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Q9QYJ3

- DNJB1_MOUSE

UniProt

Q9QYJ3 - DNJB1_MOUSE

Protein

DnaJ homolog subfamily B member 1

Gene

Dnajb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP By similarity.By similarity

    GO - Biological processi

    1. chaperone cofactor-dependent protein refolding Source: Ensembl
    2. chaperone mediated protein folding requiring cofactor Source: MGI
    3. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    ReactomeiREACT_213550. HSF1-dependent transactivation.
    REACT_222185. Regulation of HSF1-mediated heat shock response.
    REACT_223784. Attenuation phase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily B member 1
    Alternative name(s):
    Heat shock 40 kDa protein 1
    Short name:
    HSP40
    Short name:
    Heat shock protein 40
    Gene namesi
    Name:Dnajb1
    Synonyms:Hsp40, Hspf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1931874. Dnajb1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Nucleusnucleolus By similarity
    Note: Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 340339DnaJ homolog subfamily B member 1PRO_0000071017Add
    BLAST

    Proteomic databases

    MaxQBiQ9QYJ3.
    PaxDbiQ9QYJ3.
    PRIDEiQ9QYJ3.

    PTM databases

    PhosphoSiteiQ9QYJ3.

    Expressioni

    Inductioni

    By heat shock.By similarity

    Gene expression databases

    ArrayExpressiQ9QYJ3.
    BgeeiQ9QYJ3.
    CleanExiMM_DNAJB1.
    GenevestigatoriQ9QYJ3.

    Interactioni

    Subunit structurei

    Interacts with DNAJC3. Interacts with SRPK1.By similarity

    Protein-protein interaction databases

    BioGridi219875. 2 interactions.
    IntActiQ9QYJ3. 2 interactions.
    MINTiMINT-4093206.
    STRINGi10090.ENSMUSP00000005620.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYJ3.
    SMRiQ9QYJ3. Positions 1-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7069JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0484.
    GeneTreeiENSGT00720000108438.
    HOGENOMiHOG000226718.
    HOVERGENiHBG066727.
    InParanoidiQ9QYJ3.
    KOiK09507.
    OMAiNPFDNFF.
    OrthoDBiEOG7TF79F.
    PhylomeDBiQ9QYJ3.
    TreeFamiTF105141.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    [Graphical view]
    PfamiPF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 2 hits.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE    50
    AYDVLSDPRK REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA 100
    MFAEFFGGRN PFDTFFGQRN GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR 150
    PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE 200
    DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD 250
    GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 300
    GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI 340
    Length:340
    Mass (Da):38,167
    Last modified:January 23, 2007 - v3
    Checksum:iF775BFBA4A5D324E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028272 mRNA. Translation: BAA88083.1.
    AB028273 Genomic DNA. Translation: BAA95672.1.
    BC012962 mRNA. Translation: AAH12962.1.
    CCDSiCCDS22456.1.
    RefSeqiNP_061278.1. NM_018808.2.
    UniGeneiMm.282092.

    Genome annotation databases

    EnsembliENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483.
    GeneIDi81489.
    KEGGimmu:81489.
    UCSCiuc009mkp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028272 mRNA. Translation: BAA88083.1 .
    AB028273 Genomic DNA. Translation: BAA95672.1 .
    BC012962 mRNA. Translation: AAH12962.1 .
    CCDSi CCDS22456.1.
    RefSeqi NP_061278.1. NM_018808.2.
    UniGenei Mm.282092.

    3D structure databases

    ProteinModelPortali Q9QYJ3.
    SMRi Q9QYJ3. Positions 1-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219875. 2 interactions.
    IntActi Q9QYJ3. 2 interactions.
    MINTi MINT-4093206.
    STRINGi 10090.ENSMUSP00000005620.

    PTM databases

    PhosphoSitei Q9QYJ3.

    Proteomic databases

    MaxQBi Q9QYJ3.
    PaxDbi Q9QYJ3.
    PRIDEi Q9QYJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005620 ; ENSMUSP00000005620 ; ENSMUSG00000005483 .
    GeneIDi 81489.
    KEGGi mmu:81489.
    UCSCi uc009mkp.2. mouse.

    Organism-specific databases

    CTDi 3337.
    MGIi MGI:1931874. Dnajb1.

    Phylogenomic databases

    eggNOGi COG0484.
    GeneTreei ENSGT00720000108438.
    HOGENOMi HOG000226718.
    HOVERGENi HBG066727.
    InParanoidi Q9QYJ3.
    KOi K09507.
    OMAi NPFDNFF.
    OrthoDBi EOG7TF79F.
    PhylomeDBi Q9QYJ3.
    TreeFami TF105141.

    Enzyme and pathway databases

    Reactomei REACT_213550. HSF1-dependent transactivation.
    REACT_222185. Regulation of HSF1-mediated heat shock response.
    REACT_223784. Attenuation phase.

    Miscellaneous databases

    ChiTaRSi DNAJB1. mouse.
    NextBioi 350390.
    PROi Q9QYJ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYJ3.
    Bgeei Q9QYJ3.
    CleanExi MM_DNAJB1.
    Genevestigatori Q9QYJ3.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    [Graphical view ]
    Pfami PF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 2 hits.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of murine Hsp40 gene: differences in initiation sites between heat-induced and constitutive transcripts."
      Hata M., Ohtsuka K.
      DNA Seq. 11:213-223(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: BALB/c.
      Tissue: Liver and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiDNJB1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3