Q9QYN5 (BCL10_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B-cell lymphoma/leukemia 10

Alternative name(s):
B-cell CLL/lymphoma 10
Short name=Bcl-10
R-RCD1
Short name=RCD

Gene names

Name:

Bcl10

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex By similarity. Is a substrate for MALT1 By similarity.
Subunit structure	Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain By similarity. Interacts with TRAF2 and BIRC2/c-IAP2.
Subcellular location	Cytoplasm By similarity. Membrane raft By similarity. Note: Colocalized with DPP4 in membrane rafts By similarity.
Post-translational modification	Phosphorylated by IKBKB/IKKB By similarity.
Sequence similarities	Contains 1 CARD domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Membrane
Disease	Tumor suppressor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB induction of apoptosis Inferred from direct assay Ref.1. Source: RGD innate immune response Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of mature B cell apoptosis Inferred from sequence or structural similarity. Source: UniProtKB neural tube closure Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of NF-kappaB transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of interleukin-8 biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein ubiquitination Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB protein homooligomerization Inferred from sequence or structural similarity. Source: UniProtKB response to molecule of bacterial origin Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB lysosome Inferred from sequence or structural similarity. Source: UniProtKB membrane raft Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	NF-kappaB binding Inferred from sequence or structural similarity. Source: UniProtKB protein C-terminus binding Inferred from sequence or structural similarity. Source: UniProtKB protein kinase B binding Inferred from sequence or structural similarity. Source: UniProtKB protein self-association Inferred from sequence or structural similarity. Source: UniProtKB transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin binding Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin protein ligase binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	B-cell lymphoma/leukemia 10		PRO_0000144076
Regions
	Domain	13 – 101	89	CARD
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QYN5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B43274B4B825FC7D	FASTA	233	25,999
	10 20 30 40 50 60 MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 70 80 90 100 110 120 SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS 130 140 150 160 170 180 SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS TVIYHPEGES STAPFFSTES SLNLPVLEVG 190 200 210 220 230 RLENSSFSSA SLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein." Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., Sato N., Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., Ugawa S., Yamada S., Okabe M., Tohyama M. J. Biol. Chem. 275:11114-11120(2000) [PubMed: 10753917] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryonic brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB016069 mRNA. Translation: BAA88822.1. BC061772 mRNA. Translation: AAH61772.1.
IPI	IPI00214295.
RefSeq	NP_112618.1. NM_031328.1.
UniGene	Rn.13007.
3D structure databases
ProteinModelPortal	Q9QYN5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QYN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83477.
KEGG	rno:83477.
Organism-specific databases
CTD	8915.
RGD	620544. Bcl10.
Phylogenomic databases
eggNOG	roNOG16681.
GeneTree	ENSGT00490000043442.
HOVERGEN	HBG050680.
OrthoDB	EOG41JZD7.
Gene expression databases
ArrayExpress	Q9QYN5.
Genevestigator	Q9QYN5.
GermOnline	ENSRNOG00000014613. Rattus norvegicus.
Family and domain databases
InterPro	IPR001315. CARD. IPR011029. DEATH-like. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 1 hit.
KO	K07368.
Pfam	PF00619. CARD. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50209. CARD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615897.

Entry information

Entry name

BCL10_RAT

Accession

Primary (citable) accession number: Q9QYN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program