Q9QYJ3 (DNJB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily B member 1

Alternative name(s):
Heat shock 40 kDa protein 1
Short name=HSP40
Short name=Heat shock protein 40

Gene names

Name:	Dnajb1
Synonyms:	Hsp40, Hspf1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP By similarity.
Subunit structure	Interacts with DNAJC3 By similarity. Interacts with SRPK1 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Nucleus › nucleolus By similarity. Note: Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock By similarity.
Induction	By heat shock By similarity.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm Nucleus
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chaperone cofactor-dependent protein refolding Inferred from electronic annotation. Source: Compara chaperone mediated protein folding requiring cofactor Inferred from genetic interaction PubMed 14644449. Source: MGI response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 340	339	DnaJ homolog subfamily B member 1		PRO_0000071017
Regions
	Domain	2 – 70	69	J

Sequences

	Sequence		Length	Mass (Da)
	Q9QYJ3 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F775BFBA4A5D324E	FASTA	340	38,167
	10 20 30 40 50 60 MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK 70 80 90 100 110 120 REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN 130 140 150 160 170 180 GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT 190 200 210 220 230 240 KKMKISHKRL NPDGKSIRNE DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK 250 260 270 280 290 300 DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 310 320 330 340 GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of murine Hsp40 gene: differences in initiation sites between heat-induced and constitutive transcripts." Hata M., Ohtsuka K. DNA Seq. 11:213-223(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: BALB/c. Tissue: Liver and Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028272 mRNA. Translation: BAA88083.1. AB028273 Genomic DNA. Translation: BAA95672.1. BC012962 mRNA. Translation: AAH12962.1.
IPI	IPI00136253.
RefSeq	NP_061278.1. NM_018808.2.
UniGene	Mm.282092.
3D structure databases
ProteinModelPortal	Q9QYJ3.
SMR	Q9QYJ3. Positions 1-74, 157-340.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QYJ3. 1 interaction.
STRING	10090.ENSMUSP00000005620.
PTM databases
PhosphoSite	Q9QYJ3.
Proteomic databases
PaxDb	Q9QYJ3.
PRIDE	Q9QYJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483.
GeneID	81489.
KEGG	mmu:81489.
Organism-specific databases
CTD	3337.
MGI	MGI:1931874. Dnajb1.
Phylogenomic databases
eggNOG	COG0484.
GeneTree	ENSGT00690000101768.
HOGENOM	HOG000226718.
HOVERGEN	HBG066727.
InParanoid	Q9QYJ3.
KO	K09507.
OMA	PERIPVS.
OrthoDB	EOG4PVP00.
Gene expression databases
ArrayExpress	Q9QYJ3.
Bgee	Q9QYJ3.
CleanEx	MM_DNAJB1.
Genevestigator	Q9QYJ3.
GermOnline	ENSMUSG00000005483. Mus musculus.
Family and domain databases
Gene3D	1.10.287.110. 1 hit.
InterPro	IPR002939. DnaJ_C. IPR001623. DnaJ_domain. IPR018253. DnaJ_domain_CS. IPR008971. HSP40/DnaJ_pept-bd. [Graphical view]
Pfam	PF00226. DnaJ. 1 hit. PF01556. DnaJ_C. 1 hit. [Graphical view]
PRINTS	PR00625. JDOMAIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit. SSF49493. HSP40_DnaJ_pep. 2 hits.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DNAJB1. mouse.
NextBio	350390.
SOURCE	Search...

Entry information

Entry name

DNJB1_MOUSE

Accession

Primary (citable) accession number: Q9QYJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program