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Q9QYS1 (WNT16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-16
Gene names
Name:Wnt16
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-226 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-81. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

bone remodeling

Inferred from mutant phenotype PubMed 22792071. Source: MGI

cardiac epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 19156209. Source: MGI

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

keratinocyte differentiation

Inferred from electronic annotation. Source: Ensembl

keratinocyte proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell death

Inferred from electronic annotation. Source: Ensembl

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

oxidative stress-induced premature senescence

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

replicative senescence

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 364335Protein Wnt-16
PRO_0000041472

Amino acid modifications

Lipidation811S-palmitoyl cysteine By similarity
Lipidation2261O-palmitoyl serine; by PORCN By similarity
Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2651K → N in AAD49352. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9QYS1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 68A71C82DDE2D3A2

FASTA36440,727
        10         20         30         40         50         60 
MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL PLNSRQKELC 

        70         80         90        100        110        120 
KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST QLATAPLFGY ELSSGTKETA 

       130        140        150        160        170        180 
FIYAIMAAGL VHSVTRSCSA GNMTECSCDT TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK 

       190        200        210        220        230        240 
FLDLPIRNTT GKESRVLLAM NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS 

       250        260        270        280        290        300 
FEKIGHFLKD KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG 

       310        320        330        340        350        360 
IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR CRRCESMTDV 


HTCK 

« Hide

References

« Hide 'large scale' references
[1]"Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia."
McWhirter J.R., Neuteboom S.T., Wancewicz E.V., Monia B.P., Downing J.R., Murre C.
Proc. Natl. Acad. Sci. U.S.A. 96:11464-11469(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF172064, AF169964 Genomic DNA. Translation: AAD49352.2.
CH466533 Genomic DNA. Translation: EDL13846.1.
BC115811 mRNA. Translation: AAI15812.1.
BC115925 mRNA. Translation: AAI15926.1.
CCDSCCDS19936.1.
RefSeqNP_444346.3. NM_053116.4.
UniGeneMm.137403.

3D structure databases

ProteinModelPortalQ9QYS1.
SMRQ9QYS1. Positions 72-293.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QYS1.

Proteomic databases

PaxDbQ9QYS1.
PRIDEQ9QYS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
GeneID93735.
KEGGmmu:93735.
UCSCuc009baw.2. mouse.

Organism-specific databases

CTD51384.
MGIMGI:2136018. Wnt16.

Phylogenomic databases

eggNOGNOG238376.
GeneTreeENSGT00740000115400.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidQ14BF7.
KOK01558.
OMACWKTMSS.
TreeFamTF105310.

Gene expression databases

BgeeQ9QYS1.
CleanExMM_WNT16.
GenevestigatorQ9QYS1.

Family and domain databases

InterProIPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio351583.
PROQ9QYS1.
SOURCESearch...

Entry information

Entry nameWNT16_MOUSE
AccessionPrimary (citable) accession number: Q9QYS1
Secondary accession number(s): Q14BF7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot