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Q9QYP2

- CELR2_RAT

UniProt

Q9QYP2 - CELR2_RAT

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Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene
Celsr2, Megf3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. dendrite morphogenesis Source: BHF-UCL
  2. homophilic cell adhesion Source: InterPro
  3. neuropeptide signaling pathway Source: InterPro
  4. regulation of cell-cell adhesion Source: BHF-UCL
  5. spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Multiple epidermal growth factor-like domains protein 3
Short name:
Multiple EGF-like domains protein 3
Gene namesi
Name:Celsr2
Synonyms:Megf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69237. Celsr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 16051605Extracellular Reviewed predictionAdd
BLAST
Transmembranei1606 – 162621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini1627 – 164115Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1642 – 166221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini1663 – 16631Extracellular Reviewed prediction
Transmembranei1664 – 168421Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini1685 – 170521Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1706 – 172621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini1727 – 174418Extracellular Reviewed predictionAdd
BLAST
Transmembranei1745 – 176521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini1766 – 178924Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1790 – 181021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini1811 – 18166Extracellular Reviewed prediction
Transmembranei1817 – 183721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini1838 – 2144307Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 2144›2144Cadherin EGF LAG seven-pass G-type receptor 2PRO_0000070345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi407 – 4071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi437 – 4371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi457 ↔ 468 By similarity
Disulfide bondi462 ↔ 499 By similarity
Disulfide bondi501 ↔ 510 By similarity
Disulfide bondi517 ↔ 528 By similarity
Disulfide bondi522 ↔ 537 By similarity
Disulfide bondi539 ↔ 548 By similarity
Disulfide bondi557 ↔ 568 By similarity
Disulfide bondi562 ↔ 578 By similarity
Disulfide bondi580 ↔ 590 By similarity
Glycosylationi726 – 7261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi770 ↔ 796 By similarity
Glycosylationi790 – 7901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi803 ↔ 814 By similarity
Disulfide bondi808 ↔ 823 By similarity
Modified residuei816 – 8161(3R)-3-hydroxyasparagine Reviewed prediction
Disulfide bondi825 ↔ 834 By similarity
Glycosylationi966 – 9661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi986 ↔ 1016 By similarity
Disulfide bondi1022 ↔ 1033 By similarity
Disulfide bondi1027 ↔ 1042 By similarity
Modified residuei1035 – 10351(3R)-3-hydroxyasparagine Reviewed prediction
Disulfide bondi1044 ↔ 1053 By similarity
Glycosylationi1052 – 10521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1057 ↔ 1068 By similarity
Disulfide bondi1062 ↔ 1080 By similarity
Disulfide bondi1082 ↔ 1091 By similarity
Disulfide bondi1112 ↔ 1124 By similarity
Disulfide bondi1114 ↔ 1131 By similarity
Glycosylationi1125 – 11251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1133 ↔ 1146 By similarity
Disulfide bondi1149 ↔ 1161 By similarity
Disulfide bondi1151 ↔ 1168 By similarity
Disulfide bondi1170 ↔ 1179 By similarity
Disulfide bondi1182 ↔ 1194 By similarity
Glycosylationi1249 – 12491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1268 – 12681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1286 – 12861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1548 – 15481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1570 – 15701N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ9QYP2.
PRIDEiQ9QYP2.

PTM databases

PhosphoSiteiQ9QYP2.

Expressioni

Tissue specificityi

Expressed in the brain. High expression in cerebellum and olfactory bulb. Weaker expression in cerebral cortex, hippocampus and brain stem.

Gene expression databases

GenevestigatoriQ9QYP2.

Structurei

3D structure databases

ProteinModelPortaliQ9QYP2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 40›40Cadherin 1Add
BLAST
Domaini41 – 146106Cadherin 2Add
BLAST
Domaini147 – 248102Cadherin 3Add
BLAST
Domaini253 – 371119Cadherin 4Add
BLAST
Domaini453 – 51159EGF-like 1; calcium-bindingAdd
BLAST
Domaini513 – 54937EGF-like 2; calcium-bindingAdd
BLAST
Domaini553 – 59139EGF-like 3; calcium-bindingAdd
BLAST
Domaini592 – 796205Laminin G-like 1Add
BLAST
Domaini799 – 83537EGF-like 4; calcium-bindingAdd
BLAST
Domaini839 – 1016178Laminin G-like 2Add
BLAST
Domaini1018 – 105336EGF-like 5; calcium-bindingAdd
BLAST
Domaini1054 – 109239EGF-like 6; calcium-bindingAdd
BLAST
Domaini1108 – 114740EGF-like 7; calcium-bindingAdd
BLAST
Domaini1149 – 119648Laminin EGF-likeAdd
BLAST
Domaini1541 – 159353GPSAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1968 – 19736Poly-Glu

Sequence similaritiesi

Contains 4 cadherin domains.
Contains 7 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ9QYP2.
PhylomeDBiQ9QYP2.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 4 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 2 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 2 hits.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 3 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9QYP2-1 [UniParc]FASTAAdd to Basket

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EDQVSYTLAI TARDNGIPQK SDTTYLEILV NDVNDNAPQF LRDSYQGSVY     50
EDVPPFTSVL QISATDRDSG LNGRVFYTFQ GGDDGDGDFI VESTSGIVRT 100
LRRLDRENVA QYILRAYAVD KGMPPARTPM EVTVTVLDVN DNPPVFEQDE 150
FDVFVEENSP IGLAVARVTA TDPDEGTNAQ IMYQIVEGNI PEVFQLDIFS 200
GELTALVDLD YEDRPEYILV IQATSAPLVS RATVHVRLLD RNDNPPVLGN 250
FEILFNNYVT NRSSSFPGGA IGRVPAHDPD ISDSLTYSFE RGNELSLVLL 300
NASTGELRLS RALDNNRPLE AIMSVLVSDG VHSVTAQCSL RVTIITDEML 350
THSITLRLED MSPERFLSPL LGLFIQAVAA TLATPPDHVV VFNVQRDTDA 400
PGGHILNVSL SVGQPPGPGG GPPFLPSEDL QERLYLNRSL LTAISAQRVL 450
PFDDNICLRE PCENYMRCVS VLRFDSSAPF IASSSVLFRP IHPVGGLRCR 500
CPPGFTGDYC ETEVDLCYSR PCGPHGHCRS REGGYTCLCR DGYTGEHCEV 550
SARSGRCTPG VCKNGGTCVN LLVGGFKCDC PSGDFEKPFC QVTTRSFPAR 600
SFITFRGLRQ RFHFTLALSF ATKERDGLLL YNGRFNEKHD FVALEVIQEQ 650
VQLTFSAGES TTTVSPFVPG GVSDGQWHTV QLKYYNKPLL GQTGLPQGPS 700
EQKVAVVSVD GCDTGVALRF GAMLGNYSCA AQGTQGGSKK SLDLTGPLLL 750
GGVPDLPESF PVRMRHFVGC MKNLQVDSRH VDMADFIANN GTVPGCPTKK 800
NVCDSNTCHN GGTCVNQWDA FSCECPLGFG GKSCAQEMAN PQRFLGSSLV 850
AWHGLSLPIS QPWHLSLMFR TRQADGVLLQ AVTRGRSTIT LQLRAGHVVL 900
SVEGTGLQAS SLRLEPGRAN DGDWHHAQLS LGASGGPGHA ILSFDYGQQK 950
AEGNLGPRLH GLHLSNMTVG GVPGPASSVA RGFRGCLQGV RVSETPEGVS 1000
SLDPSRGESI NVEPGCSWPD PCDSNPCPTN SYCSNDWDSY SCSCDPGYYG 1050
DNCTNVCDLN PCEHQSACTR KPSAPHGYIC ECLPNYLGPY CETRIDQPCP 1100
RGWWGHPTCG PCNCDVSKGF DPDCNKTSGE CHCKENHYRP PSSPTCLLCD 1150
CYPTGSLSRV CDPEDGQCPC KPGVIGRQCD RCDNPFAEVT TNGCEVNYDS 1200
CPRAIEAGIW WPRTRFGLPA AAPCPKGSFG TAVRHCDEHR GWLPPNLFNC 1250
TSVTFSELKG FAERLQRNES GLDSGRSQRL ALLLRNATQH TSGYFGSDVK 1300
VAYQLATRLL AHESAQRGFG LSATQDVHFT ENLLRVGSAL LDAANKRHWE 1350
LIQQTEGGTA WLLQHYEAYA SALAQNMRHT YLSPFTIVTP NIVISVVRLD 1400
KGNFAGTKLP RYEALRGERP PDLETTVILP ESVFREMPPM VRSAGPGEAQ 1450
ETEELARRQR RHPELSQGEA VASVIIYHTL AGLLPHNYDP DKRSLRVPKR 1500
PVINTPVVSI SVHDDEELLP RALDKPVTVQ FRLLETEERT KPICVFWNHS 1550
ILVSGTGGWS ARGCEVVFRN ESHVSCQCNH MTSFAVLMDV SRRENGEILP 1600
LKTLTYVALG VTLAALMITF LFLTLLRALR SNQHGIRRNL TAALGLAQLV 1650
FLLGINQADL PFACTVIAIL LHFLYLCTFS WALLEALHLY RALTEVRDVN 1700
ASPMRFYYML GWGVPAFITG LAVGLDPEGY GNPDFCWLSI YDTLIWSFAG 1750
PVAFAVSMSV FLYILSARAS CAAQRQGFEK KGPVSGLRSS FTVLLLLSAT 1800
WLLALLSVNS DTLLFHYLFA ACNCVQGPFI FLSYVVLSKE VRKALKFACS 1850
RKPSPDPALT TKSTLTSSYN CPSPYADGRL YQPYGDSAGS LHSASRSGKS 1900
QPSYIPFLLR EESTLNPGQV PPGLGDPSGL FMEGQAQQHD PDTDSDSDLS 1950
LEDDQSGSYA STHSSDSEEE EEEAAFPGEQ GWDSLLGPGA ERLPLHSTPK 2000
DGGPGSGKVP WPGDFGTTTK ENSGSGPLEE RPRENGDALT REGSLGPLPG 2050
PSTQPHKGIL KKKCLPTISE KSSLLRLPLE QGTGSSRGST ASEGSRNGPP 2100
PRPPPRQSLQ EQLNGVMPIA MSIKAGTVDE DSSGSEFLFF NFLH 2144
Length:2,144
Mass (Da):233,481
Last modified:May 1, 2000 - v1
Checksum:i6EA898C1BA655ECA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011529 mRNA. Translation: BAA88687.1.
UniGeneiRn.222746.

Genome annotation databases

UCSCiRGD:69237. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011529 mRNA. Translation: BAA88687.1 .
UniGenei Rn.222746.

3D structure databases

ProteinModelPortali Q9QYP2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QYP2.

Proteomic databases

PaxDbi Q9QYP2.
PRIDEi Q9QYP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:69237. rat.

Organism-specific databases

RGDi 69237. Celsr2.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000231346.
HOVERGENi HBG050887.
InParanoidi Q9QYP2.
PhylomeDBi Q9QYP2.

Gene expression databases

Genevestigatori Q9QYP2.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 4 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 2 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 2 hits.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTi SM00112. CA. 3 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 4 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCELR2_RAT
AccessioniPrimary (citable) accession number: Q9QYP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi