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Q9QYH9

- TNF14_MOUSE

UniProt

Q9QYH9 - TNF14_MOUSE

Protein

Tumor necrosis factor ligand superfamily member 14

Gene

Tnfsf14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei81 – 822CleavageSequence Analysis

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    2. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to mechanical stimulus Source: Ensembl
    2. immune response Source: InterPro
    3. positive regulation of T cell chemotaxis Source: MGI
    4. release of cytoplasmic sequestered NF-kappaB Source: UniProtKB
    5. T cell costimulation Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 14
    Alternative name(s):
    CD_antigen: CD258
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Tnfsf14
    Synonyms:Light
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1355317. Tnfsf14.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Tumor necrosis factor ligand superfamily member 14, membrane formPRO_0000034534Add
    BLAST
    Chaini?82 – 239158Tumor necrosis factor ligand superfamily member 14, soluble formPRO_0000034535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 187By similarity
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9QYH9.

    Expressioni

    Gene expression databases

    BgeeiQ9QYH9.
    GenevestigatoriQ9QYH9.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    BioGridi206162. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYH9.
    SMRiQ9QYH9. Positions 91-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini59 – 239181ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40950.
    GeneTreeiENSGT00530000062992.
    HOGENOMiHOG000118072.
    HOVERGENiHBG061471.
    InParanoidiQ059Y9.
    KOiK05477.
    OMAiWRENSTE.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiQ9QYH9.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYH9-1 [UniParc]FASTAAdd to Basket

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    MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA    50
    TQGWFLLRLH QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN 100
    ASLIGIGGPL LWETRLGLAF LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV 150
    GCPQGLANGL PITHGLYKRT SRYPKELELL VSRRSPCGRA NSSRVWWDSS 200
    FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV 239
    Length:239
    Mass (Da):26,338
    Last modified:May 1, 2000 - v1
    Checksum:i217874AC71AD6BE3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123385 mRNA. Translation: AAF76453.1.
    AB029155 mRNA. Translation: BAA88559.1.
    AF227533 mRNA. Translation: AAF36722.1.
    BC125477 mRNA. Translation: AAI25478.1.
    BC125479 mRNA. Translation: AAI25480.1.
    CCDSiCCDS28928.1.
    RefSeqiNP_062291.1. NM_019418.3.
    UniGeneiMm.483369.

    Genome annotation databases

    EnsembliENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824.
    GeneIDi50930.
    KEGGimmu:50930.
    UCSCiuc008def.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123385 mRNA. Translation: AAF76453.1 .
    AB029155 mRNA. Translation: BAA88559.1 .
    AF227533 mRNA. Translation: AAF36722.1 .
    BC125477 mRNA. Translation: AAI25478.1 .
    BC125479 mRNA. Translation: AAI25480.1 .
    CCDSi CCDS28928.1.
    RefSeqi NP_062291.1. NM_019418.3.
    UniGenei Mm.483369.

    3D structure databases

    ProteinModelPortali Q9QYH9.
    SMRi Q9QYH9. Positions 91-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206162. 1 interaction.

    Proteomic databases

    PRIDEi Q9QYH9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005976 ; ENSMUSP00000005976 ; ENSMUSG00000005824 .
    GeneIDi 50930.
    KEGGi mmu:50930.
    UCSCi uc008def.1. mouse.

    Organism-specific databases

    CTDi 8740.
    MGIi MGI:1355317. Tnfsf14.

    Phylogenomic databases

    eggNOGi NOG40950.
    GeneTreei ENSGT00530000062992.
    HOGENOMi HOG000118072.
    HOVERGENi HBG061471.
    InParanoidi Q059Y9.
    KOi K05477.
    OMAi WRENSTE.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi Q9QYH9.
    TreeFami TF332169.

    Miscellaneous databases

    NextBioi 307951.
    PROi Q9QYH9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QYH9.
    Genevestigatori Q9QYH9.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway."
      Tamada K., Shimozaki K., Chapoval A.I., Zhu G., Sica G., Flies D., Boone T., Hsu H., Fu Y.-X., Nagata S., Ni J., Chen L.
      Nat. Med. 6:283-289(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily."
      Misawa K., Nosaka T., Kojima T., Hirai M., Kitamura T.
      Cytogenet. Cell Genet. 89:89-91(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal liver.
    3. "Mouse LIGHT; molecular genetics, ligand binding and expression."
      Force W.R., Todd P.K., Mikayama T.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lymphoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiTNF14_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYH9
    Secondary accession number(s): Q059Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3