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Protein

Protein Wnt-16

Gene

Wnt16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: GO_Central

GO - Biological processi

  1. bone remodeling Source: MGI
  2. cardiac epithelial to mesenchymal transition Source: MGI
  3. cell fate commitment Source: GO_Central
  4. keratinocyte differentiation Source: MGI
  5. keratinocyte proliferation Source: MGI
  6. negative regulation of cell death Source: MGI
  7. neuron differentiation Source: GO_Central
  8. oxidative stress-induced premature senescence Source: MGI
  9. positive regulation of gene expression Source: MGI
  10. positive regulation of JNK cascade Source: MGI
  11. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  12. replicative senescence Source: MGI
  13. Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-16
Gene namesi
Name:Wnt16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136018. Wnt16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: MGI
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 364335Protein Wnt-16PRO_0000041472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 92By similarity
Disulfide bondi138 ↔ 146By similarity
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 167By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi220 ↔ 234By similarity
Disulfide bondi222 ↔ 229By similarity
Lipidationi226 – 2261O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ9QYS1.
PRIDEiQ9QYS1.

PTM databases

PhosphoSiteiQ9QYS1.

Expressioni

Gene expression databases

BgeeiQ9QYS1.
CleanExiMM_WNT16.
ExpressionAtlasiQ9QYS1. baseline and differential.
GenevestigatoriQ9QYS1.

Structurei

3D structure databases

ProteinModelPortaliQ9QYS1.
SMRiQ9QYS1. Positions 72-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG238376.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ9QYS1.
KOiK01558.
OMAiTCWKTMS.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL
60 70 80 90 100
PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST
110 120 130 140 150
QLATAPLFGY ELSSGTKETA FIYAIMAAGL VHSVTRSCSA GNMTECSCDT
160 170 180 190 200
TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK FLDLPIRNTT GKESRVLLAM
210 220 230 240 250
NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS FEKIGHFLKD
260 270 280 290 300
KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG
310 320 330 340 350
IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR
360
CRRCESMTDV HTCK
Length:364
Mass (Da):40,727
Last modified:July 27, 2011 - v2
Checksum:i68A71C82DDE2D3A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651K → N in AAD49352 (PubMed:10500199).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172064, AF169964 Genomic DNA. Translation: AAD49352.2.
CH466533 Genomic DNA. Translation: EDL13846.1.
BC115811 mRNA. Translation: AAI15812.1.
BC115925 mRNA. Translation: AAI15926.1.
CCDSiCCDS19936.1.
RefSeqiNP_444346.3. NM_053116.4.
UniGeneiMm.137403.

Genome annotation databases

EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
GeneIDi93735.
KEGGimmu:93735.
UCSCiuc009baw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172064, AF169964 Genomic DNA. Translation: AAD49352.2.
CH466533 Genomic DNA. Translation: EDL13846.1.
BC115811 mRNA. Translation: AAI15812.1.
BC115925 mRNA. Translation: AAI15926.1.
CCDSiCCDS19936.1.
RefSeqiNP_444346.3. NM_053116.4.
UniGeneiMm.137403.

3D structure databases

ProteinModelPortaliQ9QYS1.
SMRiQ9QYS1. Positions 72-293.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QYS1.

Proteomic databases

PaxDbiQ9QYS1.
PRIDEiQ9QYS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
GeneIDi93735.
KEGGimmu:93735.
UCSCiuc009baw.2. mouse.

Organism-specific databases

CTDi51384.
MGIiMGI:2136018. Wnt16.

Phylogenomic databases

eggNOGiNOG238376.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ9QYS1.
KOiK01558.
OMAiTCWKTMS.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi351583.
PROiQ9QYS1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYS1.
CleanExiMM_WNT16.
ExpressionAtlasiQ9QYS1. baseline and differential.
GenevestigatoriQ9QYS1.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia."
    McWhirter J.R., Neuteboom S.T., Wancewicz E.V., Monia B.P., Downing J.R., Murre C.
    Proc. Natl. Acad. Sci. U.S.A. 96:11464-11469(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiWNT16_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS1
Secondary accession number(s): Q14BF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.