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Q9QYJ3

- DNJB1_MOUSE

UniProt

Q9QYJ3 - DNJB1_MOUSE

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Protein

DnaJ homolog subfamily B member 1

Gene

Dnajb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP (By similarity).By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: Ensembl

GO - Biological processi

  1. chaperone cofactor-dependent protein refolding Source: Ensembl
  2. chaperone mediated protein folding requiring cofactor Source: MGI
  3. negative regulation of inclusion body assembly Source: Ensembl
  4. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_222185. Regulation of HSF1-mediated heat shock response.
REACT_223784. Attenuation phase.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 1
Alternative name(s):
Heat shock 40 kDa protein 1
Short name:
HSP40
Short name:
Heat shock protein 40
Gene namesi
Name:Dnajb1
Synonyms:Hsp40, Hspf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1931874. Dnajb1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Nucleusnucleolus By similarity
Note: Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 340339DnaJ homolog subfamily B member 1PRO_0000071017Add
BLAST

Proteomic databases

MaxQBiQ9QYJ3.
PaxDbiQ9QYJ3.
PRIDEiQ9QYJ3.

PTM databases

PhosphoSiteiQ9QYJ3.

Expressioni

Inductioni

By heat shock.By similarity

Gene expression databases

BgeeiQ9QYJ3.
CleanExiMM_DNAJB1.
ExpressionAtlasiQ9QYJ3. baseline and differential.
GenevestigatoriQ9QYJ3.

Interactioni

Subunit structurei

Interacts with DNAJC3. Interacts with SRPK1.By similarity

Protein-protein interaction databases

BioGridi219875. 2 interactions.
IntActiQ9QYJ3. 2 interactions.
MINTiMINT-4093206.
STRINGi10090.ENSMUSP00000005620.

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ3.
SMRiQ9QYJ3. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7069JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiQ9QYJ3.
KOiK09507.
OMAiNPFDNFF.
OrthoDBiEOG7TF79F.
PhylomeDBiQ9QYJ3.
TreeFamiTF105141.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE
60 70 80 90 100
AYDVLSDPRK REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA
110 120 130 140 150
MFAEFFGGRN PFDTFFGQRN GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR
160 170 180 190 200
PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE
210 220 230 240 250
DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD
260 270 280 290 300
GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE
310 320 330 340
GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI
Length:340
Mass (Da):38,167
Last modified:January 23, 2007 - v3
Checksum:iF775BFBA4A5D324E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028272 mRNA. Translation: BAA88083.1.
AB028273 Genomic DNA. Translation: BAA95672.1.
BC012962 mRNA. Translation: AAH12962.1.
CCDSiCCDS22456.1.
RefSeqiNP_061278.1. NM_018808.2.
UniGeneiMm.282092.

Genome annotation databases

EnsembliENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483.
GeneIDi81489.
KEGGimmu:81489.
UCSCiuc009mkp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028272 mRNA. Translation: BAA88083.1 .
AB028273 Genomic DNA. Translation: BAA95672.1 .
BC012962 mRNA. Translation: AAH12962.1 .
CCDSi CCDS22456.1.
RefSeqi NP_061278.1. NM_018808.2.
UniGenei Mm.282092.

3D structure databases

ProteinModelPortali Q9QYJ3.
SMRi Q9QYJ3. Positions 1-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219875. 2 interactions.
IntActi Q9QYJ3. 2 interactions.
MINTi MINT-4093206.
STRINGi 10090.ENSMUSP00000005620.

PTM databases

PhosphoSitei Q9QYJ3.

Proteomic databases

MaxQBi Q9QYJ3.
PaxDbi Q9QYJ3.
PRIDEi Q9QYJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005620 ; ENSMUSP00000005620 ; ENSMUSG00000005483 .
GeneIDi 81489.
KEGGi mmu:81489.
UCSCi uc009mkp.2. mouse.

Organism-specific databases

CTDi 3337.
MGIi MGI:1931874. Dnajb1.

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00760000118947.
HOGENOMi HOG000226718.
HOVERGENi HBG066727.
InParanoidi Q9QYJ3.
KOi K09507.
OMAi NPFDNFF.
OrthoDBi EOG7TF79F.
PhylomeDBi Q9QYJ3.
TreeFami TF105141.

Enzyme and pathway databases

Reactomei REACT_213550. HSF1-dependent transactivation.
REACT_222185. Regulation of HSF1-mediated heat shock response.
REACT_223784. Attenuation phase.

Miscellaneous databases

ChiTaRSi DNAJB1. mouse.
NextBioi 350390.
PROi Q9QYJ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYJ3.
CleanExi MM_DNAJB1.
ExpressionAtlasi Q9QYJ3. baseline and differential.
Genevestigatori Q9QYJ3.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view ]
Pfami PF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine Hsp40 gene: differences in initiation sites between heat-induced and constitutive transcripts."
    Hata M., Ohtsuka K.
    DNA Seq. 11:213-223(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/c.
    Tissue: Liver and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiDNJB1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3