Q9QYJ7 (DUS13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 13
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
Dual specificity tyrosine phosphatase TS-DSP6
Testis- and skeletal muscle-specific DSP

Gene names

Name:	Dusp13
Synonyms:	Gm1203, Tmdp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Tissue specificity	Most abundantly expressed in the testis. Ref.4
Developmental stage	Not detectable in testis in the first 3 weeks of life. The expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood. Ref.4
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative promoter usage
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from direct assay PubMed 11432789. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]

Isoform 2 (identifier: Q9QYJ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by alternative promoter usage.

Isoform 1 (identifier: Q6B8I0-1)

The sequence of this isoform can be found in the external entry Q6B8I0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Dual specificity protein phosphatase 13		PRO_0000094821
Regions
	Domain	114 – 183	70	Tyrosine-protein phosphatase
Sites
	Active site	138	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C2493597D6D3732B	FASTA	198	22,481
	10 20 30 40 50 60 MDSLQKQELR RPKIHGAVQV SPYQPPTLAS LQRLLWVRRT ATLTHINEVW PNLFLGDAYA 70 80 90 100 110 120 ARDKGRLIQL GITHVVNVAA GKFQVDTGAK FYRGTPLEYY GIEADDNPFF DLSVHFLPVA 130 140 150 160 170 180 RYIRDALNIP RSRVLVHCAM GVSRSATIVL AFLMIFENMT LVDAIQTVQA HRDICPNSGF 190 LRQLQVLDNR LRRETGRL
	Isoform 1 [UniParc]. See Q6B8I0.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis." Nakamura K., Shima H., Watanabe M., Haneji T., Kikuchi K. Biochem. J. 344:819-825(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[2]	"Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain." Aoyama K., Nagata M., Oshima K., Matsuda T., Aoki N. J. Biol. Chem. 276:27575-27583(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2." Chen H.-H., Luche R., Wei B., Tonks N.K. J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB027003 mRNA. Translation: BAA89411.1. AF237620 mRNA. Translation: AAK15037.1. BC100421 mRNA. Translation: AAI00422.1.
IPI	IPI00515316.
RefSeq	NP_038877.2. NM_013849.3.
UniGene	Mm.390674.
3D structure databases
ProteinModelPortal	Q9QYJ7.
SMR	Q9QYJ7. Positions 24-191.
ModBase	Search...
PTM databases
PhosphoSite	Q9QYJ7.
Proteomic databases
PRIDE	Q9QYJ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000119866; ENSMUSP00000112552; ENSMUSG00000021768. ENSMUST00000120984; ENSMUSP00000113985; ENSMUSG00000021768.
GeneID	27389.
KEGG	mmu:27389.
Organism-specific databases
CTD	51207.
MGI	MGI:1351599. Dusp13.
Phylogenomic databases
eggNOG	NOG314632.
GeneTree	ENSGT00550000074474.
HOGENOM	HOG000233767.
HOVERGEN	HBG001524.
InParanoid	Q497R2.
KO	K14165.
OrthoDB	EOG402WSP.
Gene expression databases
ArrayExpress	Q9QYJ7.
Bgee	Q9QYJ7.
CleanEx	MM_DUSP13.
Genevestigator	Q9QYJ7.
GermOnline	ENSMUSG00000021768. Mus musculus.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	305348.
SOURCE	Search...

Entry information

Entry name

DUS13_MOUSE

Accession

Primary (citable) accession number: Q9QYJ7
Secondary accession number(s): Q497R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program