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Q9QYU1 (PEX19_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peroxisomal biogenesis factor 19
Alternative name(s):
Peroxin-19
Peroxisomal farnesylated protein
Gene names
Name:Pex19
Synonyms:Pxf
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 By similarity.

Subunit structure

Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF By similarity.

Subcellular location

Cytoplasm By similarity. Peroxisome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes By similarity.

Sequence similarities

Belongs to the peroxin-19 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 296295Peroxisomal biogenesis factor 19
PRO_0000218761
Propeptide297 – 2993Removed in mature form By similarity
PRO_0000396703

Regions

Region2 – 9190Necessary for PEX19 function on peroxisome biogenesis By similarity
Region2 – 5655Docking to the peroxisome membrane and binding to PEX3 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue351Phosphoserine By similarity
Modified residue2961Cysteine methyl ester By similarity
Lipidation2961S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYU1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8EDD55F1D26E53A4

FASTA29932,497
        10         20         30         40         50         60 
MAAAEGGCGA GVEADRELEE LLESALDDFD KAKPSPAPSP TISAPDASGP QKRSPGDTAK 

        70         80         90        100        110        120 
DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDAS 

       130        140        150        160        170        180 
SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE EELTKAMEGL GMDEGDGEGN ILPIMQSLMQ 

       190        200        210        220        230        240 
NLLSKDVLYP SLKEITEKYP EWLQSHQESI PPEQFEKYQQ QHSVMGKICE QFEAETPTDS 

       250        260        270        280        290 
EATHRARFEA VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM 

« Hide

References

[1]Kammerer S.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09049 mRNA. Translation: CAA70258.1.
UniGeneRn.203104.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000032453.

PTM databases

PhosphoSiteQ9QYU1.

Proteomic databases

PaxDbQ9QYU1.
PRIDEQ9QYU1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:1306913. rat.

Organism-specific databases

RGD1306913. Pex19.

Phylogenomic databases

eggNOGNOG133983.
HOGENOMHOG000038537.
HOVERGENHBG053573.
InParanoidQ9QYU1.
PhylomeDBQ9QYU1.

Gene expression databases

GenevestigatorQ9QYU1.

Family and domain databases

InterProIPR006708. Pex19.
[Graphical view]
PANTHERPTHR12774. PTHR12774. 1 hit.
PfamPF04614. Pex19. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePEX19_RAT
AccessionPrimary (citable) accession number: Q9QYU1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families