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Q9QYH9 (TNF14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 14
Alternative name(s):
CD_antigen=CD258
Gene names
Name:Tnfsf14
Synonyms:Light
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.

Subunit structure

Homotrimer By similarity.

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted By similarity.

Post-translational modification

The soluble form derives from the membrane form by proteolytic processing.

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Tumor necrosis factor ligand superfamily member 14, membrane form
PRO_0000034534
Chain?82 – 239158Tumor necrosis factor ligand superfamily member 14, soluble form
PRO_0000034535

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain59 – 239181Extracellular Potential

Sites

Site81 – 822Cleavage Potential

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Disulfide bond152 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYH9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 217874AC71AD6BE3

FASTA23926,338
        10         20         30         40         50         60 
MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA TQGWFLLRLH 

        70         80         90        100        110        120 
QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN ASLIGIGGPL LWETRLGLAF 

       130        140        150        160        170        180 
LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV GCPQGLANGL PITHGLYKRT SRYPKELELL 

       190        200        210        220        230 
VSRRSPCGRA NSSRVWWDSS FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV 

« Hide

References

« Hide 'large scale' references
[1]"Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway."
Tamada K., Shimozaki K., Chapoval A.I., Zhu G., Sica G., Flies D., Boone T., Hsu H., Fu Y.-X., Nagata S., Ni J., Chen L.
Nat. Med. 6:283-289(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily."
Misawa K., Nosaka T., Kojima T., Hirai M., Kitamura T.
Cytogenet. Cell Genet. 89:89-91(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal liver.
[3]"Mouse LIGHT; molecular genetics, ligand binding and expression."
Force W.R., Todd P.K., Mikayama T.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphoma.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF123385 mRNA. Translation: AAF76453.1.
AB029155 mRNA. Translation: BAA88559.1.
AF227533 mRNA. Translation: AAF36722.1.
BC125477 mRNA. Translation: AAI25478.1.
BC125479 mRNA. Translation: AAI25480.1.
CCDSCCDS28928.1.
RefSeqNP_062291.1. NM_019418.3.
UniGeneMm.483369.

3D structure databases

ProteinModelPortalQ9QYH9.
SMRQ9QYH9. Positions 91-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206162. 1 interaction.

Proteomic databases

PRIDEQ9QYH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824.
GeneID50930.
KEGGmmu:50930.
UCSCuc008def.1. mouse.

Organism-specific databases

CTD8740.
MGIMGI:1355317. Tnfsf14.

Phylogenomic databases

eggNOGNOG40950.
GeneTreeENSGT00530000062992.
HOGENOMHOG000118072.
HOVERGENHBG061471.
InParanoidQ059Y9.
KOK05477.
OMAWRENSTE.
OrthoDBEOG7V4B0Q.
PhylomeDBQ9QYH9.
TreeFamTF332169.

Gene expression databases

BgeeQ9QYH9.
GenevestigatorQ9QYH9.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
PRINTSPR01234. TNECROSISFCT.
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307951.
PROQ9QYH9.
SOURCESearch...

Entry information

Entry nameTNF14_MOUSE
AccessionPrimary (citable) accession number: Q9QYH9
Secondary accession number(s): Q059Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot