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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene

Ppargc1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adaptive thermogenesis Source: RGD
  • adipose tissue development Source: Ensembl
  • aging Source: RGD
  • androgen metabolic process Source: RGD
  • autophagy of mitochondrion Source: RGD
  • brown fat cell differentiation Source: InterPro
  • cellular respiration Source: GO_Central
  • cellular response to caffeine Source: RGD
  • cellular response to estradiol stimulus Source: RGD
  • cellular response to fatty acid Source: RGD
  • cellular response to follicle-stimulating hormone stimulus Source: RGD
  • cellular response to fructose stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • cellular response to ionomycin Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to nitrite Source: RGD
  • cellular response to oxidative stress Source: UniProtKB
  • cellular response to potassium ion Source: RGD
  • cellular response to resveratrol Source: RGD
  • cellular response to thyroid hormone stimulus Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • cerebellum development Source: RGD
  • circadian regulation of gene expression Source: UniProtKB
  • energy homeostasis Source: UniProtKB
  • fatty acid oxidation Source: RGD
  • flavone metabolic process Source: RGD
  • forebrain development Source: RGD
  • galactose metabolic process Source: RGD
  • gluconeogenesis Source: RGD
  • mitochondrion organization Source: RGD
  • negative regulation of glycolytic process Source: RGD
  • negative regulation of mitochondrial fission Source: RGD
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • negative regulation of neuron death Source: UniProtKB
  • negative regulation of protein phosphorylation Source: RGD
  • negative regulation of signaling receptor activity Source: RGD
  • negative regulation of smooth muscle cell migration Source: RGD
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of ATP biosynthetic process Source: UniProtKB
  • positive regulation of cellular metabolic process Source: RGD
  • positive regulation of cellular respiration Source: Ensembl
  • positive regulation of DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of fatty acid oxidation Source: RGD
  • positive regulation of glomerular visceral epithelial cell apoptotic process Source: RGD
  • positive regulation of mitochondrial DNA metabolic process Source: Ensembl
  • positive regulation of mitochondrion organization Source: UniProtKB
  • positive regulation of muscle tissue development Source: Ensembl
  • positive regulation of progesterone biosynthetic process Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of transcription, DNA-templated Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of NMDA receptor activity Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB
  • respiratory electron transport chain Source: UniProtKB
  • response to activity Source: RGD
  • response to cold Source: RGD
  • response to dietary excess Source: Ensembl
  • response to drug Source: RGD
  • response to electrical stimulus Source: RGD
  • response to electrical stimulus involved in regulation of muscle adaptation Source: RGD
  • response to epinephrine Source: RGD
  • response to fructose Source: RGD
  • response to hypoxia Source: RGD
  • response to ischemia Source: RGD
  • response to leucine Source: RGD
  • response to metformin Source: RGD
  • response to methionine Source: RGD
  • response to muscle activity Source: RGD
  • response to norepinephrine Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to reactive oxygen species Source: RGD
  • response to starvation Source: RGD
  • response to thyroid hormone Source: RGD
  • skeletal muscle atrophy Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, RNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Short name:
PGC-1-alpha
Short name:
PPAR-gamma coactivator 1-alpha
Short name:
PPARGC-1-alpha
Gene namesi
Name:Ppargc1a
Synonyms:Pgc1, Pgc1a, Ppargc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620925 Ppargc1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817351 – 796Peroxisome proliferator-activated receptor gamma coactivator 1-alphaAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77N6-acetyllysineBy similarity1
Modified residuei144N6-acetyllysineBy similarity1
Modified residuei176Phosphothreonine; by AMPKBy similarity1
Modified residuei182N6-acetyllysineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei276N6-acetyllysineBy similarity1
Modified residuei319N6-acetyllysineBy similarity1
Modified residuei345N6-acetyllysineBy similarity1
Modified residuei411N6-acetyllysineBy similarity1
Modified residuei440N6-acetyllysineBy similarity1
Modified residuei449N6-acetyllysineBy similarity1
Modified residuei537Phosphoserine; by AMPKBy similarity1
Modified residuei756N6-acetyllysineBy similarity1
Modified residuei777N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.By similarity
Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions (By similarity).By similarity
Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QYK2
PRIDEiQ9QYK2

PTM databases

iPTMnetiQ9QYK2
PhosphoSitePlusiQ9QYK2

Expressioni

Inductioni

Up-regulated in brown adipose tissue of diabetic fatty (fa/fa) rats. Exposure of fa/fa rats to cold resulted in a much smaller increase as compared to lean rats in which a 2.6 fold increase was seen. Leptin is required for normal basal and cold-stimulated expression in brown adipose tissue and hyperleptinemia rapidly up-regulates its expression. It is induced not only by cold exposure but also by prolonged low-intensity physical exercise in epitrochlearis muscle.2 Publications

Gene expression databases

BgeeiENSRNOG00000004473
GenevisibleiQ9QYK2 RN

Interactioni

Subunit structurei

Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006071

Structurei

3D structure databases

ProteinModelPortaliQ9QYK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini675 – 751RRMPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni291 – 337Interaction with PPARGBy similarityAdd BLAST47
Regioni348 – 796Mediates interaction with RNF34By similarityAdd BLAST449

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi142 – 146LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi564 – 597Arg/Ser-richAdd BLAST34
Compositional biasi619 – 631Arg/Ser-richAdd BLAST13

Phylogenomic databases

eggNOGiENOG410IIVU Eukaryota
ENOG410YQI0 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000037431
HOVERGENiHBG053678
InParanoidiQ9QYK2
KOiK07202
OMAiENGYTLR
OrthoDBiEOG091G029M
PhylomeDBiQ9QYK2
TreeFamiTF343068

Family and domain databases

CDDicd12623 RRM_PPARGC1A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034625 PGC-1alpha
IPR034833 PPARGC1A_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF10 PTHR15528:SF10, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QYK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL
60 70 80 90 100
GGLKWCSDQS EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD
110 120 130 140 150
EDGLPSFDAL TDGDVTTDNE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA
160 170 180 190 200
NTQLSYNECS GLSTQNHANH THRIRTNPAI VKTENSWSNK AKSICQQQKP
210 220 230 240 250
QRRPCSELLK YLTTNDDPPH TKPTENRNSS RDKCASKKKS HTQPQSQHAQ
260 270 280 290 300
AKPTTLSLPL TPESPNDPKG SPFENKTIER TLSVELSGTA GLTPPTTPPH
310 320 330 340 350
KANQDNPFKA SPKLKPSCKT VVPPPTKRAR YSECSGTQGS HSTKKGPEQS
360 370 380 390 400
ELYAQLSKSS VLSRGHEERK TKRPSLRLFG DHDYCQSVNS KTDILINISQ
410 420 430 440 450
ELQDSRQLDF KDASCDWQGH ICSSTDSSQC YLRETLEASK QVSPCSTRKQ
460 470 480 490 500
LQDQEIRAEL NKHFGHPSQA VFDDKVDKTS ELRDGNFSNE QFSKLPVFIN
510 520 530 540 550
SGLAMDGLFD DSEDENDKLS YPWDGTQSYS LFDVSPSCSS FNSPCRDSVS
560 570 580 590 600
PPKSLFSQRP QRMRSRSRSF SRHRSCSRSP YSRSRSRSPG SRSSSRSCYY
610 620 630 640 650
YESSHYRHRT HRNSPLYVRS RSRSPYSRRP RYDSYEANEH ERLKRDEYRR
660 670 680 690 700
EYEKRESERA KQRERQKQKA IEERRVIYVG KIRPDTTRTE LRDRFEVFGE
710 720 730 740 750
IEECTVNLRD DGDSYGFITY RYTCDAFAAL ENGYTLRRSN ETDFELYFCG
760 770 780 790
RKQFFKSNYA DLDSNSDDFD PASTKSKYDS LDFDSLLKEA QRSLRR
Length:796
Mass (Da):90,622
Last modified:May 1, 2000 - v1
Checksum:iCF30A35F95088240
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427S → L (PubMed:10913342).Curated1
Sequence conflicti564R → H (PubMed:10913342).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025784 mRNA Translation: BAA88982.1
AY237127 mRNA Translation: AAO89279.1
PIRiJC7355
RefSeqiNP_112637.1, NM_031347.1
UniGeneiRn.19172
Rn.34553

Genome annotation databases

EnsembliENSRNOT00000006071; ENSRNOP00000006071; ENSRNOG00000004473
GeneIDi83516
KEGGirno:83516

Similar proteinsi

Entry informationi

Entry nameiPRGC1_RAT
AccessioniPrimary (citable) accession number: Q9QYK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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