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Protein

Acyl-protein thioesterase 2

Gene

Lypla2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has lysophospholipase activity. Deacylates GAP43 (By similarity).By similarity

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221Charge relay systemBy similarity
Active sitei176 – 1761Charge relay systemBy similarity
Active sitei210 – 2101Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Protein family/group databases

ESTHERiratno-lypla2. LYsophospholipase_carboxylesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-protein thioesterase 2 (EC:3.1.2.-)
Short name:
APT-2
Alternative name(s):
Lysophospholipase 2
Lysophospholipase II
Short name:
LPL-II
Short name:
LysoPLA II
Gene namesi
Name:Lypla2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620210. Lypla2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Acyl-protein thioesterase 2PRO_0000102273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QYL8.
PRIDEiQ9QYL8.

PTM databases

iPTMnetiQ9QYL8.

Expressioni

Gene expression databases

GenevisibleiQ9QYL8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014415.

Structurei

3D structure databases

ProteinModelPortaliQ9QYL8.
SMRiQ9QYL8. Positions 6-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiQ9QYL8.
KOiK06130.
OMAiWLPLHRN.
OrthoDBiEOG7M0NSQ.
PhylomeDBiQ9QYL8.
TreeFamiTF314619.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGNNMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP
60 70 80 90 100
HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK
110 120 130 140 150
ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP
160 170 180 190 200
LHRNFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRTVVTPARV
210 220 230
QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V
Length:231
Mass (Da):24,807
Last modified:May 1, 2000 - v1
Checksum:i49A710C5A997C7C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021645 mRNA. Translation: BAA87911.1.
BC070503 mRNA. Translation: AAH70503.1.
RefSeqiNP_112632.1. NM_031342.1.
UniGeneiRn.8586.

Genome annotation databases

EnsembliENSRNOT00000014415; ENSRNOP00000014415; ENSRNOG00000010067.
GeneIDi83510.
KEGGirno:83510.
UCSCiRGD:620210. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021645 mRNA. Translation: BAA87911.1.
BC070503 mRNA. Translation: AAH70503.1.
RefSeqiNP_112632.1. NM_031342.1.
UniGeneiRn.8586.

3D structure databases

ProteinModelPortaliQ9QYL8.
SMRiQ9QYL8. Positions 6-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014415.

Protein family/group databases

ESTHERiratno-lypla2. LYsophospholipase_carboxylesterase.

PTM databases

iPTMnetiQ9QYL8.

Proteomic databases

PaxDbiQ9QYL8.
PRIDEiQ9QYL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014415; ENSRNOP00000014415; ENSRNOG00000010067.
GeneIDi83510.
KEGGirno:83510.
UCSCiRGD:620210. rat.

Organism-specific databases

CTDi11313.
RGDi620210. Lypla2.

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiQ9QYL8.
KOiK06130.
OMAiWLPLHRN.
OrthoDBiEOG7M0NSQ.
PhylomeDBiQ9QYL8.
TreeFamiTF314619.

Miscellaneous databases

NextBioi615954.
PROiQ9QYL8.

Gene expression databases

GenevisibleiQ9QYL8. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rat lysophospholipase II."
    Sugimoto H.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 165-190, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLYPA2_RAT
AccessioniPrimary (citable) accession number: Q9QYL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.