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Q9QYI3

- DNJC7_MOUSE

UniProt

Q9QYI3 - DNJC7_MOUSE

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Protein
DnaJ homolog subfamily C member 7
Gene
Dnajc7, Ttc2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes By similarity. Recruits NR1I3 to the cytoplasm.

GO - Biological processi

  1. chaperone cofactor-dependent protein refolding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 7
Alternative name(s):
Cytoplasmic CAR retention protein
Short name:
CCRP
MDj11
Tetratricopeptide repeat protein 2
Short name:
TPR repeat protein 2
Gene namesi
Name:Dnajc7
Synonyms:Ttc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1928373. Dnajc7.

Subcellular locationi

Cytoplasm. Nucleus By similarity. Cytoplasmcytoskeleton By similarity
Note: Colocalizes with NR1I3 at microtubules By similarity.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 494493DnaJ homolog subfamily C member 7
PRO_0000071059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QYI3.
PaxDbiQ9QYI3.
PRIDEiQ9QYI3.

2D gel databases

REPRODUCTION-2DPAGEQ9QYI3.

PTM databases

PhosphoSiteiQ9QYI3.

Expressioni

Tissue specificityi

Widely expressed with high levels in liver, skeletal muscle, kidney and testis.1 Publication

Gene expression databases

ArrayExpressiQ9QYI3.
BgeeiQ9QYI3.
CleanExiMM_DNAJC7.
GenevestigatoriQ9QYI3.

Interactioni

Subunit structurei

Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1 By similarity. Interacts with NR1I3; this complex may also include HSP90 Interacts with HSPA8 By similarity.1 Publication

Protein-protein interaction databases

BioGridi207919. 3 interactions.
STRINGi10090.ENSMUSP00000014339.

Structurei

3D structure databases

ProteinModelPortaliQ9QYI3.
SMRiQ9QYI3. Positions 22-476.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6134TPR 1
Add
BLAST
Repeati62 – 9534TPR 2
Add
BLAST
Repeati96 – 12934TPR 3
Add
BLAST
Repeati142 – 17534TPR 4
Add
BLAST
Repeati210 – 24334TPR 5
Add
BLAST
Repeati256 – 28934TPR 6
Add
BLAST
Repeati294 – 32734TPR 7
Add
BLAST
Repeati328 – 36134TPR 8
Add
BLAST
Domaini381 – 45171J
Add
BLAST

Sequence similaritiesi

Contains 1 J domain.
Contains 8 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00720000108760.
HOVERGENiHBG051376.
InParanoidiQ6VVW6.
KOiK09527.
OMAiCFQRVLE.
OrthoDBiEOG7KDF9K.
PhylomeDBiQ9QYI3.
TreeFamiTF105166.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
1.25.40.10. 3 hits.
InterProiIPR001623. DnaJ_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
PS50005. TPR. 8 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYI3-1 [UniParc]FASTAAdd to Basket

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MAATAECDVV MAATEPELLE DEDAKREAES FKEQGNAYYA KKDYNEAYNY    50
YTKAIDMCPN NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL 100
REGKCHLSLG NAMAACRSFQ RALELDHKNA QAQQEFKNAN AVMEYEKIAE 150
VDFEKRDFRK VVFCMDRALE FAPACHRFKI LKAECLAMLG RYPEAQFVAS 200
DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA PDHEKACVAC 250
RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 300
GTVNSKLRQL EDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQFEEAVRD 350
YEKVYQTEKT KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA 400
YRKRALMHHP DRHSGASAEV QKEEEKKFKE VGEAFTILSD PKKKTRYDSG 450
QDLDEEGMNM GDFDANNIFK AFFGGPGGFS FEASGPGNFY FQFG 494
Length:494
Mass (Da):56,476
Last modified:April 13, 2004 - v2
Checksum:i8D82EBFA19C556B9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 872QQ → HE in BAB27893. 1 Publication
Sequence conflicti118 – 1181S → I in BAA88309. 1 Publication
Sequence conflicti136 – 1361F → L in AAQ91291. 1 Publication
Sequence conflicti192 – 1921Y → F in BAC36133. 1 Publication
Sequence conflicti285 – 2851I → V in BAB27893. 1 Publication
Sequence conflicti489 – 4891F → L in BAA88309. 1 Publication
Sequence conflicti489 – 4891F → L in AAQ91291. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028861 mRNA. Translation: BAA88309.1.
AK011384 mRNA. Translation: BAB27584.1.
AK011875 mRNA. Translation: BAB27893.1.
AK076032 mRNA. Translation: BAC36133.1.
AK145506 mRNA. Translation: BAE26476.1.
AK166872 mRNA. Translation: BAE39083.1.
AY323828 mRNA. Translation: AAQ91291.1.
BC023681 mRNA. Translation: AAH23681.1.
BC055729 mRNA. Translation: AAH55729.1.
CCDSiCCDS25428.1.
RefSeqiNP_062769.2. NM_019795.4.
UniGeneiMm.402409.

Genome annotation databases

EnsembliENSMUST00000014339; ENSMUSP00000014339; ENSMUSG00000014195.
GeneIDi56354.
KEGGimmu:56354.
UCSCiuc007lls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028861 mRNA. Translation: BAA88309.1 .
AK011384 mRNA. Translation: BAB27584.1 .
AK011875 mRNA. Translation: BAB27893.1 .
AK076032 mRNA. Translation: BAC36133.1 .
AK145506 mRNA. Translation: BAE26476.1 .
AK166872 mRNA. Translation: BAE39083.1 .
AY323828 mRNA. Translation: AAQ91291.1 .
BC023681 mRNA. Translation: AAH23681.1 .
BC055729 mRNA. Translation: AAH55729.1 .
CCDSi CCDS25428.1.
RefSeqi NP_062769.2. NM_019795.4.
UniGenei Mm.402409.

3D structure databases

ProteinModelPortali Q9QYI3.
SMRi Q9QYI3. Positions 22-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207919. 3 interactions.
STRINGi 10090.ENSMUSP00000014339.

PTM databases

PhosphoSitei Q9QYI3.

2D gel databases

REPRODUCTION-2DPAGE Q9QYI3.

Proteomic databases

MaxQBi Q9QYI3.
PaxDbi Q9QYI3.
PRIDEi Q9QYI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014339 ; ENSMUSP00000014339 ; ENSMUSG00000014195 .
GeneIDi 56354.
KEGGi mmu:56354.
UCSCi uc007lls.1. mouse.

Organism-specific databases

CTDi 7266.
MGIi MGI:1928373. Dnajc7.

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00720000108760.
HOVERGENi HBG051376.
InParanoidi Q6VVW6.
KOi K09527.
OMAi CFQRVLE.
OrthoDBi EOG7KDF9K.
PhylomeDBi Q9QYI3.
TreeFami TF105166.

Miscellaneous databases

ChiTaRSi DNAJC7. mouse.
NextBioi 312362.
PROi Q9QYI3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QYI3.
Bgeei Q9QYI3.
CleanExi MM_DNAJC7.
Genevestigatori Q9QYI3.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
1.25.40.10. 3 hits.
InterProi IPR001623. DnaJ_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
SM00028. TPR. 7 hits.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
PS50005. TPR. 8 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature."
    Ohtsuka K., Hata M.
    Cell Stress Chaperones 5:98-112(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells."
    Kobayashi K., Sueyoshi T., Inoue K., Moore R., Negishi M.
    Mol. Pharmacol. 64:1069-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NR1I3 AND HSP90, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain.

Entry informationi

Entry nameiDNJC7_MOUSE
AccessioniPrimary (citable) accession number: Q9QYI3
Secondary accession number(s): Q3TKR1
, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi