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Protein

Kallikrein-11

Gene

Klk11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Charge relay systemBy similarity
Active sitei136 – 1361Charge relay systemBy similarity
Active sitei229 – 2291Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.257.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-11 (EC:3.4.21.-)
Alternative name(s):
Hippostasin
Serine protease 20
Gene namesi
Name:Klk11
Synonyms:Prss20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929977. Klk11.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence analysisAdd
BLAST
Propeptidei45 – 473Activation peptideSequence analysisPRO_0000224185
Chaini48 – 276229Kallikrein-11PRO_0000224186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 189PROSITE-ProRule annotation
Disulfide bondi73 ↔ 89PROSITE-ProRule annotation
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi168 ↔ 235PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi200 ↔ 214PROSITE-ProRule annotation
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi225 ↔ 250PROSITE-ProRule annotation
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9QYN3.
PRIDEiQ9QYN3.

PTM databases

iPTMnetiQ9QYN3.
PhosphoSiteiQ9QYN3.

Expressioni

Tissue specificityi

Expressed in brain and prostate (isoform 1) and prostate (isoform 2).1 Publication

Gene expression databases

BgeeiQ9QYN3.
CleanExiMM_KLK11.
ExpressionAtlasiQ9QYN3. baseline and differential.
GenevisibleiQ9QYN3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079101.

Structurei

3D structure databases

ProteinModelPortaliQ9QYN3.
SMRiQ9QYN3. Positions 18-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 274227Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9QYN3.
KOiK09620.
OMAiENAYPGN.
OrthoDBiEOG75B84T.
PhylomeDBiQ9QYN3.
TreeFamiTF331065.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9QYN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRLKSDWKL STETREPGAR PALLQARMIL RLIALALVTG HVGGETRIIK
60 70 80 90 100
GYECRPHSQP WQVALFQKTR LLCGATLIAP KWLLTAAHCR KPHYVILLGE
110 120 130 140 150
HNLEKTDGCE QRRMATESFP HPDFNNSLPN KDHRNDIMLV KMSSPVFFTR
160 170 180 190 200
AVQPLTLSPH CVAAGTSCLI SGWGTTSSPQ LRLPHSLRCA NVSIIEHKEC
210 220 230 240 250
EKAYPGNITD TMLCASVRKE GKDSCQGDSG GPLVCNGSLQ GIISWGQDPC
260 270
AVTRKPGVYT KVCKYFNWIH EVMRNN
Length:276
Mass (Da):30,754
Last modified:May 1, 2000 - v1
Checksum:i90BDC03A8AB178D6
GO
Isoform 1 (identifier: Q9QYN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:249
Mass (Da):27,604
Checksum:iF9FF9CB457D727D5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform 1. 1 PublicationVSP_017318Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016226 mRNA. Translation: BAA88825.1.
AB016227 mRNA. Translation: BAA36955.1.
AK009360 mRNA. Translation: BAB26241.2.
AK009720 mRNA. Translation: BAB26461.2.
CCDSiCCDS39935.1. [Q9QYN3-2]
CCDS52227.1. [Q9QYN3-1]
RefSeqiNP_001170844.1. NM_001177373.1. [Q9QYN3-1]
NP_064358.1. NM_019974.2. [Q9QYN3-2]
UniGeneiMm.154276.

Genome annotation databases

EnsembliENSMUST00000080211; ENSMUSP00000079101; ENSMUSG00000067616. [Q9QYN3-1]
ENSMUST00000171458; ENSMUSP00000132721; ENSMUSG00000067616. [Q9QYN3-2]
GeneIDi56538.
KEGGimmu:56538.
UCSCiuc009gnm.1. mouse. [Q9QYN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016226 mRNA. Translation: BAA88825.1.
AB016227 mRNA. Translation: BAA36955.1.
AK009360 mRNA. Translation: BAB26241.2.
AK009720 mRNA. Translation: BAB26461.2.
CCDSiCCDS39935.1. [Q9QYN3-2]
CCDS52227.1. [Q9QYN3-1]
RefSeqiNP_001170844.1. NM_001177373.1. [Q9QYN3-1]
NP_064358.1. NM_019974.2. [Q9QYN3-2]
UniGeneiMm.154276.

3D structure databases

ProteinModelPortaliQ9QYN3.
SMRiQ9QYN3. Positions 18-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079101.

Protein family/group databases

MEROPSiS01.257.

PTM databases

iPTMnetiQ9QYN3.
PhosphoSiteiQ9QYN3.

Proteomic databases

PaxDbiQ9QYN3.
PRIDEiQ9QYN3.

Protocols and materials databases

DNASUi56538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080211; ENSMUSP00000079101; ENSMUSG00000067616. [Q9QYN3-1]
ENSMUST00000171458; ENSMUSP00000132721; ENSMUSG00000067616. [Q9QYN3-2]
GeneIDi56538.
KEGGimmu:56538.
UCSCiuc009gnm.1. mouse. [Q9QYN3-1]

Organism-specific databases

CTDi11012.
MGIiMGI:1929977. Klk11.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9QYN3.
KOiK09620.
OMAiENAYPGN.
OrthoDBiEOG75B84T.
PhylomeDBiQ9QYN3.
TreeFamiTF331065.

Miscellaneous databases

NextBioi312902.
PROiQ9QYN3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYN3.
CleanExiMM_KLK11.
ExpressionAtlasiQ9QYN3. baseline and differential.
GenevisibleiQ9QYN3. MM.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20)."
    Mitsui S., Okui A., Kominami K., Uemura H., Yamagushi N.
    Biochim. Biophys. Acta 1494:206-210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Brain and Prostate.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Tongue.

Entry informationi

Entry nameiKLK11_MOUSE
AccessioniPrimary (citable) accession number: Q9QYN3
Secondary accession number(s): Q9QYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.