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Q9QYP2

- CELR2_RAT

UniProt

Q9QYP2 - CELR2_RAT

Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

Celsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor that may have an important role in cell/cell signaling during nervous system formation.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. dendrite morphogenesis Source: BHF-UCL
    2. homophilic cell adhesion Source: InterPro
    3. neuropeptide signaling pathway Source: InterPro
    4. regulation of cell-cell adhesion Source: BHF-UCL
    5. spermatogenesis Source: RGD

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin EGF LAG seven-pass G-type receptor 2
    Alternative name(s):
    Multiple epidermal growth factor-like domains protein 3
    Short name:
    Multiple EGF-like domains protein 3
    Gene namesi
    Name:Celsr2
    Synonyms:Megf3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69237. Celsr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 2144›2144Cadherin EGF LAG seven-pass G-type receptor 2PRO_0000070345Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi457 ↔ 468By similarity
    Disulfide bondi462 ↔ 499By similarity
    Disulfide bondi501 ↔ 510By similarity
    Disulfide bondi517 ↔ 528By similarity
    Disulfide bondi522 ↔ 537By similarity
    Disulfide bondi539 ↔ 548By similarity
    Disulfide bondi557 ↔ 568By similarity
    Disulfide bondi562 ↔ 578By similarity
    Disulfide bondi580 ↔ 590By similarity
    Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi770 ↔ 796By similarity
    Glycosylationi790 – 7901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi803 ↔ 814By similarity
    Disulfide bondi808 ↔ 823By similarity
    Modified residuei816 – 8161(3R)-3-hydroxyasparagineSequence Analysis
    Disulfide bondi825 ↔ 834By similarity
    Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi986 ↔ 1016By similarity
    Disulfide bondi1022 ↔ 1033By similarity
    Disulfide bondi1027 ↔ 1042By similarity
    Modified residuei1035 – 10351(3R)-3-hydroxyasparagineSequence Analysis
    Disulfide bondi1044 ↔ 1053By similarity
    Glycosylationi1052 – 10521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1057 ↔ 1068By similarity
    Disulfide bondi1062 ↔ 1080By similarity
    Disulfide bondi1082 ↔ 1091By similarity
    Disulfide bondi1112 ↔ 1124By similarity
    Disulfide bondi1114 ↔ 1131By similarity
    Glycosylationi1125 – 11251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1133 ↔ 1146By similarity
    Disulfide bondi1149 ↔ 1161By similarity
    Disulfide bondi1151 ↔ 1168By similarity
    Disulfide bondi1170 ↔ 1179By similarity
    Disulfide bondi1182 ↔ 1194By similarity
    Glycosylationi1249 – 12491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1268 – 12681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1286 – 12861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1548 – 15481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1570 – 15701N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiQ9QYP2.
    PRIDEiQ9QYP2.

    PTM databases

    PhosphoSiteiQ9QYP2.

    Expressioni

    Tissue specificityi

    Expressed in the brain. High expression in cerebellum and olfactory bulb. Weaker expression in cerebral cortex, hippocampus and brain stem.

    Gene expression databases

    GenevestigatoriQ9QYP2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 16051605ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1627 – 164115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1663 – 16631ExtracellularSequence Analysis
    Topological domaini1685 – 170521CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1727 – 174418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1766 – 178924CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1811 – 18166ExtracellularSequence Analysis
    Topological domaini1838 – 2144307CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1606 – 162621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei1642 – 166221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei1664 – 168421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei1706 – 172621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1745 – 176521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1790 – 181021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1817 – 183721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 40›40Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini41 – 146106Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini147 – 248102Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini253 – 371119Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini453 – 51159EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini513 – 54937EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini553 – 59139EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini592 – 796205Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini799 – 83537EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini839 – 1016178Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1018 – 105336EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1054 – 109239EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1108 – 114740EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1149 – 119648Laminin EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini1541 – 159353GPSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1968 – 19736Poly-Glu

    Sequence similaritiesi

    Contains 4 cadherin domains.PROSITE-ProRule annotation
    Contains 7 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 laminin EGF-like domain.PROSITE-ProRule annotation
    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Laminin EGF-like domain, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000231346.
    HOVERGENiHBG050887.
    InParanoidiQ9QYP2.
    PhylomeDBiQ9QYP2.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    2.60.40.60. 4 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR002049. EGF_laminin.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR001791. Laminin_G.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF00028. Cadherin. 2 hits.
    PF12003. DUF3497. 1 hit.
    PF00008. EGF. 2 hits.
    PF01825. GPS. 1 hit.
    PF00053. Laminin_EGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR00249. GPCRSECRETIN.
    SMARTiSM00112. CA. 3 hits.
    SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 1 hit.
    SM00180. EGF_Lam. 1 hit.
    SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00282. LamG. 2 hits.
    SM00208. TNFR. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 4 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
    PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 4 hits.
    PS00022. EGF_1. 6 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 2 hits.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9QYP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    EDQVSYTLAI TARDNGIPQK SDTTYLEILV NDVNDNAPQF LRDSYQGSVY     50
    EDVPPFTSVL QISATDRDSG LNGRVFYTFQ GGDDGDGDFI VESTSGIVRT 100
    LRRLDRENVA QYILRAYAVD KGMPPARTPM EVTVTVLDVN DNPPVFEQDE 150
    FDVFVEENSP IGLAVARVTA TDPDEGTNAQ IMYQIVEGNI PEVFQLDIFS 200
    GELTALVDLD YEDRPEYILV IQATSAPLVS RATVHVRLLD RNDNPPVLGN 250
    FEILFNNYVT NRSSSFPGGA IGRVPAHDPD ISDSLTYSFE RGNELSLVLL 300
    NASTGELRLS RALDNNRPLE AIMSVLVSDG VHSVTAQCSL RVTIITDEML 350
    THSITLRLED MSPERFLSPL LGLFIQAVAA TLATPPDHVV VFNVQRDTDA 400
    PGGHILNVSL SVGQPPGPGG GPPFLPSEDL QERLYLNRSL LTAISAQRVL 450
    PFDDNICLRE PCENYMRCVS VLRFDSSAPF IASSSVLFRP IHPVGGLRCR 500
    CPPGFTGDYC ETEVDLCYSR PCGPHGHCRS REGGYTCLCR DGYTGEHCEV 550
    SARSGRCTPG VCKNGGTCVN LLVGGFKCDC PSGDFEKPFC QVTTRSFPAR 600
    SFITFRGLRQ RFHFTLALSF ATKERDGLLL YNGRFNEKHD FVALEVIQEQ 650
    VQLTFSAGES TTTVSPFVPG GVSDGQWHTV QLKYYNKPLL GQTGLPQGPS 700
    EQKVAVVSVD GCDTGVALRF GAMLGNYSCA AQGTQGGSKK SLDLTGPLLL 750
    GGVPDLPESF PVRMRHFVGC MKNLQVDSRH VDMADFIANN GTVPGCPTKK 800
    NVCDSNTCHN GGTCVNQWDA FSCECPLGFG GKSCAQEMAN PQRFLGSSLV 850
    AWHGLSLPIS QPWHLSLMFR TRQADGVLLQ AVTRGRSTIT LQLRAGHVVL 900
    SVEGTGLQAS SLRLEPGRAN DGDWHHAQLS LGASGGPGHA ILSFDYGQQK 950
    AEGNLGPRLH GLHLSNMTVG GVPGPASSVA RGFRGCLQGV RVSETPEGVS 1000
    SLDPSRGESI NVEPGCSWPD PCDSNPCPTN SYCSNDWDSY SCSCDPGYYG 1050
    DNCTNVCDLN PCEHQSACTR KPSAPHGYIC ECLPNYLGPY CETRIDQPCP 1100
    RGWWGHPTCG PCNCDVSKGF DPDCNKTSGE CHCKENHYRP PSSPTCLLCD 1150
    CYPTGSLSRV CDPEDGQCPC KPGVIGRQCD RCDNPFAEVT TNGCEVNYDS 1200
    CPRAIEAGIW WPRTRFGLPA AAPCPKGSFG TAVRHCDEHR GWLPPNLFNC 1250
    TSVTFSELKG FAERLQRNES GLDSGRSQRL ALLLRNATQH TSGYFGSDVK 1300
    VAYQLATRLL AHESAQRGFG LSATQDVHFT ENLLRVGSAL LDAANKRHWE 1350
    LIQQTEGGTA WLLQHYEAYA SALAQNMRHT YLSPFTIVTP NIVISVVRLD 1400
    KGNFAGTKLP RYEALRGERP PDLETTVILP ESVFREMPPM VRSAGPGEAQ 1450
    ETEELARRQR RHPELSQGEA VASVIIYHTL AGLLPHNYDP DKRSLRVPKR 1500
    PVINTPVVSI SVHDDEELLP RALDKPVTVQ FRLLETEERT KPICVFWNHS 1550
    ILVSGTGGWS ARGCEVVFRN ESHVSCQCNH MTSFAVLMDV SRRENGEILP 1600
    LKTLTYVALG VTLAALMITF LFLTLLRALR SNQHGIRRNL TAALGLAQLV 1650
    FLLGINQADL PFACTVIAIL LHFLYLCTFS WALLEALHLY RALTEVRDVN 1700
    ASPMRFYYML GWGVPAFITG LAVGLDPEGY GNPDFCWLSI YDTLIWSFAG 1750
    PVAFAVSMSV FLYILSARAS CAAQRQGFEK KGPVSGLRSS FTVLLLLSAT 1800
    WLLALLSVNS DTLLFHYLFA ACNCVQGPFI FLSYVVLSKE VRKALKFACS 1850
    RKPSPDPALT TKSTLTSSYN CPSPYADGRL YQPYGDSAGS LHSASRSGKS 1900
    QPSYIPFLLR EESTLNPGQV PPGLGDPSGL FMEGQAQQHD PDTDSDSDLS 1950
    LEDDQSGSYA STHSSDSEEE EEEAAFPGEQ GWDSLLGPGA ERLPLHSTPK 2000
    DGGPGSGKVP WPGDFGTTTK ENSGSGPLEE RPRENGDALT REGSLGPLPG 2050
    PSTQPHKGIL KKKCLPTISE KSSLLRLPLE QGTGSSRGST ASEGSRNGPP 2100
    PRPPPRQSLQ EQLNGVMPIA MSIKAGTVDE DSSGSEFLFF NFLH 2144
    Length:2,144
    Mass (Da):233,481
    Last modified:May 1, 2000 - v1
    Checksum:i6EA898C1BA655ECA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011529 mRNA. Translation: BAA88687.1.
    UniGeneiRn.222746.

    Genome annotation databases

    UCSCiRGD:69237. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011529 mRNA. Translation: BAA88687.1 .
    UniGenei Rn.222746.

    3D structure databases

    ProteinModelPortali Q9QYP2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9QYP2.

    Proteomic databases

    PaxDbi Q9QYP2.
    PRIDEi Q9QYP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:69237. rat.

    Organism-specific databases

    RGDi 69237. Celsr2.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000231346.
    HOVERGENi HBG050887.
    InParanoidi Q9QYP2.
    PhylomeDBi Q9QYP2.

    Gene expression databases

    Genevestigatori Q9QYP2.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    2.60.40.60. 4 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR002049. EGF_laminin.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR001791. Laminin_G.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF00028. Cadherin. 2 hits.
    PF12003. DUF3497. 1 hit.
    PF00008. EGF. 2 hits.
    PF01825. GPS. 1 hit.
    PF00053. Laminin_EGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR00249. GPCRSECRETIN.
    SMARTi SM00112. CA. 3 hits.
    SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 1 hit.
    SM00180. EGF_Lam. 1 hit.
    SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00282. LamG. 2 hits.
    SM00208. TNFR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 4 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
    PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 4 hits.
    PS00022. EGF_1. 6 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 2 hits.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCELR2_RAT
    AccessioniPrimary (citable) accession number: Q9QYP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3