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Protein

DnaJ homolog subfamily B member 1

Gene

Dnajb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP (By similarity).By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: MGI
  2. ATPase binding Source: MGI
  3. chaperone binding Source: MGI
  4. Hsp70 protein binding Source: MGI
  5. unfolded protein binding Source: MGI

GO - Biological processi

  1. chaperone cofactor-dependent protein refolding Source: MGI
  2. chaperone mediated protein folding requiring cofactor Source: MGI
  3. negative regulation of inclusion body assembly Source: MGI
  4. positive regulation of ATPase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_222185. Regulation of HSF1-mediated heat shock response.
REACT_223784. Attenuation phase.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 1
Alternative name(s):
Heat shock 40 kDa protein 1
Short name:
HSP40
Short name:
Heat shock protein 40
Gene namesi
Name:Dnajb1
Synonyms:Hsp40, Hspf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1931874. Dnajb1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Nucleusnucleolus By similarity
Note: Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.By similarity

GO - Cellular componenti

  1. cytosol Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. nucleolus Source: UniProtKB-SubCell
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 340339DnaJ homolog subfamily B member 1PRO_0000071017Add
BLAST

Proteomic databases

MaxQBiQ9QYJ3.
PaxDbiQ9QYJ3.
PRIDEiQ9QYJ3.

PTM databases

PhosphoSiteiQ9QYJ3.

Expressioni

Inductioni

By heat shock.By similarity

Gene expression databases

BgeeiQ9QYJ3.
CleanExiMM_DNAJB1.
ExpressionAtlasiQ9QYJ3. baseline and differential.
GenevestigatoriQ9QYJ3.

Interactioni

Subunit structurei

Interacts with DNAJC3. Interacts with SRPK1.By similarity

Protein-protein interaction databases

BioGridi219875. 2 interactions.
IntActiQ9QYJ3. 2 interactions.
MINTiMINT-4093206.
STRINGi10090.ENSMUSP00000005620.

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ3.
SMRiQ9QYJ3. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7069JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiQ9QYJ3.
KOiK09507.
OMAiPERIPVS.
OrthoDBiEOG7TF79F.
PhylomeDBiQ9QYJ3.
TreeFamiTF105141.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE
60 70 80 90 100
AYDVLSDPRK REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA
110 120 130 140 150
MFAEFFGGRN PFDTFFGQRN GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR
160 170 180 190 200
PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE
210 220 230 240 250
DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD
260 270 280 290 300
GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE
310 320 330 340
GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI
Length:340
Mass (Da):38,167
Last modified:January 23, 2007 - v3
Checksum:iF775BFBA4A5D324E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028272 mRNA. Translation: BAA88083.1.
AB028273 Genomic DNA. Translation: BAA95672.1.
BC012962 mRNA. Translation: AAH12962.1.
CCDSiCCDS22456.1.
RefSeqiNP_061278.1. NM_018808.2.
UniGeneiMm.282092.

Genome annotation databases

EnsembliENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483.
GeneIDi81489.
KEGGimmu:81489.
UCSCiuc009mkp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028272 mRNA. Translation: BAA88083.1.
AB028273 Genomic DNA. Translation: BAA95672.1.
BC012962 mRNA. Translation: AAH12962.1.
CCDSiCCDS22456.1.
RefSeqiNP_061278.1. NM_018808.2.
UniGeneiMm.282092.

3D structure databases

ProteinModelPortaliQ9QYJ3.
SMRiQ9QYJ3. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219875. 2 interactions.
IntActiQ9QYJ3. 2 interactions.
MINTiMINT-4093206.
STRINGi10090.ENSMUSP00000005620.

PTM databases

PhosphoSiteiQ9QYJ3.

Proteomic databases

MaxQBiQ9QYJ3.
PaxDbiQ9QYJ3.
PRIDEiQ9QYJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483.
GeneIDi81489.
KEGGimmu:81489.
UCSCiuc009mkp.2. mouse.

Organism-specific databases

CTDi3337.
MGIiMGI:1931874. Dnajb1.

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiQ9QYJ3.
KOiK09507.
OMAiPERIPVS.
OrthoDBiEOG7TF79F.
PhylomeDBiQ9QYJ3.
TreeFamiTF105141.

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_222185. Regulation of HSF1-mediated heat shock response.
REACT_223784. Attenuation phase.

Miscellaneous databases

ChiTaRSiDnajb1. mouse.
NextBioi350390.
PROiQ9QYJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYJ3.
CleanExiMM_DNAJB1.
ExpressionAtlasiQ9QYJ3. baseline and differential.
GenevestigatoriQ9QYJ3.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine Hsp40 gene: differences in initiation sites between heat-induced and constitutive transcripts."
    Hata M., Ohtsuka K.
    DNA Seq. 11:213-223(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/c.
    Tissue: Liver and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiDNJB1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.