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Q9QYJ3 (DNJB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily B member 1
Alternative name(s):
Heat shock 40 kDa protein 1
Short name=HSP40
Short name=Heat shock protein 40
Gene names
Name:Dnajb1
Synonyms:Hsp40, Hspf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP By similarity.

Subunit structure

Interacts with DNAJC3 By similarity. Interacts with SRPK1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Nucleusnucleolus By similarity. Note: Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock By similarity.

Induction

By heat shock By similarity.

Sequence similarities

Contains 1 J domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 340339DnaJ homolog subfamily B member 1
PRO_0000071017

Regions

Domain2 – 7069J

Sequences

Sequence LengthMass (Da)Tools
Q9QYJ3 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F775BFBA4A5D324E

FASTA34038,167
        10         20         30         40         50         60 
MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK 

        70         80         90        100        110        120 
REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN 

       130        140        150        160        170        180 
GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT 

       190        200        210        220        230        240 
KKMKISHKRL NPDGKSIRNE DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK 

       250        260        270        280        290        300 
DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 

       310        320        330        340 
GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine Hsp40 gene: differences in initiation sites between heat-induced and constitutive transcripts."
Hata M., Ohtsuka K.
DNA Seq. 11:213-223(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: BALB/c.
Tissue: Liver and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028272 mRNA. Translation: BAA88083.1.
AB028273 Genomic DNA. Translation: BAA95672.1.
BC012962 mRNA. Translation: AAH12962.1.
CCDSCCDS22456.1.
RefSeqNP_061278.1. NM_018808.2.
UniGeneMm.282092.

3D structure databases

ProteinModelPortalQ9QYJ3.
SMRQ9QYJ3. Positions 1-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid219875. 2 interactions.
IntActQ9QYJ3. 2 interactions.
MINTMINT-4093206.
STRING10090.ENSMUSP00000005620.

PTM databases

PhosphoSiteQ9QYJ3.

Proteomic databases

MaxQBQ9QYJ3.
PaxDbQ9QYJ3.
PRIDEQ9QYJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483.
GeneID81489.
KEGGmmu:81489.
UCSCuc009mkp.2. mouse.

Organism-specific databases

CTD3337.
MGIMGI:1931874. Dnajb1.

Phylogenomic databases

eggNOGCOG0484.
GeneTreeENSGT00720000108438.
HOGENOMHOG000226718.
HOVERGENHBG066727.
InParanoidQ9QYJ3.
KOK09507.
OMANPFDNFF.
OrthoDBEOG7TF79F.
PhylomeDBQ9QYJ3.
TreeFamTF105141.

Gene expression databases

ArrayExpressQ9QYJ3.
BgeeQ9QYJ3.
CleanExMM_DNAJB1.
GenevestigatorQ9QYJ3.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDNAJB1. mouse.
NextBio350390.
PROQ9QYJ3.
SOURCESearch...

Entry information

Entry nameDNJB1_MOUSE
AccessionPrimary (citable) accession number: Q9QYJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot