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Protein

Peroxisomal biogenesis factor 19

Gene

Pex19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 19
Alternative name(s):
Peroxin-19
Peroxisomal farnesylated protein
Gene namesi
Name:Pex19
Synonyms:Pxf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306913 Pex19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002187612 – 296Peroxisomal biogenesis factor 19Add BLAST295
PropeptideiPRO_0000396703297 – 299Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei236PhosphothreonineBy similarity1
Modified residuei296Cysteine methyl esterBy similarity1
Lipidationi296S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ9QYU1
PRIDEiQ9QYU1

PTM databases

iPTMnetiQ9QYU1
PhosphoSitePlusiQ9QYU1

Interactioni

Subunit structurei

Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065867

Structurei

3D structure databases

SMRiQ9QYU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 91Necessary for PEX19 function on peroxisome biogenesisBy similarityAdd BLAST90
Regioni2 – 56Docking to the peroxisome membrane and binding to PEX3By similarityAdd BLAST55

Sequence similaritiesi

Belongs to the peroxin-19 family.Curated

Phylogenomic databases

eggNOGiKOG3133 Eukaryota
ENOG4111QGU LUCA
HOGENOMiHOG000038537
HOVERGENiHBG053573
InParanoidiQ9QYU1
PhylomeDBiQ9QYU1

Family and domain databases

Gene3Di1.20.120.900, 1 hit
InterProiView protein in InterPro
IPR006708 Pex19
IPR038322 Pex19_C_sf
PANTHERiPTHR12774 PTHR12774, 1 hit
PfamiView protein in Pfam
PF04614 Pex19, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEGGCGA GVEADRELEE LLESALDDFD KAKPSPAPSP TISAPDASGP
60 70 80 90 100
QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH
110 120 130 140 150
LVEQFQKLSE AAGRVGSDAS SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE
160 170 180 190 200
EELTKAMEGL GMDEGDGEGN ILPIMQSLMQ NLLSKDVLYP SLKEITEKYP
210 220 230 240 250
EWLQSHQESI PPEQFEKYQQ QHSVMGKICE QFEAETPTDS EATHRARFEA
260 270 280 290
VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM
Length:299
Mass (Da):32,497
Last modified:May 1, 2000 - v1
Checksum:i8EDD55F1D26E53A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09049 mRNA Translation: CAA70258.1
UniGeneiRn.203104

Genome annotation databases

UCSCiRGD:1306913 rat

Similar proteinsi

Entry informationi

Entry nameiPEX19_RAT
AccessioniPrimary (citable) accession number: Q9QYU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health