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Protein

B-cell lymphoma/leukemia 10

Gene

Bcl10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma/leukemia 10
Alternative name(s):
B-cell CLL/lymphoma 10
Short name:
Bcl-10
R-RCD1
Short name:
RCD
Gene namesi
Name:Bcl10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620544. Bcl10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233B-cell lymphoma/leukemia 10PRO_0000144076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by IKBKB/IKKB.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QYN5.
PRIDEiQ9QYN5.

PTM databases

PhosphoSiteiQ9QYN5.

Expressioni

Gene expression databases

GenevisibleiQ9QYN5. RN.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain (By similarity). Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019911.

Structurei

3D structure databases

ProteinModelPortaliQ9QYN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10189CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVMM. Eukaryota.
ENOG4111JRA. LUCA.
GeneTreeiENSGT00490000043442.
HOGENOMiHOG000008671.
HOVERGENiHBG050680.
InParanoidiQ9QYN5.
KOiK07368.
OMAiRHYLCDK.
OrthoDBiEOG79W97M.
PhylomeDBiQ9QYN5.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR033238. BCL10/E10.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PANTHERiPTHR34920:SF1. PTHR34920:SF1. 1 hit.
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE
60 70 80 90 100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT
110 120 130 140 150
DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS
160 170 180 190 200
TVIYHPEGES STAPFFSTES SLNLPVLEVG RLENSSFSSA SLPRPGDPGA
210 220 230
PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ
Length:233
Mass (Da):25,999
Last modified:May 1, 2000 - v1
Checksum:iB43274B4B825FC7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016069 mRNA. Translation: BAA88822.1.
BC061772 mRNA. Translation: AAH61772.1.
RefSeqiNP_112618.1. NM_031328.1.
UniGeneiRn.13007.

Genome annotation databases

EnsembliENSRNOT00000019911; ENSRNOP00000019911; ENSRNOG00000042389.
GeneIDi83477.
KEGGirno:83477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016069 mRNA. Translation: BAA88822.1.
BC061772 mRNA. Translation: AAH61772.1.
RefSeqiNP_112618.1. NM_031328.1.
UniGeneiRn.13007.

3D structure databases

ProteinModelPortaliQ9QYN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019911.

PTM databases

PhosphoSiteiQ9QYN5.

Proteomic databases

PaxDbiQ9QYN5.
PRIDEiQ9QYN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019911; ENSRNOP00000019911; ENSRNOG00000042389.
GeneIDi83477.
KEGGirno:83477.

Organism-specific databases

CTDi8915.
RGDi620544. Bcl10.

Phylogenomic databases

eggNOGiENOG410IVMM. Eukaryota.
ENOG4111JRA. LUCA.
GeneTreeiENSGT00490000043442.
HOGENOMiHOG000008671.
HOVERGENiHBG050680.
InParanoidiQ9QYN5.
KOiK07368.
OMAiRHYLCDK.
OrthoDBiEOG79W97M.
PhylomeDBiQ9QYN5.

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.

Miscellaneous databases

NextBioi615897.
PROiQ9QYN5.

Gene expression databases

GenevisibleiQ9QYN5. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR033238. BCL10/E10.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PANTHERiPTHR34920:SF1. PTHR34920:SF1. 1 hit.
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein."
    Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., Sato N., Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., Ugawa S., Yamada S., Okabe M., Tohyama M.
    J. Biol. Chem. 275:11114-11120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiBCL10_RAT
AccessioniPrimary (citable) accession number: Q9QYN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.