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Q9QYS2

- GRM3_MOUSE

UniProt

Q9QYS2 - GRM3_MOUSE

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Protein
Metabotropic glutamate receptor 3
Gene
Grm3, Gprc1c, Mglur3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511Glutamate By similarity
Binding sitei222 – 2221Glutamate By similarity
Binding sitei301 – 3011Glutamate By similarity
Binding sitei389 – 3891Glutamate By similarity

GO - Molecular functioni

  1. calcium channel regulator activity Source: MGI
  2. group II metabotropic glutamate receptor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: GOC
  2. regulation of sensory perception of pain Source: UniProtKB
  3. regulation of synaptic transmission, glutamatergic Source: RefGenome
  4. sensory perception of pain Source: UniProtKB
  5. synaptic transmission, glutamatergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 3
Short name:
mGluR3
Gene namesi
Name:Grm3
Synonyms:Gprc1c, Mglur3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1351340. Grm3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 576554Extracellular Reviewed prediction
Add
BLAST
Transmembranei577 – 59923Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini600 – 61314Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei614 – 63421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini635 – 64511Extracellular Reviewed prediction
Add
BLAST
Transmembranei646 – 66419Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini665 – 68824Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei689 – 70921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini710 – 73425Extracellular Reviewed prediction
Add
BLAST
Transmembranei735 – 75622Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini757 – 76913Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei770 – 79223Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini793 – 80210Extracellular Reviewed prediction
Transmembranei803 – 82826Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini829 – 87951Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. astrocyte projection Source: Ensembl
  2. axon Source: UniProtKB
  3. dendritic spine Source: UniProtKB
  4. integral component of plasma membrane Source: RefGenome
  5. neuron projection Source: MGI
  6. plasma membrane Source: UniProtKB
  7. postsynaptic density Source: MGI
  8. postsynaptic membrane Source: UniProtKB
  9. presynaptic active zone Source: UniProtKB
  10. presynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 879857Metabotropic glutamate receptor 3
PRO_0000012928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 99 By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi240 ↔ 527 By similarity
Glycosylationi292 – 2921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi361 ↔ 373 By similarity
Disulfide bondi412 ↔ 419 By similarity
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi509 ↔ 528 By similarity
Disulfide bondi513 ↔ 531 By similarity
Disulfide bondi534 ↔ 546 By similarity
Disulfide bondi549 ↔ 562 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QYS2.
PRIDEiQ9QYS2.

PTM databases

PhosphoSiteiQ9QYS2.

Expressioni

Gene expression databases

ArrayExpressiQ9QYS2.
BgeeiQ9QYS2.
CleanExiMM_GRM3.
GenevestigatoriQ9QYS2.

Interactioni

Subunit structurei

Interacts with GRASP By similarity.

Protein-protein interaction databases

IntActiQ9QYS2. 3 interactions.
MINTiMINT-4101874.

Structurei

3D structure databases

ProteinModelPortaliQ9QYS2.
SMRiQ9QYS2. Positions 28-834.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1743Glutamate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00750000117490.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ14DJ9.
KOiK04605.
OMAiCTCIVVT.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ9QYS2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYS2-1 [UniParc]FASTAAdd to Basket

« Hide

MKMLTRLQVL MLALFSKGFL VSLGDHNFMR REIKIEGDLV LGGLFPINEK    50
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDNYLLPGVK LGVHILDTCS 100
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY 150
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA 200
MAEILRYFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS 250
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR VNASFTWVAS 300
DGWGAQESIV KGSEHVAYGA ITLELASHPV RQFDRYFQSL NPYNNHRNPW 350
FRDFWEQKFQ CSLQNKRNHR QICDKHLAID SSNYEQESKI MFVVNAVYAM 400
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKGA 450
DSIVKFDTYG DGMGRYNVFN FQHIGGKYSY LKVGHWAETL YLDVDSIHWS 500
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL VDEFTCMDCG 550
PGQWPTADLS GCYNLPEDYI RWEDAWAIGP VTIACLGFMC TCIVITVFIK 600
HNNTPLVKAS GRELCYILLF GVSLSYCMTF FFIAKPSPVI CALRRLGLGT 650
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI 700
VMVSVWLILE TPGTRRYTLP EKRETVILKC NVKDSSMLIS LTYDVVLVIL 750
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT 800
TTMCISVSLS GFVVLGCLFA PKVHIVLFQP QKNVVTHRLH LNRFSVSGTA 850
TTYSQSSAST YVPTVCNGRE VLDSTTSSL 879
Length:879
Mass (Da):99,114
Last modified:May 1, 2000 - v1
Checksum:iF3A8B26CE96679EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170701
, AF170697, AF170698, AF170699, AF170700 Genomic DNA. Translation: AAF06741.1.
BC111891 mRNA. Translation: AAI11892.1.
BC113170 mRNA. Translation: AAI13171.1.
CCDSiCCDS19090.1.
PIRiJC7160.
RefSeqiNP_862898.1. NM_181850.2.
UniGeneiMm.318966.

Genome annotation databases

EnsembliENSMUST00000004076; ENSMUSP00000004076; ENSMUSG00000003974.
GeneIDi108069.
KEGGimmu:108069.
UCSCiuc008wll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170701
, AF170697 , AF170698 , AF170699 , AF170700 Genomic DNA. Translation: AAF06741.1 .
BC111891 mRNA. Translation: AAI11892.1 .
BC113170 mRNA. Translation: AAI13171.1 .
CCDSi CCDS19090.1.
PIRi JC7160.
RefSeqi NP_862898.1. NM_181850.2.
UniGenei Mm.318966.

3D structure databases

ProteinModelPortali Q9QYS2.
SMRi Q9QYS2. Positions 28-834.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9QYS2. 3 interactions.
MINTi MINT-4101874.

Chemistry

BindingDBi Q9QYS2.
GuidetoPHARMACOLOGYi 291.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QYS2.

Proteomic databases

PaxDbi Q9QYS2.
PRIDEi Q9QYS2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004076 ; ENSMUSP00000004076 ; ENSMUSG00000003974 .
GeneIDi 108069.
KEGGi mmu:108069.
UCSCi uc008wll.1. mouse.

Organism-specific databases

CTDi 2913.
MGIi MGI:1351340. Grm3.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00750000117490.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi Q14DJ9.
KOi K04605.
OMAi CTCIVVT.
OrthoDBi EOG7Z0JXG.
PhylomeDBi Q9QYS2.
TreeFami TF313240.

Miscellaneous databases

NextBioi 359984.
PROi Q9QYS2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QYS2.
Bgeei Q9QYS2.
CleanExi MM_GRM3.
Genevestigatori Q9QYS2.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes."
    Minoshima T., Nakanishi S.
    J. Biochem. 126:889-896(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGRM3_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS2
Secondary accession number(s): Q14DJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi