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Q9QYH9

- TNF14_MOUSE

UniProt

Q9QYH9 - TNF14_MOUSE

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Protein

Tumor necrosis factor ligand superfamily member 14

Gene
Tnfsf14, Light
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei81 – 822Cleavage Reviewed prediction

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  2. receptor binding Source: UniProtKB

GO - Biological processi

  1. cellular response to mechanical stimulus Source: Ensembl
  2. immune response Source: InterPro
  3. positive regulation of T cell chemotaxis Source: MGI
  4. release of cytoplasmic sequestered NF-kappaB Source: UniProtKB
  5. T cell costimulation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 14
Alternative name(s):
CD_antigen: CD258
Cleaved into the following 2 chains:
Gene namesi
Name:Tnfsf14
Synonyms:Light
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1355317. Tnfsf14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini59 – 239181Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Tumor necrosis factor ligand superfamily member 14, membrane formPRO_0000034534Add
BLAST
Chaini?82 – 239158Tumor necrosis factor ligand superfamily member 14, soluble formPRO_0000034535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi152 ↔ 187 By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9QYH9.

Expressioni

Gene expression databases

BgeeiQ9QYH9.
GenevestigatoriQ9QYH9.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

BioGridi206162. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QYH9.
SMRiQ9QYH9. Positions 91-239.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40950.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000118072.
HOVERGENiHBG061471.
InParanoidiQ059Y9.
KOiK05477.
OMAiWRENSTE.
OrthoDBiEOG7V4B0Q.
PhylomeDBiQ9QYH9.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYH9-1 [UniParc]FASTAAdd to Basket

« Hide

MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA    50
TQGWFLLRLH QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN 100
ASLIGIGGPL LWETRLGLAF LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV 150
GCPQGLANGL PITHGLYKRT SRYPKELELL VSRRSPCGRA NSSRVWWDSS 200
FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV 239
Length:239
Mass (Da):26,338
Last modified:May 1, 2000 - v1
Checksum:i217874AC71AD6BE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF123385 mRNA. Translation: AAF76453.1.
AB029155 mRNA. Translation: BAA88559.1.
AF227533 mRNA. Translation: AAF36722.1.
BC125477 mRNA. Translation: AAI25478.1.
BC125479 mRNA. Translation: AAI25480.1.
CCDSiCCDS28928.1.
RefSeqiNP_062291.1. NM_019418.3.
UniGeneiMm.483369.

Genome annotation databases

EnsembliENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824.
GeneIDi50930.
KEGGimmu:50930.
UCSCiuc008def.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF123385 mRNA. Translation: AAF76453.1 .
AB029155 mRNA. Translation: BAA88559.1 .
AF227533 mRNA. Translation: AAF36722.1 .
BC125477 mRNA. Translation: AAI25478.1 .
BC125479 mRNA. Translation: AAI25480.1 .
CCDSi CCDS28928.1.
RefSeqi NP_062291.1. NM_019418.3.
UniGenei Mm.483369.

3D structure databases

ProteinModelPortali Q9QYH9.
SMRi Q9QYH9. Positions 91-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206162. 1 interaction.

Proteomic databases

PRIDEi Q9QYH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005976 ; ENSMUSP00000005976 ; ENSMUSG00000005824 .
GeneIDi 50930.
KEGGi mmu:50930.
UCSCi uc008def.1. mouse.

Organism-specific databases

CTDi 8740.
MGIi MGI:1355317. Tnfsf14.

Phylogenomic databases

eggNOGi NOG40950.
GeneTreei ENSGT00530000062992.
HOGENOMi HOG000118072.
HOVERGENi HBG061471.
InParanoidi Q059Y9.
KOi K05477.
OMAi WRENSTE.
OrthoDBi EOG7V4B0Q.
PhylomeDBi Q9QYH9.
TreeFami TF332169.

Miscellaneous databases

NextBioi 307951.
PROi Q9QYH9.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYH9.
Genevestigatori Q9QYH9.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway."
    Tamada K., Shimozaki K., Chapoval A.I., Zhu G., Sica G., Flies D., Boone T., Hsu H., Fu Y.-X., Nagata S., Ni J., Chen L.
    Nat. Med. 6:283-289(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily."
    Misawa K., Nosaka T., Kojima T., Hirai M., Kitamura T.
    Cytogenet. Cell Genet. 89:89-91(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal liver.
  3. "Mouse LIGHT; molecular genetics, ligand binding and expression."
    Force W.R., Todd P.K., Mikayama T.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiTNF14_MOUSE
AccessioniPrimary (citable) accession number: Q9QYH9
Secondary accession number(s): Q059Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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