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Reviewed, UniProtKB/Swiss-Prot Q9QYK9 (KCC1B_MOUSE)

Last modified February 9, 2010. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Calcium/calmodulin-dependent protein kinase type 1B
    EC=2.7.11.17
Alternative name(s):
    CaM kinase I beta
      Short name=CaM kinase IB
      Short name=CaM-KI beta
      Short name=CaMKI-beta
    Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog
Gene names
Name: Pnck
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by Ca2+/calmodulin By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Expressed at highest levels in adult brain, and expressed in embryo. In the adult brain detected at high levels in the anterior olfactory nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal cells, dentate granule cells, amygdala, hypothalamic nuclei, parabrachial nucleus, and nucleus of the solitary tract. Expressed at lower levels in adult ovary and heart and at very low levels in testis, lung and muscle. Ref.1 Ref.2

Developmental stage

During embryogenesis detected at E10 and expression gradually increases thereafter. Expressed mainly in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS detected in the mantle zone, but not in the ventricular zone. Detected at postnatal day 23 with highest levels in mesencephalon. Also expressed in developing bone and gut. Ref.1 Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Calcium/calmodulin-dependent protein kinase type 1B
PRO_0000086080

Regions

Domain15 – 270256Protein kinase
Nucleotide binding21 – 299ATP By similarity
Region290 – 31122Calmodulin-binding By similarity

Sites

Active site1361Proton acceptor By similarity
Binding site441ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYK9-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1B4A28D36E7A936E

FASTA34338,519
        10         20         30         40         50         60 
MLLLKKQTED ISSVYEIREK LGSGAFSEVM LAQERGSAHL VALKCIPKKA LRGKEALVEN 

        70         80         90        100        110        120 
EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV 

       130        140        150        160        170        180 
LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA 

       190        200        210        220        230        240 
PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS 

       250        260        270        280        290        300 
ESAKDFIRHL LERDPQKRFT CQQALQHLWI SGDAAFDRDI LGSVSEQIQK NFARTHWKRA 

       310        320        330        340 
FNATSFLRHI RKLGQSPEGE EASRQCMTRH SHPGLGTSQS PKW 

« Hide

References

« Hide 'large scale' references
[1]"Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system."
Ueda T., Sakagami H., Abe K., Oishi I., Maruo A., Kondo H., Terashima T., Ichihashi M., Yamamura H., Minami Y.
J. Neurochem. 73:2119-2129(1999) [PubMed: 10537072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"Cloning, characterization, and chromosomal localization of Pnck, a Ca2+/calmodulin-pependent protein kinase."
Gardner H.P., Rajan J.V., Ha S.I., Copeland N.G., Gilbert D.J., Jenkins N.A., Marquis S.T., Chodosh L.A.
Genomics 63:279-288(2000) [PubMed: 10673339] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Brain and Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023027 mRNA. Translation: BAA87926.1.
AF181984 mRNA. Translation: AAF29157.1.
BC051996 mRNA. Translation: AAH51996.1. Different initiation.
BC055891 mRNA. Translation: AAH55891.1.
IPIIPI00136288.
RefSeqNP_036170.1.
UniGeneMm.89564

3D structure databases

SMRQ9QYK9. Positions 6-310.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9QYK9.

Proteomic databases

PRIDEQ9QYK9.

Genome annotation databases

EnsemblENSMUST00000002087; ENSMUSP00000002087; ENSMUSG00000002012; Mus musculus. [Genome view]
ENSMUST00000114472; ENSMUSP00000110116; ENSMUSG00000002012; Mus musculus. [Genome view]
ENSMUST00000114473; ENSMUSP00000110117; ENSMUSG00000002012; Mus musculus. [Genome view]
GeneID93843.
KEGGmmu:93843.
UCSCuc009tmc.1. mouse.

Organism-specific databases

CTD93843.
MGIMGI:1347357. Pnck.

Phylogenomic databases

HOGENOMHBG755340.
HOVERGENQ9QYK9.
InParanoidQ9QYK9.
OMAIYESPTH.
OrthoDBEOG9N5ZGB.
PhylomeDBQ9QYK9.

Enzyme and pathway databases

BRENDA2.7.11.17. 244.

Gene expression databases

ArrayExpressQ9QYK9.
BgeeQ9QYK9.
GenevestigatorQ9QYK9.
GermOnlineENSMUSG00000002012. Mus musculus.

Family and domain databases

InterProIPR020636. Ca/CaM-dep_prot_kinase-like.
IPR015734. Ca/CaM-dep_prot_kinase1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PANTHERPTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit.
PTHR22982:SF34. CaMKI. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio351709.
SOURCESearch...

Entry information

Entry nameKCC1B_MOUSE
AccessionPrimary (citable) accession number: Q9QYK9
Secondary accession number(s): Q80W07
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents