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Q9QYJ7

- DS13B_MOUSE

UniProt

Q9QYJ7 - DS13B_MOUSE

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Protein

Dual specificity protein phosphatase 13 isoform B

Gene
Dusp13, Gm1203, Tmdp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: MGI
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 13 isoform B (EC:3.1.3.16, EC:3.1.3.48)
Short name:
DUSP13B
Alternative name(s):
Dual specificity tyrosine phosphatase TS-DSP6
Testis- and skeletal muscle-specific DSP
Gene namesi
Name:Dusp13
Synonyms:Gm1203, Tmdp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1351599. Dusp13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Dual specificity protein phosphatase 13 isoform BPRO_0000094821Add
BLAST

Proteomic databases

PRIDEiQ9QYJ7.

PTM databases

PhosphoSiteiQ9QYJ7.

Expressioni

Tissue specificityi

Most abundantly expressed in the testis.1 Publication

Developmental stagei

Not detectable in testis in the first 3 weeks of life. The expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood.1 Publication

Gene expression databases

ArrayExpressiQ9QYJ7.
BgeeiQ9QYJ7.
CleanExiMM_DUSP13.
GenevestigatoriQ9QYJ7.

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ7.
SMRiQ9QYJ7. Positions 24-191.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 18370Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG314632.
GeneTreeiENSGT00550000074474.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ497R2.
KOiK14165.
OrthoDBiEOG7CZK7N.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 2 (identifier: Q9QYJ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSLQKQELR RPKIHGAVQV SPYQPPTLAS LQRLLWVRRT ATLTHINEVW    50
PNLFLGDAYA ARDKGRLIQL GITHVVNVAA GKFQVDTGAK FYRGTPLEYY 100
GIEADDNPFF DLSVHFLPVA RYIRDALNIP RSRVLVHCAM GVSRSATIVL 150
AFLMIFENMT LVDAIQTVQA HRDICPNSGF LRQLQVLDNR LRRETGRL 198

Note: Produced by alternative promoter usage.

Length:198
Mass (Da):22,481
Last modified:May 1, 2000 - v1
Checksum:iC2493597D6D3732B
GO
Isoform 1 (identifier: Q6B8I0-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6B8I0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:188
Mass (Da):20,646
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027003 mRNA. Translation: BAA89411.1.
AF237620 mRNA. Translation: AAK15037.1.
BC100421 mRNA. Translation: AAI00422.1.
RefSeqiNP_038877.2. NM_013849.3.
XP_006519139.1. XM_006519076.1. [Q9QYJ7-1]
UniGeneiMm.390674.

Genome annotation databases

EnsembliENSMUST00000120984; ENSMUSP00000113985; ENSMUSG00000021768. [Q9QYJ7-1]
ENSMUST00000184703; ENSMUSP00000138972; ENSMUSG00000021768. [Q9QYJ7-1]
GeneIDi27389.
KEGGimmu:27389.
UCSCiuc007slm.2. mouse. [Q9QYJ7-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027003 mRNA. Translation: BAA89411.1 .
AF237620 mRNA. Translation: AAK15037.1 .
BC100421 mRNA. Translation: AAI00422.1 .
RefSeqi NP_038877.2. NM_013849.3.
XP_006519139.1. XM_006519076.1. [Q9QYJ7-1 ]
UniGenei Mm.390674.

3D structure databases

ProteinModelPortali Q9QYJ7.
SMRi Q9QYJ7. Positions 24-191.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYJ7.

Proteomic databases

PRIDEi Q9QYJ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000120984 ; ENSMUSP00000113985 ; ENSMUSG00000021768 . [Q9QYJ7-1 ]
ENSMUST00000184703 ; ENSMUSP00000138972 ; ENSMUSG00000021768 . [Q9QYJ7-1 ]
GeneIDi 27389.
KEGGi mmu:27389.
UCSCi uc007slm.2. mouse. [Q9QYJ7-1 ]

Organism-specific databases

CTDi 51207.
MGIi MGI:1351599. Dusp13.

Phylogenomic databases

eggNOGi NOG314632.
GeneTreei ENSGT00550000074474.
HOGENOMi HOG000233767.
HOVERGENi HBG001524.
InParanoidi Q497R2.
KOi K14165.
OrthoDBi EOG7CZK7N.

Miscellaneous databases

NextBioi 305348.
PROi Q9QYJ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QYJ7.
Bgeei Q9QYJ7.
CleanExi MM_DUSP13.
Genevestigatori Q9QYJ7.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis."
    Nakamura K., Shima H., Watanabe M., Haneji T., Kikuchi K.
    Biochem. J. 344:819-825(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION.
  2. "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain."
    Aoyama K., Nagata M., Oshima K., Matsuda T., Aoki N.
    J. Biol. Chem. 276:27575-27583(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
    Chen H.-H., Luche R., Wei B., Tonks N.K.
    J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDS13B_MOUSE
AccessioniPrimary (citable) accession number: Q9QYJ7
Secondary accession number(s): Q497R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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