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Q9QYJ7

- DS13B_MOUSE

UniProt

Q9QYJ7 - DS13B_MOUSE

Protein

Dual specificity protein phosphatase 13 isoform B

Gene

Dusp13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: MGI
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 13 isoform B (EC:3.1.3.16, EC:3.1.3.48)
    Short name:
    DUSP13B
    Alternative name(s):
    Dual specificity tyrosine phosphatase TS-DSP6
    Testis- and skeletal muscle-specific DSP
    Gene namesi
    Name:Dusp13
    Synonyms:Gm1203, Tmdp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1351599. Dusp13.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Dual specificity protein phosphatase 13 isoform BPRO_0000094821Add
    BLAST

    Proteomic databases

    PRIDEiQ9QYJ7.

    PTM databases

    PhosphoSiteiQ9QYJ7.

    Expressioni

    Tissue specificityi

    Most abundantly expressed in the testis.1 Publication

    Developmental stagei

    Not detectable in testis in the first 3 weeks of life. The expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood.1 Publication

    Gene expression databases

    ArrayExpressiQ9QYJ7.
    BgeeiQ9QYJ7.
    CleanExiMM_DUSP13.
    GenevestigatoriQ9QYJ7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYJ7.
    SMRiQ9QYJ7. Positions 24-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 18370Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG314632.
    GeneTreeiENSGT00550000074474.
    HOGENOMiHOG000233767.
    HOVERGENiHBG001524.
    InParanoidiQ497R2.
    KOiK14165.
    OrthoDBiEOG7CZK7N.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform 2 (identifier: Q9QYJ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSLQKQELR RPKIHGAVQV SPYQPPTLAS LQRLLWVRRT ATLTHINEVW    50
    PNLFLGDAYA ARDKGRLIQL GITHVVNVAA GKFQVDTGAK FYRGTPLEYY 100
    GIEADDNPFF DLSVHFLPVA RYIRDALNIP RSRVLVHCAM GVSRSATIVL 150
    AFLMIFENMT LVDAIQTVQA HRDICPNSGF LRQLQVLDNR LRRETGRL 198

    Note: Produced by alternative promoter usage.

    Length:198
    Mass (Da):22,481
    Last modified:May 1, 2000 - v1
    Checksum:iC2493597D6D3732B
    GO
    Isoform 1 (identifier: Q6B8I0-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q6B8I0.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:188
    Mass (Da):20,646
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027003 mRNA. Translation: BAA89411.1.
    AF237620 mRNA. Translation: AAK15037.1.
    BC100421 mRNA. Translation: AAI00422.1.
    RefSeqiNP_038877.2. NM_013849.3.
    XP_006519139.1. XM_006519076.1. [Q9QYJ7-1]
    UniGeneiMm.390674.

    Genome annotation databases

    EnsembliENSMUST00000120984; ENSMUSP00000113985; ENSMUSG00000021768. [Q9QYJ7-1]
    ENSMUST00000184703; ENSMUSP00000138972; ENSMUSG00000021768. [Q9QYJ7-1]
    GeneIDi27389.
    KEGGimmu:27389.
    UCSCiuc007slm.2. mouse. [Q9QYJ7-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027003 mRNA. Translation: BAA89411.1 .
    AF237620 mRNA. Translation: AAK15037.1 .
    BC100421 mRNA. Translation: AAI00422.1 .
    RefSeqi NP_038877.2. NM_013849.3.
    XP_006519139.1. XM_006519076.1. [Q9QYJ7-1 ]
    UniGenei Mm.390674.

    3D structure databases

    ProteinModelPortali Q9QYJ7.
    SMRi Q9QYJ7. Positions 24-191.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QYJ7.

    Proteomic databases

    PRIDEi Q9QYJ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000120984 ; ENSMUSP00000113985 ; ENSMUSG00000021768 . [Q9QYJ7-1 ]
    ENSMUST00000184703 ; ENSMUSP00000138972 ; ENSMUSG00000021768 . [Q9QYJ7-1 ]
    GeneIDi 27389.
    KEGGi mmu:27389.
    UCSCi uc007slm.2. mouse. [Q9QYJ7-1 ]

    Organism-specific databases

    CTDi 51207.
    MGIi MGI:1351599. Dusp13.

    Phylogenomic databases

    eggNOGi NOG314632.
    GeneTreei ENSGT00550000074474.
    HOGENOMi HOG000233767.
    HOVERGENi HBG001524.
    InParanoidi Q497R2.
    KOi K14165.
    OrthoDBi EOG7CZK7N.

    Miscellaneous databases

    NextBioi 305348.
    PROi Q9QYJ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYJ7.
    Bgeei Q9QYJ7.
    CleanExi MM_DUSP13.
    Genevestigatori Q9QYJ7.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis."
      Nakamura K., Shima H., Watanabe M., Haneji T., Kikuchi K.
      Biochem. J. 344:819-825(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION.
    2. "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain."
      Aoyama K., Nagata M., Oshima K., Matsuda T., Aoki N.
      J. Biol. Chem. 276:27575-27583(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
      Chen H.-H., Luche R., Wei B., Tonks N.K.
      J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiDS13B_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYJ7
    Secondary accession number(s): Q497R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3