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Protein

Kallikrein-11

Gene

Klk11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Charge relay systemBy similarity1
Active sitei136Charge relay systemBy similarity1
Active sitei229Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.257.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-11 (EC:3.4.21.-)
Alternative name(s):
Hippostasin
Serine protease 20
Gene namesi
Name:Klk11
Synonyms:Prss20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929977. Klk11.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
PropeptideiPRO_000022418545 – 47Activation peptideSequence analysis3
ChainiPRO_000022418648 – 276Kallikrein-11Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 189PROSITE-ProRule annotation
Disulfide bondi73 ↔ 89PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 235PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi200 ↔ 214PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi225 ↔ 250PROSITE-ProRule annotation
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9QYN3.
PRIDEiQ9QYN3.

PTM databases

iPTMnetiQ9QYN3.
PhosphoSitePlusiQ9QYN3.

Expressioni

Tissue specificityi

Expressed in brain and prostate (isoform 1) and prostate (isoform 2).1 Publication

Gene expression databases

BgeeiENSMUSG00000067616.
CleanExiMM_KLK11.
ExpressionAtlasiQ9QYN3. baseline and differential.
GenevisibleiQ9QYN3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079101.

Structurei

3D structure databases

ProteinModelPortaliQ9QYN3.
SMRiQ9QYN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 274Peptidase S1PROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9QYN3.
KOiK09620.
OMAiGCEQRRM.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9QYN3.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9QYN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRLKSDWKL STETREPGAR PALLQARMIL RLIALALVTG HVGGETRIIK
60 70 80 90 100
GYECRPHSQP WQVALFQKTR LLCGATLIAP KWLLTAAHCR KPHYVILLGE
110 120 130 140 150
HNLEKTDGCE QRRMATESFP HPDFNNSLPN KDHRNDIMLV KMSSPVFFTR
160 170 180 190 200
AVQPLTLSPH CVAAGTSCLI SGWGTTSSPQ LRLPHSLRCA NVSIIEHKEC
210 220 230 240 250
EKAYPGNITD TMLCASVRKE GKDSCQGDSG GPLVCNGSLQ GIISWGQDPC
260 270
AVTRKPGVYT KVCKYFNWIH EVMRNN
Length:276
Mass (Da):30,754
Last modified:May 1, 2000 - v1
Checksum:i90BDC03A8AB178D6
GO
Isoform 1 (identifier: Q9QYN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:249
Mass (Da):27,604
Checksum:iF9FF9CB457D727D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173181 – 27Missing in isoform 1. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016226 mRNA. Translation: BAA88825.1.
AB016227 mRNA. Translation: BAA36955.1.
AK009360 mRNA. Translation: BAB26241.2.
AK009720 mRNA. Translation: BAB26461.2.
CCDSiCCDS39935.1. [Q9QYN3-2]
CCDS52227.1. [Q9QYN3-1]
RefSeqiNP_001170844.1. NM_001177373.1. [Q9QYN3-1]
NP_064358.1. NM_019974.2. [Q9QYN3-2]
UniGeneiMm.154276.

Genome annotation databases

EnsembliENSMUST00000080211; ENSMUSP00000079101; ENSMUSG00000067616. [Q9QYN3-1]
ENSMUST00000171458; ENSMUSP00000132721; ENSMUSG00000067616. [Q9QYN3-2]
GeneIDi56538.
KEGGimmu:56538.
UCSCiuc009gnm.1. mouse. [Q9QYN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016226 mRNA. Translation: BAA88825.1.
AB016227 mRNA. Translation: BAA36955.1.
AK009360 mRNA. Translation: BAB26241.2.
AK009720 mRNA. Translation: BAB26461.2.
CCDSiCCDS39935.1. [Q9QYN3-2]
CCDS52227.1. [Q9QYN3-1]
RefSeqiNP_001170844.1. NM_001177373.1. [Q9QYN3-1]
NP_064358.1. NM_019974.2. [Q9QYN3-2]
UniGeneiMm.154276.

3D structure databases

ProteinModelPortaliQ9QYN3.
SMRiQ9QYN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079101.

Protein family/group databases

MEROPSiS01.257.

PTM databases

iPTMnetiQ9QYN3.
PhosphoSitePlusiQ9QYN3.

Proteomic databases

PaxDbiQ9QYN3.
PRIDEiQ9QYN3.

Protocols and materials databases

DNASUi56538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080211; ENSMUSP00000079101; ENSMUSG00000067616. [Q9QYN3-1]
ENSMUST00000171458; ENSMUSP00000132721; ENSMUSG00000067616. [Q9QYN3-2]
GeneIDi56538.
KEGGimmu:56538.
UCSCiuc009gnm.1. mouse. [Q9QYN3-1]

Organism-specific databases

CTDi11012.
MGIiMGI:1929977. Klk11.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9QYN3.
KOiK09620.
OMAiGCEQRRM.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9QYN3.
TreeFamiTF331065.

Miscellaneous databases

PROiQ9QYN3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067616.
CleanExiMM_KLK11.
ExpressionAtlasiQ9QYN3. baseline and differential.
GenevisibleiQ9QYN3. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK11_MOUSE
AccessioniPrimary (citable) accession number: Q9QYN3
Secondary accession number(s): Q9QYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.