Reviewed, UniProtKB/Swiss-Prot Q9QYJ6 (PDE10_RAT)

Names and origin

Protein names

Recommended name:
    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    EC=3.1.4.17
    EC=3.1.4.35

Gene names

Name:

Pde10a

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	794 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Ref.1
Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. Ref.2 Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. Ref.2
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Enzyme regulation	Inhibited by dipyridamole and moderately by IBMX, zaprinast and rolipram. Ref.1
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Detected in striatum and testis (at protein level). Detected in whole brain, hippocampus, olfactory bulb, striatum neurons and testis. Ref.1 Ref.2
Induction	Up-regulated in brain after seizures. Up-regulated in the hippocampus one hour after induction of long-term potentiation. Ref.1 Ref.2
Domain	The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity. Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.
Biophysicochemical properties	Kinetic parameters: KM=0.26 µM for cAMP KM=9.3 µM for cGMP

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Metal-binding Nucleotide-binding cAMP cAMP-binding cGMP cGMP-binding
Molecular function	Hydrolase
Technical term	3D-structure Allosteric enzyme
Gene Ontology (GO)
Biological process	cAMP catabolic process Ref.1 Inferred from direct assay. Source: RGD cGMP catabolic process Ref.1 Inferred from direct assay. Source: RGD signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Inferred from direct assay. Source: RGD perikaryon Inferred from direct assay. Source: RGD soluble fraction Ref.1 Inferred from direct assay. Source: RGD
Molecular function	3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC cAMP binding Ref.1 Inferred from direct assay. Source: RGD cGMP binding Ref.1 Inferred from direct assay. Source: RGD drug binding Ref.1 Inferred from direct assay. Source: RGD magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9QYJ6-1)

Also known as: PDE10A2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QYJ6-2)

Also known as: PDE10A3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEDGPSNNASCFRRLTECFLSPS → MSNDSPEGAVGSCNATG

Isoform 3 (identifier: Q9QYJ6-3)

Also known as: PDE10A11;

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEDGPSNNASCFRRLTECFLSPS → MSKKRKALEG...GAVGSCNATG

Isoform 4 (identifier: Q9QYJ6-4)

Also known as: PDE10A12;

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEDGPSNNASCFRRLTECFLSPS → MSKKRKALEG...SDSRLALCMG

Isoform 5 (identifier: Q9QYJ6-5)

Also known as: PDE10A13;

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Isoform 6 (identifier: Q9QYJ6-6)

Also known as: PDE10A14;

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 794

794

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PRO_0000355559

Regions

Region

296 – 297

2

Allosteric effector binding By similarity

Region

340 – 341

2

Allosteric effector binding By similarity

Sites

Active site

525

1

Proton donor By similarity

Metal binding

529

1

Divalent metal cation 1

Metal binding

563

1

Divalent metal cation 1

Metal binding

564

1

Divalent metal cation 1

Metal binding

564

1

Divalent metal cation 2

Metal binding

674

1

Divalent metal cation 1

Binding site

374

1

Allosteric effector By similarity

Binding site

393

1

Allosteric effector By similarity

Binding site

525

1

Substrate By similarity

Binding site

726

1

Substrate By similarity

Natural variations

Alternative sequence

1 – 141

141

Missing in isoform 6.

VSP_035919

Alternative sequence

1 – 80

80

Missing in isoform 5.

VSP_035920

Alternative sequence

1 – 23

23

MEDGP…FLSPS → MSNDSPEGAVGSCNATG in isoform 2.

VSP_035921

Alternative sequence

1 – 23

23

MEDGP…FLSPS → MSKKRKALEGGGGGGEPQLP EEEPTAWFGGSSEEPAGCLP ITFKGGSKGPALLALRNRTD SRGQMSNDSPEGAVGSCNAT G in isoform 3.

VSP_035922

Alternative sequence

1 – 23

23

MEDGP…FLSPS → MSKKRKALEGGGGGGEPQLP EEEPTAWFGGSSEEPAGCLP ITFKGGSKGPALLALRNRTD SRGQMSNDSPEGAVGSCNAT GSTGSTGELGKEFHTPPRRK SASDSRLALCMG in isoform 4.

VSP_035923

Secondary structure

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794

Helix Strand Turn

Details...

Helix

466 – 471

6

Helix

483 – 485

3

Helix

490 – 497

8

Helix

505 – 517

13

Beta strand

523 – 526

4

Helix

527 – 542

16

Helix

550 – 553

4

Helix

557 – 562

6

Turn

563 – 566

4

Helix

572 – 578

7

Helix

581 – 585

5

Beta strand

587 – 589

3

Helix

590 – 604

15

Turn

610 – 613

4

Helix

616 – 632

17

Helix

635 – 638

4

Helix

642 – 650

9

Helix

659 – 665

7

Helix

669 – 674

6

Helix

676 – 679

4

Helix

682 – 698

17

Turn

702 – 705

4

Helix

712 – 714

3

Helix

716 – 721

6

Turn

730 – 733

4

Helix

734 – 744

11

Helix

746 – 748

3

Helix

749 – 766

18

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PDE10A2) [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A36C4678B385846E	FASTA	794	90,161
	10 20 30 40 50 60 MEDGPSNNAS CFRRLTECFL SPSLTDEKVK AYLSLHPQVL DEFVSESVSA ETVEKWLKRK 70 80 90 100 110 120 NNKAEDEPSP KEVSRYQDTN MQGVVYELNS YIEQRLDTGG DNHLLLYELS SIIRIATKAD 130 140 150 160 170 180 GFALYFLGEC NNSLCVFTPP GMKEGQPRLI PAGPITQGTT ISAYVAKSRK TLLVEDILGD 190 200 210 220 230 240 ERFPRGTGLE SGTRIQSVLC LPIVTAIGDL IGILELYRHW GKEAFCLSHQ EVATANLAWA 250 260 270 280 290 300 SVAIHQVQVC RGLAKQTELN DFLLDVSKTY FDNIVAIDSL LEHIMIYAKN LVNADRCALF 310 320 330 340 350 360 QVDHKNKELY SDLFDIGEEK EGKPVFKKTK EIRFSIEKGI AGQVARTGEV LNIPDAYADP 370 380 390 400 410 420 RFNREVDLYT GYTTRNILCM PIVSRGSVIG VVQMVNKISG SAFSKTDENN FKMFAVFCAL 430 440 450 460 470 480 ALHCANMYHR IRHSECIYRV TMEKLSYHSI CTSEEWQGLM HFNLPARICR DIELFHFDIG 490 500 510 520 530 540 PFENMWPGIF VYMIHRSCGT SCFELEKLCR FIMSVKKNYR RVPYHNWKHA VTVAHCMYAI 550 560 570 580 590 600 LQNNNGLFTD LERKGLLIAC LCHDLDHRGF SNSYLQKFDH PLAALYSTST MEQHHFSQTV 610 620 630 640 650 660 SILQLEGHNI FSTLSSSEYE QVLEIIRKAI IATDLALYFG NRKQLEEMYQ TGSLNLHNQS 670 680 690 700 710 720 HRDRVIGLMM TACDLCSVTK LWPVTKLTAN DIYAEFWAEG DEMKKLGIQP IPMMDRDKRD 730 740 750 760 770 780 EVPQGQLGFY NAVAIPCYTT LTQILPPTEP LLKACRDNLN QWEKVIRGEE TAMWISGPAT 790 SKSTSEKPTR KVDD
	Isoform 2 (PDE10A3). Checksum: 44F421DF1CC8FBA0	FASTA	788	89,196
	10 20 30 40 50 60 MSNDSPEGAV GSCNATGLTD EKVKAYLSLH PQVLDEFVSE SVSAETVEKW LKRKNNKAED 70 80 90 100 110 120 EPSPKEVSRY QDTNMQGVVY ELNSYIEQRL DTGGDNHLLL YELSSIIRIA TKADGFALYF 130 140 150 160 170 180 LGECNNSLCV FTPPGMKEGQ PRLIPAGPIT QGTTISAYVA KSRKTLLVED ILGDERFPRG 190 200 210 220 230 240 TGLESGTRIQ SVLCLPIVTA IGDLIGILEL YRHWGKEAFC LSHQEVATAN LAWASVAIHQ 250 260 270 280 290 300 VQVCRGLAKQ TELNDFLLDV SKTYFDNIVA IDSLLEHIMI YAKNLVNADR CALFQVDHKN 310 320 330 340 350 360 KELYSDLFDI GEEKEGKPVF KKTKEIRFSI EKGIAGQVAR TGEVLNIPDA YADPRFNREV 370 380 390 400 410 420 DLYTGYTTRN ILCMPIVSRG SVIGVVQMVN KISGSAFSKT DENNFKMFAV FCALALHCAN 430 440 450 460 470 480 MYHRIRHSEC IYRVTMEKLS YHSICTSEEW QGLMHFNLPA RICRDIELFH FDIGPFENMW 490 500 510 520 530 540 PGIFVYMIHR SCGTSCFELE KLCRFIMSVK KNYRRVPYHN WKHAVTVAHC MYAILQNNNG 550 560 570 580 590 600 LFTDLERKGL LIACLCHDLD HRGFSNSYLQ KFDHPLAALY STSTMEQHHF SQTVSILQLE 610 620 630 640 650 660 GHNIFSTLSS SEYEQVLEII RKAIIATDLA LYFGNRKQLE EMYQTGSLNL HNQSHRDRVI 670 680 690 700 710 720 GLMMTACDLC SVTKLWPVTK LTANDIYAEF WAEGDEMKKL GIQPIPMMDR DKRDEVPQGQ 730 740 750 760 770 780 LGFYNAVAIP CYTTLTQILP PTEPLLKACR DNLNQWEKVI RGEETAMWIS GPATSKSTSE KPTRKVDD
	Isoform 3 (PDE10A11). Checksum: 31F6E5D4DDB8F60B	FASTA	852	95,777
	10 20 30 40 50 60 MSKKRKALEG GGGGGEPQLP EEEPTAWFGG SSEEPAGCLP ITFKGGSKGP ALLALRNRTD 70 80 90 100 110 120 SRGQMSNDSP EGAVGSCNAT GLTDEKVKAY LSLHPQVLDE FVSESVSAET VEKWLKRKNN 130 140 150 160 170 180 KAEDEPSPKE VSRYQDTNMQ GVVYELNSYI EQRLDTGGDN HLLLYELSSI IRIATKADGF 190 200 210 220 230 240 ALYFLGECNN SLCVFTPPGM KEGQPRLIPA GPITQGTTIS AYVAKSRKTL LVEDILGDER 250 260 270 280 290 300 FPRGTGLESG TRIQSVLCLP IVTAIGDLIG ILELYRHWGK EAFCLSHQEV ATANLAWASV 310 320 330 340 350 360 AIHQVQVCRG LAKQTELNDF LLDVSKTYFD NIVAIDSLLE HIMIYAKNLV NADRCALFQV 370 380 390 400 410 420 DHKNKELYSD LFDIGEEKEG KPVFKKTKEI RFSIEKGIAG QVARTGEVLN IPDAYADPRF 430 440 450 460 470 480 NREVDLYTGY TTRNILCMPI VSRGSVIGVV QMVNKISGSA FSKTDENNFK MFAVFCALAL 490 500 510 520 530 540 HCANMYHRIR HSECIYRVTM EKLSYHSICT SEEWQGLMHF NLPARICRDI ELFHFDIGPF 550 560 570 580 590 600 ENMWPGIFVY MIHRSCGTSC FELEKLCRFI MSVKKNYRRV PYHNWKHAVT VAHCMYAILQ 610 620 630 640 650 660 NNNGLFTDLE RKGLLIACLC HDLDHRGFSN SYLQKFDHPL AALYSTSTME QHHFSQTVSI 670 680 690 700 710 720 LQLEGHNIFS TLSSSEYEQV LEIIRKAIIA TDLALYFGNR KQLEEMYQTG SLNLHNQSHR 730 740 750 760 770 780 DRVIGLMMTA CDLCSVTKLW PVTKLTANDI YAEFWAEGDE MKKLGIQPIP MMDRDKRDEV 790 800 810 820 830 840 PQGQLGFYNA VAIPCYTTLT QILPPTEPLL KACRDNLNQW EKVIRGEETA MWISGPATSK 850 STSEKPTRKV DD
	Isoform 4 (PDE10A12). Checksum: 86527DFF337E4B4F	FASTA	883	99,036
	10 20 30 40 50 60 MSKKRKALEG GGGGGEPQLP EEEPTAWFGG SSEEPAGCLP ITFKGGSKGP ALLALRNRTD 70 80 90 100 110 120 SRGQMSNDSP EGAVGSCNAT GSTGSTGELG KEFHTPPRRK SASDSRLALC MGLTDEKVKA 130 140 150 160 170 180 YLSLHPQVLD EFVSESVSAE TVEKWLKRKN NKAEDEPSPK EVSRYQDTNM QGVVYELNSY 190 200 210 220 230 240 IEQRLDTGGD NHLLLYELSS IIRIATKADG FALYFLGECN NSLCVFTPPG MKEGQPRLIP 250 260 270 280 290 300 AGPITQGTTI SAYVAKSRKT LLVEDILGDE RFPRGTGLES GTRIQSVLCL PIVTAIGDLI 310 320 330 340 350 360 GILELYRHWG KEAFCLSHQE VATANLAWAS VAIHQVQVCR GLAKQTELND FLLDVSKTYF 370 380 390 400 410 420 DNIVAIDSLL EHIMIYAKNL VNADRCALFQ VDHKNKELYS DLFDIGEEKE GKPVFKKTKE 430 440 450 460 470 480 IRFSIEKGIA GQVARTGEVL NIPDAYADPR FNREVDLYTG YTTRNILCMP IVSRGSVIGV 490 500 510 520 530 540 VQMVNKISGS AFSKTDENNF KMFAVFCALA LHCANMYHRI RHSECIYRVT MEKLSYHSIC 550 560 570 580 590 600 TSEEWQGLMH FNLPARICRD IELFHFDIGP FENMWPGIFV YMIHRSCGTS CFELEKLCRF 610 620 630 640 650 660 IMSVKKNYRR VPYHNWKHAV TVAHCMYAIL QNNNGLFTDL ERKGLLIACL CHDLDHRGFS 670 680 690 700 710 720 NSYLQKFDHP LAALYSTSTM EQHHFSQTVS ILQLEGHNIF STLSSSEYEQ VLEIIRKAII 730 740 750 760 770 780 ATDLALYFGN RKQLEEMYQT GSLNLHNQSH RDRVIGLMMT ACDLCSVTKL WPVTKLTAND 790 800 810 820 830 840 IYAEFWAEGD EMKKLGIQPI PMMDRDKRDE VPQGQLGFYN AVAIPCYTTL TQILPPTEPL 850 860 870 880 LKACRDNLNQ WEKVIRGEET AMWISGPATS KSTSEKPTRK VDD
	Isoform 5 (PDE10A13). Checksum: 5AFBCD366955F8F6	FASTA	714	81,028
	10 20 30 40 50 60 MQGVVYELNS YIEQRLDTGG DNHLLLYELS SIIRIATKAD GFALYFLGEC NNSLCVFTPP 70 80 90 100 110 120 GMKEGQPRLI PAGPITQGTT ISAYVAKSRK TLLVEDILGD ERFPRGTGLE SGTRIQSVLC 130 140 150 160 170 180 LPIVTAIGDL IGILELYRHW GKEAFCLSHQ EVATANLAWA SVAIHQVQVC RGLAKQTELN 190 200 210 220 230 240 DFLLDVSKTY FDNIVAIDSL LEHIMIYAKN LVNADRCALF QVDHKNKELY SDLFDIGEEK 250 260 270 280 290 300 EGKPVFKKTK EIRFSIEKGI AGQVARTGEV LNIPDAYADP RFNREVDLYT GYTTRNILCM 310 320 330 340 350 360 PIVSRGSVIG VVQMVNKISG SAFSKTDENN FKMFAVFCAL ALHCANMYHR IRHSECIYRV 370 380 390 400 410 420 TMEKLSYHSI CTSEEWQGLM HFNLPARICR DIELFHFDIG PFENMWPGIF VYMIHRSCGT 430 440 450 460 470 480 SCFELEKLCR FIMSVKKNYR RVPYHNWKHA VTVAHCMYAI LQNNNGLFTD LERKGLLIAC 490 500 510 520 530 540 LCHDLDHRGF SNSYLQKFDH PLAALYSTST MEQHHFSQTV SILQLEGHNI FSTLSSSEYE 550 560 570 580 590 600 QVLEIIRKAI IATDLALYFG NRKQLEEMYQ TGSLNLHNQS HRDRVIGLMM TACDLCSVTK 610 620 630 640 650 660 LWPVTKLTAN DIYAEFWAEG DEMKKLGIQP IPMMDRDKRD EVPQGQLGFY NAVAIPCYTT 670 680 690 700 710 LTQILPPTEP LLKACRDNLN QWEKVIRGEE TAMWISGPAT SKSTSEKPTR KVDD
	Isoform 6 (PDE10A14). Checksum: C712183FC1CFA76F	FASTA	653	74,275
	10 20 30 40 50 60 MKEGQPRLIP AGPITQGTTI SAYVAKSRKT LLVEDILGDE RFPRGTGLES GTRIQSVLCL 70 80 90 100 110 120 PIVTAIGDLI GILELYRHWG KEAFCLSHQE VATANLAWAS VAIHQVQVCR GLAKQTELND 130 140 150 160 170 180 FLLDVSKTYF DNIVAIDSLL EHIMIYAKNL VNADRCALFQ VDHKNKELYS DLFDIGEEKE 190 200 210 220 230 240 GKPVFKKTKE IRFSIEKGIA GQVARTGEVL NIPDAYADPR FNREVDLYTG YTTRNILCMP 250 260 270 280 290 300 IVSRGSVIGV VQMVNKISGS AFSKTDENNF KMFAVFCALA LHCANMYHRI RHSECIYRVT 310 320 330 340 350 360 MEKLSYHSIC TSEEWQGLMH FNLPARICRD IELFHFDIGP FENMWPGIFV YMIHRSCGTS 370 380 390 400 410 420 CFELEKLCRF IMSVKKNYRR VPYHNWKHAV TVAHCMYAIL QNNNGLFTDL ERKGLLIACL 430 440 450 460 470 480 CHDLDHRGFS NSYLQKFDHP LAALYSTSTM EQHHFSQTVS ILQLEGHNIF STLSSSEYEQ 490 500 510 520 530 540 VLEIIRKAII ATDLALYFGN RKQLEEMYQT GSLNLHNQSH RDRVIGLMMT ACDLCSVTKL 550 560 570 580 590 600 WPVTKLTAND IYAEFWAEGD EMKKLGIQPI PMMDRDKRDE VPQGQLGFYN AVAIPCYTTL 610 620 630 640 650 TQILPPTEPL LKACRDNLNQ WEKVIRGEET AMWISGPATS KSTSEKPTRK VDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A." Fujishige K., Kotera J., Omori K. Eur. J. Biochem. 266:1118-1127(1999) [PubMed: 10583409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants." O'Connor V., Genin A., Davis S., Karishma K.K., Doyere V., De Zeeuw C.I., Sanger G., Hunt S.P., Richter-Levin G., Mallet J., Laroche S., Bliss T.V.P., French P.J. J. Biol. Chem. 279:15841-15849(2004) [PubMed: 14752115] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), TISSUE SPECIFICITY, CATALYTIC ACTIVITY, INDUCTION. Strain: Wistar.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors." Chappie T.A., Humphrey J.M., Allen M.P., Estep K.G., Fox C.B., Lebel L.A., Liras S., Marr E.S., Menniti F.S., Pandit J., Schmidt C.J., Tu M., Williams R.D., Yang F.V. J. Med. Chem. 50:182-185(2007) [PubMed: 17228859] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 452-794 IN COMPLEXES WITH ZINC; MAGNESIUM AND A SYNTHETIC INHIBITOR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB027155 mRNA. Translation: BAA88996.1.
AB027156 mRNA. Translation: BAA88997.1.
AY462091 mRNA. Translation: AAS21243.1.
AY462092 mRNA. Translation: AAS21244.1.
AY462093 mRNA. Translation: AAS21245.1.
AY462094 mRNA. Translation: AAS21246.1.
AY462095 mRNA. Translation: AAS21247.1.
CH474059 Genomic DNA. Translation: EDL83106.1.

IPI

IPI00213904.
IPI00454225.
IPI00561300.
IPI00915539.
IPI00915561.
IPI00915566.

RefSeq

NP_071572.1.

UniGene

Rn.44869

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2O8H	X-ray	1.80	A	452-794	[»]
2OVV	X-ray	2.00	A	452-794	[»]
2OVY	X-ray	1.80	A	452-794	[»]
3HQW	X-ray	1.70	A	452-794	[»]
3HQY	X-ray	2.00	A	452-794	[»]
3HQZ	X-ray	1.70	A	452-794	[»]
3HR1	X-ray	1.53	A	452-794	[»]

SMR

Q9QYJ6. Positions 256-432.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9QYJ6.

Proteomic databases

PRIDE

Q9QYJ6.

Genome annotation databases

Ensembl

ENSRNOT00000043474; ENSRNOP00000042134; ENSRNOG00000011310; Rattus norvegicus. [Genome view]

GeneID

63885.

KEGG

rno:63885.

Organism-specific databases

CTD

63885.

RGD

68434. Pde10a.

Phylogenomic databases

eggNOG

roNOG04269.

HOVERGEN

Q9QYJ6.

OMA

QQEGHNI.

OrthoDB

EOG9JT2R3.

Gene expression databases

ArrayExpress

Q9QYJ6.

Genevestigator

Q9QYJ6.

Family and domain databases

InterPro

IPR003018. GAF.
IPR003607. Metal-dep_PHydrolase_HD_dom.
IPR002073. PDEase.
[Graphical view]

Pfam

PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]

PRINTS

PR00387. PDIESTERASE1.

SMART

SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]

PROSITE

PS00126. PDEASE_I. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

BindingDB

Q9QYJ6.

NextBio

612518.

PMAP-CutDB

Q9QYJ6.

Entry information

Entry name

PDE10_RAT

Accession

Primary (citable) accession number: Q9QYJ6
Secondary accession number(s): Q6S9E6 , Q6S9E7, Q6S9E8, Q6S9E9, Q9QYJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)