Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 14

Gene

Tnfsf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei81 – 822CleavageSequence Analysis

GO - Molecular functioni

GO - Biological processi

  • cellular response to mechanical stimulus Source: Ensembl
  • immune response Source: InterPro
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • positive regulation of myoblast differentiation Source: MGI
  • positive regulation of myoblast fusion Source: MGI
  • positive regulation of T cell chemotaxis Source: MGI
  • release of cytoplasmic sequestered NF-kappaB Source: UniProtKB
  • T cell costimulation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 14
Alternative name(s):
CD_antigen: CD258
Cleaved into the following 2 chains:
Gene namesi
Name:Tnfsf14
Synonyms:Light
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1355317. Tnfsf14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini59 – 239181ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Tumor necrosis factor ligand superfamily member 14, membrane formPRO_0000034534Add
BLAST
Chaini?82 – 239158Tumor necrosis factor ligand superfamily member 14, soluble formPRO_0000034535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 187By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QYH9.
PRIDEiQ9QYH9.

Expressioni

Gene expression databases

BgeeiQ9QYH9.
GenevisibleiQ9QYH9. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi206162. 1 interaction.
STRINGi10090.ENSMUSP00000005976.

Structurei

3D structure databases

ProteinModelPortaliQ9QYH9.
SMRiQ9QYH9. Positions 91-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40950.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000118072.
HOVERGENiHBG061471.
InParanoidiQ9QYH9.
KOiK05477.
OMAiDGQTDIP.
OrthoDBiEOG7V4B0Q.
PhylomeDBiQ9QYH9.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA
60 70 80 90 100
TQGWFLLRLH QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN
110 120 130 140 150
ASLIGIGGPL LWETRLGLAF LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV
160 170 180 190 200
GCPQGLANGL PITHGLYKRT SRYPKELELL VSRRSPCGRA NSSRVWWDSS
210 220 230
FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV
Length:239
Mass (Da):26,338
Last modified:May 1, 2000 - v1
Checksum:i217874AC71AD6BE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123385 mRNA. Translation: AAF76453.1.
AB029155 mRNA. Translation: BAA88559.1.
AF227533 mRNA. Translation: AAF36722.1.
BC125477 mRNA. Translation: AAI25478.1.
BC125479 mRNA. Translation: AAI25480.1.
CCDSiCCDS28928.1.
RefSeqiNP_062291.1. NM_019418.3.
UniGeneiMm.483369.

Genome annotation databases

EnsembliENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824.
GeneIDi50930.
KEGGimmu:50930.
UCSCiuc008def.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123385 mRNA. Translation: AAF76453.1.
AB029155 mRNA. Translation: BAA88559.1.
AF227533 mRNA. Translation: AAF36722.1.
BC125477 mRNA. Translation: AAI25478.1.
BC125479 mRNA. Translation: AAI25480.1.
CCDSiCCDS28928.1.
RefSeqiNP_062291.1. NM_019418.3.
UniGeneiMm.483369.

3D structure databases

ProteinModelPortaliQ9QYH9.
SMRiQ9QYH9. Positions 91-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206162. 1 interaction.
STRINGi10090.ENSMUSP00000005976.

Proteomic databases

MaxQBiQ9QYH9.
PRIDEiQ9QYH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824.
GeneIDi50930.
KEGGimmu:50930.
UCSCiuc008def.1. mouse.

Organism-specific databases

CTDi8740.
MGIiMGI:1355317. Tnfsf14.

Phylogenomic databases

eggNOGiNOG40950.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000118072.
HOVERGENiHBG061471.
InParanoidiQ9QYH9.
KOiK05477.
OMAiDGQTDIP.
OrthoDBiEOG7V4B0Q.
PhylomeDBiQ9QYH9.
TreeFamiTF332169.

Miscellaneous databases

NextBioi307951.
PROiQ9QYH9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYH9.
GenevisibleiQ9QYH9. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway."
    Tamada K., Shimozaki K., Chapoval A.I., Zhu G., Sica G., Flies D., Boone T., Hsu H., Fu Y.-X., Nagata S., Ni J., Chen L.
    Nat. Med. 6:283-289(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily."
    Misawa K., Nosaka T., Kojima T., Hirai M., Kitamura T.
    Cytogenet. Cell Genet. 89:89-91(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal liver.
  3. "Mouse LIGHT; molecular genetics, ligand binding and expression."
    Force W.R., Todd P.K., Mikayama T.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiTNF14_MOUSE
AccessioniPrimary (citable) accession number: Q9QYH9
Secondary accession number(s): Q059Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.