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Protein

Multidrug resistance-associated protein 5

Gene

Abcc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi595 – 602ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1226 – 1233ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
  • transmembrane transport Source: GO_Central

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Gene namesi
Name:Abcc5
Synonyms:Abcc5a, Mrp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi70913 Abcc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei179 – 199HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei219 – 239HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei317 – 337HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei400 – 420HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei426 – 446HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei608 – 628HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei847 – 867HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei916 – 936HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei996 – 1016HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1017 – 1037HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1101 – 1121HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1126 – 1146HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933651 – 1436Multidrug resistance-associated protein 5Add BLAST1436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei505PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei513PhosphothreonineBy similarity1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi684N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi889N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi896N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1043N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1416N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QYM0
PRIDEiQ9QYM0

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002316

Structurei

3D structure databases

ProteinModelPortaliQ9QYM0
SMRiQ9QYM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 459ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini562 – 783ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini858 – 1154ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST297
Domaini1192 – 1426ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
HOVERGENiHBG108314
InParanoidiQ9QYM0
KOiK05668
PhylomeDBiQ9QYM0

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030238 ABCC5
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF196 PTHR24223:SF196, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9QYM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIDMGKEY IIPSPGYRSV RDRSTIPGQH GDREEPRFRR TRSLECQDAL
60 70 80 90 100
ETAARVEGLS LDISVHSHLQ ILDEEHTKGK YHHGLSALKP FRTTTKHQHP
110 120 130 140 150
VDNAGLFSYM TFSWLSPLAQ VVHKKGELLM EDVWPLSKYE SSDVNCRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFV
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAVLTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA
360 370 380 390 400
TDDRVQKMNE VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSTQSSP KLTPKVKKDK RAPKGKKEKS RQLQHTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKQIHAG SMRLQRTLYN IDLEIEEGKL VGICGSVGSG
610 620 630 640 650
KTSLISAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK RLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKEA
810 820 830 840 850
SGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV PWSVYWVYIQ
860 870 880 890 900
AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVFEGNRSSV
910 920 930 940 950
SDSMRDNPFL QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL
960 970 980 990 1000
FRRILRSPMK FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF
1010 1020 1030 1040 1050
FCVGMIAGVF PWFLVAVGPL LILFSVLHIV SRVLIRELKR LDNITQSPFL
1060 1070 1080 1090 1100
SHITSSIQGL ATIHAYNKRQ EFLHRYQELL DDNQAPFFLF TCAMRWLAVR
1110 1120 1130 1140 1150
LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG LFQFTVRLAS
1160 1170 1180 1190 1200
ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EITFENAEMR
1210 1220 1230 1240 1250
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI
1260 1270 1280 1290 1300
KIDGVRISDI GLADLRSKLT IIPQEPVLFS GTVRSNLDPF NQYTEEQIWD
1310 1320 1330 1340 1350
ALERTHMKEC IAQLPLKLES EVMENGDNFS VGERQLLCIA RALLRHCKIL
1360 1370 1380 1390 1400
ILDEATAAMD TETDLLIQET IREAFADCTM LTIAHRLHTV LGSDRIMVLA
1410 1420 1430
QGQVVEFDTP SVLLSNDSSR FYAMCAAAEN KVAVKG
Length:1,436
Mass (Da):160,857
Last modified:May 1, 2000 - v1
Checksum:i10FE53B800531598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020209 mRNA Translation: BAA88897.1
RefSeqiNP_446376.1, NM_053924.1
UniGeneiRn.9491

Genome annotation databases

GeneIDi116721
KEGGirno:116721

Similar proteinsi

Entry informationi

Entry nameiMRP5_RAT
AccessioniPrimary (citable) accession number: Q9QYM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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