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Q9QYT7

- PIGQ_MOUSE

UniProt

Q9QYT7 - PIGQ_MOUSE

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Protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
Gene
Pigq, Gpi1h, Mgpi1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi

GO - Molecular functioni

  1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. GPI anchor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BRENDAi2.4.1.198. 3474.
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC:2.4.1.198)
Alternative name(s):
MGpi1p
N-acetylglucosamyl transferase component GPI1
Phosphatidylinositol-glycan biosynthesis class Q protein
Short name:
PIG-Q
Gene namesi
Name:Pigq
Synonyms:Gpi1h, Mgpi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333114. Pigq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei276 – 29823Helical; Reviewed prediction
Add
BLAST
Transmembranei344 – 36623Helical; Reviewed prediction
Add
BLAST
Transmembranei381 – 40323Helical; Reviewed prediction
Add
BLAST
Transmembranei446 – 46823Helical; Reviewed prediction
Add
BLAST
Transmembranei478 – 50023Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 581580Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
PRO_0000215665Add
BLAST

Proteomic databases

PaxDbiQ9QYT7.
PRIDEiQ9QYT7.

PTM databases

PhosphoSiteiQ9QYT7.

Expressioni

Gene expression databases

ArrayExpressiQ9QYT7.
BgeeiQ9QYT7.
GenevestigatoriQ9QYT7.

Interactioni

Subunit structurei

Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.

Structurei

3D structure databases

ProteinModelPortaliQ9QYT7.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGQ family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242183.
GeneTreeiENSGT00390000004994.
HOGENOMiHOG000070446.
HOVERGENiHBG036559.
KOiK03860.
PhylomeDBiQ9QYT7.
TreeFamiTF321258.

Family and domain databases

InterProiIPR007720. GlcNAc_Gpi1.
[Graphical view]
PfamiPF05024. Gpi1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYT7-1 [UniParc]FASTAAdd to Basket

« Hide

MVLKVFFPTC CASADSGLLV GRWVPGQSSA VILAVVHFPF IPIQVKELLA    50
QVQKASQVPV AVLGTWCHRQ QEPQESLGNF LEGLGTIFSH DPWLQLCRER 100
GTRLWSCKAT YPQMSNPLDM HPEEQVMLIF YDQRKLLLSW LHPPPVLPAC 150
QMGDTTASTG GLADIFDTVA RSEVLFRNDQ FDERPVRLSH WQSEGVEASI 200
LVELAKRASG PVCLLLASLL SLISAASACR LWKLWPLSFI RSKLSTCEQL 250
HHRLKHLSFI FSTEKAQNPM QLMRKANMLV SVLLDVALGL LLLSWLHSNN 300
RIGQLANALV PVADRVAEEL QHLLQWLMGA PAGLKMNRAL DQVLGRFFLY 350
HIHLWISYIH LMSPFIEHIL WHVGLSACLG LTVALSIFSD IIALLTFHIY 400
CFYVYGARLY CLKIYGLSSL WRLFRGKKWN VLRQRVDSCS YDLDQLFIGT 450
LLFTILVFLL PTTALYYLVF TLLRLLVITV QGLIHLLVDL INSLPLYSLG 500
LRLCRPYRLA AGVKFRVLEK EAGRPLRLLM QINPLSYNHV MHIYRLPRCG 550
CHPKHSWGTL CRKLVFGELI YPWRQREDKQ D 581
Length:581
Mass (Da):66,264
Last modified:January 23, 2007 - v3
Checksum:i081084B32D09D7E6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → A in AAC79574. 1 Publication
Sequence conflicti28 – 281S → N in AAC79574. 1 Publication
Sequence conflicti59 – 613PVA → QVT in AAC79574. 1 Publication
Sequence conflicti74 – 741Q → E in AAC79574. 1 Publication
Sequence conflicti79 – 791N → K in AAC79574. 1 Publication
Sequence conflicti86 – 861T → A in AAC79574. 1 Publication
Sequence conflicti91 – 911D → N in AAC79574. 1 Publication
Sequence conflicti100 – 1001R → K in AAC79574. 1 Publication
Sequence conflicti104 – 1041L → F in AAC79574. 1 Publication
Sequence conflicti112 – 1121P → H in AAC79574. 1 Publication
Sequence conflicti116 – 1249NPLDMHPEE → STLDTPTED in AAC79574. 1 Publication
Sequence conflicti149 – 1491A → D in AAC79574. 1 Publication
Sequence conflicti152 – 1521M → I in AAC79574. 1 Publication
Sequence conflicti155 – 1551T → S in AAC79574. 1 Publication
Sequence conflicti184 – 1841R → G in AAC79574. 1 Publication
Sequence conflicti235 – 2351W → G in AAC79574. 1 Publication
Sequence conflicti238 – 2381S → A in AAC79574. 1 Publication
Sequence conflicti251 – 2511H → Q in AAC79574. 1 Publication
Sequence conflicti268 – 2681N → S in AAC79574. 1 Publication
Sequence conflicti467 – 4671Y → C in BAA23615. 1 Publication
Sequence conflicti536 – 5438SYNHVMHI → PYSHVVHT in AAC79574. 1 Publication
Sequence conflicti548 – 5481R → S in AAC79574. 1 Publication
Sequence conflicti565 – 5651V → F in AAC79574. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030178 mRNA. Translation: AAC79574.1.
AB008895 mRNA. Translation: BAA23615.1.
AB008921 Genomic DNA. Translation: BAA84658.1.
BC014287 mRNA. Translation: AAH14287.1.
BC003917 mRNA. Translation: AAH03917.1.
CCDSiCCDS28538.1.
RefSeqiNP_035952.2. NM_011822.4.
UniGeneiMm.362054.

Genome annotation databases

EnsembliENSMUST00000026823; ENSMUSP00000026823; ENSMUSG00000025728.
GeneIDi14755.
KEGGimmu:14755.
UCSCiuc008bcp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030178 mRNA. Translation: AAC79574.1 .
AB008895 mRNA. Translation: BAA23615.1 .
AB008921 Genomic DNA. Translation: BAA84658.1 .
BC014287 mRNA. Translation: AAH14287.1 .
BC003917 mRNA. Translation: AAH03917.1 .
CCDSi CCDS28538.1.
RefSeqi NP_035952.2. NM_011822.4.
UniGenei Mm.362054.

3D structure databases

ProteinModelPortali Q9QYT7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYT7.

Proteomic databases

PaxDbi Q9QYT7.
PRIDEi Q9QYT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026823 ; ENSMUSP00000026823 ; ENSMUSG00000025728 .
GeneIDi 14755.
KEGGi mmu:14755.
UCSCi uc008bcp.1. mouse.

Organism-specific databases

CTDi 9091.
MGIi MGI:1333114. Pigq.

Phylogenomic databases

eggNOGi NOG242183.
GeneTreei ENSGT00390000004994.
HOGENOMi HOG000070446.
HOVERGENi HBG036559.
KOi K03860.
PhylomeDBi Q9QYT7.
TreeFami TF321258.

Enzyme and pathway databases

UniPathwayi UPA00196 .
BRENDAi 2.4.1.198. 3474.

Miscellaneous databases

ChiTaRSi PIGQ. mouse.
NextBioi 286819.
PROi Q9QYT7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QYT7.
Bgeei Q9QYT7.
Genevestigatori Q9QYT7.

Family and domain databases

InterProi IPR007720. GlcNAc_Gpi1.
[Graphical view ]
Pfami PF05024. Gpi1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants."
    Tiede A., Schubert J., Nischan C., Jensen I., Westfall B., Taron C.H., Orlean P., Schmidt R.E.
    Biochem. J. 334:609-616(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis."
    Hong Y., Ohishi K., Watanabe R., Endo Y., Maeda Y., Kinoshita T.
    J. Biol. Chem. 274:18582-18588(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor and Salivary gland.

Entry informationi

Entry nameiPIGQ_MOUSE
AccessioniPrimary (citable) accession number: Q9QYT7
Secondary accession number(s): O35120, O35456, Q99L11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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