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Q9QYS1

- WNT16_MOUSE

UniProt

Q9QYS1 - WNT16_MOUSE

Protein

Protein Wnt-16

Gene

Wnt16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. bone remodeling Source: MGI
    2. cardiac epithelial to mesenchymal transition Source: MGI
    3. cell fate commitment Source: RefGenome
    4. keratinocyte differentiation Source: Ensembl
    5. keratinocyte proliferation Source: Ensembl
    6. negative regulation of cell death Source: Ensembl
    7. neuron differentiation Source: RefGenome
    8. oxidative stress-induced premature senescence Source: Ensembl
    9. positive regulation of gene expression Source: Ensembl
    10. positive regulation of JNK cascade Source: Ensembl
    11. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    12. replicative senescence Source: Ensembl
    13. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-16
    Gene namesi
    Name:Wnt16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2136018. Wnt16.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: RefGenome
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 364335Protein Wnt-16PRO_0000041472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi81 ↔ 92By similarity
    Disulfide bondi138 ↔ 146By similarity
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 167By similarity
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi220 ↔ 234By similarity
    Disulfide bondi222 ↔ 229By similarity
    Lipidationi226 – 2261O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi309 ↔ 324By similarity
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi339 ↔ 354By similarity
    Disulfide bondi341 ↔ 351By similarity
    Disulfide bondi346 ↔ 347By similarity

    Post-translational modificationi

    Palmitoylation at Ser-226 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9QYS1.
    PRIDEiQ9QYS1.

    PTM databases

    PhosphoSiteiQ9QYS1.

    Expressioni

    Gene expression databases

    BgeeiQ9QYS1.
    CleanExiMM_WNT16.
    GenevestigatoriQ9QYS1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYS1.
    SMRiQ9QYS1. Positions 72-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG238376.
    GeneTreeiENSGT00740000115400.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ14BF7.
    KOiK01558.
    OMAiCWKTMSS.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013304. Wnt16.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01895. WNT16PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL    50
    PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST 100
    QLATAPLFGY ELSSGTKETA FIYAIMAAGL VHSVTRSCSA GNMTECSCDT 150
    TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK FLDLPIRNTT GKESRVLLAM 200
    NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS FEKIGHFLKD 250
    KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG 300
    IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR 350
    CRRCESMTDV HTCK 364
    Length:364
    Mass (Da):40,727
    Last modified:July 27, 2011 - v2
    Checksum:i68A71C82DDE2D3A2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti265 – 2651K → N in AAD49352. (PubMed:10500199)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF172064, AF169964 Genomic DNA. Translation: AAD49352.2.
    CH466533 Genomic DNA. Translation: EDL13846.1.
    BC115811 mRNA. Translation: AAI15812.1.
    BC115925 mRNA. Translation: AAI15926.1.
    CCDSiCCDS19936.1.
    RefSeqiNP_444346.3. NM_053116.4.
    UniGeneiMm.137403.

    Genome annotation databases

    EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
    GeneIDi93735.
    KEGGimmu:93735.
    UCSCiuc009baw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF172064 , AF169964 Genomic DNA. Translation: AAD49352.2 .
    CH466533 Genomic DNA. Translation: EDL13846.1 .
    BC115811 mRNA. Translation: AAI15812.1 .
    BC115925 mRNA. Translation: AAI15926.1 .
    CCDSi CCDS19936.1.
    RefSeqi NP_444346.3. NM_053116.4.
    UniGenei Mm.137403.

    3D structure databases

    ProteinModelPortali Q9QYS1.
    SMRi Q9QYS1. Positions 72-293.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QYS1.

    Proteomic databases

    PaxDbi Q9QYS1.
    PRIDEi Q9QYS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031681 ; ENSMUSP00000031681 ; ENSMUSG00000029671 .
    GeneIDi 93735.
    KEGGi mmu:93735.
    UCSCi uc009baw.2. mouse.

    Organism-specific databases

    CTDi 51384.
    MGIi MGI:2136018. Wnt16.

    Phylogenomic databases

    eggNOGi NOG238376.
    GeneTreei ENSGT00740000115400.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q14BF7.
    KOi K01558.
    OMAi CWKTMSS.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 351583.
    PROi Q9QYS1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QYS1.
    CleanExi MM_WNT16.
    Genevestigatori Q9QYS1.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013304. Wnt16.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01895. WNT16PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia."
      McWhirter J.R., Neuteboom S.T., Wancewicz E.V., Monia B.P., Downing J.R., Murre C.
      Proc. Natl. Acad. Sci. U.S.A. 96:11464-11469(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiWNT16_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYS1
    Secondary accession number(s): Q14BF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3