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Q9QYI3

- DNJC7_MOUSE

UniProt

Q9QYI3 - DNJC7_MOUSE

Protein

DnaJ homolog subfamily C member 7

Gene

Dnajc7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes By similarity. Recruits NR1I3 to the cytoplasm.By similarity

    GO - Biological processi

    1. chaperone cofactor-dependent protein refolding Source: Ensembl

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily C member 7
    Alternative name(s):
    Cytoplasmic CAR retention protein
    Short name:
    CCRP
    MDj11
    Tetratricopeptide repeat protein 2
    Short name:
    TPR repeat protein 2
    Gene namesi
    Name:Dnajc7
    Synonyms:Ttc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1928373. Dnajc7.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus By similarity. Cytoplasmcytoskeleton By similarity
    Note: Colocalizes with NR1I3 at microtubules.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. cytoskeleton Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 494493DnaJ homolog subfamily C member 7PRO_0000071059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9QYI3.
    PaxDbiQ9QYI3.
    PRIDEiQ9QYI3.

    2D gel databases

    REPRODUCTION-2DPAGEQ9QYI3.

    PTM databases

    PhosphoSiteiQ9QYI3.

    Expressioni

    Tissue specificityi

    Widely expressed with high levels in liver, skeletal muscle, kidney and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9QYI3.
    BgeeiQ9QYI3.
    CleanExiMM_DNAJC7.
    GenevestigatoriQ9QYI3.

    Interactioni

    Subunit structurei

    Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1 By similarity. Interacts with NR1I3; this complex may also include HSP90 Interacts with HSPA8 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi207919. 3 interactions.
    STRINGi10090.ENSMUSP00000014339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYI3.
    SMRiQ9QYI3. Positions 22-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 6134TPR 1Add
    BLAST
    Repeati62 – 9534TPR 2Add
    BLAST
    Repeati96 – 12934TPR 3Add
    BLAST
    Repeati142 – 17534TPR 4Add
    BLAST
    Repeati210 – 24334TPR 5Add
    BLAST
    Repeati256 – 28934TPR 6Add
    BLAST
    Repeati294 – 32734TPR 7Add
    BLAST
    Repeati328 – 36134TPR 8Add
    BLAST
    Domaini381 – 45171JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation
    Contains 8 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0484.
    GeneTreeiENSGT00720000108760.
    HOVERGENiHBG051376.
    InParanoidiQ6VVW6.
    KOiK09527.
    OMAiCFQRVLE.
    OrthoDBiEOG7KDF9K.
    PhylomeDBiQ9QYI3.
    TreeFamiTF105166.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    1.25.40.10. 3 hits.
    InterProiIPR001623. DnaJ_domain.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    PF00515. TPR_1. 2 hits.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    SM00028. TPR. 7 hits.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS50076. DNAJ_2. 1 hit.
    PS50005. TPR. 8 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYI3-1 [UniParc]FASTAAdd to Basket

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    MAATAECDVV MAATEPELLE DEDAKREAES FKEQGNAYYA KKDYNEAYNY    50
    YTKAIDMCPN NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL 100
    REGKCHLSLG NAMAACRSFQ RALELDHKNA QAQQEFKNAN AVMEYEKIAE 150
    VDFEKRDFRK VVFCMDRALE FAPACHRFKI LKAECLAMLG RYPEAQFVAS 200
    DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA PDHEKACVAC 250
    RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 300
    GTVNSKLRQL EDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQFEEAVRD 350
    YEKVYQTEKT KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA 400
    YRKRALMHHP DRHSGASAEV QKEEEKKFKE VGEAFTILSD PKKKTRYDSG 450
    QDLDEEGMNM GDFDANNIFK AFFGGPGGFS FEASGPGNFY FQFG 494
    Length:494
    Mass (Da):56,476
    Last modified:April 13, 2004 - v2
    Checksum:i8D82EBFA19C556B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 872QQ → HE in BAB27893. (PubMed:16141072)Curated
    Sequence conflicti118 – 1181S → I in BAA88309. (PubMed:11147971)Curated
    Sequence conflicti136 – 1361F → L in AAQ91291. (PubMed:14573755)Curated
    Sequence conflicti192 – 1921Y → F in BAC36133. (PubMed:16141072)Curated
    Sequence conflicti285 – 2851I → V in BAB27893. (PubMed:16141072)Curated
    Sequence conflicti489 – 4891F → L in BAA88309. (PubMed:11147971)Curated
    Sequence conflicti489 – 4891F → L in AAQ91291. (PubMed:14573755)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028861 mRNA. Translation: BAA88309.1.
    AK011384 mRNA. Translation: BAB27584.1.
    AK011875 mRNA. Translation: BAB27893.1.
    AK076032 mRNA. Translation: BAC36133.1.
    AK145506 mRNA. Translation: BAE26476.1.
    AK166872 mRNA. Translation: BAE39083.1.
    AY323828 mRNA. Translation: AAQ91291.1.
    BC023681 mRNA. Translation: AAH23681.1.
    BC055729 mRNA. Translation: AAH55729.1.
    CCDSiCCDS25428.1.
    RefSeqiNP_062769.2. NM_019795.4.
    UniGeneiMm.402409.

    Genome annotation databases

    EnsembliENSMUST00000014339; ENSMUSP00000014339; ENSMUSG00000014195.
    GeneIDi56354.
    KEGGimmu:56354.
    UCSCiuc007lls.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028861 mRNA. Translation: BAA88309.1 .
    AK011384 mRNA. Translation: BAB27584.1 .
    AK011875 mRNA. Translation: BAB27893.1 .
    AK076032 mRNA. Translation: BAC36133.1 .
    AK145506 mRNA. Translation: BAE26476.1 .
    AK166872 mRNA. Translation: BAE39083.1 .
    AY323828 mRNA. Translation: AAQ91291.1 .
    BC023681 mRNA. Translation: AAH23681.1 .
    BC055729 mRNA. Translation: AAH55729.1 .
    CCDSi CCDS25428.1.
    RefSeqi NP_062769.2. NM_019795.4.
    UniGenei Mm.402409.

    3D structure databases

    ProteinModelPortali Q9QYI3.
    SMRi Q9QYI3. Positions 22-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207919. 3 interactions.
    STRINGi 10090.ENSMUSP00000014339.

    PTM databases

    PhosphoSitei Q9QYI3.

    2D gel databases

    REPRODUCTION-2DPAGE Q9QYI3.

    Proteomic databases

    MaxQBi Q9QYI3.
    PaxDbi Q9QYI3.
    PRIDEi Q9QYI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014339 ; ENSMUSP00000014339 ; ENSMUSG00000014195 .
    GeneIDi 56354.
    KEGGi mmu:56354.
    UCSCi uc007lls.1. mouse.

    Organism-specific databases

    CTDi 7266.
    MGIi MGI:1928373. Dnajc7.

    Phylogenomic databases

    eggNOGi COG0484.
    GeneTreei ENSGT00720000108760.
    HOVERGENi HBG051376.
    InParanoidi Q6VVW6.
    KOi K09527.
    OMAi CFQRVLE.
    OrthoDBi EOG7KDF9K.
    PhylomeDBi Q9QYI3.
    TreeFami TF105166.

    Miscellaneous databases

    ChiTaRSi DNAJC7. mouse.
    NextBioi 312362.
    PROi Q9QYI3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYI3.
    Bgeei Q9QYI3.
    CleanExi MM_DNAJC7.
    Genevestigatori Q9QYI3.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    1.25.40.10. 3 hits.
    InterProi IPR001623. DnaJ_domain.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    PF00515. TPR_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    SM00028. TPR. 7 hits.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS50076. DNAJ_2. 1 hit.
    PS50005. TPR. 8 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature."
      Ohtsuka K., Hata M.
      Cell Stress Chaperones 5:98-112(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells."
      Kobayashi K., Sueyoshi T., Inoue K., Moore R., Negishi M.
      Mol. Pharmacol. 64:1069-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NR1I3 AND HSP90, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain.

    Entry informationi

    Entry nameiDNJC7_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYI3
    Secondary accession number(s): Q3TKR1
    , Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3