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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

Gene

Pigq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC:2.4.1.198)
Alternative name(s):
MGpi1p
N-acetylglucosamyl transferase component GPI1
Phosphatidylinositol-glycan biosynthesis class Q protein
Short name:
PIG-Q
Gene namesi
Name:Pigq
Synonyms:Gpi1h, Mgpi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333114. Pigq.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei276 – 298HelicalSequence analysisAdd BLAST23
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Transmembranei381 – 403HelicalSequence analysisAdd BLAST23
Transmembranei446 – 468HelicalSequence analysisAdd BLAST23
Transmembranei478 – 500HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002156652 – 581Phosphatidylinositol N-acetylglucosaminyltransferase subunit QAdd BLAST580

Proteomic databases

EPDiQ9QYT7.
MaxQBiQ9QYT7.
PaxDbiQ9QYT7.
PRIDEiQ9QYT7.

PTM databases

iPTMnetiQ9QYT7.
PhosphoSitePlusiQ9QYT7.
SwissPalmiQ9QYT7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025728.
ExpressionAtlasiQ9QYT7. baseline and differential.
GenevisibleiQ9QYT7. MM.

Interactioni

Subunit structurei

Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026823.

Structurei

3D structure databases

ProteinModelPortaliQ9QYT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGQ family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1183. Eukaryota.
ENOG410XSXI. LUCA.
GeneTreeiENSGT00390000004994.
HOGENOMiHOG000070446.
HOVERGENiHBG036559.
InParanoidiQ9QYT7.
KOiK03860.
PhylomeDBiQ9QYT7.
TreeFamiTF321258.

Family and domain databases

InterProiIPR007720. GlcNAc_Gpi1.
[Graphical view]
PfamiPF05024. Gpi1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLKVFFPTC CASADSGLLV GRWVPGQSSA VILAVVHFPF IPIQVKELLA
60 70 80 90 100
QVQKASQVPV AVLGTWCHRQ QEPQESLGNF LEGLGTIFSH DPWLQLCRER
110 120 130 140 150
GTRLWSCKAT YPQMSNPLDM HPEEQVMLIF YDQRKLLLSW LHPPPVLPAC
160 170 180 190 200
QMGDTTASTG GLADIFDTVA RSEVLFRNDQ FDERPVRLSH WQSEGVEASI
210 220 230 240 250
LVELAKRASG PVCLLLASLL SLISAASACR LWKLWPLSFI RSKLSTCEQL
260 270 280 290 300
HHRLKHLSFI FSTEKAQNPM QLMRKANMLV SVLLDVALGL LLLSWLHSNN
310 320 330 340 350
RIGQLANALV PVADRVAEEL QHLLQWLMGA PAGLKMNRAL DQVLGRFFLY
360 370 380 390 400
HIHLWISYIH LMSPFIEHIL WHVGLSACLG LTVALSIFSD IIALLTFHIY
410 420 430 440 450
CFYVYGARLY CLKIYGLSSL WRLFRGKKWN VLRQRVDSCS YDLDQLFIGT
460 470 480 490 500
LLFTILVFLL PTTALYYLVF TLLRLLVITV QGLIHLLVDL INSLPLYSLG
510 520 530 540 550
LRLCRPYRLA AGVKFRVLEK EAGRPLRLLM QINPLSYNHV MHIYRLPRCG
560 570 580
CHPKHSWGTL CRKLVFGELI YPWRQREDKQ D
Length:581
Mass (Da):66,264
Last modified:January 23, 2007 - v3
Checksum:i081084B32D09D7E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5V → A in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti28S → N in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti59 – 61PVA → QVT in AAC79574 (PubMed:9729469).Curated3
Sequence conflicti74Q → E in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti79N → K in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti86T → A in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti91D → N in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti100R → K in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti104L → F in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti112P → H in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti116 – 124NPLDMHPEE → STLDTPTED in AAC79574 (PubMed:9729469).Curated9
Sequence conflicti149A → D in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti152M → I in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti155T → S in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti184R → G in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti235W → G in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti238S → A in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti251H → Q in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti268N → S in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti467Y → C in BAA23615 (PubMed:10373468).Curated1
Sequence conflicti536 – 543SYNHVMHI → PYSHVVHT in AAC79574 (PubMed:9729469).Curated8
Sequence conflicti548R → S in AAC79574 (PubMed:9729469).Curated1
Sequence conflicti565V → F in AAC79574 (PubMed:9729469).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030178 mRNA. Translation: AAC79574.1.
AB008895 mRNA. Translation: BAA23615.1.
AB008921 Genomic DNA. Translation: BAA84658.1.
BC014287 mRNA. Translation: AAH14287.1.
BC003917 mRNA. Translation: AAH03917.1.
CCDSiCCDS28538.1.
RefSeqiNP_035952.2. NM_011822.4.
UniGeneiMm.362054.

Genome annotation databases

EnsembliENSMUST00000026823; ENSMUSP00000026823; ENSMUSG00000025728.
ENSMUST00000208043; ENSMUSP00000146704; ENSMUSG00000025728.
GeneIDi14755.
KEGGimmu:14755.
UCSCiuc008bcp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030178 mRNA. Translation: AAC79574.1.
AB008895 mRNA. Translation: BAA23615.1.
AB008921 Genomic DNA. Translation: BAA84658.1.
BC014287 mRNA. Translation: AAH14287.1.
BC003917 mRNA. Translation: AAH03917.1.
CCDSiCCDS28538.1.
RefSeqiNP_035952.2. NM_011822.4.
UniGeneiMm.362054.

3D structure databases

ProteinModelPortaliQ9QYT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026823.

PTM databases

iPTMnetiQ9QYT7.
PhosphoSitePlusiQ9QYT7.
SwissPalmiQ9QYT7.

Proteomic databases

EPDiQ9QYT7.
MaxQBiQ9QYT7.
PaxDbiQ9QYT7.
PRIDEiQ9QYT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026823; ENSMUSP00000026823; ENSMUSG00000025728.
ENSMUST00000208043; ENSMUSP00000146704; ENSMUSG00000025728.
GeneIDi14755.
KEGGimmu:14755.
UCSCiuc008bcp.2. mouse.

Organism-specific databases

CTDi9091.
MGIiMGI:1333114. Pigq.

Phylogenomic databases

eggNOGiKOG1183. Eukaryota.
ENOG410XSXI. LUCA.
GeneTreeiENSGT00390000004994.
HOGENOMiHOG000070446.
HOVERGENiHBG036559.
InParanoidiQ9QYT7.
KOiK03860.
PhylomeDBiQ9QYT7.
TreeFamiTF321258.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiR-MMU-162710. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

ChiTaRSiPigq. mouse.
PROiQ9QYT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025728.
ExpressionAtlasiQ9QYT7. baseline and differential.
GenevisibleiQ9QYT7. MM.

Family and domain databases

InterProiIPR007720. GlcNAc_Gpi1.
[Graphical view]
PfamiPF05024. Gpi1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGQ_MOUSE
AccessioniPrimary (citable) accession number: Q9QYT7
Secondary accession number(s): O35120, O35456, Q99L11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.