Q9QYU1 (PEX19_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal biogenesis factor 19

Alternative name(s):
Peroxin-19
Peroxisomal farnesylated protein

Gene names

Name:	Pex19
Synonyms:	Pxf

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 By similarity.
Subunit structure	Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF By similarity.
Subcellular location	Cytoplasm By similarity. Peroxisome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes By similarity.
Sequence similarities	Belongs to the peroxin-19 family.

Ontologies

Keywords
Biological process	Peroxisome biogenesis
Cellular component	Cytoplasm Membrane Peroxisome
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peroxisome organization Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	brush border membrane Inferred from direct assay PubMed 14558883. Source: RGD peroxisomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell peroxisome Inferred from direct assay PubMed 10704444. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Peroxisomal biogenesis factor 19		PRO_0000218761
	Propeptide	297 – 299	3	Removed in mature form By similarity		PRO_0000396703
Regions
	Region	1 – 91	91	Necessary for PEX19 function on peroxisome biogenesis By similarity
	Region	1 – 56	56	Docking to the peroxisome membrane and binding to PEX3 By similarity
Amino acid modifications
	Modified residue	296	1	Cysteine methyl ester By similarity
	Lipidation	296	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QYU1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8EDD55F1D26E53A4	FASTA	299	32,497
	10 20 30 40 50 60 MAAAEGGCGA GVEADRELEE LLESALDDFD KAKPSPAPSP TISAPDASGP QKRSPGDTAK 70 80 90 100 110 120 DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDAS 130 140 150 160 170 180 SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE EELTKAMEGL GMDEGDGEGN ILPIMQSLMQ 190 200 210 220 230 240 NLLSKDVLYP SLKEITEKYP EWLQSHQESI PPEQFEKYQQ QHSVMGKICE QFEAETPTDS 250 260 270 280 290 EATHRARFEA VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM

References

[1]	Kammerer S. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y09049 mRNA. Translation: CAA70258.1.
IPI	IPI00768301.
UniGene	Rn.203104.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000032453.
PTM databases
PhosphoSite	Q9QYU1.
Proteomic databases
PaxDb	Q9QYU1.
PRIDE	Q9QYU1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:1306913. rat.
Organism-specific databases
RGD	1306913. Pex19.
Phylogenomic databases
eggNOG	NOG133983.
HOGENOM	HOG000038537.
HOVERGEN	HBG053573.
InParanoid	Q9QYU1.
OrthoDB	EOG40K80Z.
Gene expression databases
Genevestigator	Q9QYU1.
GermOnline	ENSRNOG00000022572. Rattus norvegicus.
Family and domain databases
InterPro	IPR006708. Pex19. [Graphical view]
PANTHER	PTHR12774. PTHR12774. 1 hit.
Pfam	PF04614. Pex19. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PEX19_RAT

Accession

Primary (citable) accession number: Q9QYU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program