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Protein

DnaJ homolog subfamily B member 8

Gene

Dnajb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 8
Alternative name(s):
mDj6
Gene namesi
Name:Dnajb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1922801. Dnajb8.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710301 – 227DnaJ homolog subfamily B member 8Add BLAST227

Proteomic databases

PaxDbiQ9QYI7.
PRIDEiQ9QYI7.

PTM databases

iPTMnetiQ9QYI7.
PhosphoSitePlusiQ9QYI7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048206.
CleanExiMM_DNAJB8.
ExpressionAtlasiQ9QYI7. baseline and differential.
GenevisibleiQ9QYI7. MM.

Interactioni

Subunit structurei

Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056592.

Structurei

3D structure databases

ProteinModelPortaliQ9QYI7.
SMRiQ9QYI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 69JPROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 181Ser-richAdd BLAST35

Domaini

The antiaggregation activity resides in the serine-rich region and the C-terminus.By similarity

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiQ9QYI7.
KOiK09514.
OMAiANYYEVL.
OrthoDBiEOG091G152F.
PhylomeDBiQ9QYI7.
TreeFamiTF105142.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYYEVLGV QSSASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKQVS
60 70 80 90 100
EAYEVLSDSK KRSVYDRAGC DRWRAGGGAN VPHSSPFGAG YPFRNPEDIF
110 120 130 140 150
REFFGGLDPF SFEFWDTPFS GRGRPHGLHR VFPSGFGEFP AFMEALSSFN
160 170 180 190 200
TLGHGGGSRS TFSSASFGGS GSSGFKSVMS STEMVNGRKV TTKRIIENGQ
210 220
ERVEVEEDGQ LRSVTVNGKE KLMRVDK
Length:227
Mass (Da):25,230
Last modified:May 1, 2000 - v1
Checksum:i7A6E4CB7989FC095
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028856 mRNA. Translation: BAA88304.1.
AK006026 mRNA. Translation: BAB24372.1.
BC049591 mRNA. Translation: AAH49591.1.
BC061112 mRNA. Translation: AAH61112.1.
CCDSiCCDS20334.1.
RefSeqiNP_064348.1. NM_019964.1.
UniGeneiMm.272871.

Genome annotation databases

EnsembliENSMUST00000061866; ENSMUSP00000056592; ENSMUSG00000048206.
GeneIDi56691.
KEGGimmu:56691.
UCSCiuc009cve.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDNJB8_MOUSE
AccessioniPrimary (citable) accession number: Q9QYI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot