Q9QYS1 (WNT16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-16

Gene names

Name:

Wnt16

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Post-translational modification	Palmitoylation at Ser-226 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-81. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome axonogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cardiac epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 19156209. Source: MGI keratinocyte differentiation Inferred from electronic annotation. Source: Compara keratinocyte proliferation Inferred from electronic annotation. Source: Compara negative regulation of cell death Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome oxidative stress-induced premature senescence Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara replicative senescence Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	frizzled binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 364	335	Protein Wnt-16		PRO_0000041472
Amino acid modifications
	Lipidation	81	1	S-palmitoyl cysteine By similarity
	Lipidation	226	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	142	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	265	1	K → N in AAD49352. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9QYS1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 68A71C82DDE2D3A2	FASTA	364	40,727
	10 20 30 40 50 60 MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL PLNSRQKELC 70 80 90 100 110 120 KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST QLATAPLFGY ELSSGTKETA 130 140 150 160 170 180 FIYAIMAAGL VHSVTRSCSA GNMTECSCDT TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK 190 200 210 220 230 240 FLDLPIRNTT GKESRVLLAM NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS 250 260 270 280 290 300 FEKIGHFLKD KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG 310 320 330 340 350 360 IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR CRRCESMTDV HTCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia." McWhirter J.R., Neuteboom S.T., Wancewicz E.V., Monia B.P., Downing J.R., Murre C. Proc. Natl. Acad. Sci. U.S.A. 96:11464-11469(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF172064, AF169964 Genomic DNA. Translation: AAD49352.2. CH466533 Genomic DNA. Translation: EDL13846.1. BC115811 mRNA. Translation: AAI15812.1. BC115925 mRNA. Translation: AAI15926.1.
IPI	IPI00136715.
RefSeq	NP_444346.3. NM_053116.4.
UniGene	Mm.137403.
3D structure databases
ProteinModelPortal	Q9QYS1.
ModBase	Search...
PTM databases
PhosphoSite	Q9QYS1.
Proteomic databases
PaxDb	Q9QYS1.
PRIDE	Q9QYS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
GeneID	93735.
KEGG	mmu:93735.
UCSC	uc009baw.2. mouse.
Organism-specific databases
CTD	51384.
MGI	MGI:2136018. Wnt16.
Phylogenomic databases
eggNOG	NOG238376.
GeneTree	ENSGT00700000104317.
HOGENOM	HOG000039529.
HOVERGEN	HBG001595.
InParanoid	Q14BF7.
KO	K01558.
OMA	CWKTMSS.
OrthoDB	EOG4CNQRR.
Gene expression databases
ArrayExpress	Q9QYS1.
Bgee	Q9QYS1.
CleanEx	MM_WNT16.
Genevestigator	Q9QYS1.
GermOnline	ENSMUSG00000029671. Mus musculus.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013304. Wnt16. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF12. PTHR12027:SF12. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01895. WNT16PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	351583.
SOURCE	Search...

Entry information

Entry name

WNT16_MOUSE

Accession

Primary (citable) accession number: Q9QYS1
Secondary accession number(s): Q14BF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program