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Q9QYM8 (CENPH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centromere protein H

Short name=CENP-H
Gene names
Name:Cenph
Synonyms:Enp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate By similarity.

Subunit structure

Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS By similarity. Interacts directly with CENPK By similarity. Interacts with KIF2C and NDC80 By similarity. Interacts with TRIM36. Ref.4

Subcellular location

Nucleus. Chromosomecentromerekinetochore. Note: Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase. Ref.1

Tissue specificity

Abundantly expressed in thymus, spleen, uterus, ovary, testis and muscle, and weakly expressed in small intestine, lung and stomach. Barely detectable expression in kidney, liver, skin and prostate gland. Not detected in brain, heart or adrenal gland. Also expressed weakly in various hematopoietic cell lines. Ref.1

Developmental stage

Abundantly expressed between embryonic day 9.5 and 12.5. Ref.1

Sequence similarities

Belongs to the centromere protein H family.

Sequence caution

The sequence BAB27505.1 differs from that shown. Reason: Frameshift at position 195.

The sequence BAB27810.1 differs from that shown. Reason: Frameshift at position 195.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Centromere protein H
PRO_0000089479

Regions

Coiled coil28 – 186159 Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict2391N → T in AAH25084. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9QYM8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: A56CD10AFE07D0AD

FASTA24128,135
        10         20         30         40         50         60 
MEEQPRERSE AGAEACEEKR GLSQAAEERI EDRISLLLRL RAQTKQQLLE YKSMIDTNEE 

        70         80         90        100        110        120 
KTPEQIMQEK QIEVKIEELE NEIEDVKSNI EMKSLALSRM KLSVALRDNM ENMGPENCVL 

       130        140        150        160        170        180 
TDDMKHILKL QKLIMKSQEE SSELEKKLLD VRKKRLQLKQ ASRSKLLEIQ IEKNKQKEDV 

       190        200        210        220        230        240 
DKMENSEMIK TMKKKLQTEI KITTVVQHTF QGLILASKTN WAEDPALRET VLQLEKDLNT 


L 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel kinetochore protein, CENP-H."
Sugata N., Munekata E., Todokoro K.
J. Biol. Chem. 274:27343-27346(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[4]"TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression."
Miyajima N., Maruyama S., Nonomura K., Hatakeyama S.
Biochem. Biophys. Res. Commun. 381:383-387(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRIM36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB017634 mRNA. Translation: BAA88520.1.
AK011264 mRNA. Translation: BAB27505.1. Frameshift.
AK011738 mRNA. Translation: BAB27810.1. Frameshift.
BC025084 mRNA. Translation: AAH25084.1.
CCDSCCDS26738.1.
RefSeqNP_068686.1. NM_021886.1.
UniGeneMm.273502.

3D structure databases

ProteinModelPortalQ9QYM8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QYM8.

Proteomic databases

PaxDbQ9QYM8.
PRIDEQ9QYM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075550; ENSMUSP00000074988; ENSMUSG00000045273.
GeneID26886.
KEGGmmu:26886.
UCSCuc007rrn.1. mouse.

Organism-specific databases

CTD64946.
MGIMGI:1349448. Cenph.

Phylogenomic databases

eggNOGNOG10470.
GeneTreeENSGT00390000009578.
HOGENOMHOG000013068.
HOVERGENHBG081083.
InParanoidQ9QYM8.
KOK11500.
OMAQMEIKIT.
OrthoDBEOG7JQBRQ.
PhylomeDBQ9QYM8.
TreeFamTF101134.

Gene expression databases

BgeeQ9QYM8.
CleanExMM_CENPH.
GenevestigatorQ9QYM8.

Family and domain databases

InterProIPR008426. CENP-H.
[Graphical view]
PfamPF05837. CENP-H. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304703.
PROQ9QYM8.
SOURCESearch...

Entry information

Entry nameCENPH_MOUSE
AccessionPrimary (citable) accession number: Q9QYM8
Secondary accession number(s): Q8R3K9, Q9D079, Q9D0N1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot