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Protein

DnaJ homolog subfamily B member 2

Gene

Dnajb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 2
Alternative name(s):
DnaJ homolog subfamily B member 10
mDj8
Gene namesi
Name:Dnajb2
Synonyms:Dnajb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1928739. Dnajb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000710352 – 277DnaJ homolog subfamily B member 2Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9QYI5.
PeptideAtlasiQ9QYI5.
PRIDEiQ9QYI5.

PTM databases

iPTMnetiQ9QYI5.
PhosphoSitePlusiQ9QYI5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026203.
ExpressionAtlasiQ9QYI5. baseline and differential.
GenevisibleiQ9QYI5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080796.

Structurei

3D structure databases

ProteinModelPortaliQ9QYI5.
SMRiQ9QYI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 69JPROSITE-ProRule annotationAdd BLAST67
Domaini207 – 226UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini250 – 269UIM 2PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 158Poly-Ser8

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiQ9QYI5.
KOiK09508.
TreeFamiTF105142.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR003903. UIM_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00726. UIM. 2 hits.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QYI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASYYEILDV PRSASPDDIK KAYRKKALQW HPDKNPDNKE FAEKKFKEVA
60 70 80 90 100
EAYEVLSDKH KREIYDRYGR EGLTGAGSGP SRSETGGAGP GFTFTFRSPE
110 120 130 140 150
EVFREFFGSG DPFSELFDDL GVFSELQNQG PRLTGPFFTF SSSFPANSDF
160 170 180 190 200
SSSSFSFSPG AGAFRSVSTS TTFVQGRRIT TRRIMENGQE RVEVEEDGQL
210 220 230 240 250
KSVSINGVPD DLALGLELSR REQQPSVAPG LGVMQVRPTS LSRPPDHDLS
260 270
EDEDLQLAMA YSLSEMEAAG QKPADVF
Length:277
Mass (Da):30,615
Last modified:February 26, 2008 - v2
Checksum:i989193A574FA1AD2
GO
Isoform 2 (identifier: Q9QYI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-77: KHKREIYDRYGREGLTGAG → R

Show »
Length:259
Mass (Da):28,583
Checksum:i0DD1670B36FD6108
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15S → F in AAH11090 (PubMed:15489334).Curated1
Sequence conflicti102V → F in BAA88306 (PubMed:11147971).Curated1
Sequence conflicti111D → N in BAA88306 (PubMed:11147971).Curated1
Sequence conflicti183R → K in BAA88306 (PubMed:11147971).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03165059 – 77KHKRE…LTGAG → R in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028858 mRNA. Translation: BAA88306.1.
AK076061 mRNA. Translation: BAC36155.1.
BC011090 mRNA. Translation: AAH11090.1.
CCDSiCCDS15068.1. [Q9QYI5-2]
CCDS35624.1. [Q9QYI5-1]
RefSeqiNP_001153356.1. NM_001159884.1. [Q9QYI5-1]
NP_001153357.1. NM_001159885.1. [Q9QYI5-1]
NP_064662.2. NM_020266.2. [Q9QYI5-2]
NP_835156.1. NM_178055.4. [Q9QYI5-1]
UniGeneiMm.489660.

Genome annotation databases

EnsembliENSMUST00000055223; ENSMUSP00000052520; ENSMUSG00000026203. [Q9QYI5-2]
ENSMUST00000082158; ENSMUSP00000080796; ENSMUSG00000026203. [Q9QYI5-1]
ENSMUST00000187058; ENSMUSP00000140637; ENSMUSG00000026203. [Q9QYI5-2]
ENSMUST00000188290; ENSMUSP00000140634; ENSMUSG00000026203. [Q9QYI5-1]
ENSMUST00000188346; ENSMUSP00000140588; ENSMUSG00000026203. [Q9QYI5-1]
GeneIDi56812.
KEGGimmu:56812.
UCSCiuc007bom.2. mouse. [Q9QYI5-1]
uc007bop.2. mouse. [Q9QYI5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028858 mRNA. Translation: BAA88306.1.
AK076061 mRNA. Translation: BAC36155.1.
BC011090 mRNA. Translation: AAH11090.1.
CCDSiCCDS15068.1. [Q9QYI5-2]
CCDS35624.1. [Q9QYI5-1]
RefSeqiNP_001153356.1. NM_001159884.1. [Q9QYI5-1]
NP_001153357.1. NM_001159885.1. [Q9QYI5-1]
NP_064662.2. NM_020266.2. [Q9QYI5-2]
NP_835156.1. NM_178055.4. [Q9QYI5-1]
UniGeneiMm.489660.

3D structure databases

ProteinModelPortaliQ9QYI5.
SMRiQ9QYI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080796.

PTM databases

iPTMnetiQ9QYI5.
PhosphoSitePlusiQ9QYI5.

Proteomic databases

PaxDbiQ9QYI5.
PeptideAtlasiQ9QYI5.
PRIDEiQ9QYI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055223; ENSMUSP00000052520; ENSMUSG00000026203. [Q9QYI5-2]
ENSMUST00000082158; ENSMUSP00000080796; ENSMUSG00000026203. [Q9QYI5-1]
ENSMUST00000187058; ENSMUSP00000140637; ENSMUSG00000026203. [Q9QYI5-2]
ENSMUST00000188290; ENSMUSP00000140634; ENSMUSG00000026203. [Q9QYI5-1]
ENSMUST00000188346; ENSMUSP00000140588; ENSMUSG00000026203. [Q9QYI5-1]
GeneIDi56812.
KEGGimmu:56812.
UCSCiuc007bom.2. mouse. [Q9QYI5-1]
uc007bop.2. mouse. [Q9QYI5-2]

Organism-specific databases

CTDi3300.
MGIiMGI:1928739. Dnajb2.

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiQ9QYI5.
KOiK09508.
TreeFamiTF105142.

Miscellaneous databases

ChiTaRSiDnajb2. mouse.
PROiQ9QYI5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026203.
ExpressionAtlasiQ9QYI5. baseline and differential.
GenevisibleiQ9QYI5. MM.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR003903. UIM_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00726. UIM. 2 hits.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJB2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYI5
Secondary accession number(s): Q8BPF6, Q921S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.