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Protein

DnaJ homolog subfamily B member 9

Gene

Dnajb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 9
Alternative name(s):
Endoplasmic reticulum DNA J domain-containing protein 4
Short name:
ER-resident protein ERdj4
Short name:
ERdj4
mDj7
Gene namesi
Name:Dnajb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1351618. Dnajb9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000007103224 – 222DnaJ homolog subfamily B member 9Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QYI6.
PaxDbiQ9QYI6.
PeptideAtlasiQ9QYI6.
PRIDEiQ9QYI6.

PTM databases

iPTMnetiQ9QYI6.
PhosphoSitePlusiQ9QYI6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014905.
CleanExiMM_DNAJB9.
GenevisibleiQ9QYI6. MM.

Interactioni

Subunit structurei

Interacts with DERL1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015049.

Structurei

3D structure databases

ProteinModelPortaliQ9QYI6.
SMRiQ9QYI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 90JPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290187.
HOVERGENiHBG051372.
InParanoidiQ9QYI6.
KOiK09515.
OMAiTTNRHTV.
OrthoDBiEOG091G15JG.
TreeFamiTF105143.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR036869. DnaJ_dom_sf.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPQSVFVF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA
60 70 80 90 100
MKYHPDKNKS PDAEAKFREI AEAYETLSDA NSRKEYDTIG HSAFTNGKGQ
110 120 130 140 150
RGNGSPFEQS FNFNFDDLFK DFNFFGQNQN TRSKKHFENH FHTRQDGSSR
160 170 180 190 200
QRHHFQEFSF GGGLFDDMFE DMEKMFSFSG FDTTNRHTVQ TENRFHGSSK
210 220
HCRTVTQRRG NMVTTYTDCS GQ
Length:222
Mass (Da):25,616
Last modified:October 3, 2012 - v2
Checksum:i4A737D704E760069
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133S → F in BAA88305 (PubMed:11147971).Curated1
Sequence conflicti148S → F in BAA88305 (PubMed:11147971).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028857 mRNA. Translation: BAA88305.1.
AK005475 mRNA. Translation: BAB24065.1.
CT010304 mRNA. Translation: CAJ18512.1.
CT010444 Genomic DNA. No translation available.
BC042713 mRNA. Translation: AAH42713.1.
BC096676 mRNA. Translation: AAH96676.1.
CCDSiCCDS25897.1.
RefSeqiNP_038788.2. NM_013760.4.
UniGeneiMm.27432.

Genome annotation databases

EnsembliENSMUST00000015049; ENSMUSP00000015049; ENSMUSG00000014905.
GeneIDi27362.
KEGGimmu:27362.
UCSCiuc007nlo.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDNJB9_MOUSE
AccessioniPrimary (citable) accession number: Q9QYI6
Secondary accession number(s): Q5D0C3, Q9DAW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 3, 2012
Last modified: October 25, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot