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Protein

Tumor necrosis factor ligand superfamily member 14

Gene

Tnfsf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.

GO - Molecular functioni

GO - Biological processi

  • cellular response to mechanical stimulus Source: Ensembl
  • immune response Source: InterPro
  • positive regulation of myoblast differentiation Source: MGI
  • positive regulation of myoblast fusion Source: MGI
  • positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • positive regulation of T cell chemotaxis Source: MGI
  • T cell costimulation Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 14
Alternative name(s):
CD_antigen: CD258
Cleaved into the following 2 chains:
Gene namesi
Name:Tnfsf14
Synonyms:Light
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1355317 Tnfsf14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 239ExtracellularSequence analysisAdd BLAST181

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000345341 – 239Tumor necrosis factor ligand superfamily member 14, membrane formAdd BLAST239
ChainiPRO_0000034535?82 – 239Tumor necrosis factor ligand superfamily member 14, soluble formAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 187By similarity
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei81 – 82CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QYH9
PaxDbiQ9QYH9
PRIDEiQ9QYH9

PTM databases

PhosphoSitePlusiQ9QYH9

Expressioni

Gene expression databases

BgeeiENSMUSG00000005824
ExpressionAtlasiQ9QYH9 baseline and differential
GenevisibleiQ9QYH9 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206162, 1 interactor
IntActiQ9QYH9, 2 interactors
STRINGi10090.ENSMUSP00000005976

Structurei

3D structure databases

ProteinModelPortaliQ9QYH9
SMRiQ9QYH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVET Eukaryota
ENOG41124FT LUCA
GeneTreeiENSGT00530000062992
HOGENOMiHOG000118072
HOVERGENiHBG061471
InParanoidiQ9QYH9
KOiK05477
OMAiQTDIPFR
OrthoDBiEOG091G0MFC
PhylomeDBiQ9QYH9
TreeFamiTF332169

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA
60 70 80 90 100
TQGWFLLRLH QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN
110 120 130 140 150
ASLIGIGGPL LWETRLGLAF LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV
160 170 180 190 200
GCPQGLANGL PITHGLYKRT SRYPKELELL VSRRSPCGRA NSSRVWWDSS
210 220 230
FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV
Length:239
Mass (Da):26,338
Last modified:May 1, 2000 - v1
Checksum:i217874AC71AD6BE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123385 mRNA Translation: AAF76453.1
AB029155 mRNA Translation: BAA88559.1
AF227533 mRNA Translation: AAF36722.1
BC125477 mRNA Translation: AAI25478.1
BC125479 mRNA Translation: AAI25480.1
CCDSiCCDS28928.1
RefSeqiNP_062291.1, NM_019418.3
UniGeneiMm.483369

Genome annotation databases

EnsembliENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824
GeneIDi50930
KEGGimmu:50930
UCSCiuc008def.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTNF14_MOUSE
AccessioniPrimary (citable) accession number: Q9QYH9
Secondary accession number(s): Q059Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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