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Protein

Protein Wnt-16

Gene

Wnt16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-16
Gene namesi
Name:Wnt16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136018. Wnt16.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004147230 – 364Protein Wnt-16Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 92By similarity
Disulfide bondi138 ↔ 146By similarity
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 167By similarity
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 234By similarity
Disulfide bondi222 ↔ 229By similarity
Lipidationi226O-palmitoleyl serine; by PORCNBy similarity1
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ9QYS1.
PRIDEiQ9QYS1.

PTM databases

PhosphoSitePlusiQ9QYS1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029671.
CleanExiMM_WNT16.
ExpressionAtlasiQ9QYS1. baseline and differential.
GenevisibleiQ9QYS1. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031681.

Structurei

3D structure databases

ProteinModelPortaliQ9QYS1.
SMRiQ9QYS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ9QYS1.
KOiK01558.
OMAiFIWCCYV.
OrthoDBiEOG091G0OFF.
TreeFamiTF105310.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
PRINTSiPR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.
PROSITEiView protein in PROSITE
PS00246. WNT1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL
60 70 80 90 100
PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST
110 120 130 140 150
QLATAPLFGY ELSSGTKETA FIYAIMAAGL VHSVTRSCSA GNMTECSCDT
160 170 180 190 200
TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK FLDLPIRNTT GKESRVLLAM
210 220 230 240 250
NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS FEKIGHFLKD
260 270 280 290 300
KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG
310 320 330 340 350
IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR
360
CRRCESMTDV HTCK
Length:364
Mass (Da):40,727
Last modified:July 27, 2011 - v2
Checksum:i68A71C82DDE2D3A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265K → N in AAD49352 (PubMed:10500199).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172064, AF169964 Genomic DNA. Translation: AAD49352.2.
CH466533 Genomic DNA. Translation: EDL13846.1.
BC115811 mRNA. Translation: AAI15812.1.
BC115925 mRNA. Translation: AAI15926.1.
CCDSiCCDS19936.1.
RefSeqiNP_444346.3. NM_053116.4.
UniGeneiMm.137403.

Genome annotation databases

EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
GeneIDi93735.
KEGGimmu:93735.
UCSCiuc009bax.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiWNT16_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS1
Secondary accession number(s): Q14BF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: June 7, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families