Metabotropic glutamate receptor 3 precursor

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Q9QYS2 (GRM3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 3
Short name=mGluR3

Gene names

Name:	Grm3
Synonyms:	Gprc1c, Mglur3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	879 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
Subunit structure	Interacts with GRASP By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of sensory perception of pain Non-traceable author statement PubMed 11099825. Source: UniProtKB regulation of synaptic transmission Inferred from electronic annotation. Source: Compara sensory perception of pain Traceable author statement PubMed 11099825. Source: UniProtKB synaptic transmission, glutamatergic Traceable author statement PubMed 11591452. Source: UniProtKB
Cellular_component	axon Inferred from direct assay PubMed 11591452. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 11591452. Source: UniProtKB postsynaptic density Inferred from direct assay PubMed 15579147. Source: MGI postsynaptic membrane Inferred from direct assay PubMed 11591452. Source: UniProtKB presynaptic active zone Non-traceable author statement PubMed 11591452. Source: UniProtKB presynaptic membrane Inferred from direct assay PubMed 11591452. Source: UniProtKB
Molecular_function	calcium channel regulator activity Inferred from direct assay PubMed 7965099. Source: MGI group II metabotropic glutamate receptor activity Inferred from direct assay PubMed 7965099. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Potential

Chain

23 – 879

857

Metabotropic glutamate receptor 3

PRO_0000012928

Regions

Topological domain

23 – 576

554

Extracellular Potential

Transmembrane

577 – 599

Helical; Name=1; Potential

Topological domain

600 – 613

Cytoplasmic Potential

Transmembrane

614 – 634

Helical; Name=2; Potential

Topological domain

635 – 645

Extracellular Potential

Transmembrane

646 – 664

Helical; Name=3; Potential

Topological domain

665 – 688

Cytoplasmic Potential

Transmembrane

689 – 709

Helical; Name=4; Potential

Topological domain

710 – 734

Extracellular Potential

Transmembrane

735 – 756

Helical; Name=5; Potential

Topological domain

757 – 769

Cytoplasmic Potential

Transmembrane

770 – 792

Helical; Name=6; Potential

Topological domain

793 – 802

Extracellular Potential

Transmembrane

803 – 828

Helical; Name=7; Potential

Topological domain

829 – 879

Cytoplasmic Potential

Amino acid modifications

Glycosylation

209

N-linked (GlcNAc...) Potential

Glycosylation

292

N-linked (GlcNAc...) Potential

Glycosylation

414

N-linked (GlcNAc...) Potential

Glycosylation

439

N-linked (GlcNAc...) Potential

Disulfide bond

57 ↔ 99

By similarity

Disulfide bond

240 ↔ 527

By similarity

Disulfide bond

361 ↔ 373

By similarity

Disulfide bond

412 ↔ 419

By similarity

Disulfide bond

509 ↔ 528

By similarity

Disulfide bond

513 ↔ 531

By similarity

Disulfide bond

534 ↔ 546

By similarity

Disulfide bond

549 ↔ 562

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QYS2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F3A8B26CE96679EF
Show »

FASTA

879

99,114

        10         20         30         40         50         60 
MKMLTRLQVL MLALFSKGFL VSLGDHNFMR REIKIEGDLV LGGLFPINEK GTGTEECGRI 

        70         80         90        100        110        120 
NEDRGIQRLE AMLFAIDEIN KDNYLLPGVK LGVHILDTCS RDTYALEQSL EFVRASLTKV 

       130        140        150        160        170        180 
DEAEYMCPDG SYAIQENIPL LIAGVIGGSY SSVSIQVANL LRLFQIPQIS YASTSAKLSD 

       190        200        210        220        230        240 
KSRYDYFART VPPDFYQAKA MAEILRYFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC 

       250        260        270        280        290        300 
IATAEKVGRS NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR VNASFTWVAS 

       310        320        330        340        350        360 
DGWGAQESIV KGSEHVAYGA ITLELASHPV RQFDRYFQSL NPYNNHRNPW FRDFWEQKFQ 

       370        380        390        400        410        420 
CSLQNKRNHR QICDKHLAID SSNYEQESKI MFVVNAVYAM AHALHKMQRT LCPNTTKLCD 

       430        440        450        460        470        480 
AMKILDGKKL YKDYLLKINF TAPFNPNKGA DSIVKFDTYG DGMGRYNVFN FQHIGGKYSY 

       490        500        510        520        530        540 
LKVGHWAETL YLDVDSIHWS RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL 

       550        560        570        580        590        600 
VDEFTCMDCG PGQWPTADLS GCYNLPEDYI RWEDAWAIGP VTIACLGFMC TCIVITVFIK 

       610        620        630        640        650        660 
HNNTPLVKAS GRELCYILLF GVSLSYCMTF FFIAKPSPVI CALRRLGLGT SFAICYSALL 

       670        680        690        700        710        720 
TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI VMVSVWLILE TPGTRRYTLP 

       730        740        750        760        770        780 
EKRETVILKC NVKDSSMLIS LTYDVVLVIL CTVYAFKTRK CPENFNEAKF IGFTMYTTCI 

       790        800        810        820        830        840 
IWLAFLPIFY VTSSDYRVQT TTMCISVSLS GFVVLGCLFA PKVHIVLFQP QKNVVTHRLH 

       850        860        870 
LNRFSVSGTA TTYSQSSAST YVPTVCNGRE VLDSTTSSL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes." Minoshima T., Nakanishi S. J. Biochem. 126:889-896(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF170701 , AF170697, AF170698, AF170699, AF170700 Genomic DNA. Translation: AAF06741.1. BC111891 mRNA. Translation: AAI11892.1. BC113170 mRNA. Translation: AAI13171.1.
IPI	IPI00136716.
PIR	JC7160.
RefSeq	NP_862898.1. NM_181850.2.
UniGene	Mm.318966.
3D structure databases
ProteinModelPortal	Q9QYS2.
SMR	Q9QYS2. Positions 28-567.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QYS2. 2 interactions.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9QYS2.
Proteomic databases
PaxDb	Q9QYS2.
PRIDE	Q9QYS2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000004076; ENSMUSP00000004076; ENSMUSG00000003974.
GeneID	108069.
KEGG	mmu:108069.
UCSC	uc008wll.1. mouse.
Organism-specific databases
CTD	2913.
MGI	MGI:1351340. Grm3.
Phylogenomic databases
eggNOG	NOG295200.
GeneTree	ENSGT00640000091090.
HOGENOM	HOG000218635.
HOVERGEN	HBG107965.
InParanoid	Q14DJ9.
KO	K04605.
OMA	CVDCGPG.
OrthoDB	EOG49ZXNJ.
Gene expression databases
ArrayExpress	Q9QYS2.
Bgee	Q9QYS2.
CleanEx	MM_GRM3.
Genevestigator	Q9QYS2.
GermOnline	ENSMUSG00000003974. Mus musculus.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. IPR000162. GPCR_3_mtglu_rcpt. IPR001234. GPCR_3_mtglu_rcpt_3. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR. PR01053. MTABOTROPC3R. PR00593. MTABOTROPICR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. 1 hit. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9QYS2.
ChEMBL	CHEMBL3824.
NextBio	359984.
SOURCE	Search...

Entry information

Entry name

GRM3_MOUSE

Accession

Primary (citable) accession number: Q9QYS2
Secondary accession number(s): Q14DJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents