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Q9QYT7

- PIGQ_MOUSE

UniProt

Q9QYT7 - PIGQ_MOUSE

Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

Gene

Pigq

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    BRENDAi2.4.1.198. 3474.
    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC:2.4.1.198)
    Alternative name(s):
    MGpi1p
    N-acetylglucosamyl transferase component GPI1
    Phosphatidylinositol-glycan biosynthesis class Q protein
    Short name:
    PIG-Q
    Gene namesi
    Name:Pigq
    Synonyms:Gpi1h, Mgpi1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1333114. Pigq.

    Subcellular locationi

    GO - Cellular componenti

    1. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 581580Phosphatidylinositol N-acetylglucosaminyltransferase subunit QPRO_0000215665Add
    BLAST

    Proteomic databases

    PaxDbiQ9QYT7.
    PRIDEiQ9QYT7.

    PTM databases

    PhosphoSiteiQ9QYT7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QYT7.
    BgeeiQ9QYT7.
    GenevestigatoriQ9QYT7.

    Interactioni

    Subunit structurei

    Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei276 – 29823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 50023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGQ family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242183.
    GeneTreeiENSGT00390000004994.
    HOGENOMiHOG000070446.
    HOVERGENiHBG036559.
    KOiK03860.
    PhylomeDBiQ9QYT7.
    TreeFamiTF321258.

    Family and domain databases

    InterProiIPR007720. GlcNAc_Gpi1.
    [Graphical view]
    PfamiPF05024. Gpi1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYT7-1 [UniParc]FASTAAdd to Basket

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    MVLKVFFPTC CASADSGLLV GRWVPGQSSA VILAVVHFPF IPIQVKELLA    50
    QVQKASQVPV AVLGTWCHRQ QEPQESLGNF LEGLGTIFSH DPWLQLCRER 100
    GTRLWSCKAT YPQMSNPLDM HPEEQVMLIF YDQRKLLLSW LHPPPVLPAC 150
    QMGDTTASTG GLADIFDTVA RSEVLFRNDQ FDERPVRLSH WQSEGVEASI 200
    LVELAKRASG PVCLLLASLL SLISAASACR LWKLWPLSFI RSKLSTCEQL 250
    HHRLKHLSFI FSTEKAQNPM QLMRKANMLV SVLLDVALGL LLLSWLHSNN 300
    RIGQLANALV PVADRVAEEL QHLLQWLMGA PAGLKMNRAL DQVLGRFFLY 350
    HIHLWISYIH LMSPFIEHIL WHVGLSACLG LTVALSIFSD IIALLTFHIY 400
    CFYVYGARLY CLKIYGLSSL WRLFRGKKWN VLRQRVDSCS YDLDQLFIGT 450
    LLFTILVFLL PTTALYYLVF TLLRLLVITV QGLIHLLVDL INSLPLYSLG 500
    LRLCRPYRLA AGVKFRVLEK EAGRPLRLLM QINPLSYNHV MHIYRLPRCG 550
    CHPKHSWGTL CRKLVFGELI YPWRQREDKQ D 581
    Length:581
    Mass (Da):66,264
    Last modified:January 23, 2007 - v3
    Checksum:i081084B32D09D7E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51V → A in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti28 – 281S → N in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti59 – 613PVA → QVT in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti74 – 741Q → E in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti79 – 791N → K in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti86 – 861T → A in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti91 – 911D → N in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti100 – 1001R → K in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti104 – 1041L → F in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti112 – 1121P → H in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti116 – 1249NPLDMHPEE → STLDTPTED in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti149 – 1491A → D in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti152 – 1521M → I in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti155 – 1551T → S in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti184 – 1841R → G in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti235 – 2351W → G in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti238 – 2381S → A in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti251 – 2511H → Q in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti268 – 2681N → S in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti467 – 4671Y → C in BAA23615. (PubMed:10373468)Curated
    Sequence conflicti536 – 5438SYNHVMHI → PYSHVVHT in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti548 – 5481R → S in AAC79574. (PubMed:9729469)Curated
    Sequence conflicti565 – 5651V → F in AAC79574. (PubMed:9729469)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030178 mRNA. Translation: AAC79574.1.
    AB008895 mRNA. Translation: BAA23615.1.
    AB008921 Genomic DNA. Translation: BAA84658.1.
    BC014287 mRNA. Translation: AAH14287.1.
    BC003917 mRNA. Translation: AAH03917.1.
    CCDSiCCDS28538.1.
    RefSeqiNP_035952.2. NM_011822.4.
    UniGeneiMm.362054.

    Genome annotation databases

    EnsembliENSMUST00000026823; ENSMUSP00000026823; ENSMUSG00000025728.
    GeneIDi14755.
    KEGGimmu:14755.
    UCSCiuc008bcp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030178 mRNA. Translation: AAC79574.1 .
    AB008895 mRNA. Translation: BAA23615.1 .
    AB008921 Genomic DNA. Translation: BAA84658.1 .
    BC014287 mRNA. Translation: AAH14287.1 .
    BC003917 mRNA. Translation: AAH03917.1 .
    CCDSi CCDS28538.1.
    RefSeqi NP_035952.2. NM_011822.4.
    UniGenei Mm.362054.

    3D structure databases

    ProteinModelPortali Q9QYT7.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QYT7.

    Proteomic databases

    PaxDbi Q9QYT7.
    PRIDEi Q9QYT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026823 ; ENSMUSP00000026823 ; ENSMUSG00000025728 .
    GeneIDi 14755.
    KEGGi mmu:14755.
    UCSCi uc008bcp.1. mouse.

    Organism-specific databases

    CTDi 9091.
    MGIi MGI:1333114. Pigq.

    Phylogenomic databases

    eggNOGi NOG242183.
    GeneTreei ENSGT00390000004994.
    HOGENOMi HOG000070446.
    HOVERGENi HBG036559.
    KOi K03860.
    PhylomeDBi Q9QYT7.
    TreeFami TF321258.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .
    BRENDAi 2.4.1.198. 3474.

    Miscellaneous databases

    ChiTaRSi PIGQ. mouse.
    NextBioi 286819.
    PROi Q9QYT7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYT7.
    Bgeei Q9QYT7.
    Genevestigatori Q9QYT7.

    Family and domain databases

    InterProi IPR007720. GlcNAc_Gpi1.
    [Graphical view ]
    Pfami PF05024. Gpi1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants."
      Tiede A., Schubert J., Nischan C., Jensen I., Westfall B., Taron C.H., Orlean P., Schmidt R.E.
      Biochem. J. 334:609-616(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    2. "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis."
      Hong Y., Ohishi K., Watanabe R., Endo Y., Maeda Y., Kinoshita T.
      J. Biol. Chem. 274:18582-18588(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor and Salivary gland.

    Entry informationi

    Entry nameiPIGQ_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYT7
    Secondary accession number(s): O35120, O35456, Q99L11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3