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Protein

Ketimine reductase mu-crystallin

Gene

Crym

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).By similarity

Catalytic activityi

Thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H.

Cofactori

NAD+By similarity, NADP+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167NADPBy similarity1
Binding sitei168NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 147NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • mitochondrial transport Source: RGD
  • response to hormone Source: RGD
  • response to vitamin D Source: RGD
  • thyroid hormone metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ketimine reductase mu-crystallin (EC:1.5.1.25)
Alternative name(s):
CDK108
NADP-regulated thyroid-hormone-binding protein
Gene namesi
Name:Crym
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620943. Crym.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002006801 – 313Ketimine reductase mu-crystallinAdd BLAST313

Proteomic databases

PaxDbiQ9QYU4.
PRIDEiQ9QYU4.

2D gel databases

World-2DPAGE0004:Q9QYU4.

PTM databases

iPTMnetiQ9QYU4.
PhosphoSitePlusiQ9QYU4.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi250625. 1 interactor.
STRINGi10116.ENSRNOP00000066476.

Structurei

3D structure databases

ProteinModelPortaliQ9QYU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3007. Eukaryota.
COG2423. LUCA.
HOVERGENiHBG005408.
InParanoidiQ9QYU4.
KOiK18258.
PhylomeDBiQ9QYU4.

Family and domain databases

Gene3Di3.30.1780.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003462. ODC_Mu_crystall.
IPR023401. ODC_N.
[Graphical view]
PfamiPF02423. OCD_Mu_crystall. 1 hit.
[Graphical view]
PIRSFiPIRSF001439. CryM. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAPAFLSA DEVQDHLRSS SLLIPPLEAA LANFSKGPDG GVMQPVRTVV
60 70 80 90 100
PVAKHRGFLG VMPAYSAAED ALTTKLVTFY EGHSNNAVPS HQASVLLFDP
110 120 130 140 150
SNGSLLAVMD GNVITAKRTA AVSAIATKFL KPPGSDVLCI LGAGVQAYSH
160 170 180 190 200
YEIFTEQFSF KEVRMWNRTR ENAEKFASSV QGDVRVCSSV QEAVTGADVI
210 220 230 240 250
ITVTMATEPI LFGEWVKPGA HINAVGASRP DWRELDDELM KQAVLYVDSR
260 270 280 290 300
EAALKESGDV LLSGADIFAE LGEVVSGAKP AYCEKTTVFK SLGMAVEDLV
310
AAKLVYDSWS SGK
Length:313
Mass (Da):33,554
Last modified:May 1, 2000 - v1
Checksum:iE2F1839D9E5EC5ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17328 mRNA. Translation: CAB56625.1.
BC088121 mRNA. Translation: AAH88121.1.
RefSeqiNP_446407.1. NM_053955.1.
UniGeneiRn.24561.

Genome annotation databases

GeneIDi117024.
KEGGirno:117024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17328 mRNA. Translation: CAB56625.1.
BC088121 mRNA. Translation: AAH88121.1.
RefSeqiNP_446407.1. NM_053955.1.
UniGeneiRn.24561.

3D structure databases

ProteinModelPortaliQ9QYU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250625. 1 interactor.
STRINGi10116.ENSRNOP00000066476.

PTM databases

iPTMnetiQ9QYU4.
PhosphoSitePlusiQ9QYU4.

2D gel databases

World-2DPAGE0004:Q9QYU4.

Proteomic databases

PaxDbiQ9QYU4.
PRIDEiQ9QYU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117024.
KEGGirno:117024.

Organism-specific databases

CTDi1428.
RGDi620943. Crym.

Phylogenomic databases

eggNOGiKOG3007. Eukaryota.
COG2423. LUCA.
HOVERGENiHBG005408.
InParanoidiQ9QYU4.
KOiK18258.
PhylomeDBiQ9QYU4.

Miscellaneous databases

PROiQ9QYU4.

Family and domain databases

Gene3Di3.30.1780.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003462. ODC_Mu_crystall.
IPR023401. ODC_N.
[Graphical view]
PfamiPF02423. OCD_Mu_crystall. 1 hit.
[Graphical view]
PIRSFiPIRSF001439. CryM. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRYM_RAT
AccessioniPrimary (citable) accession number: Q9QYU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.