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Q9QYS2

- GRM3_MOUSE

UniProt

Q9QYS2 - GRM3_MOUSE

Protein

Metabotropic glutamate receptor 3

Gene

Grm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei151 – 1511GlutamateBy similarity
    Binding sitei222 – 2221GlutamateBy similarity
    Binding sitei301 – 3011GlutamateBy similarity
    Binding sitei389 – 3891GlutamateBy similarity

    GO - Molecular functioni

    1. calcium channel regulator activity Source: MGI
    2. group II metabotropic glutamate receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: GOC
    2. regulation of sensory perception of pain Source: UniProtKB
    3. regulation of synaptic transmission, glutamatergic Source: RefGenome
    4. sensory perception of pain Source: UniProtKB
    5. synaptic transmission, glutamatergic Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 3
    Short name:
    mGluR3
    Gene namesi
    Name:Grm3
    Synonyms:Gprc1c, Mglur3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1351340. Grm3.

    Subcellular locationi

    GO - Cellular componenti

    1. astrocyte projection Source: Ensembl
    2. axon Source: UniProtKB
    3. dendritic spine Source: UniProtKB
    4. integral component of plasma membrane Source: RefGenome
    5. neuron projection Source: MGI
    6. plasma membrane Source: UniProtKB
    7. postsynaptic density Source: MGI
    8. postsynaptic membrane Source: UniProtKB
    9. presynaptic active zone Source: UniProtKB
    10. presynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 879857Metabotropic glutamate receptor 3PRO_0000012928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 99By similarity
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi240 ↔ 527By similarity
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi361 ↔ 373By similarity
    Disulfide bondi412 ↔ 419By similarity
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi509 ↔ 528By similarity
    Disulfide bondi513 ↔ 531By similarity
    Disulfide bondi534 ↔ 546By similarity
    Disulfide bondi549 ↔ 562By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9QYS2.
    PRIDEiQ9QYS2.

    PTM databases

    PhosphoSiteiQ9QYS2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QYS2.
    BgeeiQ9QYS2.
    CleanExiMM_GRM3.
    GenevestigatoriQ9QYS2.

    Interactioni

    Subunit structurei

    Interacts with GRASP.By similarity

    Protein-protein interaction databases

    IntActiQ9QYS2. 3 interactions.
    MINTiMINT-4101874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYS2.
    SMRiQ9QYS2. Positions 28-834.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 576554ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini600 – 61314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini635 – 64511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini665 – 68824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini710 – 73425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini757 – 76913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini793 – 80210ExtracellularSequence Analysis
    Topological domaini829 – 87951CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei577 – 59923Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei614 – 63421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei646 – 66419Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei689 – 70921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei735 – 75622Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei770 – 79223Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei803 – 82826Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni172 – 1743Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    GeneTreeiENSGT00750000117490.
    HOGENOMiHOG000218635.
    HOVERGENiHBG107965.
    InParanoidiQ14DJ9.
    KOiK04605.
    OMAiCTCIVVT.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiQ9QYS2.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001234. GPCR_3_mtglu_rcpt_3.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01053. MTABOTROPC3R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYS2-1 [UniParc]FASTAAdd to Basket

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    MKMLTRLQVL MLALFSKGFL VSLGDHNFMR REIKIEGDLV LGGLFPINEK    50
    GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDNYLLPGVK LGVHILDTCS 100
    RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY 150
    SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA 200
    MAEILRYFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS 250
    NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR VNASFTWVAS 300
    DGWGAQESIV KGSEHVAYGA ITLELASHPV RQFDRYFQSL NPYNNHRNPW 350
    FRDFWEQKFQ CSLQNKRNHR QICDKHLAID SSNYEQESKI MFVVNAVYAM 400
    AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKGA 450
    DSIVKFDTYG DGMGRYNVFN FQHIGGKYSY LKVGHWAETL YLDVDSIHWS 500
    RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL VDEFTCMDCG 550
    PGQWPTADLS GCYNLPEDYI RWEDAWAIGP VTIACLGFMC TCIVITVFIK 600
    HNNTPLVKAS GRELCYILLF GVSLSYCMTF FFIAKPSPVI CALRRLGLGT 650
    SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI 700
    VMVSVWLILE TPGTRRYTLP EKRETVILKC NVKDSSMLIS LTYDVVLVIL 750
    CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT 800
    TTMCISVSLS GFVVLGCLFA PKVHIVLFQP QKNVVTHRLH LNRFSVSGTA 850
    TTYSQSSAST YVPTVCNGRE VLDSTTSSL 879
    Length:879
    Mass (Da):99,114
    Last modified:May 1, 2000 - v1
    Checksum:iF3A8B26CE96679EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170701
    , AF170697, AF170698, AF170699, AF170700 Genomic DNA. Translation: AAF06741.1.
    BC111891 mRNA. Translation: AAI11892.1.
    BC113170 mRNA. Translation: AAI13171.1.
    CCDSiCCDS19090.1.
    PIRiJC7160.
    RefSeqiNP_862898.1. NM_181850.2.
    UniGeneiMm.318966.

    Genome annotation databases

    EnsembliENSMUST00000004076; ENSMUSP00000004076; ENSMUSG00000003974.
    GeneIDi108069.
    KEGGimmu:108069.
    UCSCiuc008wll.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170701
    , AF170697 , AF170698 , AF170699 , AF170700 Genomic DNA. Translation: AAF06741.1 .
    BC111891 mRNA. Translation: AAI11892.1 .
    BC113170 mRNA. Translation: AAI13171.1 .
    CCDSi CCDS19090.1.
    PIRi JC7160.
    RefSeqi NP_862898.1. NM_181850.2.
    UniGenei Mm.318966.

    3D structure databases

    ProteinModelPortali Q9QYS2.
    SMRi Q9QYS2. Positions 28-834.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QYS2. 3 interactions.
    MINTi MINT-4101874.

    Chemistry

    BindingDBi Q9QYS2.
    GuidetoPHARMACOLOGYi 291.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9QYS2.

    Proteomic databases

    PaxDbi Q9QYS2.
    PRIDEi Q9QYS2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004076 ; ENSMUSP00000004076 ; ENSMUSG00000003974 .
    GeneIDi 108069.
    KEGGi mmu:108069.
    UCSCi uc008wll.1. mouse.

    Organism-specific databases

    CTDi 2913.
    MGIi MGI:1351340. Grm3.

    Phylogenomic databases

    eggNOGi NOG295200.
    GeneTreei ENSGT00750000117490.
    HOGENOMi HOG000218635.
    HOVERGENi HBG107965.
    InParanoidi Q14DJ9.
    KOi K04605.
    OMAi CTCIVVT.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi Q9QYS2.
    TreeFami TF313240.

    Miscellaneous databases

    NextBioi 359984.
    PROi Q9QYS2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYS2.
    Bgeei Q9QYS2.
    CleanExi MM_GRM3.
    Genevestigatori Q9QYS2.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001234. GPCR_3_mtglu_rcpt_3.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01053. MTABOTROPC3R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes."
      Minoshima T., Nakanishi S.
      J. Biochem. 126:889-896(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGRM3_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYS2
    Secondary accession number(s): Q14DJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3