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Protein

Potassium voltage-gated channel subfamily G member 2

Gene

Kcng2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-1296072. Voltage gated Potassium channels.
R-RNO-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Cardiac potassium channel subunit
Voltage-gated potassium channel subunit Kv6.2
Gene namesi
Name:Kcng2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1309521. Kcng2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence analysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=Segment S1Sequence analysisAdd
BLAST
Transmembranei231 – 25121Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini252 – 26514CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=Segment S3Sequence analysisAdd
BLAST
Transmembranei301 – 32121Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini322 – 33413CytoplasmicSequence analysisAdd
BLAST
Transmembranei335 – 35521Helical; Name=Segment S5Sequence analysisAdd
BLAST
Intramembranei370 – 39021Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Transmembranei398 – 41821Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini419 – 48062CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Potassium voltage-gated channel subfamily G member 2PRO_0000054075Add
BLAST

Proteomic databases

PaxDbiQ9QYU3.
PRIDEiQ9QYU3.

PTM databases

iPTMnetiQ9QYU3.
PhosphoSiteiQ9QYU3.

Expressioni

Tissue specificityi

Highly expressed in heart, in particular in right and left atrium, and detected at lower levels in the right and left ventricle.

Gene expression databases

BgeeiENSRNOG00000017189.
GenevisibleiQ9QYU3. RN.

Interactioni

Subunit structurei

Heterodimer with KCNB1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023089.

Structurei

3D structure databases

ProteinModelPortaliQ9QYU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi382 – 3876Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ9QYU3.
KOiK04901.
OMAiSETTQCA.
OrthoDBiEOG091G0DSU.
PhylomeDBiQ9QYU3.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLPGHPEV PGAEPGSAVR GGRGGRGARA RHVIINVGGC RVRLAWAALA
60 70 80 90 100
RCPLARLERL RACRGHDELL RVCDDYDVSR DEFFFDRSPC AFRAIVALLR
110 120 130 140 150
AGKLRLLRGP CALAFRDELA YWGIDEARLE RCCLRRLRRR EEEAAEARAT
160 170 180 190 200
PPARGPQTSP GRALGSGRLE RGRRRLRDVV ENPHSGLAGK LFAYVSVAFV
210 220 230 240 250
AVTAVGLCLS TMPDVRAEEE RGECSTKCRN LFVLETVCVA WFSFEFLLRS
260 270 280 290 300
LQAESKCAFL RTPLAIIDIL AILPFYVSLL AGLAAGPTGS KMLERAGLVL
310 320 330 340 350
RLLRALRVLY VMRLARHSLG LRSLGLTVRR CAREFGLLLL FLCVAMALFA
360 370 380 390 400
PLVHLAEREL GAHRDFSSVP ASYWWAVISM TTVGYGDMVP RSLPGQVVAL
410 420 430 440 450
SSILSGILLM AFPVTSIFHT FSRSYSELKE QQQRAASPEP VLREDSTRDD
460 470 480
STRSASATED SSQDPETAGA AGSLPGPVGP
Length:480
Mass (Da):52,536
Last modified:May 1, 2000 - v1
Checksum:i601C86531B01F6FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011020 mRNA. Translation: CAB56852.1.
RefSeqiNP_001100842.1. NM_001107372.1.
XP_006255009.1. XM_006254947.2.
XP_006255010.1. XM_006254948.2.
XP_006255012.1. XM_006254950.2.
XP_008770358.1. XM_008772136.1.
XP_008770359.1. XM_008772137.1.
UniGeneiRn.163389.

Genome annotation databases

EnsembliENSRNOT00000088054; ENSRNOP00000069556; ENSRNOG00000053640.
GeneIDi307234.
KEGGirno:307234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011020 mRNA. Translation: CAB56852.1.
RefSeqiNP_001100842.1. NM_001107372.1.
XP_006255009.1. XM_006254947.2.
XP_006255010.1. XM_006254948.2.
XP_006255012.1. XM_006254950.2.
XP_008770358.1. XM_008772136.1.
XP_008770359.1. XM_008772137.1.
UniGeneiRn.163389.

3D structure databases

ProteinModelPortaliQ9QYU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023089.

PTM databases

iPTMnetiQ9QYU3.
PhosphoSiteiQ9QYU3.

Proteomic databases

PaxDbiQ9QYU3.
PRIDEiQ9QYU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000088054; ENSRNOP00000069556; ENSRNOG00000053640.
GeneIDi307234.
KEGGirno:307234.

Organism-specific databases

CTDi26251.
RGDi1309521. Kcng2.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ9QYU3.
KOiK04901.
OMAiSETTQCA.
OrthoDBiEOG091G0DSU.
PhylomeDBiQ9QYU3.

Enzyme and pathway databases

ReactomeiR-RNO-1296072. Voltage gated Potassium channels.
R-RNO-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Miscellaneous databases

PROiQ9QYU3.

Gene expression databases

BgeeiENSRNOG00000017189.
GenevisibleiQ9QYU3. RN.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG2_RAT
AccessioniPrimary (citable) accession number: Q9QYU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.