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Q9QYJ7 (DS13B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 13 isoform B

Short name=DUSP13B
EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Dual specificity tyrosine phosphatase TS-DSP6
Testis- and skeletal muscle-specific DSP
Gene names
Name:Dusp13
Synonyms:Gm1203, Tmdp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Tissue specificity

Most abundantly expressed in the testis. Ref.4

Developmental stage

Not detectable in testis in the first 3 weeks of life. The expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood. Ref.4

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]
Isoform 2 (identifier: Q9QYJ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative promoter usage.
Isoform 1 (identifier: Q6B8I0-1)

The sequence of this isoform can be found in the external entry Q6B8I0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Dual specificity protein phosphatase 13 isoform B
PRO_0000094821

Regions

Domain114 – 18370Tyrosine-protein phosphatase

Sites

Active site1381Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C2493597D6D3732B

FASTA19822,481
        10         20         30         40         50         60 
MDSLQKQELR RPKIHGAVQV SPYQPPTLAS LQRLLWVRRT ATLTHINEVW PNLFLGDAYA 

        70         80         90        100        110        120 
ARDKGRLIQL GITHVVNVAA GKFQVDTGAK FYRGTPLEYY GIEADDNPFF DLSVHFLPVA 

       130        140        150        160        170        180 
RYIRDALNIP RSRVLVHCAM GVSRSATIVL AFLMIFENMT LVDAIQTVQA HRDICPNSGF 

       190 
LRQLQVLDNR LRRETGRL 

« Hide

Isoform 1 [UniParc].

See Q6B8I0.

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis."
Nakamura K., Shima H., Watanabe M., Haneji T., Kikuchi K.
Biochem. J. 344:819-825(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION.
[2]"Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain."
Aoyama K., Nagata M., Oshima K., Matsuda T., Aoki N.
J. Biol. Chem. 276:27575-27583(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
Chen H.-H., Luche R., Wei B., Tonks N.K.
J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027003 mRNA. Translation: BAA89411.1.
AF237620 mRNA. Translation: AAK15037.1.
BC100421 mRNA. Translation: AAI00422.1.
RefSeqNP_038877.2. NM_013849.3.
XP_006519139.1. XM_006519076.1. [Q9QYJ7-1]
UniGeneMm.390674.

3D structure databases

ProteinModelPortalQ9QYJ7.
SMRQ9QYJ7. Positions 24-191.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QYJ7.

Proteomic databases

PRIDEQ9QYJ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000120984; ENSMUSP00000113985; ENSMUSG00000021768. [Q9QYJ7-1]
ENSMUST00000184703; ENSMUSP00000138972; ENSMUSG00000021768. [Q9QYJ7-1]
GeneID27389.
KEGGmmu:27389.
UCSCuc007slm.2. mouse. [Q9QYJ7-1]

Organism-specific databases

CTD51207.
MGIMGI:1351599. Dusp13.

Phylogenomic databases

eggNOGNOG314632.
GeneTreeENSGT00550000074474.
HOGENOMHOG000233767.
HOVERGENHBG001524.
InParanoidQ497R2.
KOK14165.
OrthoDBEOG7CZK7N.

Gene expression databases

ArrayExpressQ9QYJ7.
BgeeQ9QYJ7.
CleanExMM_DUSP13.
GenevestigatorQ9QYJ7.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio305348.
PROQ9QYJ7.
SOURCESearch...

Entry information

Entry nameDS13B_MOUSE
AccessionPrimary (citable) accession number: Q9QYJ7
Secondary accession number(s): Q497R2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot