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Protein

Metabotropic glutamate receptor 3

Gene

Grm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151GlutamateBy similarity1
Binding sitei222GlutamateBy similarity1
Binding sitei301GlutamateBy similarity1
Binding sitei389GlutamateBy similarity1

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI
  • group II metabotropic glutamate receptor activity Source: MGI

GO - Biological processi

  • regulation of sensory perception of pain Source: UniProtKB
  • regulation of synaptic transmission, glutamatergic Source: GO_Central
  • sensory perception of pain Source: UniProtKB
  • synaptic transmission, glutamatergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 3
Short name:
mGluR3
Gene namesi
Name:Grm3
Synonyms:Gprc1c, Mglur3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1351340. Grm3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 576ExtracellularSequence analysisAdd BLAST554
Transmembranei577 – 599Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini600 – 613CytoplasmicSequence analysisAdd BLAST14
Transmembranei614 – 634Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini635 – 645ExtracellularSequence analysisAdd BLAST11
Transmembranei646 – 664Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini665 – 688CytoplasmicSequence analysisAdd BLAST24
Transmembranei689 – 709Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini710 – 734ExtracellularSequence analysisAdd BLAST25
Transmembranei735 – 756Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini757 – 769CytoplasmicSequence analysisAdd BLAST13
Transmembranei770 – 792Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini793 – 802ExtracellularSequence analysis10
Transmembranei803 – 828Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini829 – 879CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • axon Source: UniProtKB
  • dendritic spine Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • neuron projection Source: MGI
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: MGI
  • postsynaptic membrane Source: UniProtKB
  • presynaptic active zone Source: UniProtKB
  • presynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001292823 – 879Metabotropic glutamate receptor 3Add BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 99By similarity
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi240 ↔ 527By similarity
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi361 ↔ 373By similarity
Disulfide bondi412 ↔ 419By similarity
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi509 ↔ 528By similarity
Disulfide bondi513 ↔ 531By similarity
Disulfide bondi534 ↔ 546By similarity
Disulfide bondi549 ↔ 562By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QYS2.
PaxDbiQ9QYS2.
PeptideAtlasiQ9QYS2.
PRIDEiQ9QYS2.

PTM databases

iPTMnetiQ9QYS2.
PhosphoSitePlusiQ9QYS2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003974.
CleanExiMM_GRM3.
GenevisibleiQ9QYS2. MM.

Interactioni

Subunit structurei

Interacts with GRASP.By similarity

Protein-protein interaction databases

IntActiQ9QYS2. 3 interactors.
MINTiMINT-4101874.
STRINGi10090.ENSMUSP00000004076.

Structurei

3D structure databases

ProteinModelPortaliQ9QYS2.
SMRiQ9QYS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 174Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ9QYS2.
KOiK04605.
OMAiCTCIVVT.
OrthoDBiEOG091G177R.
PhylomeDBiQ9QYS2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLTRLQVL MLALFSKGFL VSLGDHNFMR REIKIEGDLV LGGLFPINEK
60 70 80 90 100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDNYLLPGVK LGVHILDTCS
110 120 130 140 150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY
160 170 180 190 200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA
210 220 230 240 250
MAEILRYFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS
260 270 280 290 300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR VNASFTWVAS
310 320 330 340 350
DGWGAQESIV KGSEHVAYGA ITLELASHPV RQFDRYFQSL NPYNNHRNPW
360 370 380 390 400
FRDFWEQKFQ CSLQNKRNHR QICDKHLAID SSNYEQESKI MFVVNAVYAM
410 420 430 440 450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKGA
460 470 480 490 500
DSIVKFDTYG DGMGRYNVFN FQHIGGKYSY LKVGHWAETL YLDVDSIHWS
510 520 530 540 550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL VDEFTCMDCG
560 570 580 590 600
PGQWPTADLS GCYNLPEDYI RWEDAWAIGP VTIACLGFMC TCIVITVFIK
610 620 630 640 650
HNNTPLVKAS GRELCYILLF GVSLSYCMTF FFIAKPSPVI CALRRLGLGT
660 670 680 690 700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI
710 720 730 740 750
VMVSVWLILE TPGTRRYTLP EKRETVILKC NVKDSSMLIS LTYDVVLVIL
760 770 780 790 800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT
810 820 830 840 850
TTMCISVSLS GFVVLGCLFA PKVHIVLFQP QKNVVTHRLH LNRFSVSGTA
860 870
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
Length:879
Mass (Da):99,114
Last modified:May 1, 2000 - v1
Checksum:iF3A8B26CE96679EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170701
, AF170697, AF170698, AF170699, AF170700 Genomic DNA. Translation: AAF06741.1.
BC111891 mRNA. Translation: AAI11892.1.
BC113170 mRNA. Translation: AAI13171.1.
CCDSiCCDS19090.1.
PIRiJC7160.
RefSeqiNP_862898.1. NM_181850.2.
UniGeneiMm.318966.

Genome annotation databases

EnsembliENSMUST00000004076; ENSMUSP00000004076; ENSMUSG00000003974.
GeneIDi108069.
KEGGimmu:108069.
UCSCiuc008wll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170701
, AF170697, AF170698, AF170699, AF170700 Genomic DNA. Translation: AAF06741.1.
BC111891 mRNA. Translation: AAI11892.1.
BC113170 mRNA. Translation: AAI13171.1.
CCDSiCCDS19090.1.
PIRiJC7160.
RefSeqiNP_862898.1. NM_181850.2.
UniGeneiMm.318966.

3D structure databases

ProteinModelPortaliQ9QYS2.
SMRiQ9QYS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QYS2. 3 interactors.
MINTiMINT-4101874.
STRINGi10090.ENSMUSP00000004076.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9QYS2.
PhosphoSitePlusiQ9QYS2.

Proteomic databases

MaxQBiQ9QYS2.
PaxDbiQ9QYS2.
PeptideAtlasiQ9QYS2.
PRIDEiQ9QYS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004076; ENSMUSP00000004076; ENSMUSG00000003974.
GeneIDi108069.
KEGGimmu:108069.
UCSCiuc008wll.1. mouse.

Organism-specific databases

CTDi2913.
MGIiMGI:1351340. Grm3.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ9QYS2.
KOiK04605.
OMAiCTCIVVT.
OrthoDBiEOG091G177R.
PhylomeDBiQ9QYS2.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

ChiTaRSiGrm3. mouse.
PROiQ9QYS2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003974.
CleanExiMM_GRM3.
GenevisibleiQ9QYS2. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRM3_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS2
Secondary accession number(s): Q14DJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.