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Q9QYS2

- GRM3_MOUSE

UniProt

Q9QYS2 - GRM3_MOUSE

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Protein

Metabotropic glutamate receptor 3

Gene

Grm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511GlutamateBy similarity
Binding sitei222 – 2221GlutamateBy similarity
Binding sitei301 – 3011GlutamateBy similarity
Binding sitei389 – 3891GlutamateBy similarity

GO - Molecular functioni

  1. calcium channel regulator activity Source: MGI
  2. group II metabotropic glutamate receptor activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: GOC
  2. regulation of sensory perception of pain Source: UniProtKB
  3. regulation of synaptic transmission, glutamatergic Source: RefGenome
  4. sensory perception of pain Source: UniProtKB
  5. synaptic transmission, glutamatergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 3
Short name:
mGluR3
Gene namesi
Name:Grm3
Synonyms:Gprc1c, Mglur3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1351340. Grm3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 576554ExtracellularSequence AnalysisAdd
BLAST
Transmembranei577 – 59923Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini600 – 61314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei614 – 63421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini635 – 64511ExtracellularSequence AnalysisAdd
BLAST
Transmembranei646 – 66419Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini665 – 68824CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei689 – 70921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini710 – 73425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei735 – 75622Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini757 – 76913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei770 – 79223Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini793 – 80210ExtracellularSequence Analysis
Transmembranei803 – 82826Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini829 – 87951CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. astrocyte projection Source: Ensembl
  2. axon Source: UniProtKB
  3. dendritic spine Source: UniProtKB
  4. integral component of plasma membrane Source: RefGenome
  5. neuron projection Source: MGI
  6. plasma membrane Source: UniProtKB
  7. postsynaptic density Source: MGI
  8. postsynaptic membrane Source: UniProtKB
  9. presynaptic active zone Source: UniProtKB
  10. presynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 879857Metabotropic glutamate receptor 3PRO_0000012928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 99By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi240 ↔ 527By similarity
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi361 ↔ 373By similarity
Disulfide bondi412 ↔ 419By similarity
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi509 ↔ 528By similarity
Disulfide bondi513 ↔ 531By similarity
Disulfide bondi534 ↔ 546By similarity
Disulfide bondi549 ↔ 562By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QYS2.
PaxDbiQ9QYS2.
PRIDEiQ9QYS2.

PTM databases

PhosphoSiteiQ9QYS2.

Expressioni

Gene expression databases

BgeeiQ9QYS2.
CleanExiMM_GRM3.
ExpressionAtlasiQ9QYS2. baseline and differential.
GenevestigatoriQ9QYS2.

Interactioni

Subunit structurei

Interacts with GRASP.By similarity

Protein-protein interaction databases

IntActiQ9QYS2. 3 interactions.
MINTiMINT-4101874.

Structurei

3D structure databases

ProteinModelPortaliQ9QYS2.
SMRiQ9QYS2. Positions 28-670, 686-833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1743Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ9QYS2.
KOiK04605.
OMAiCTCIVVT.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ9QYS2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMLTRLQVL MLALFSKGFL VSLGDHNFMR REIKIEGDLV LGGLFPINEK
60 70 80 90 100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDNYLLPGVK LGVHILDTCS
110 120 130 140 150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY
160 170 180 190 200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA
210 220 230 240 250
MAEILRYFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS
260 270 280 290 300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR VNASFTWVAS
310 320 330 340 350
DGWGAQESIV KGSEHVAYGA ITLELASHPV RQFDRYFQSL NPYNNHRNPW
360 370 380 390 400
FRDFWEQKFQ CSLQNKRNHR QICDKHLAID SSNYEQESKI MFVVNAVYAM
410 420 430 440 450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKGA
460 470 480 490 500
DSIVKFDTYG DGMGRYNVFN FQHIGGKYSY LKVGHWAETL YLDVDSIHWS
510 520 530 540 550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL VDEFTCMDCG
560 570 580 590 600
PGQWPTADLS GCYNLPEDYI RWEDAWAIGP VTIACLGFMC TCIVITVFIK
610 620 630 640 650
HNNTPLVKAS GRELCYILLF GVSLSYCMTF FFIAKPSPVI CALRRLGLGT
660 670 680 690 700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI
710 720 730 740 750
VMVSVWLILE TPGTRRYTLP EKRETVILKC NVKDSSMLIS LTYDVVLVIL
760 770 780 790 800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT
810 820 830 840 850
TTMCISVSLS GFVVLGCLFA PKVHIVLFQP QKNVVTHRLH LNRFSVSGTA
860 870
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
Length:879
Mass (Da):99,114
Last modified:May 1, 2000 - v1
Checksum:iF3A8B26CE96679EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170701
, AF170697, AF170698, AF170699, AF170700 Genomic DNA. Translation: AAF06741.1.
BC111891 mRNA. Translation: AAI11892.1.
BC113170 mRNA. Translation: AAI13171.1.
CCDSiCCDS19090.1.
PIRiJC7160.
RefSeqiNP_862898.1. NM_181850.2.
UniGeneiMm.318966.

Genome annotation databases

EnsembliENSMUST00000004076; ENSMUSP00000004076; ENSMUSG00000003974.
GeneIDi108069.
KEGGimmu:108069.
UCSCiuc008wll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170701
, AF170697 , AF170698 , AF170699 , AF170700 Genomic DNA. Translation: AAF06741.1 .
BC111891 mRNA. Translation: AAI11892.1 .
BC113170 mRNA. Translation: AAI13171.1 .
CCDSi CCDS19090.1.
PIRi JC7160.
RefSeqi NP_862898.1. NM_181850.2.
UniGenei Mm.318966.

3D structure databases

ProteinModelPortali Q9QYS2.
SMRi Q9QYS2. Positions 28-670, 686-833.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QYS2. 3 interactions.
MINTi MINT-4101874.

Chemistry

GuidetoPHARMACOLOGYi 291.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QYS2.

Proteomic databases

MaxQBi Q9QYS2.
PaxDbi Q9QYS2.
PRIDEi Q9QYS2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004076 ; ENSMUSP00000004076 ; ENSMUSG00000003974 .
GeneIDi 108069.
KEGGi mmu:108069.
UCSCi uc008wll.1. mouse.

Organism-specific databases

CTDi 2913.
MGIi MGI:1351340. Grm3.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00760000118884.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi Q9QYS2.
KOi K04605.
OMAi CTCIVVT.
OrthoDBi EOG7Z0JXG.
PhylomeDBi Q9QYS2.
TreeFami TF313240.

Enzyme and pathway databases

Reactomei REACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

ChiTaRSi Grm3. mouse.
NextBioi 359984.
PROi Q9QYS2.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYS2.
CleanExi MM_GRM3.
ExpressionAtlasi Q9QYS2. baseline and differential.
Genevestigatori Q9QYS2.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes."
    Minoshima T., Nakanishi S.
    J. Biochem. 126:889-896(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGRM3_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS2
Secondary accession number(s): Q14DJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3