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Protein

DnaJ homolog subfamily B member 12

Gene

Dnajb12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 12
Alternative name(s):
mDj10
Gene namesi
Name:Dnajb12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1931881. Dnajb12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376DnaJ homolog subfamily B member 12PRO_0000071038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QYI4.
MaxQBiQ9QYI4.
PaxDbiQ9QYI4.
PRIDEiQ9QYI4.

PTM databases

iPTMnetiQ9QYI4.
PhosphoSiteiQ9QYI4.

Expressioni

Gene expression databases

BgeeiQ9QYI4.
CleanExiMM_DNAJB12.
ExpressionAtlasiQ9QYI4. baseline and differential.
GenevisibleiQ9QYI4. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9QYI4. 1 interaction.
STRINGi10090.ENSMUSP00000020309.

Structurei

3D structure databases

ProteinModelPortaliQ9QYI4.
SMRiQ9QYI4. Positions 110-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 17565JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000233608.
HOVERGENiHBG051373.
InParanoidiQ9QYI4.
KOiK09518.
PhylomeDBiQ9QYI4.
TreeFamiTF105145.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR015399. DUF1977_DnaJ-like.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF09320. DUF1977. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNKDEAER CISIALKAIQ SNQPERALRF LEKAQRLYPT PRVSALIESL
60 70 80 90 100
NQKPQSTGDH PQPTDTTHTT TKKAGGTETP SANGEAGGGE SAKGYTSEQV
110 120 130 140 150
AAVKRVKQCK DYYEILGVSR SASDEDLKKA YRKLALKFHP DKNHAPGATE
160 170 180 190 200
AFKAIGTAYA VLSNPEKRKQ YDQFGDDKSQ AARHGHSHGD FHRGFEADIS
210 220 230 240 250
PEDLFNMFFG GGFPSSNVHV YSNGRMRYTY QQRQDRRDNQ GDGGLGVFVQ
260 270 280 290 300
LMPILILILV SALSQLMVSS PPYSLSPRPS VGHIHKRVTD HLNVAYYVAD
310 320 330 340 350
TFSEEYTGSS LKTVERNVED DYIANLRNNC WKEKQQKEGL LYRARYFGDT
360 370
DMYHRAQKMG TPSCNRLSEV QASLHG
Length:376
Mass (Da):41,988
Last modified:July 27, 2011 - v2
Checksum:i33560A17E4B14235
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti321 – 3211D → E in BAA88308 (PubMed:11147971).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028860 mRNA. Translation: BAA88308.1.
AK138495 mRNA. Translation: BAE23683.1.
AK166224 mRNA. Translation: BAE38642.1.
AK172274 mRNA. Translation: BAE42919.1.
CH466553 Genomic DNA. Translation: EDL32192.1.
CH466553 Genomic DNA. Translation: EDL32193.1.
CH466553 Genomic DNA. Translation: EDL32195.1.
BC034162 mRNA. Translation: AAH34162.1.
CCDSiCCDS23867.1.
RefSeqiNP_064349.2. NM_019965.2.
XP_006513967.1. XM_006513904.2.
UniGeneiMm.103610.
Mm.443586.

Genome annotation databases

EnsembliENSMUST00000020309; ENSMUSP00000020309; ENSMUSG00000020109.
ENSMUST00000142819; ENSMUSP00000118088; ENSMUSG00000020109.
ENSMUST00000146590; ENSMUSP00000122056; ENSMUSG00000020109.
GeneIDi56709.
KEGGimmu:56709.
UCSCiuc007fdz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028860 mRNA. Translation: BAA88308.1.
AK138495 mRNA. Translation: BAE23683.1.
AK166224 mRNA. Translation: BAE38642.1.
AK172274 mRNA. Translation: BAE42919.1.
CH466553 Genomic DNA. Translation: EDL32192.1.
CH466553 Genomic DNA. Translation: EDL32193.1.
CH466553 Genomic DNA. Translation: EDL32195.1.
BC034162 mRNA. Translation: AAH34162.1.
CCDSiCCDS23867.1.
RefSeqiNP_064349.2. NM_019965.2.
XP_006513967.1. XM_006513904.2.
UniGeneiMm.103610.
Mm.443586.

3D structure databases

ProteinModelPortaliQ9QYI4.
SMRiQ9QYI4. Positions 110-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QYI4. 1 interaction.
STRINGi10090.ENSMUSP00000020309.

PTM databases

iPTMnetiQ9QYI4.
PhosphoSiteiQ9QYI4.

Proteomic databases

EPDiQ9QYI4.
MaxQBiQ9QYI4.
PaxDbiQ9QYI4.
PRIDEiQ9QYI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020309; ENSMUSP00000020309; ENSMUSG00000020109.
ENSMUST00000142819; ENSMUSP00000118088; ENSMUSG00000020109.
ENSMUST00000146590; ENSMUSP00000122056; ENSMUSG00000020109.
GeneIDi56709.
KEGGimmu:56709.
UCSCiuc007fdz.1. mouse.

Organism-specific databases

CTDi54788.
MGIiMGI:1931881. Dnajb12.

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000233608.
HOVERGENiHBG051373.
InParanoidiQ9QYI4.
KOiK09518.
PhylomeDBiQ9QYI4.
TreeFamiTF105145.

Miscellaneous databases

ChiTaRSiDnajb12. mouse.
PROiQ9QYI4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYI4.
CleanExiMM_DNAJB12.
ExpressionAtlasiQ9QYI4. baseline and differential.
GenevisibleiQ9QYI4. MM.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR015399. DUF1977_DnaJ-like.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF09320. DUF1977. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature."
    Ohtsuka K., Hata M.
    Cell Stress Chaperones 5:98-112(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Mammary gland, Spinal cord and Spleen.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver and Pancreas.

Entry informationi

Entry nameiDJB12_MOUSE
AccessioniPrimary (citable) accession number: Q9QYI4
Secondary accession number(s): Q8K037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.