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Q9QYS1

- WNT16_MOUSE

UniProt

Q9QYS1 - WNT16_MOUSE

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Protein

Protein Wnt-16

Gene

Wnt16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: RefGenome

GO - Biological processi

  1. bone remodeling Source: MGI
  2. cardiac epithelial to mesenchymal transition Source: MGI
  3. cell fate commitment Source: RefGenome
  4. keratinocyte differentiation Source: Ensembl
  5. keratinocyte proliferation Source: Ensembl
  6. negative regulation of cell death Source: Ensembl
  7. neuron differentiation Source: RefGenome
  8. oxidative stress-induced premature senescence Source: Ensembl
  9. positive regulation of gene expression Source: Ensembl
  10. positive regulation of JNK cascade Source: Ensembl
  11. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  12. replicative senescence Source: Ensembl
  13. Wnt signaling pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-16
Gene namesi
Name:Wnt16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2136018. Wnt16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: RefGenome
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 364335Protein Wnt-16PRO_0000041472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 92By similarity
Disulfide bondi138 ↔ 146By similarity
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 167By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi220 ↔ 234By similarity
Disulfide bondi222 ↔ 229By similarity
Lipidationi226 – 2261O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoylation at Ser-226 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9QYS1.
PRIDEiQ9QYS1.

PTM databases

PhosphoSiteiQ9QYS1.

Expressioni

Gene expression databases

BgeeiQ9QYS1.
CleanExiMM_WNT16.
ExpressionAtlasiQ9QYS1. baseline and differential.
GenevestigatoriQ9QYS1.

Structurei

3D structure databases

ProteinModelPortaliQ9QYS1.
SMRiQ9QYS1. Positions 72-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG238376.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ9QYS1.
KOiK01558.
OMAiCWKTMSS.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL
60 70 80 90 100
PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST
110 120 130 140 150
QLATAPLFGY ELSSGTKETA FIYAIMAAGL VHSVTRSCSA GNMTECSCDT
160 170 180 190 200
TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK FLDLPIRNTT GKESRVLLAM
210 220 230 240 250
NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS FEKIGHFLKD
260 270 280 290 300
KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG
310 320 330 340 350
IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR
360
CRRCESMTDV HTCK
Length:364
Mass (Da):40,727
Last modified:July 27, 2011 - v2
Checksum:i68A71C82DDE2D3A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651K → N in AAD49352. (PubMed:10500199)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF172064, AF169964 Genomic DNA. Translation: AAD49352.2.
CH466533 Genomic DNA. Translation: EDL13846.1.
BC115811 mRNA. Translation: AAI15812.1.
BC115925 mRNA. Translation: AAI15926.1.
CCDSiCCDS19936.1.
RefSeqiNP_444346.3. NM_053116.4.
UniGeneiMm.137403.

Genome annotation databases

EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
GeneIDi93735.
KEGGimmu:93735.
UCSCiuc009baw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF172064 , AF169964 Genomic DNA. Translation: AAD49352.2 .
CH466533 Genomic DNA. Translation: EDL13846.1 .
BC115811 mRNA. Translation: AAI15812.1 .
BC115925 mRNA. Translation: AAI15926.1 .
CCDSi CCDS19936.1.
RefSeqi NP_444346.3. NM_053116.4.
UniGenei Mm.137403.

3D structure databases

ProteinModelPortali Q9QYS1.
SMRi Q9QYS1. Positions 72-293.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYS1.

Proteomic databases

PaxDbi Q9QYS1.
PRIDEi Q9QYS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031681 ; ENSMUSP00000031681 ; ENSMUSG00000029671 .
GeneIDi 93735.
KEGGi mmu:93735.
UCSCi uc009baw.2. mouse.

Organism-specific databases

CTDi 51384.
MGIi MGI:2136018. Wnt16.

Phylogenomic databases

eggNOGi NOG238376.
GeneTreei ENSGT00760000118943.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi Q9QYS1.
KOi K01558.
OMAi CWKTMSS.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi 351583.
PROi Q9QYS1.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYS1.
CleanExi MM_WNT16.
ExpressionAtlasi Q9QYS1. baseline and differential.
Genevestigatori Q9QYS1.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia."
    McWhirter J.R., Neuteboom S.T., Wancewicz E.V., Monia B.P., Downing J.R., Murre C.
    Proc. Natl. Acad. Sci. U.S.A. 96:11464-11469(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiWNT16_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS1
Secondary accession number(s): Q14BF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3