Q9QYR6 (MAP1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein 1A
Short name=MAP-1A

Cleaved into the following chain:

1. MAP1 light chain LC2

Gene names

Name:	Map1a
Synonyms:	Mtap1, Mtap1a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2776 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Subunit structure	3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with guanylate kinase-like domain of DLG1, DLG2 and DLG4. Binds to CSNK1D By similarity. Interacts with TIAM2. Ref.5
Subcellular location	Cytoplasm › cytoskeleton Probable.
Tissue specificity	Both isoforms highly expressed in brain, and to a lesser extent in embryo. Isoform 1 is also expressed at a low level in other tissues including heart and muscle. Ref.3
Domain	The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by MAP1A By similarity. Ref.4 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 LC2 is generated from MAP1A by proteolytic processing. It is free to associate with both MAP1A and MAP1B By similarity.
Sequence similarities	Belongs to the MAP1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	sensory perception of sound Inferred from direct assay. Source: MGI
Cellular component	cytosol Inferred from direct assay. Source: MGI microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9QYR6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QYR6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → METTPELGLQ...LNPEPVLPTM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2776	2776	Microtubule-associated protein 1A		PRO_0000072753
	Chain	?2466 – 2776	311	MAP1 light chain LC2		PRO_0000269727
Regions
	Repeat	336 – 338	3	1
	Repeat	415 – 417	3	2
	Repeat	420 – 422	3	3
	Repeat	424 – 426	3	4
	Repeat	427 – 429	3	5
	Repeat	431 – 433	3	6
	Repeat	436 – 438	3	7
	Repeat	440 – 442	3	8
	Repeat	444 – 446	3	9
	Repeat	449 – 451	3	10
	Repeat	539 – 541	3	11
	Region	336 – 541	206	11 X 3 AA approximate repeats of K-K-[DE]
	Compositional bias	338 – 677	340	Glu-rich
	Compositional bias	1748 – 2303	556	Pro-rich
	Compositional bias	2530 – 2551	22	Pro-rich
	Compositional bias	2747 – 2750	4	Poly-Gln
Amino acid modifications
	Modified residue	114	1	Phosphoserine Ref.8
	Modified residue	177	1	Phosphotyrosine Ref.7
	Modified residue	504	1	Phosphothreonine By similarity
	Modified residue	526	1	Phosphoserine Ref.4 Ref.6 Ref.10
	Modified residue	527	1	Phosphoserine Ref.4 Ref.6 Ref.8 Ref.9 Ref.10
	Modified residue	611	1	Phosphoserine By similarity
	Modified residue	633	1	Phosphothreonine Ref.4 Ref.8
	Modified residue	644	1	Phosphoserine Ref.4
	Modified residue	667	1	Phosphoserine Ref.4 Ref.9
	Modified residue	772	1	Phosphotyrosine By similarity
	Modified residue	895	1	Phosphoserine By similarity
	Modified residue	899	1	Phosphoserine By similarity
	Modified residue	991	1	Phosphoserine Ref.9
	Modified residue	1008	1	Phosphoserine By similarity
	Modified residue	1062	1	Phosphoserine By similarity
	Modified residue	1147	1	Phosphoserine By similarity
	Modified residue	1205	1	Phosphoserine By similarity
	Modified residue	1310	1	Phosphoserine By similarity
	Modified residue	1313	1	Phosphoserine By similarity
	Modified residue	1634	1	Phosphoserine By similarity
	Modified residue	1648	1	Phosphoserine By similarity
	Modified residue	1747	1	Phosphoserine By similarity
	Modified residue	1762	1	Phosphoserine By similarity
	Modified residue	1768	1	Phosphoserine By similarity
	Modified residue	1772	1	Phosphoserine By similarity
	Modified residue	1789	1	Phosphoserine By similarity
	Modified residue	1990	1	Phosphoserine By similarity
	Modified residue	1993	1	Phosphoserine By similarity
	Modified residue	2082	1	Phosphoserine Ref.9
	Modified residue	2226	1	Phosphoserine By similarity
	Modified residue	2230	1	Phosphoserine By similarity
	Modified residue	2234	1	Phosphoserine By similarity
	Modified residue	2235	1	Phosphoserine By similarity
	Modified residue	2344	1	Phosphoserine By similarity
	Modified residue	2425	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1	1	M → METTPELGLQSLGAPPAQNP AEPLCEAGAAVAAARWDLRK YSLLIVIGDIGTESQLRAVR AHLEQGILSWNIDLSSFDLN QQLRLFITRHLAHFSSEVKG QRTLCHQSETLETIILVNPT ADSISSEVHHLLSSPSAHKL LILSGQTLEPEGDLILQSGT YSYQNFAQVLHKPEIAQLLS NRDPGIQAFLTVSCLGEGDW SHLGLSSSQETLHLRLNPEP VLPTM in isoform 2.		VSP_003201
Experimental info
	Sequence conflict	349	1	R → C in BAE27940. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 62A8CC584CCAB21A	FASTA	2,776	300,140
	10 20 30 40 50 60 MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS ALFAVNGFNI 70 80 90 100 110 120 LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING LLQRKVAELE EEQSQGSSSY 130 140 150 160 170 180 SDWVKNLISP ELGVVFFNVP DKLRLPDASR KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV 190 200 210 220 230 240 SNTIEPLTLF HKMGVGRLDM YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LANGKEAEIS 250 260 270 280 290 300 VPYLTSITAL VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA 310 320 330 340 350 360 AGAVPANLKP SKIKHRADSK ESLKAAPKTA MSKLAKREEV LEEGAKEARS ELAKELAKSE 370 380 390 400 410 420 KKAKEPSEKP PEKPSKPERV RTESSEALKA EKRKLIKDKV GKKHLKEKIS KLEEKRDKEK 430 440 450 460 470 480 KEIKKERKEL KKEEGRKEEK KDAKKDEKRK DTKPELKKFS KPDLKPFTPE VRKTLYKAKA 490 500 510 520 530 540 PGRLKVDKGR AARGEKELSS EPRTPPAQKG AAPPPAASGH RELALSSPED LTQDFEELKR 550 560 570 580 590 600 EERGLLAEPR DTELGEKPLP ADASEQGRPS TAIQVTQPPA SVLEQEQVER EKEVVPDFPE 610 620 630 640 650 660 DKGSKNRAPD SGAEVEREKE TWEERKPREA ELTPENIAAA REESEPEVKE DVIEKAELEE 670 680 690 700 710 720 MEEVHPSDEE EEETKAESFY QKHMQEALKV IPKGREALGG RELGFQGKAP EKETASFLSS 730 740 750 760 770 780 LATPAGAAEH VSYIQDETIP GYSETEQTIS DEEIHDEPDE RPAPPRFPTS TYDLSGPEGP 790 800 810 820 830 840 GPFEASQSAE SAVPASSSKT YGAPETELTY PPNMVAAPLA EEEHVSSATS ITECDKLSSF 850 860 870 880 890 900 ATSVAEDQSV ASLTAPQTEE TGKSSLLLDT VTSIPSSRTE ATQGLDYVPS AGTISPTSSL 910 920 930 940 950 960 EEDKGFKSPP CEDFSVTGES EKKGESVGRG LTGEKAVGKE EKNVTTSEKL SSQYAAVFGA 970 980 990 1000 1010 1020 PGHALHPGEP ALGEVEERCL SPDDSTVKMA SPPPSGPPSA AHTPFHQSPV EEKSEPQDFQ 1030 1040 1050 1060 1070 1080 EDSWGDTKHA PGVSKEDAEE QTVKPGPEEA MSEEGKVPLS RSPQAQDTLG SLAGGQTGCT 1090 1100 1110 1120 1130 1140 IQLLPEQDKA VVFETGEAGA ASGAGSLPGE VRTQEPAEPQ KDELLGFTDQ SFSPEDAESL 1150 1160 1170 1180 1190 1200 SVLSVVSPDT AKQEATPRSP CTPKEQQLHK DLWPMVSPED TQSLSFSEES PSKETSLDIS 1210 1220 1230 1240 1250 1260 SKQLSPESLG TLQFGELSLG KEEKGPLVKA EDNSCHLAPV SIPEPHTATV SPPTDEAAGE 1270 1280 1290 1300 1310 1320 AGLTDESPAG NLPGSSFSHS ALSGDRKHSP GEITGPGGHF MTSDSSLTKS PESLSSPAME 1330 1340 1350 1360 1370 1380 DLAMEWGGKA PGSEDRATEQ KEKELERKSE TLQQKDQILS EKAALVQRDS VMHQKDEALD 1390 1400 1410 1420 1430 1440 EENKPGGQQD KTSEQKGRDL DKKDTAVELG KGPEPKGKDL YLEDQGLAEK DKALEQRGAA 1450 1460 1470 1480 1490 1500 LQQTQAPEPR ARAQEHRDLE QKDEHLELRD KTPEEKDKVL VLEDRAPEHI IPQPTQTDRA 1510 1520 1530 1540 1550 1560 PEHRSKVDKE QKDEASEEKE QVLEQKDWAR EKEGAALDQD NRAAGQKDGT LKEDKTQGQK 1570 1580 1590 1600 1610 1620 SSFLEDKSTT PKEMTLDQKS PEKAKGVEQQ DGAVPEKTRA LGLEESPEEE GKAREQEEKY 1630 1640 1650 1660 1670 1680 WKEQDVVQGW RETSPTRGEP VPAWEGKSPE QEVRYWRDRD ITLQQDAYWK ELSCERKVWF 1690 1700 1710 1720 1730 1740 PHELDGQGAR PRYSEEREST FLDEGPNEQE ITPLQHTPRS PWASDFKDFQ EPLPQKGLEV 1750 1760 1770 1780 1790 1800 ERWLAESPVG LPPEEEDKLT RSPFEIISPP ASPPEMTGQR VPSAPGQESP VPDTKSTPPT 1810 1820 1830 1840 1850 1860 RNEPTTPSWL AEIPPWVPKD RPLPPAPLSP APAPPTPAPD PHAPAPFSWG IAEYDSVVAA 1870 1880 1890 1900 1910 1920 VQEGAAELEG GPYSPLGKDY RKAEGEREGE GGAGAPDSSS FSSKVPEVTE SHTTRDAEQT 1930 1940 1950 1960 1970 1980 EPEQREPTPY PDERSFQYAD IYEQMMLTGL GPACPTREPP LGASGDWPPH LSTKEEAAGR 1990 2000 2010 2020 2030 2040 NKSAEKELSS AVSPPNLHSD TPTFSYASLA GPTIPPRQEP EPGPNVEPSF TPPAVPPRAP 2050 2060 2070 2080 2090 2100 ISLSQDPSPP LNGSTTSCGP DRRTPSPKEA GRSHWDDGTN DSDLEKGARE QPEKETQSPS 2110 2120 2130 2140 2150 2160 PHHPMPVGHP SLWPETEAHS SLSSDSHLGP VRPSLDFPAS AFGFSSLQPA PPQLPSPAEP 2170 2180 2190 2200 2210 2220 RSAPCGSLAF SGDRALALVP GTPTRTRHDE YLEVTKAPSL DSSLPQLPSP SSPGAPLLSN 2230 2240 2250 2260 2270 2280 LPRPASPALS EGSSSEATTP VISSVAERFP PGLEVAEQSS GELGPGNEPA AHSLWDLTPL 2290 2300 2310 2320 2330 2340 SPAPLASRDL APAPAPAPAP SLPGNLGDGT LSCRPECSGE LTKKPSPFLS HSGDHEANGP 2350 2360 2370 2380 2390 2400 GETSLNPPGF ATATAEKEEA EALHAWERGS WPEGAERSSR PDTLLSSEQR PGKSSGGPPC 2410 2420 2430 2440 2450 2460 SLSSEVEAGP QGCATDPRPH CGELSPSFLN PPLPPSTDDS DLSTEEARLA GKGGRRRAGR 2470 2480 2490 2500 2510 2520 PGATGGPCPM ADETPPTSAS DSGSSQSDSD VPPETEECPS ITAEAALDSD EDGDFLPVDK 2530 2540 2550 2560 2570 2580 AGGVSGTHHP RPGHDPPPAP LPDPRPPPPR PDVCMADPEG LSSESGRVER LREKVQGRPG 2590 2600 2610 2620 2630 2640 RKAPGRAKPA SPARRLDIRG KRSPTPGKGP VDRTSRALPR PRSTPSQVTS EEKDGHSPMS 2650 2660 2670 2680 2690 2700 KGLVNGLKAG STALGSKGSS GPPVYVDLAY IPNHCSGKTA DQDFFRRVRA SYYVVSGNDP 2710 2720 2730 2740 2750 2760 ANGEPSRAVL DALLEGKAQW GENLQVTLIP THDTEVTREW YQQTHEQQQQ LNVLVLASSS 2770 TVVMQDESFP ACKIEF
	Isoform 2 [UniParc]. Checksum: 58EB524496EB49C9	FASTA	3,000	324,586
	10 20 30 40 50 60 METTPELGLQ SLGAPPAQNP AEPLCEAGAA VAAARWDLRK YSLLIVIGDI GTESQLRAVR 70 80 90 100 110 120 AHLEQGILSW NIDLSSFDLN QQLRLFITRH LAHFSSEVKG QRTLCHQSET LETIILVNPT 130 140 150 160 170 180 ADSISSEVHH LLSSPSAHKL LILSGQTLEP EGDLILQSGT YSYQNFAQVL HKPEIAQLLS 190 200 210 220 230 240 NRDPGIQAFL TVSCLGEGDW SHLGLSSSQE TLHLRLNPEP VLPTMDGVAE FSEYVSETVD 250 260 270 280 290 300 VPSPFDLLEP PTSGGFLKLS KPCCYIFPGG RGDSALFAVN GFNILVDGGS DRKSCFWKLV 310 320 330 340 350 360 RHLDRIDSVL LTHIGADNLP GINGLLQRKV AELEEEQSQG SSSYSDWVKN LISPELGVVF 370 380 390 400 410 420 FNVPDKLRLP DASRKAKRSI EEACLTLQHL NRLGIQAEPL YRVVSNTIEP LTLFHKMGVG 430 440 450 460 470 480 RLDMYVLNPV KDSKEMQFLM QKWAGNSKAK TGIVLANGKE AEISVPYLTS ITALVVWLPA 490 500 510 520 530 540 NPTEKIVRVL FPGNAPQNKI LEGLEKLRHL DFLRYPVATQ KDLAAGAVPA NLKPSKIKHR 550 560 570 580 590 600 ADSKESLKAA PKTAMSKLAK REEVLEEGAK EARSELAKEL AKSEKKAKEP SEKPPEKPSK 610 620 630 640 650 660 PERVRTESSE ALKAEKRKLI KDKVGKKHLK EKISKLEEKR DKEKKEIKKE RKELKKEEGR 670 680 690 700 710 720 KEEKKDAKKD EKRKDTKPEL KKFSKPDLKP FTPEVRKTLY KAKAPGRLKV DKGRAARGEK 730 740 750 760 770 780 ELSSEPRTPP AQKGAAPPPA ASGHRELALS SPEDLTQDFE ELKREERGLL AEPRDTELGE 790 800 810 820 830 840 KPLPADASEQ GRPSTAIQVT QPPASVLEQE QVEREKEVVP DFPEDKGSKN RAPDSGAEVE 850 860 870 880 890 900 REKETWEERK PREAELTPEN IAAAREESEP EVKEDVIEKA ELEEMEEVHP SDEEEEETKA 910 920 930 940 950 960 ESFYQKHMQE ALKVIPKGRE ALGGRELGFQ GKAPEKETAS FLSSLATPAG AAEHVSYIQD 970 980 990 1000 1010 1020 ETIPGYSETE QTISDEEIHD EPDERPAPPR FPTSTYDLSG PEGPGPFEAS QSAESAVPAS 1030 1040 1050 1060 1070 1080 SSKTYGAPET ELTYPPNMVA APLAEEEHVS SATSITECDK LSSFATSVAE DQSVASLTAP 1090 1100 1110 1120 1130 1140 QTEETGKSSL LLDTVTSIPS SRTEATQGLD YVPSAGTISP TSSLEEDKGF KSPPCEDFSV 1150 1160 1170 1180 1190 1200 TGESEKKGES VGRGLTGEKA VGKEEKNVTT SEKLSSQYAA VFGAPGHALH PGEPALGEVE 1210 1220 1230 1240 1250 1260 ERCLSPDDST VKMASPPPSG PPSAAHTPFH QSPVEEKSEP QDFQEDSWGD TKHAPGVSKE 1270 1280 1290 1300 1310 1320 DAEEQTVKPG PEEAMSEEGK VPLSRSPQAQ DTLGSLAGGQ TGCTIQLLPE QDKAVVFETG 1330 1340 1350 1360 1370 1380 EAGAASGAGS LPGEVRTQEP AEPQKDELLG FTDQSFSPED AESLSVLSVV SPDTAKQEAT 1390 1400 1410 1420 1430 1440 PRSPCTPKEQ QLHKDLWPMV SPEDTQSLSF SEESPSKETS LDISSKQLSP ESLGTLQFGE 1450 1460 1470 1480 1490 1500 LSLGKEEKGP LVKAEDNSCH LAPVSIPEPH TATVSPPTDE AAGEAGLTDE SPAGNLPGSS 1510 1520 1530 1540 1550 1560 FSHSALSGDR KHSPGEITGP GGHFMTSDSS LTKSPESLSS PAMEDLAMEW GGKAPGSEDR 1570 1580 1590 1600 1610 1620 ATEQKEKELE RKSETLQQKD QILSEKAALV QRDSVMHQKD EALDEENKPG GQQDKTSEQK 1630 1640 1650 1660 1670 1680 GRDLDKKDTA VELGKGPEPK GKDLYLEDQG LAEKDKALEQ RGAALQQTQA PEPRARAQEH 1690 1700 1710 1720 1730 1740 RDLEQKDEHL ELRDKTPEEK DKVLVLEDRA PEHIIPQPTQ TDRAPEHRSK VDKEQKDEAS 1750 1760 1770 1780 1790 1800 EEKEQVLEQK DWAREKEGAA LDQDNRAAGQ KDGTLKEDKT QGQKSSFLED KSTTPKEMTL 1810 1820 1830 1840 1850 1860 DQKSPEKAKG VEQQDGAVPE KTRALGLEES PEEEGKAREQ EEKYWKEQDV VQGWRETSPT 1870 1880 1890 1900 1910 1920 RGEPVPAWEG KSPEQEVRYW RDRDITLQQD AYWKELSCER KVWFPHELDG QGARPRYSEE 1930 1940 1950 1960 1970 1980 RESTFLDEGP NEQEITPLQH TPRSPWASDF KDFQEPLPQK GLEVERWLAE SPVGLPPEEE 1990 2000 2010 2020 2030 2040 DKLTRSPFEI ISPPASPPEM TGQRVPSAPG QESPVPDTKS TPPTRNEPTT PSWLAEIPPW 2050 2060 2070 2080 2090 2100 VPKDRPLPPA PLSPAPAPPT PAPDPHAPAP FSWGIAEYDS VVAAVQEGAA ELEGGPYSPL 2110 2120 2130 2140 2150 2160 GKDYRKAEGE REGEGGAGAP DSSSFSSKVP EVTESHTTRD AEQTEPEQRE PTPYPDERSF 2170 2180 2190 2200 2210 2220 QYADIYEQMM LTGLGPACPT REPPLGASGD WPPHLSTKEE AAGRNKSAEK ELSSAVSPPN 2230 2240 2250 2260 2270 2280 LHSDTPTFSY ASLAGPTIPP RQEPEPGPNV EPSFTPPAVP PRAPISLSQD PSPPLNGSTT 2290 2300 2310 2320 2330 2340 SCGPDRRTPS PKEAGRSHWD DGTNDSDLEK GAREQPEKET QSPSPHHPMP VGHPSLWPET 2350 2360 2370 2380 2390 2400 EAHSSLSSDS HLGPVRPSLD FPASAFGFSS LQPAPPQLPS PAEPRSAPCG SLAFSGDRAL 2410 2420 2430 2440 2450 2460 ALVPGTPTRT RHDEYLEVTK APSLDSSLPQ LPSPSSPGAP LLSNLPRPAS PALSEGSSSE 2470 2480 2490 2500 2510 2520 ATTPVISSVA ERFPPGLEVA EQSSGELGPG NEPAAHSLWD LTPLSPAPLA SRDLAPAPAP 2530 2540 2550 2560 2570 2580 APAPSLPGNL GDGTLSCRPE CSGELTKKPS PFLSHSGDHE ANGPGETSLN PPGFATATAE 2590 2600 2610 2620 2630 2640 KEEAEALHAW ERGSWPEGAE RSSRPDTLLS SEQRPGKSSG GPPCSLSSEV EAGPQGCATD 2650 2660 2670 2680 2690 2700 PRPHCGELSP SFLNPPLPPS TDDSDLSTEE ARLAGKGGRR RAGRPGATGG PCPMADETPP 2710 2720 2730 2740 2750 2760 TSASDSGSSQ SDSDVPPETE ECPSITAEAA LDSDEDGDFL PVDKAGGVSG THHPRPGHDP 2770 2780 2790 2800 2810 2820 PPAPLPDPRP PPPRPDVCMA DPEGLSSESG RVERLREKVQ GRPGRKAPGR AKPASPARRL 2830 2840 2850 2860 2870 2880 DIRGKRSPTP GKGPVDRTSR ALPRPRSTPS QVTSEEKDGH SPMSKGLVNG LKAGSTALGS 2890 2900 2910 2920 2930 2940 KGSSGPPVYV DLAYIPNHCS GKTADQDFFR RVRASYYVVS GNDPANGEPS RAVLDALLEG 2950 2960 2970 2980 2990 3000 KAQWGENLQV TLIPTHDTEV TREWYQQTHE QQQQLNVLVL ASSSTVVMQD ESFPACKIEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Corpora quadrigemina.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Characterization of two promoters that regulate alternative transcripts in the microtubule-associated protein (MAP) 1A gene." Nakayama A., Odajima T., Murakami H., Mori N., Takahashi M. Biochim. Biophys. Acta 1518:260-266(2001) [PubMed: 11311937] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-224 (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Brain.
[4]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed: 16452087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526; SER-527; THR-633; SER-644 AND SER-667, MASS SPECTROMETRY. Tissue: Brain.
[5]	"Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation." Takefuji M., Mori K., Morita Y., Arimura N., Nishimura T., Nakayama M., Hoshino M., Iwamatsu A., Murohara T., Kaibuchi K., Amano M. Biochem. Biophys. Res. Commun. 355:788-794(2007) [PubMed: 17320046] [Abstract] Cited for: INTERACTION WITH TIAM2.
[6]	"A differential phosphoproteomic analysis of retinoic acid-treated P19 cells." Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D. J. Proteome Res. 6:3174-3186(2007) [PubMed: 17622165] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526 AND SER-527, MASS SPECTROMETRY. Tissue: Teratocarcinoma.
[7]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-177, MASS SPECTROMETRY. Tissue: Brain.
[8]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-527 AND THR-633, MASS SPECTROMETRY. Tissue: Brain cortex.
[9]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527; SER-667; SER-991 AND SER-2082, MASS SPECTROMETRY. Tissue: Melanoma.
[10]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed: 19131326] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526 AND SER-527, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK147474 mRNA. Translation: BAE27940.1. AK160546 mRNA. Translation: BAE35863.1. AK163468 mRNA. Translation: BAE37354.1. AL845466 Genomic DNA. Translation: CAM24218.1. AF182211, AF182208, AF182209 Genomic DNA. Translation: AAF06164.1. AF182211 Genomic DNA. Translation: AAF06163.1. AF182213 mRNA. Translation: AAD55790.1. AF182212 mRNA. Translation: AAD55789.1.
IPI	IPI00408909. IPI00676243.
RefSeq	NP_001166977.1. NM_001173506.1. NP_115769.1. NM_032393.2.
UniGene	Mm.36501.
3D structure databases
ProteinModelPortal	Q9QYR6.
SMR	Q9QYR6. Positions 44-105.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QYR6. 3 interactions.
MINT	MINT-1203191.
STRING	Q9QYR6.
PTM databases
PhosphoSite	Q9QYR6.
Proteomic databases
PRIDE	Q9QYR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000110639; ENSMUSP00000106269; ENSMUSG00000027254.
GeneID	17754.
KEGG	mmu:17754.
UCSC	uc008lyj.2. mouse.
Organism-specific databases
CTD	17754.
MGI	MGI:1306776. Mtap1a.
Phylogenomic databases
eggNOG	roNOG14193.
GeneTree	ENSGT00550000074593.
HOVERGEN	HBG052408.
InParanoid	Q9QYR6.
OrthoDB	EOG483D46.
Gene expression databases
ArrayExpress	Q9QYR6.
Bgee	Q9QYR6.
CleanEx	MM_MTAP1A.
Genevestigator	Q9QYR6.
GermOnline	ENSMUSG00000027254. Mus musculus.
Family and domain databases
KO	K10429.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

MAP1A_MOUSE

Accession

Primary (citable) accession number: Q9QYR6
Secondary accession number(s): A2ARN9 , Q3TQM8, Q3TUV8, Q3UHB7, Q9QZH9, Q9QZI0, Q9QZI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program