Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QYT7

- PIGQ_MOUSE

UniProt

Q9QYT7 - PIGQ_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

Gene

Pigq

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi

GO - Molecular functioni

  1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. GPI anchor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BRENDAi2.4.1.198. 3474.
ReactomeiREACT_243945. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC:2.4.1.198)
Alternative name(s):
MGpi1p
N-acetylglucosamyl transferase component GPI1
Phosphatidylinositol-glycan biosynthesis class Q protein
Short name:
PIG-Q
Gene namesi
Name:Pigq
Synonyms:Gpi1h, Mgpi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333114. Pigq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei276 – 29823HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36623HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40323HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46823HelicalSequence AnalysisAdd
BLAST
Transmembranei478 – 50023HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 581580Phosphatidylinositol N-acetylglucosaminyltransferase subunit QPRO_0000215665Add
BLAST

Proteomic databases

PaxDbiQ9QYT7.
PRIDEiQ9QYT7.

PTM databases

PhosphoSiteiQ9QYT7.

Expressioni

Gene expression databases

BgeeiQ9QYT7.
ExpressionAtlasiQ9QYT7. baseline and differential.
GenevestigatoriQ9QYT7.

Interactioni

Subunit structurei

Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.

Structurei

3D structure databases

ProteinModelPortaliQ9QYT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGQ family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242183.
GeneTreeiENSGT00390000004994.
HOGENOMiHOG000070446.
HOVERGENiHBG036559.
InParanoidiQ9QYT7.
KOiK03860.
PhylomeDBiQ9QYT7.
TreeFamiTF321258.

Family and domain databases

InterProiIPR007720. GlcNAc_Gpi1.
[Graphical view]
PfamiPF05024. Gpi1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLKVFFPTC CASADSGLLV GRWVPGQSSA VILAVVHFPF IPIQVKELLA
60 70 80 90 100
QVQKASQVPV AVLGTWCHRQ QEPQESLGNF LEGLGTIFSH DPWLQLCRER
110 120 130 140 150
GTRLWSCKAT YPQMSNPLDM HPEEQVMLIF YDQRKLLLSW LHPPPVLPAC
160 170 180 190 200
QMGDTTASTG GLADIFDTVA RSEVLFRNDQ FDERPVRLSH WQSEGVEASI
210 220 230 240 250
LVELAKRASG PVCLLLASLL SLISAASACR LWKLWPLSFI RSKLSTCEQL
260 270 280 290 300
HHRLKHLSFI FSTEKAQNPM QLMRKANMLV SVLLDVALGL LLLSWLHSNN
310 320 330 340 350
RIGQLANALV PVADRVAEEL QHLLQWLMGA PAGLKMNRAL DQVLGRFFLY
360 370 380 390 400
HIHLWISYIH LMSPFIEHIL WHVGLSACLG LTVALSIFSD IIALLTFHIY
410 420 430 440 450
CFYVYGARLY CLKIYGLSSL WRLFRGKKWN VLRQRVDSCS YDLDQLFIGT
460 470 480 490 500
LLFTILVFLL PTTALYYLVF TLLRLLVITV QGLIHLLVDL INSLPLYSLG
510 520 530 540 550
LRLCRPYRLA AGVKFRVLEK EAGRPLRLLM QINPLSYNHV MHIYRLPRCG
560 570 580
CHPKHSWGTL CRKLVFGELI YPWRQREDKQ D
Length:581
Mass (Da):66,264
Last modified:January 23, 2007 - v3
Checksum:i081084B32D09D7E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → A in AAC79574. (PubMed:9729469)Curated
Sequence conflicti28 – 281S → N in AAC79574. (PubMed:9729469)Curated
Sequence conflicti59 – 613PVA → QVT in AAC79574. (PubMed:9729469)Curated
Sequence conflicti74 – 741Q → E in AAC79574. (PubMed:9729469)Curated
Sequence conflicti79 – 791N → K in AAC79574. (PubMed:9729469)Curated
Sequence conflicti86 – 861T → A in AAC79574. (PubMed:9729469)Curated
Sequence conflicti91 – 911D → N in AAC79574. (PubMed:9729469)Curated
Sequence conflicti100 – 1001R → K in AAC79574. (PubMed:9729469)Curated
Sequence conflicti104 – 1041L → F in AAC79574. (PubMed:9729469)Curated
Sequence conflicti112 – 1121P → H in AAC79574. (PubMed:9729469)Curated
Sequence conflicti116 – 1249NPLDMHPEE → STLDTPTED in AAC79574. (PubMed:9729469)Curated
Sequence conflicti149 – 1491A → D in AAC79574. (PubMed:9729469)Curated
Sequence conflicti152 – 1521M → I in AAC79574. (PubMed:9729469)Curated
Sequence conflicti155 – 1551T → S in AAC79574. (PubMed:9729469)Curated
Sequence conflicti184 – 1841R → G in AAC79574. (PubMed:9729469)Curated
Sequence conflicti235 – 2351W → G in AAC79574. (PubMed:9729469)Curated
Sequence conflicti238 – 2381S → A in AAC79574. (PubMed:9729469)Curated
Sequence conflicti251 – 2511H → Q in AAC79574. (PubMed:9729469)Curated
Sequence conflicti268 – 2681N → S in AAC79574. (PubMed:9729469)Curated
Sequence conflicti467 – 4671Y → C in BAA23615. (PubMed:10373468)Curated
Sequence conflicti536 – 5438SYNHVMHI → PYSHVVHT in AAC79574. (PubMed:9729469)Curated
Sequence conflicti548 – 5481R → S in AAC79574. (PubMed:9729469)Curated
Sequence conflicti565 – 5651V → F in AAC79574. (PubMed:9729469)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030178 mRNA. Translation: AAC79574.1.
AB008895 mRNA. Translation: BAA23615.1.
AB008921 Genomic DNA. Translation: BAA84658.1.
BC014287 mRNA. Translation: AAH14287.1.
BC003917 mRNA. Translation: AAH03917.1.
CCDSiCCDS28538.1.
RefSeqiNP_035952.2. NM_011822.4.
UniGeneiMm.362054.

Genome annotation databases

EnsembliENSMUST00000026823; ENSMUSP00000026823; ENSMUSG00000025728.
GeneIDi14755.
KEGGimmu:14755.
UCSCiuc008bcp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030178 mRNA. Translation: AAC79574.1 .
AB008895 mRNA. Translation: BAA23615.1 .
AB008921 Genomic DNA. Translation: BAA84658.1 .
BC014287 mRNA. Translation: AAH14287.1 .
BC003917 mRNA. Translation: AAH03917.1 .
CCDSi CCDS28538.1.
RefSeqi NP_035952.2. NM_011822.4.
UniGenei Mm.362054.

3D structure databases

ProteinModelPortali Q9QYT7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYT7.

Proteomic databases

PaxDbi Q9QYT7.
PRIDEi Q9QYT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026823 ; ENSMUSP00000026823 ; ENSMUSG00000025728 .
GeneIDi 14755.
KEGGi mmu:14755.
UCSCi uc008bcp.1. mouse.

Organism-specific databases

CTDi 9091.
MGIi MGI:1333114. Pigq.

Phylogenomic databases

eggNOGi NOG242183.
GeneTreei ENSGT00390000004994.
HOGENOMi HOG000070446.
HOVERGENi HBG036559.
InParanoidi Q9QYT7.
KOi K03860.
PhylomeDBi Q9QYT7.
TreeFami TF321258.

Enzyme and pathway databases

UniPathwayi UPA00196 .
BRENDAi 2.4.1.198. 3474.
Reactomei REACT_243945. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

ChiTaRSi Pigq. mouse.
NextBioi 286819.
PROi Q9QYT7.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYT7.
ExpressionAtlasi Q9QYT7. baseline and differential.
Genevestigatori Q9QYT7.

Family and domain databases

InterProi IPR007720. GlcNAc_Gpi1.
[Graphical view ]
Pfami PF05024. Gpi1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants."
    Tiede A., Schubert J., Nischan C., Jensen I., Westfall B., Taron C.H., Orlean P., Schmidt R.E.
    Biochem. J. 334:609-616(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis."
    Hong Y., Ohishi K., Watanabe R., Endo Y., Maeda Y., Kinoshita T.
    J. Biol. Chem. 274:18582-18588(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor and Salivary gland.

Entry informationi

Entry nameiPIGQ_MOUSE
AccessioniPrimary (citable) accession number: Q9QYT7
Secondary accession number(s): O35120, O35456, Q99L11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3