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Protein

Activator of basal transcription 1

Gene

Abt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes.

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of basal transcription 1
Gene namesi
Name:Abt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1353636. Abt1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB-SubCell
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Activator of basal transcription 1PRO_0000233169Add
BLAST

Proteomic databases

EPDiQ9QYL7.
MaxQBiQ9QYL7.
PaxDbiQ9QYL7.
PRIDEiQ9QYL7.

PTM databases

iPTMnetiQ9QYL7.
PhosphoSiteiQ9QYL7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9QYL7.
CleanExiMM_ABT1.
GenevisibleiQ9QYL7. MM.

Interactioni

Subunit structurei

Interacts with ESF1/ABTAP. Interacts with IGHMBP2.By similarity

Protein-protein interaction databases

BioGridi206023. 4 interactions.
STRINGi10090.ENSMUSP00000045888.

Structurei

3D structure databases

ProteinModelPortaliQ9QYL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 14598RRMAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 2925Sequence analysisAdd
BLAST
Coiled coili164 – 19431Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 394Poly-Ser
Compositional biasi40 – 445Poly-Lys
Compositional biasi92 – 965Poly-Ala

Sequence similaritiesi

Belongs to the ESF2/ABP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3152. Eukaryota.
ENOG4111JJV. LUCA.
GeneTreeiENSGT00390000002062.
HOGENOMiHOG000242500.
HOVERGENiHBG057308.
InParanoidiQ9QYL7.
KOiK14785.
OMAiHVPPRFR.
OrthoDBiEOG7Q2N67.
PhylomeDBiQ9QYL7.
TreeFamiTF314506.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAGELVEQ QKAAMEEEAN AEAAEDQEEP EDTACSSSSK KKKKVVPGIV
60 70 80 90 100
YLGHVPPRFR PLHVRNLLSA YGEVGRVFFQ AEDHFVKRKK KAAAAAGGKK
110 120 130 140 150
GAKYSKDYTE GWVEFRDKRV AKRVAASLHN TPMGARKRSP FRYDLWNLKY
160 170 180 190 200
LHRFTWSHLS EHLAFERQVR RQRLRAEVAQ AKRETDFYLR NVEQGQHFLA
210 220 230 240 250
ADGDATRPNS SWTFTQRPTE QEFRARKAAR PGGRERARLA NVEDQARSNR
260
GLLAKIFGAP LPAESKEKP
Length:269
Mass (Da):30,659
Last modified:May 1, 2000 - v1
Checksum:i1C52B1E55C0B0DD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731E → R in BAB26356 (PubMed:16141072).Curated
Sequence conflicti111 – 1111G → D in BAB26356 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021860 mRNA. Translation: BAA87912.1.
AK009557 mRNA. Translation: BAB26356.1.
AK029222 mRNA. Translation: BAC26353.1.
AL714025 Genomic DNA. Translation: CAI24231.1.
BC082609 mRNA. Translation: AAH82609.1.
CCDSiCCDS26338.1.
RefSeqiNP_038952.1. NM_013924.3.
UniGeneiMm.292094.

Genome annotation databases

EnsembliENSMUST00000041782; ENSMUSP00000045888; ENSMUSG00000036376.
GeneIDi30946.
KEGGimmu:30946.
UCSCiuc007pto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021860 mRNA. Translation: BAA87912.1.
AK009557 mRNA. Translation: BAB26356.1.
AK029222 mRNA. Translation: BAC26353.1.
AL714025 Genomic DNA. Translation: CAI24231.1.
BC082609 mRNA. Translation: AAH82609.1.
CCDSiCCDS26338.1.
RefSeqiNP_038952.1. NM_013924.3.
UniGeneiMm.292094.

3D structure databases

ProteinModelPortaliQ9QYL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206023. 4 interactions.
STRINGi10090.ENSMUSP00000045888.

PTM databases

iPTMnetiQ9QYL7.
PhosphoSiteiQ9QYL7.

Proteomic databases

EPDiQ9QYL7.
MaxQBiQ9QYL7.
PaxDbiQ9QYL7.
PRIDEiQ9QYL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041782; ENSMUSP00000045888; ENSMUSG00000036376.
GeneIDi30946.
KEGGimmu:30946.
UCSCiuc007pto.1. mouse.

Organism-specific databases

CTDi29777.
MGIiMGI:1353636. Abt1.

Phylogenomic databases

eggNOGiKOG3152. Eukaryota.
ENOG4111JJV. LUCA.
GeneTreeiENSGT00390000002062.
HOGENOMiHOG000242500.
HOVERGENiHBG057308.
InParanoidiQ9QYL7.
KOiK14785.
OMAiHVPPRFR.
OrthoDBiEOG7Q2N67.
PhylomeDBiQ9QYL7.
TreeFamiTF314506.

Miscellaneous databases

PROiQ9QYL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYL7.
CleanExiMM_ABT1.
GenevisibleiQ9QYL7. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth."
    Oda T., Kayukawa K., Hagiwara H., Yudate H.T., Masuho Y., Murakami Y., Tamura T.-A., Muramatsu M.-A.
    Mol. Cell. Biol. 20:1407-1418(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fibroblast.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.

Entry informationi

Entry nameiABT1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYL7
Secondary accession number(s): Q0VGU7, Q9D762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.