databases

eggNOGiENOG410KCWX. Eukaryota.
ENOG410XQG4. LUCA.
GeneTreeiENSGT00730000110884.
HOGENOMiHOG000154541.
HOVERGENiHBG053816.
InParanoidiQ9QYV1.
OMAiNIDCSGH.
OrthoDBiEOG091G0AKU.
PhylomeDBiQ9QYV1.

Miscellaneous databases

PROiQ9QYV1.

Gene expression databases

BgeeiENSRNOG00000008034.
GenevisibleiQ9QYV1. RN.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS51465. KAZAL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEFF1_RAT
AccessioniPrimary (citable) accession number: Q9QYV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.