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Q9QYI6

- DNJB9_MOUSE

UniProt

Q9QYI6 - DNJB9_MOUSE

Protein

DnaJ homolog subfamily B member 9

Gene

Dnajb9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily B member 9
    Alternative name(s):
    Endoplasmic reticulum DNA J domain-containing protein 4
    Short name:
    ER-resident protein ERdj4
    Short name:
    ERdj4
    mDj7
    Gene namesi
    Name:Dnajb9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1351618. Dnajb9.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 222199DnaJ homolog subfamily B member 9PRO_0000071032Add
    BLAST

    Proteomic databases

    PaxDbiQ9QYI6.
    PRIDEiQ9QYI6.

    PTM databases

    PhosphoSiteiQ9QYI6.

    Expressioni

    Gene expression databases

    CleanExiMM_DNAJB9.
    GenevestigatoriQ9QYI6.

    Interactioni

    Subunit structurei

    Interacts with DERL1.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000015049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYI6.
    SMRiQ9QYI6. Positions 23-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 9065JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0484.
    GeneTreeiENSGT00730000110396.
    HOGENOMiHOG000290187.
    HOVERGENiHBG051372.
    InParanoidiQ9QYI6.
    KOiK09515.
    OMAiATPQSIF.
    OrthoDBiEOG71CFND.
    TreeFamiTF105143.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPQSVFVF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA    50
    MKYHPDKNKS PDAEAKFREI AEAYETLSDA NSRKEYDTIG HSAFTNGKGQ 100
    RGNGSPFEQS FNFNFDDLFK DFNFFGQNQN TRSKKHFENH FHTRQDGSSR 150
    QRHHFQEFSF GGGLFDDMFE DMEKMFSFSG FDTTNRHTVQ TENRFHGSSK 200
    HCRTVTQRRG NMVTTYTDCS GQ 222
    Length:222
    Mass (Da):25,616
    Last modified:October 3, 2012 - v2
    Checksum:i4A737D704E760069
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331S → F in BAA88305. (PubMed:11147971)Curated
    Sequence conflicti148 – 1481S → F in BAA88305. (PubMed:11147971)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028857 mRNA. Translation: BAA88305.1.
    AK005475 mRNA. Translation: BAB24065.1.
    CT010304 mRNA. Translation: CAJ18512.1.
    CT010444 Genomic DNA. No translation available.
    BC042713 mRNA. Translation: AAH42713.1.
    BC096676 mRNA. Translation: AAH96676.1.
    CCDSiCCDS25897.1.
    RefSeqiNP_038788.2. NM_013760.4.
    UniGeneiMm.27432.

    Genome annotation databases

    EnsembliENSMUST00000015049; ENSMUSP00000015049; ENSMUSG00000014905.
    GeneIDi27362.
    KEGGimmu:27362.
    UCSCiuc007nlo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028857 mRNA. Translation: BAA88305.1 .
    AK005475 mRNA. Translation: BAB24065.1 .
    CT010304 mRNA. Translation: CAJ18512.1 .
    CT010444 Genomic DNA. No translation available.
    BC042713 mRNA. Translation: AAH42713.1 .
    BC096676 mRNA. Translation: AAH96676.1 .
    CCDSi CCDS25897.1.
    RefSeqi NP_038788.2. NM_013760.4.
    UniGenei Mm.27432.

    3D structure databases

    ProteinModelPortali Q9QYI6.
    SMRi Q9QYI6. Positions 23-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000015049.

    PTM databases

    PhosphoSitei Q9QYI6.

    Proteomic databases

    PaxDbi Q9QYI6.
    PRIDEi Q9QYI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015049 ; ENSMUSP00000015049 ; ENSMUSG00000014905 .
    GeneIDi 27362.
    KEGGi mmu:27362.
    UCSCi uc007nlo.1. mouse.

    Organism-specific databases

    CTDi 4189.
    MGIi MGI:1351618. Dnajb9.

    Phylogenomic databases

    eggNOGi COG0484.
    GeneTreei ENSGT00730000110396.
    HOGENOMi HOG000290187.
    HOVERGENi HBG051372.
    InParanoidi Q9QYI6.
    KOi K09515.
    OMAi ATPQSIF.
    OrthoDBi EOG71CFND.
    TreeFami TF105143.

    Enzyme and pathway databases

    Reactomei REACT_106572. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 305240.
    PROi Q9QYI6.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DNAJB9.
    Genevestigatori Q9QYI6.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature."
      Ohtsuka K., Hata M.
      Cell Stress Chaperones 5:98-112(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Placenta.
    3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary gland and Mammary tumor.
    6. "ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery."
      Lai C.W., Otero J.H., Hendershot L.M., Snapp E.
      J. Biol. Chem. 287:7969-7978(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DERL1.

    Entry informationi

    Entry nameiDNJB9_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYI6
    Secondary accession number(s): Q5D0C3, Q9DAW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3