Q9QYK9 (KCC1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Calcium/calmodulin-dependent protein kinase type 1B EC=2.7.11.17 Alternative name(s): CaM kinase I beta Short name=CaM kinase IB Short name=CaM-KI beta Short name=CaMKI-beta Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 343 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Enzyme regulation | Activated by Ca2+/calmodulin By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed at highest levels in adult brain, and expressed in embryo. In the adult brain detected at high levels in the anterior olfactory nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal cells, dentate granule cells, amygdala, hypothalamic nuclei, parabrachial nucleus, and nucleus of the solitary tract. Expressed at lower levels in adult ovary and heart and at very low levels in testis, lung and muscle. Ref.1 Ref.2 |
| Developmental stage | During embryogenesis detected at E10 and expression gradually increases thereafter. Expressed mainly in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS detected in the mantle zone, but not in the ventricular zone. Detected at postnatal day 23 with highest levels in mesencephalon. Also expressed in developing bone and gut. Ref.1 Ref.2 |
| Sequence similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. |
| Sequence caution | The sequence AAH51996.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Ligand | ATP-binding Calcium Calmodulin-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | calcium- and calmodulin-dependent protein kinase complex Traceable author statement. Source: UniProtKB cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin bindingInferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 343 | 343 | Calcium/calmodulin-dependent protein kinase type 1B | PRO_0000086080 | |||||
Regions | |||||||||
| Domain | 15 – 270 | 256 | Protein kinase | ||||||
| Nucleotide binding | 21 – 29 | 9 | ATP By similarity | ||||||
| Region | 290 – 311 | 22 | Calmodulin-binding By similarity | ||||||
Sites | |||||||||
| Active site | 136 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 44 | 1 | ATP By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system." Ueda T., Sakagami H., Abe K., Oishi I., Maruo A., Kondo H., Terashima T., Ichihashi M., Yamamura H., Minami Y. J. Neurochem. 73:2119-2129(1999) [PubMed: 10537072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. |
| [2] | "Cloning, characterization, and chromosomal localization of Pnck, a Ca2+/calmodulin-pependent protein kinase." Gardner H.P., Rajan J.V., Ha S.I., Copeland N.G., Gilbert D.J., Jenkins N.A., Marquis S.T., Chodosh L.A. Genomics 63:279-288(2000) [PubMed: 10673339] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Brain. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Brain and Colon. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB023027 mRNA. Translation: BAA87926.1. AF181984 mRNA. Translation: AAF29157.1. BC051996 mRNA. Translation: AAH51996.1. Different initiation. BC055891 mRNA. Translation: AAH55891.1. |
| IPI | IPI00136288. |
| RefSeq | NP_001186280.1. NM_001199351.1. NP_001186281.1. NM_001199352.1. NP_036170.1. NM_012040.3. |
| UniGene | Mm.89564. |
3D structure databases | |
| ProteinModelPortal | Q9QYK9. |
| SMR | Q9QYK9. Positions 8-294. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9QYK9. |
PTM databases | |
| PhosphoSite | Q9QYK9. |
Proteomic databases | |
| PRIDE | Q9QYK9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000002087; ENSMUSP00000002087; ENSMUSG00000002012. ENSMUST00000114472; ENSMUSP00000110116; ENSMUSG00000002012. ENSMUST00000114473; ENSMUSP00000110117; ENSMUSG00000002012. |
| GeneID | 93843. |
| KEGG | mmu:93843. |
Organism-specific databases | |
| CTD | 139728. |
| MGI | MGI:1347357. Pnck. |
Phylogenomic databases | |
| GeneTree | ENSGT00600000084207. |
| HOGENOM | HBG755340. |
| HOVERGEN | HBG108055. |
| InParanoid | Q9QYK9. |
| OMA | IYESPTH. |
| OrthoDB | EOG4T4CVW. |
| PhylomeDB | Q9QYK9. |
Gene expression databases | |
| ArrayExpress | Q9QYK9. |
| Bgee | Q9QYK9. |
| Genevestigator | Q9QYK9. |
| GermOnline | ENSMUSG00000002012. Mus musculus. |
Family and domain databases | |
| InterPro | IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view] |
| KO | K08795. |
| PANTHER | PTHR24347. PTHR24347. 1 hit. |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 351709. |
| SOURCE | Search... |
Entry information
| Entry name | KCC1B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9QYK9 Secondary accession number(s): Q80W07 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with