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Q9QYP2 (CELR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Multiple epidermal growth factor-like domains protein 3
Short name=Multiple EGF-like domains protein 3
Gene names
Name:Celsr2
Synonyms:Megf3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length2144 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the brain. High expression in cerebellum and olfactory bulb. Weaker expression in cerebral cortex, hippocampus and brain stem.

Post-translational modification

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 4 cadherin domains.

Contains 7 EGF-like domains.

Contains 1 GPS domain.

Contains 1 laminin EGF-like domain.

Contains 2 laminin G-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 2144›2144Cadherin EGF LAG seven-pass G-type receptor 2
PRO_0000070345

Regions

Topological domain1 – 16051605Extracellular Potential
Transmembrane1606 – 162621Helical; Name=1; Potential
Topological domain1627 – 164115Cytoplasmic Potential
Transmembrane1642 – 166221Helical; Name=2; Potential
Topological domain16631Extracellular Potential
Transmembrane1664 – 168421Helical; Name=3; Potential
Topological domain1685 – 170521Cytoplasmic Potential
Transmembrane1706 – 172621Helical; Name=4; Potential
Topological domain1727 – 174418Extracellular Potential
Transmembrane1745 – 176521Helical; Name=5; Potential
Topological domain1766 – 178924Cytoplasmic Potential
Transmembrane1790 – 181021Helical; Name=6; Potential
Topological domain1811 – 18166Extracellular Potential
Transmembrane1817 – 183721Helical; Name=7; Potential
Topological domain1838 – 2144307Cytoplasmic Potential
Domain‹1 – 40›40Cadherin 1
Domain41 – 146106Cadherin 2
Domain147 – 248102Cadherin 3
Domain253 – 371119Cadherin 4
Domain453 – 51159EGF-like 1; calcium-binding
Domain513 – 54937EGF-like 2; calcium-binding
Domain553 – 59139EGF-like 3; calcium-binding
Domain592 – 796205Laminin G-like 1
Domain799 – 83537EGF-like 4; calcium-binding
Domain839 – 1016178Laminin G-like 2
Domain1018 – 105336EGF-like 5; calcium-binding
Domain1054 – 109239EGF-like 6; calcium-binding
Domain1108 – 114740EGF-like 7; calcium-binding
Domain1149 – 119648Laminin EGF-like
Domain1541 – 159353GPS
Compositional bias1968 – 19736Poly-Glu

Amino acid modifications

Modified residue8161(3R)-3-hydroxyasparagine Potential
Modified residue10351(3R)-3-hydroxyasparagine Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation7261N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation9661N-linked (GlcNAc...) Potential
Glycosylation10521N-linked (GlcNAc...) Potential
Glycosylation11251N-linked (GlcNAc...) Potential
Glycosylation12491N-linked (GlcNAc...) Potential
Glycosylation12681N-linked (GlcNAc...) Potential
Glycosylation12861N-linked (GlcNAc...) Potential
Glycosylation15481N-linked (GlcNAc...) Potential
Glycosylation15701N-linked (GlcNAc...) Potential
Disulfide bond457 ↔ 468 By similarity
Disulfide bond462 ↔ 499 By similarity
Disulfide bond501 ↔ 510 By similarity
Disulfide bond517 ↔ 528 By similarity
Disulfide bond522 ↔ 537 By similarity
Disulfide bond539 ↔ 548 By similarity
Disulfide bond557 ↔ 568 By similarity
Disulfide bond562 ↔ 578 By similarity
Disulfide bond580 ↔ 590 By similarity
Disulfide bond770 ↔ 796 By similarity
Disulfide bond803 ↔ 814 By similarity
Disulfide bond808 ↔ 823 By similarity
Disulfide bond825 ↔ 834 By similarity
Disulfide bond986 ↔ 1016 By similarity
Disulfide bond1022 ↔ 1033 By similarity
Disulfide bond1027 ↔ 1042 By similarity
Disulfide bond1044 ↔ 1053 By similarity
Disulfide bond1057 ↔ 1068 By similarity
Disulfide bond1062 ↔ 1080 By similarity
Disulfide bond1082 ↔ 1091 By similarity
Disulfide bond1112 ↔ 1124 By similarity
Disulfide bond1114 ↔ 1131 By similarity
Disulfide bond1133 ↔ 1146 By similarity
Disulfide bond1149 ↔ 1161 By similarity
Disulfide bond1151 ↔ 1168 By similarity
Disulfide bond1170 ↔ 1179 By similarity
Disulfide bond1182 ↔ 1194 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q9QYP2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 6EA898C1BA655ECA

FASTA2,144233,481
        10         20         30         40         50         60 
EDQVSYTLAI TARDNGIPQK SDTTYLEILV NDVNDNAPQF LRDSYQGSVY EDVPPFTSVL 

        70         80         90        100        110        120 
QISATDRDSG LNGRVFYTFQ GGDDGDGDFI VESTSGIVRT LRRLDRENVA QYILRAYAVD 

       130        140        150        160        170        180 
KGMPPARTPM EVTVTVLDVN DNPPVFEQDE FDVFVEENSP IGLAVARVTA TDPDEGTNAQ 

       190        200        210        220        230        240 
IMYQIVEGNI PEVFQLDIFS GELTALVDLD YEDRPEYILV IQATSAPLVS RATVHVRLLD 

       250        260        270        280        290        300 
RNDNPPVLGN FEILFNNYVT NRSSSFPGGA IGRVPAHDPD ISDSLTYSFE RGNELSLVLL 

       310        320        330        340        350        360 
NASTGELRLS RALDNNRPLE AIMSVLVSDG VHSVTAQCSL RVTIITDEML THSITLRLED 

       370        380        390        400        410        420 
MSPERFLSPL LGLFIQAVAA TLATPPDHVV VFNVQRDTDA PGGHILNVSL SVGQPPGPGG 

       430        440        450        460        470        480 
GPPFLPSEDL QERLYLNRSL LTAISAQRVL PFDDNICLRE PCENYMRCVS VLRFDSSAPF 

       490        500        510        520        530        540 
IASSSVLFRP IHPVGGLRCR CPPGFTGDYC ETEVDLCYSR PCGPHGHCRS REGGYTCLCR 

       550        560        570        580        590        600 
DGYTGEHCEV SARSGRCTPG VCKNGGTCVN LLVGGFKCDC PSGDFEKPFC QVTTRSFPAR 

       610        620        630        640        650        660 
SFITFRGLRQ RFHFTLALSF ATKERDGLLL YNGRFNEKHD FVALEVIQEQ VQLTFSAGES 

       670        680        690        700        710        720 
TTTVSPFVPG GVSDGQWHTV QLKYYNKPLL GQTGLPQGPS EQKVAVVSVD GCDTGVALRF 

       730        740        750        760        770        780 
GAMLGNYSCA AQGTQGGSKK SLDLTGPLLL GGVPDLPESF PVRMRHFVGC MKNLQVDSRH 

       790        800        810        820        830        840 
VDMADFIANN GTVPGCPTKK NVCDSNTCHN GGTCVNQWDA FSCECPLGFG GKSCAQEMAN 

       850        860        870        880        890        900 
PQRFLGSSLV AWHGLSLPIS QPWHLSLMFR TRQADGVLLQ AVTRGRSTIT LQLRAGHVVL 

       910        920        930        940        950        960 
SVEGTGLQAS SLRLEPGRAN DGDWHHAQLS LGASGGPGHA ILSFDYGQQK AEGNLGPRLH 

       970        980        990       1000       1010       1020 
GLHLSNMTVG GVPGPASSVA RGFRGCLQGV RVSETPEGVS SLDPSRGESI NVEPGCSWPD 

      1030       1040       1050       1060       1070       1080 
PCDSNPCPTN SYCSNDWDSY SCSCDPGYYG DNCTNVCDLN PCEHQSACTR KPSAPHGYIC 

      1090       1100       1110       1120       1130       1140 
ECLPNYLGPY CETRIDQPCP RGWWGHPTCG PCNCDVSKGF DPDCNKTSGE CHCKENHYRP 

      1150       1160       1170       1180       1190       1200 
PSSPTCLLCD CYPTGSLSRV CDPEDGQCPC KPGVIGRQCD RCDNPFAEVT TNGCEVNYDS 

      1210       1220       1230       1240       1250       1260 
CPRAIEAGIW WPRTRFGLPA AAPCPKGSFG TAVRHCDEHR GWLPPNLFNC TSVTFSELKG 

      1270       1280       1290       1300       1310       1320 
FAERLQRNES GLDSGRSQRL ALLLRNATQH TSGYFGSDVK VAYQLATRLL AHESAQRGFG 

      1330       1340       1350       1360       1370       1380 
LSATQDVHFT ENLLRVGSAL LDAANKRHWE LIQQTEGGTA WLLQHYEAYA SALAQNMRHT 

      1390       1400       1410       1420       1430       1440 
YLSPFTIVTP NIVISVVRLD KGNFAGTKLP RYEALRGERP PDLETTVILP ESVFREMPPM 

      1450       1460       1470       1480       1490       1500 
VRSAGPGEAQ ETEELARRQR RHPELSQGEA VASVIIYHTL AGLLPHNYDP DKRSLRVPKR 

      1510       1520       1530       1540       1550       1560 
PVINTPVVSI SVHDDEELLP RALDKPVTVQ FRLLETEERT KPICVFWNHS ILVSGTGGWS 

      1570       1580       1590       1600       1610       1620 
ARGCEVVFRN ESHVSCQCNH MTSFAVLMDV SRRENGEILP LKTLTYVALG VTLAALMITF 

      1630       1640       1650       1660       1670       1680 
LFLTLLRALR SNQHGIRRNL TAALGLAQLV FLLGINQADL PFACTVIAIL LHFLYLCTFS 

      1690       1700       1710       1720       1730       1740 
WALLEALHLY RALTEVRDVN ASPMRFYYML GWGVPAFITG LAVGLDPEGY GNPDFCWLSI 

      1750       1760       1770       1780       1790       1800 
YDTLIWSFAG PVAFAVSMSV FLYILSARAS CAAQRQGFEK KGPVSGLRSS FTVLLLLSAT 

      1810       1820       1830       1840       1850       1860 
WLLALLSVNS DTLLFHYLFA ACNCVQGPFI FLSYVVLSKE VRKALKFACS RKPSPDPALT 

      1870       1880       1890       1900       1910       1920 
TKSTLTSSYN CPSPYADGRL YQPYGDSAGS LHSASRSGKS QPSYIPFLLR EESTLNPGQV 

      1930       1940       1950       1960       1970       1980 
PPGLGDPSGL FMEGQAQQHD PDTDSDSDLS LEDDQSGSYA STHSSDSEEE EEEAAFPGEQ 

      1990       2000       2010       2020       2030       2040 
GWDSLLGPGA ERLPLHSTPK DGGPGSGKVP WPGDFGTTTK ENSGSGPLEE RPRENGDALT 

      2050       2060       2070       2080       2090       2100 
REGSLGPLPG PSTQPHKGIL KKKCLPTISE KSSLLRLPLE QGTGSSRGST ASEGSRNGPP 

      2110       2120       2130       2140 
PRPPPRQSLQ EQLNGVMPIA MSIKAGTVDE DSSGSEFLFF NFLH 

« Hide

References

[1]"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011529 mRNA. Translation: BAA88687.1.
UniGeneRn.222746.

3D structure databases

ProteinModelPortalQ9QYP2.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9QYP2.

Proteomic databases

PaxDbQ9QYP2.
PRIDEQ9QYP2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:69237. rat.

Organism-specific databases

RGD69237. Celsr2.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000231346.
HOVERGENHBG050887.
InParanoidQ9QYP2.
PhylomeDBQ9QYP2.

Gene expression databases

GenevestigatorQ9QYP2.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
2.60.40.60. 4 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 2 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 2 hits.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTSM00112. CA. 3 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view]
SUPFAMSSF49313. SSF49313. 4 hits.
SSF49899. SSF49899. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCELR2_RAT
AccessionPrimary (citable) accession number: Q9QYP2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries