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Q9QYU1

- PEX19_RAT

UniProt

Q9QYU1 - PEX19_RAT

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Protein

Peroxisomal biogenesis factor 19

Gene
Pex19, Pxf
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. peroxisome organization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 19
Alternative name(s):
Peroxin-19
Peroxisomal farnesylated protein
Gene namesi
Name:Pex19
Synonyms:Pxf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306913. Pex19.

Subcellular locationi

Cytoplasm By similarity. Peroxisome membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes By similarity.

GO - Cellular componenti

  1. brush border membrane Source: RGD
  2. cytoplasm Source: UniProtKB
  3. peroxisomal membrane Source: UniProtKB-SubCell
  4. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 296295Peroxisomal biogenesis factor 19PRO_0000218761Add
BLAST
Propeptidei297 – 2993Removed in mature form By similarityPRO_0000396703

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei35 – 351Phosphoserine By similarity
Modified residuei296 – 2961Cysteine methyl ester By similarity
Lipidationi296 – 2961S-farnesyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ9QYU1.
PRIDEiQ9QYU1.

PTM databases

PhosphoSiteiQ9QYU1.

Expressioni

Gene expression databases

GenevestigatoriQ9QYU1.

Interactioni

Subunit structurei

Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032453.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 9190Necessary for PEX19 function on peroxisome biogenesis By similarityAdd
BLAST
Regioni2 – 5655Docking to the peroxisome membrane and binding to PEX3 By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peroxin-19 family.

Phylogenomic databases

eggNOGiNOG133983.
HOGENOMiHOG000038537.
HOVERGENiHBG053573.
InParanoidiQ9QYU1.
PhylomeDBiQ9QYU1.

Family and domain databases

InterProiIPR006708. Pex19.
[Graphical view]
PANTHERiPTHR12774. PTHR12774. 1 hit.
PfamiPF04614. Pex19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYU1-1 [UniParc]FASTAAdd to Basket

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MAAAEGGCGA GVEADRELEE LLESALDDFD KAKPSPAPSP TISAPDASGP    50
QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH 100
LVEQFQKLSE AAGRVGSDAS SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE 150
EELTKAMEGL GMDEGDGEGN ILPIMQSLMQ NLLSKDVLYP SLKEITEKYP 200
EWLQSHQESI PPEQFEKYQQ QHSVMGKICE QFEAETPTDS EATHRARFEA 250
VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM 299
Length:299
Mass (Da):32,497
Last modified:May 1, 2000 - v1
Checksum:i8EDD55F1D26E53A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09049 mRNA. Translation: CAA70258.1.
UniGeneiRn.203104.

Genome annotation databases

UCSCiRGD:1306913. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09049 mRNA. Translation: CAA70258.1 .
UniGenei Rn.203104.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000032453.

PTM databases

PhosphoSitei Q9QYU1.

Proteomic databases

PaxDbi Q9QYU1.
PRIDEi Q9QYU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1306913. rat.

Organism-specific databases

RGDi 1306913. Pex19.

Phylogenomic databases

eggNOGi NOG133983.
HOGENOMi HOG000038537.
HOVERGENi HBG053573.
InParanoidi Q9QYU1.
PhylomeDBi Q9QYU1.

Gene expression databases

Genevestigatori Q9QYU1.

Family and domain databases

InterProi IPR006708. Pex19.
[Graphical view ]
PANTHERi PTHR12774. PTHR12774. 1 hit.
Pfami PF04614. Pex19. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kammerer S.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPEX19_RAT
AccessioniPrimary (citable) accession number: Q9QYU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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