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Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

Celsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • dendrite morphogenesis Source: BHF-UCL
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • regulation of cell-cell adhesion Source: BHF-UCL
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Multiple epidermal growth factor-like domains protein 3
Short name:
Multiple EGF-like domains protein 3
Gene namesi
Name:Celsr2
Synonyms:Megf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69237 Celsr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 1605ExtracellularSequence analysisAdd BLAST1605
Transmembranei1606 – 1626Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini1627 – 1641CytoplasmicSequence analysisAdd BLAST15
Transmembranei1642 – 1662Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini1663ExtracellularSequence analysis1
Transmembranei1664 – 1684Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1685 – 1705CytoplasmicSequence analysisAdd BLAST21
Transmembranei1706 – 1726Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1727 – 1744ExtracellularSequence analysisAdd BLAST18
Transmembranei1745 – 1765Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1766 – 1789CytoplasmicSequence analysisAdd BLAST24
Transmembranei1790 – 1810Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1811 – 1816ExtracellularSequence analysis6
Transmembranei1817 – 1837Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1838 – 2144CytoplasmicSequence analysisAdd BLAST307

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000070345‹1 – 2144Cadherin EGF LAG seven-pass G-type receptor 2Add BLAST›2144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi457 ↔ 468By similarity
Disulfide bondi462 ↔ 499By similarity
Disulfide bondi501 ↔ 510By similarity
Disulfide bondi517 ↔ 528By similarity
Disulfide bondi522 ↔ 537By similarity
Disulfide bondi539 ↔ 548By similarity
Disulfide bondi557 ↔ 568By similarity
Disulfide bondi562 ↔ 578By similarity
Disulfide bondi580 ↔ 590By similarity
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi770 ↔ 796By similarity
Glycosylationi790N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi803 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
Modified residuei816(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi825 ↔ 834By similarity
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi986 ↔ 1016By similarity
Disulfide bondi1022 ↔ 1033By similarity
Disulfide bondi1027 ↔ 1042By similarity
Modified residuei1035(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1044 ↔ 1053By similarity
Glycosylationi1052N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1057 ↔ 1068By similarity
Disulfide bondi1062 ↔ 1080By similarity
Disulfide bondi1082 ↔ 1091By similarity
Disulfide bondi1112 ↔ 1124By similarity
Disulfide bondi1114 ↔ 1131By similarity
Glycosylationi1125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1133 ↔ 1146By similarity
Disulfide bondi1149 ↔ 1161By similarity
Disulfide bondi1151 ↔ 1168By similarity
Disulfide bondi1170 ↔ 1179By similarity
Disulfide bondi1182 ↔ 1194By similarity
Glycosylationi1249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1570N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ9QYP2
PRIDEiQ9QYP2

PTM databases

iPTMnetiQ9QYP2
PhosphoSitePlusiQ9QYP2
UniCarbKBiQ9QYP2

Expressioni

Tissue specificityi

Expressed in the brain. High expression in cerebellum and olfactory bulb. Weaker expression in cerebral cortex, hippocampus and brain stem.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027263

Structurei

3D structure databases

ProteinModelPortaliQ9QYP2
SMRiQ9QYP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 40Cadherin 1PROSITE-ProRule annotationAdd BLAST›40
Domaini41 – 146Cadherin 2PROSITE-ProRule annotationAdd BLAST106
Domaini147 – 248Cadherin 3PROSITE-ProRule annotationAdd BLAST102
Domaini253 – 371Cadherin 4PROSITE-ProRule annotationAdd BLAST119
Domaini453 – 511EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini513 – 549EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini553 – 591EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini592 – 796Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini799 – 835EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini839 – 1016Laminin G-like 2PROSITE-ProRule annotationAdd BLAST178
Domaini1018 – 1053EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1054 – 1092EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1108 – 1147EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1149 – 1196Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini1541 – 1593GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1968 – 1973Poly-Glu6

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
HOGENOMiHOG000231346
HOVERGENiHBG050887
InParanoidiQ9QYP2
PhylomeDBiQ9QYP2

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 2 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 3 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 4 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

Sequencei

Sequence statusi: Fragment.

Q9QYP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EDQVSYTLAI TARDNGIPQK SDTTYLEILV NDVNDNAPQF LRDSYQGSVY
60 70 80 90 100
EDVPPFTSVL QISATDRDSG LNGRVFYTFQ GGDDGDGDFI VESTSGIVRT
110 120 130 140 150
LRRLDRENVA QYILRAYAVD KGMPPARTPM EVTVTVLDVN DNPPVFEQDE
160 170 180 190 200
FDVFVEENSP IGLAVARVTA TDPDEGTNAQ IMYQIVEGNI PEVFQLDIFS
210 220 230 240 250
GELTALVDLD YEDRPEYILV IQATSAPLVS RATVHVRLLD RNDNPPVLGN
260 270 280 290 300
FEILFNNYVT NRSSSFPGGA IGRVPAHDPD ISDSLTYSFE RGNELSLVLL
310 320 330 340 350
NASTGELRLS RALDNNRPLE AIMSVLVSDG VHSVTAQCSL RVTIITDEML
360 370 380 390 400
THSITLRLED MSPERFLSPL LGLFIQAVAA TLATPPDHVV VFNVQRDTDA
410 420 430 440 450
PGGHILNVSL SVGQPPGPGG GPPFLPSEDL QERLYLNRSL LTAISAQRVL
460 470 480 490 500
PFDDNICLRE PCENYMRCVS VLRFDSSAPF IASSSVLFRP IHPVGGLRCR
510 520 530 540 550
CPPGFTGDYC ETEVDLCYSR PCGPHGHCRS REGGYTCLCR DGYTGEHCEV
560 570 580 590 600
SARSGRCTPG VCKNGGTCVN LLVGGFKCDC PSGDFEKPFC QVTTRSFPAR
610 620 630 640 650
SFITFRGLRQ RFHFTLALSF ATKERDGLLL YNGRFNEKHD FVALEVIQEQ
660 670 680 690 700
VQLTFSAGES TTTVSPFVPG GVSDGQWHTV QLKYYNKPLL GQTGLPQGPS
710 720 730 740 750
EQKVAVVSVD GCDTGVALRF GAMLGNYSCA AQGTQGGSKK SLDLTGPLLL
760 770 780 790 800
GGVPDLPESF PVRMRHFVGC MKNLQVDSRH VDMADFIANN GTVPGCPTKK
810 820 830 840 850
NVCDSNTCHN GGTCVNQWDA FSCECPLGFG GKSCAQEMAN PQRFLGSSLV
860 870 880 890 900
AWHGLSLPIS QPWHLSLMFR TRQADGVLLQ AVTRGRSTIT LQLRAGHVVL
910 920 930 940 950
SVEGTGLQAS SLRLEPGRAN DGDWHHAQLS LGASGGPGHA ILSFDYGQQK
960 970 980 990 1000
AEGNLGPRLH GLHLSNMTVG GVPGPASSVA RGFRGCLQGV RVSETPEGVS
1010 1020 1030 1040 1050
SLDPSRGESI NVEPGCSWPD PCDSNPCPTN SYCSNDWDSY SCSCDPGYYG
1060 1070 1080 1090 1100
DNCTNVCDLN PCEHQSACTR KPSAPHGYIC ECLPNYLGPY CETRIDQPCP
1110 1120 1130 1140 1150
RGWWGHPTCG PCNCDVSKGF DPDCNKTSGE CHCKENHYRP PSSPTCLLCD
1160 1170 1180 1190 1200
CYPTGSLSRV CDPEDGQCPC KPGVIGRQCD RCDNPFAEVT TNGCEVNYDS
1210 1220 1230 1240 1250
CPRAIEAGIW WPRTRFGLPA AAPCPKGSFG TAVRHCDEHR GWLPPNLFNC
1260 1270 1280 1290 1300
TSVTFSELKG FAERLQRNES GLDSGRSQRL ALLLRNATQH TSGYFGSDVK
1310 1320 1330 1340 1350
VAYQLATRLL AHESAQRGFG LSATQDVHFT ENLLRVGSAL LDAANKRHWE
1360 1370 1380 1390 1400
LIQQTEGGTA WLLQHYEAYA SALAQNMRHT YLSPFTIVTP NIVISVVRLD
1410 1420 1430 1440 1450
KGNFAGTKLP RYEALRGERP PDLETTVILP ESVFREMPPM VRSAGPGEAQ
1460 1470 1480 1490 1500
ETEELARRQR RHPELSQGEA VASVIIYHTL AGLLPHNYDP DKRSLRVPKR
1510 1520 1530 1540 1550
PVINTPVVSI SVHDDEELLP RALDKPVTVQ FRLLETEERT KPICVFWNHS
1560 1570 1580 1590 1600
ILVSGTGGWS ARGCEVVFRN ESHVSCQCNH MTSFAVLMDV SRRENGEILP
1610 1620 1630 1640 1650
LKTLTYVALG VTLAALMITF LFLTLLRALR SNQHGIRRNL TAALGLAQLV
1660 1670 1680 1690 1700
FLLGINQADL PFACTVIAIL LHFLYLCTFS WALLEALHLY RALTEVRDVN
1710 1720 1730 1740 1750
ASPMRFYYML GWGVPAFITG LAVGLDPEGY GNPDFCWLSI YDTLIWSFAG
1760 1770 1780 1790 1800
PVAFAVSMSV FLYILSARAS CAAQRQGFEK KGPVSGLRSS FTVLLLLSAT
1810 1820 1830 1840 1850
WLLALLSVNS DTLLFHYLFA ACNCVQGPFI FLSYVVLSKE VRKALKFACS
1860 1870 1880 1890 1900
RKPSPDPALT TKSTLTSSYN CPSPYADGRL YQPYGDSAGS LHSASRSGKS
1910 1920 1930 1940 1950
QPSYIPFLLR EESTLNPGQV PPGLGDPSGL FMEGQAQQHD PDTDSDSDLS
1960 1970 1980 1990 2000
LEDDQSGSYA STHSSDSEEE EEEAAFPGEQ GWDSLLGPGA ERLPLHSTPK
2010 2020 2030 2040 2050
DGGPGSGKVP WPGDFGTTTK ENSGSGPLEE RPRENGDALT REGSLGPLPG
2060 2070 2080 2090 2100
PSTQPHKGIL KKKCLPTISE KSSLLRLPLE QGTGSSRGST ASEGSRNGPP
2110 2120 2130 2140
PRPPPRQSLQ EQLNGVMPIA MSIKAGTVDE DSSGSEFLFF NFLH
Length:2,144
Mass (Da):233,481
Last modified:May 1, 2000 - v1
Checksum:i6EA898C1BA655ECA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011529 mRNA Translation: BAA88687.1
UniGeneiRn.222746

Genome annotation databases

UCSCiRGD:69237 rat

Similar proteinsi

Entry informationi

Entry nameiCELR2_RAT
AccessioniPrimary (citable) accession number: Q9QYP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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