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Protein

Activator of basal transcription 1

Gene

Abt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of basal transcription 1
Gene namesi
Name:Abt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1353636 Abt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331691 – 269Activator of basal transcription 1Add BLAST269

Proteomic databases

EPDiQ9QYL7
MaxQBiQ9QYL7
PaxDbiQ9QYL7
PeptideAtlasiQ9QYL7
PRIDEiQ9QYL7

PTM databases

iPTMnetiQ9QYL7
PhosphoSitePlusiQ9QYL7

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000036376
CleanExiMM_ABT1
GenevisibleiQ9QYL7 MM

Interactioni

Subunit structurei

Interacts with ESF1/ABTAP. Interacts with IGHMBP2.By similarity

Protein-protein interaction databases

BioGridi206023, 4 interactors
STRINGi10090.ENSMUSP00000045888

Structurei

3D structure databases

ProteinModelPortaliQ9QYL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 145RRMAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 29Sequence analysisAdd BLAST25
Coiled coili164 – 194Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 39Poly-Ser4
Compositional biasi40 – 44Poly-Lys5
Compositional biasi92 – 96Poly-Ala5

Sequence similaritiesi

Belongs to the ESF2/ABP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3152 Eukaryota
ENOG4111JJV LUCA
GeneTreeiENSGT00390000002062
HOGENOMiHOG000242500
HOVERGENiHBG057308
InParanoidiQ9QYL7
KOiK14785
OMAiLSGFKWV
OrthoDBiEOG091G0G6C
PhylomeDBiQ9QYL7
TreeFamiTF314506

Family and domain databases

CDDicd12263 RRM_ABT1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034353 ABT1/ESF2_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
SUPFAMiSSF54928 SSF54928, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QYL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAGELVEQ QKAAMEEEAN AEAAEDQEEP EDTACSSSSK KKKKVVPGIV
60 70 80 90 100
YLGHVPPRFR PLHVRNLLSA YGEVGRVFFQ AEDHFVKRKK KAAAAAGGKK
110 120 130 140 150
GAKYSKDYTE GWVEFRDKRV AKRVAASLHN TPMGARKRSP FRYDLWNLKY
160 170 180 190 200
LHRFTWSHLS EHLAFERQVR RQRLRAEVAQ AKRETDFYLR NVEQGQHFLA
210 220 230 240 250
ADGDATRPNS SWTFTQRPTE QEFRARKAAR PGGRERARLA NVEDQARSNR
260
GLLAKIFGAP LPAESKEKP
Length:269
Mass (Da):30,659
Last modified:May 1, 2000 - v1
Checksum:i1C52B1E55C0B0DD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73E → R in BAB26356 (PubMed:16141072).Curated1
Sequence conflicti111G → D in BAB26356 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021860 mRNA Translation: BAA87912.1
AK009557 mRNA Translation: BAB26356.1
AK029222 mRNA Translation: BAC26353.1
AL714025 Genomic DNA No translation available.
BC082609 mRNA Translation: AAH82609.1
CCDSiCCDS26338.1
RefSeqiNP_038952.1, NM_013924.3
UniGeneiMm.292094

Genome annotation databases

EnsembliENSMUST00000041782; ENSMUSP00000045888; ENSMUSG00000036376
GeneIDi30946
KEGGimmu:30946
UCSCiuc007pto.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABT1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYL7
Secondary accession number(s): Q0VGU7, Q9D762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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