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Q9QYU1

- PEX19_RAT

UniProt

Q9QYU1 - PEX19_RAT

Protein

Peroxisomal biogenesis factor 19

Gene

Pex19

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. peroxisome organization Source: UniProtKB-KW

    Keywords - Biological processi

    Peroxisome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal biogenesis factor 19
    Alternative name(s):
    Peroxin-19
    Peroxisomal farnesylated protein
    Gene namesi
    Name:Pex19
    Synonyms:Pxf
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306913. Pex19.

    Subcellular locationi

    Cytoplasm By similarity. Peroxisome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes.By similarity

    GO - Cellular componenti

    1. brush border membrane Source: RGD
    2. cytoplasm Source: UniProtKB
    3. peroxisomal membrane Source: UniProtKB-SubCell
    4. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 296295Peroxisomal biogenesis factor 19PRO_0000218761Add
    BLAST
    Propeptidei297 – 2993Removed in mature formBy similarityPRO_0000396703

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei35 – 351PhosphoserineBy similarity
    Modified residuei296 – 2961Cysteine methyl esterBy similarity
    Lipidationi296 – 2961S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ9QYU1.
    PRIDEiQ9QYU1.

    PTM databases

    PhosphoSiteiQ9QYU1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QYU1.

    Interactioni

    Subunit structurei

    Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000032453.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 9190Necessary for PEX19 function on peroxisome biogenesisBy similarityAdd
    BLAST
    Regioni2 – 5655Docking to the peroxisome membrane and binding to PEX3By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxin-19 family.Curated

    Phylogenomic databases

    eggNOGiNOG133983.
    HOGENOMiHOG000038537.
    HOVERGENiHBG053573.
    InParanoidiQ9QYU1.
    PhylomeDBiQ9QYU1.

    Family and domain databases

    InterProiIPR006708. Pex19.
    [Graphical view]
    PANTHERiPTHR12774. PTHR12774. 1 hit.
    PfamiPF04614. Pex19. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYU1-1 [UniParc]FASTAAdd to Basket

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    MAAAEGGCGA GVEADRELEE LLESALDDFD KAKPSPAPSP TISAPDASGP    50
    QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH 100
    LVEQFQKLSE AAGRVGSDAS SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE 150
    EELTKAMEGL GMDEGDGEGN ILPIMQSLMQ NLLSKDVLYP SLKEITEKYP 200
    EWLQSHQESI PPEQFEKYQQ QHSVMGKICE QFEAETPTDS EATHRARFEA 250
    VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM 299
    Length:299
    Mass (Da):32,497
    Last modified:May 1, 2000 - v1
    Checksum:i8EDD55F1D26E53A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09049 mRNA. Translation: CAA70258.1.
    UniGeneiRn.203104.

    Genome annotation databases

    UCSCiRGD:1306913. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09049 mRNA. Translation: CAA70258.1 .
    UniGenei Rn.203104.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000032453.

    PTM databases

    PhosphoSitei Q9QYU1.

    Proteomic databases

    PaxDbi Q9QYU1.
    PRIDEi Q9QYU1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1306913. rat.

    Organism-specific databases

    RGDi 1306913. Pex19.

    Phylogenomic databases

    eggNOGi NOG133983.
    HOGENOMi HOG000038537.
    HOVERGENi HBG053573.
    InParanoidi Q9QYU1.
    PhylomeDBi Q9QYU1.

    Gene expression databases

    Genevestigatori Q9QYU1.

    Family and domain databases

    InterProi IPR006708. Pex19.
    [Graphical view ]
    PANTHERi PTHR12774. PTHR12774. 1 hit.
    Pfami PF04614. Pex19. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kammerer S.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPEX19_RAT
    AccessioniPrimary (citable) accession number: Q9QYU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3