Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance-associated protein 5

Gene

Abcc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi595 – 6028ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1226 – 12338ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Gene namesi
Name:Abcc5
Synonyms:Abcc5a, Mrp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70913. Abcc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei179 – 19921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei219 – 23921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei317 – 33721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei400 – 42021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei426 – 44621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei608 – 62821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei847 – 86721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei916 – 93621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei996 – 101621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1017 – 103721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1101 – 112121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1126 – 114621HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14361436Multidrug resistance-associated protein 5PRO_0000093365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineBy similarity
Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence analysis
Modified residuei505 – 5051PhosphoserineBy similarity
Modified residuei509 – 5091PhosphoserineBy similarity
Modified residuei513 – 5131PhosphothreonineBy similarity
Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence analysis
Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence analysis
Glycosylationi889 – 8891N-linked (GlcNAc...)Sequence analysis
Glycosylationi896 – 8961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1043 – 10431N-linked (GlcNAc...)Sequence analysis
Glycosylationi1328 – 13281N-linked (GlcNAc...)Sequence analysis
Glycosylationi1416 – 14161N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QYM0.
PRIDEiQ9QYM0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002316.

Structurei

3D structure databases

ProteinModelPortaliQ9QYM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 459281ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini562 – 783222ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini858 – 1154297ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1192 – 1426235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ9QYM0.
KOiK05668.
PhylomeDBiQ9QYM0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030238. ABCC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF196. PTHR24223:SF196. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIDMGKEY IIPSPGYRSV RDRSTIPGQH GDREEPRFRR TRSLECQDAL
60 70 80 90 100
ETAARVEGLS LDISVHSHLQ ILDEEHTKGK YHHGLSALKP FRTTTKHQHP
110 120 130 140 150
VDNAGLFSYM TFSWLSPLAQ VVHKKGELLM EDVWPLSKYE SSDVNCRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFV
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAVLTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA
360 370 380 390 400
TDDRVQKMNE VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSTQSSP KLTPKVKKDK RAPKGKKEKS RQLQHTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKQIHAG SMRLQRTLYN IDLEIEEGKL VGICGSVGSG
610 620 630 640 650
KTSLISAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK RLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKEA
810 820 830 840 850
SGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV PWSVYWVYIQ
860 870 880 890 900
AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVFEGNRSSV
910 920 930 940 950
SDSMRDNPFL QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL
960 970 980 990 1000
FRRILRSPMK FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF
1010 1020 1030 1040 1050
FCVGMIAGVF PWFLVAVGPL LILFSVLHIV SRVLIRELKR LDNITQSPFL
1060 1070 1080 1090 1100
SHITSSIQGL ATIHAYNKRQ EFLHRYQELL DDNQAPFFLF TCAMRWLAVR
1110 1120 1130 1140 1150
LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG LFQFTVRLAS
1160 1170 1180 1190 1200
ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EITFENAEMR
1210 1220 1230 1240 1250
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI
1260 1270 1280 1290 1300
KIDGVRISDI GLADLRSKLT IIPQEPVLFS GTVRSNLDPF NQYTEEQIWD
1310 1320 1330 1340 1350
ALERTHMKEC IAQLPLKLES EVMENGDNFS VGERQLLCIA RALLRHCKIL
1360 1370 1380 1390 1400
ILDEATAAMD TETDLLIQET IREAFADCTM LTIAHRLHTV LGSDRIMVLA
1410 1420 1430
QGQVVEFDTP SVLLSNDSSR FYAMCAAAEN KVAVKG
Length:1,436
Mass (Da):160,857
Last modified:May 1, 2000 - v1
Checksum:i10FE53B800531598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020209 mRNA. Translation: BAA88897.1.
RefSeqiNP_446376.1. NM_053924.1.
UniGeneiRn.9491.

Genome annotation databases

GeneIDi116721.
KEGGirno:116721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020209 mRNA. Translation: BAA88897.1.
RefSeqiNP_446376.1. NM_053924.1.
UniGeneiRn.9491.

3D structure databases

ProteinModelPortaliQ9QYM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002316.

Proteomic databases

PaxDbiQ9QYM0.
PRIDEiQ9QYM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116721.
KEGGirno:116721.

Organism-specific databases

CTDi10057.
RGDi70913. Abcc5.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ9QYM0.
KOiK05668.
PhylomeDBiQ9QYM0.

Miscellaneous databases

PROiQ9QYM0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030238. ABCC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF196. PTHR24223:SF196. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Homma M., Suzuki H., Sugiyama Y.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiMRP5_RAT
AccessioniPrimary (citable) accession number: Q9QYM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.