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Protein

ATP-binding cassette sub-family B member 9

Gene

Abcb9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi535 – 542ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeptide transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 9
Alternative name(s):
ATP-binding cassette transporter 9
Short name:
ABC transporter 9 protein
TAP-like protein
Short name:
TAPL
Gene namesi
Name:Abcb9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620254. Abcb9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei47 – 67HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei84 – 104HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei116 – 136HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei181 – 201HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei221 – 241HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei315 – 335HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei412 – 432HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000002541 – 762ATP-binding cassette sub-family B member 9Add BLAST762

Proteomic databases

PaxDbiQ9QYJ4.
PRIDEiQ9QYJ4.

PTM databases

PhosphoSitePlusiQ9QYJ4.

Expressioni

Tissue specificityi

Found in testis, particularly in the Sertoli cells of the seminiferous tubules. Also expressed in kidney, brain, heart, lung, spleen, thymus, intestine and testis. Higher expression detected in brain and testis than in thymus and intestine.2 Publications

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051058.

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ4.
SMRiQ9QYJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 467ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini500 – 736ABC transporterPROSITE-ProRule annotationAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 385Poly-Glu6

Domaini

The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG008358.
InParanoidiQ9QYJ4.
KOiK05656.
PhylomeDBiQ9QYJ4.
TreeFamiTF105197.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030254. ABCB9.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24221:SF242. PTHR24221:SF242. 1 hit.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QYJ4-1) [UniParc]FASTAAdd to basket
Also known as: TAPLa, C-I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLWKAVVVT LAFVSMDVGV TTAIYAFSHL DRSLLEDIRH FNIFDSVLDL
60 70 80 90 100
WAACLYRSCL LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMAK
110 120 130 140 150
LLLFSEVRRP IRDPWFWALF VWTYISLAAS FLLWGLLATV RPDAEALEPG
160 170 180 190 200
NEGFHGEGGA PAEQASGATL QKLLSYTKPD VAFLVAASFF LIVAALGETF
210 220 230 240 250
LPYYTGRAID SIVIQKSMDQ FTTAVVVVCL LAIGSSLAAG IRGGIFTLVF
260 270 280 290 300
ARLNIRLRNC LFRSLVSQET SFFDENRTGD LISRLTSDTT MVSDLVSQNI
310 320 330 340 350
NIFLRNTVKV TGVVVFMFSL SWQLSLVTFM GFPIIMMVSN IYGKYYKRLS
360 370 380 390 400
KEVQSALARA STTAEETISA MKTVRSFANE EEEAEVFLRK LQQVYKLNRK
410 420 430 440 450
EAAAYMSYVW GSGLTLLVVQ VSILYYGGHL VISGQMSSGN LIAFIIYEFV
460 470 480 490 500
LGDCMESVGS VYSGLMQGVG AAEKVFEFID RQPTMVHDGR LAPDHLEGRV
510 520 530 540 550
DFENVTFTYR TRPHTQVLQN VSFSLSPGKV TALVGPSGSG KSSCVNILEN
560 570 580 590 600
FYPLQGGRVL LDGEPIGAYD HKYLHRVISL VSQEPVLFAR SITDNISYGL
610 620 630 640 650
PTVPFEMVVE AAQKANAHGF IMELQDGYST ETGEKGAQLS GGQKQRVAMA
660 670 680 690 700
RALVRNPPVL ILDEATSALD AESEYLIQQA IHGNLQRHTV LIIAHRLSTV
710 720 730 740 750
ERAHLIVVLD KGRVVQQGTH QQLLAQGGLY AKLVQRQMLG LEHPLDYTAG
760
HKEPPSNTEH KA
Length:762
Mass (Da):84,033
Last modified:May 1, 2000 - v1
Checksum:iE39D3B42CFBD88EF
GO
Isoform 2 (identifier: Q9QYJ4-2) [UniParc]FASTAAdd to basket
Also known as: TAPLb, C-II

The sequence of this isoform differs from the canonical sequence as follows:
     721-762: QQLLAQGGLY...EPPSNTEHKA → LPLLSTPATL...WFKILGELGQ

Show »
Length:766
Mass (Da):84,281
Checksum:i9EFF44B28F15AF0E
GO
Isoform 3 (identifier: Q9QYJ4-3) [UniParc]FASTAAdd to basket
Also known as: C-III

The sequence of this isoform differs from the canonical sequence as follows:
     677-762: IQQAIHGNLQ...EPPSNTEHKA → VALADLKYREIHPSPQD

Show »
Length:693
Mass (Da):76,377
Checksum:iEEDEDCB2071256CB
GO
Isoform 4 (identifier: Q9QYJ4-4) [UniParc]FASTAAdd to basket
Also known as: C-IV

The sequence of this isoform differs from the canonical sequence as follows:
     677-762: IQQAIHGNLQ...EPPSNTEHKA → SEAQTPGLEHTPHPATTAWLEATLSPKPGCQG

Show »
Length:708
Mass (Da):77,739
Checksum:iE1B48C06C6215E14
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041888677 – 762IQQAI…TEHKA → VALADLKYREIHPSPQD in isoform 3. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_041887677 – 762IQQAI…TEHKA → SEAQTPGLEHTPHPATTAWL EATLSPKPGCQG in isoform 4. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_000034721 – 762QQLLA…TEHKA → LPLLSTPATLQRNLVCKMYS QIGGGDRGNAQGLALSWFKI LGELGQ in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027520 mRNA. Translation: BAA85306.1.
AB116264 mRNA. Translation: BAD10852.1.
AB116265 mRNA. Translation: BAD10853.1.
RefSeqiNP_071574.1. NM_022238.1. [Q9QYJ4-1]
UniGeneiRn.44870.

Genome annotation databases

GeneIDi63886.
KEGGirno:63886.
UCSCiRGD:620254. rat. [Q9QYJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABCB9_RAT
AccessioniPrimary (citable) accession number: Q9QYJ4
Secondary accession number(s): Q764Q5, Q764Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families