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Q9QYM8

- CENPH_MOUSE

UniProt

Q9QYM8 - CENPH_MOUSE

Protein

Centromere protein H

Gene

Cenph

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate By similarity.By similarity

    GO - Molecular functioni

    1. kinetochore binding Source: UniProtKB

    GO - Biological processi

    1. chromosome segregation Source: MGI
    2. kinetochore assembly Source: InterPro
    3. kinetochore organization Source: UniProtKB
    4. mitotic nuclear division Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein H
    Short name:
    CENP-H
    Gene namesi
    Name:CenphImported
    Synonyms:EnpImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1349448. Cenph.

    Subcellular locationi

    Nucleus 1 Publication. Chromosomecentromerekinetochore 1 Publication
    Note: Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. kinetochore Source: MGI
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Centromere protein HPRO_0000089479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9QYM8.
    PRIDEiQ9QYM8.

    PTM databases

    PhosphoSiteiQ9QYM8.

    Expressioni

    Tissue specificityi

    Abundantly expressed in thymus, spleen, uterus, ovary, testis and muscle, and weakly expressed in small intestine, lung and stomach. Barely detectable expression in kidney, liver, skin and prostate gland. Not detected in brain, heart or adrenal gland. Also expressed weakly in various hematopoietic cell lines.1 Publication

    Developmental stagei

    Abundantly expressed between embryonic day 9.5 and 12.5.1 Publication

    Gene expression databases

    BgeeiQ9QYM8.
    CleanExiMM_CENPH.
    GenevestigatoriQ9QYM8.

    Interactioni

    Subunit structurei

    Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS By similarity. Interacts directly with CENPK By similarity. Interacts with KIF2C and NDC80 By similarity. Interacts with TRIM36.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili28 – 186159Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the centromere protein H family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG10470.
    GeneTreeiENSGT00390000009578.
    HOGENOMiHOG000013068.
    HOVERGENiHBG081083.
    InParanoidiQ9QYM8.
    KOiK11500.
    OMAiQMEIKIT.
    OrthoDBiEOG7JQBRQ.
    PhylomeDBiQ9QYM8.
    TreeFamiTF101134.

    Family and domain databases

    InterProiIPR008426. CENP-H.
    [Graphical view]
    PfamiPF05837. CENP-H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QYM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEQPRERSE AGAEACEEKR GLSQAAEERI EDRISLLLRL RAQTKQQLLE    50
    YKSMIDTNEE KTPEQIMQEK QIEVKIEELE NEIEDVKSNI EMKSLALSRM 100
    KLSVALRDNM ENMGPENCVL TDDMKHILKL QKLIMKSQEE SSELEKKLLD 150
    VRKKRLQLKQ ASRSKLLEIQ IEKNKQKEDV DKMENSEMIK TMKKKLQTEI 200
    KITTVVQHTF QGLILASKTN WAEDPALRET VLQLEKDLNT L 241
    Length:241
    Mass (Da):28,135
    Last modified:May 1, 2000 - v1
    Checksum:iA56CD10AFE07D0AD
    GO

    Sequence cautioni

    The sequence BAB27505.1 differs from that shown. Reason: Frameshift at position 195.
    The sequence BAB27810.1 differs from that shown. Reason: Frameshift at position 195.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391N → T in AAH25084. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017634 mRNA. Translation: BAA88520.1.
    AK011264 mRNA. Translation: BAB27505.1. Frameshift.
    AK011738 mRNA. Translation: BAB27810.1. Frameshift.
    BC025084 mRNA. Translation: AAH25084.1.
    CCDSiCCDS26738.1.
    RefSeqiNP_068686.1. NM_021886.1.
    UniGeneiMm.273502.

    Genome annotation databases

    EnsembliENSMUST00000075550; ENSMUSP00000074988; ENSMUSG00000045273.
    GeneIDi26886.
    KEGGimmu:26886.
    UCSCiuc007rrn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017634 mRNA. Translation: BAA88520.1 .
    AK011264 mRNA. Translation: BAB27505.1 . Frameshift.
    AK011738 mRNA. Translation: BAB27810.1 . Frameshift.
    BC025084 mRNA. Translation: AAH25084.1 .
    CCDSi CCDS26738.1.
    RefSeqi NP_068686.1. NM_021886.1.
    UniGenei Mm.273502.

    3D structure databases

    ProteinModelPortali Q9QYM8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QYM8.

    Proteomic databases

    PaxDbi Q9QYM8.
    PRIDEi Q9QYM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075550 ; ENSMUSP00000074988 ; ENSMUSG00000045273 .
    GeneIDi 26886.
    KEGGi mmu:26886.
    UCSCi uc007rrn.1. mouse.

    Organism-specific databases

    CTDi 64946.
    MGIi MGI:1349448. Cenph.

    Phylogenomic databases

    eggNOGi NOG10470.
    GeneTreei ENSGT00390000009578.
    HOGENOMi HOG000013068.
    HOVERGENi HBG081083.
    InParanoidi Q9QYM8.
    KOi K11500.
    OMAi QMEIKIT.
    OrthoDBi EOG7JQBRQ.
    PhylomeDBi Q9QYM8.
    TreeFami TF101134.

    Enzyme and pathway databases

    Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 304703.
    PROi Q9QYM8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QYM8.
    CleanExi MM_CENPH.
    Genevestigatori Q9QYM8.

    Family and domain databases

    InterProi IPR008426. CENP-H.
    [Graphical view ]
    Pfami PF05837. CENP-H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel kinetochore protein, CENP-H."
      Sugata N., Munekata E., Todokoro K.
      J. Biol. Chem. 274:27343-27346(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: EmbryoImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary glandImported.
    4. "TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression."
      Miyajima N., Maruyama S., Nonomura K., Hatakeyama S.
      Biochem. Biophys. Res. Commun. 381:383-387(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRIM36.

    Entry informationi

    Entry nameiCENPH_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYM8
    Secondary accession number(s): Q8R3K9, Q9D079, Q9D0N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3