Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QYM8

- CENPH_MOUSE

UniProt

Q9QYM8 - CENPH_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Centromere protein H

Gene

Cenph

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity).By similarity

GO - Molecular functioni

  1. kinetochore binding Source: UniProtKB

GO - Biological processi

  1. chromosome segregation Source: MGI
  2. kinetochore assembly Source: InterPro
  3. kinetochore organization Source: UniProtKB
  4. mitotic nuclear division Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein H
Short name:
CENP-H
Gene namesi
Name:CenphImported
Synonyms:EnpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1349448. Cenph.

Subcellular locationi

Nucleus 1 Publication. Chromosomecentromerekinetochore 1 Publication
Note: Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.

GO - Cellular componenti

  1. kinetochore Source: MGI
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Centromere protein HPRO_0000089479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QYM8.
PaxDbiQ9QYM8.
PRIDEiQ9QYM8.

PTM databases

PhosphoSiteiQ9QYM8.

Expressioni

Tissue specificityi

Abundantly expressed in thymus, spleen, uterus, ovary, testis and muscle, and weakly expressed in small intestine, lung and stomach. Barely detectable expression in kidney, liver, skin and prostate gland. Not detected in brain, heart or adrenal gland. Also expressed weakly in various hematopoietic cell lines.1 Publication

Developmental stagei

Abundantly expressed between embryonic day 9.5 and 12.5.1 Publication

Gene expression databases

BgeeiQ9QYM8.
CleanExiMM_CENPH.
GenevestigatoriQ9QYM8.

Interactioni

Subunit structurei

Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity). Interacts directly with CENPK (By similarity). Interacts with KIF2C and NDC80 (By similarity). Interacts with TRIM36.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9QYM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili28 – 186159Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the centromere protein H family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG10470.
GeneTreeiENSGT00390000009578.
HOGENOMiHOG000013068.
HOVERGENiHBG081083.
InParanoidiQ9QYM8.
KOiK11500.
OMAiQMEIKIT.
OrthoDBiEOG7JQBRQ.
PhylomeDBiQ9QYM8.
TreeFamiTF101134.

Family and domain databases

InterProiIPR008426. CENP-H.
[Graphical view]
PfamiPF05837. CENP-H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEQPRERSE AGAEACEEKR GLSQAAEERI EDRISLLLRL RAQTKQQLLE
60 70 80 90 100
YKSMIDTNEE KTPEQIMQEK QIEVKIEELE NEIEDVKSNI EMKSLALSRM
110 120 130 140 150
KLSVALRDNM ENMGPENCVL TDDMKHILKL QKLIMKSQEE SSELEKKLLD
160 170 180 190 200
VRKKRLQLKQ ASRSKLLEIQ IEKNKQKEDV DKMENSEMIK TMKKKLQTEI
210 220 230 240
KITTVVQHTF QGLILASKTN WAEDPALRET VLQLEKDLNT L
Length:241
Mass (Da):28,135
Last modified:May 1, 2000 - v1
Checksum:iA56CD10AFE07D0AD
GO

Sequence cautioni

The sequence BAB27505.1 differs from that shown. Reason: Frameshift at position 195.
The sequence BAB27810.1 differs from that shown. Reason: Frameshift at position 195.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391N → T in AAH25084. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017634 mRNA. Translation: BAA88520.1.
AK011264 mRNA. Translation: BAB27505.1. Frameshift.
AK011738 mRNA. Translation: BAB27810.1. Frameshift.
BC025084 mRNA. Translation: AAH25084.1.
CCDSiCCDS26738.1.
RefSeqiNP_068686.1. NM_021886.1.
UniGeneiMm.273502.

Genome annotation databases

EnsembliENSMUST00000075550; ENSMUSP00000074988; ENSMUSG00000045273.
GeneIDi26886.
KEGGimmu:26886.
UCSCiuc007rrn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017634 mRNA. Translation: BAA88520.1 .
AK011264 mRNA. Translation: BAB27505.1 . Frameshift.
AK011738 mRNA. Translation: BAB27810.1 . Frameshift.
BC025084 mRNA. Translation: AAH25084.1 .
CCDSi CCDS26738.1.
RefSeqi NP_068686.1. NM_021886.1.
UniGenei Mm.273502.

3D structure databases

ProteinModelPortali Q9QYM8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYM8.

Proteomic databases

MaxQBi Q9QYM8.
PaxDbi Q9QYM8.
PRIDEi Q9QYM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075550 ; ENSMUSP00000074988 ; ENSMUSG00000045273 .
GeneIDi 26886.
KEGGi mmu:26886.
UCSCi uc007rrn.1. mouse.

Organism-specific databases

CTDi 64946.
MGIi MGI:1349448. Cenph.

Phylogenomic databases

eggNOGi NOG10470.
GeneTreei ENSGT00390000009578.
HOGENOMi HOG000013068.
HOVERGENi HBG081083.
InParanoidi Q9QYM8.
KOi K11500.
OMAi QMEIKIT.
OrthoDBi EOG7JQBRQ.
PhylomeDBi Q9QYM8.
TreeFami TF101134.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 304703.
PROi Q9QYM8.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYM8.
CleanExi MM_CENPH.
Genevestigatori Q9QYM8.

Family and domain databases

InterProi IPR008426. CENP-H.
[Graphical view ]
Pfami PF05837. CENP-H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel kinetochore protein, CENP-H."
    Sugata N., Munekata E., Todokoro K.
    J. Biol. Chem. 274:27343-27346(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary glandImported.
  4. "TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression."
    Miyajima N., Maruyama S., Nonomura K., Hatakeyama S.
    Biochem. Biophys. Res. Commun. 381:383-387(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRIM36.

Entry informationi

Entry nameiCENPH_MOUSE
AccessioniPrimary (citable) accession number: Q9QYM8
Secondary accession number(s): Q8R3K9, Q9D079, Q9D0N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3