Reviewed, UniProtKB/Swiss-Prot Q9QYH1 (MPP4_RAT)

Names and origin

Protein names

Recommended name:
    MAGUK p55 subfamily member 4
Alternative name(s):
    Discs large homolog 6
      Short name=rDLG6

Gene names

Name:	Mpp4
Synonyms:	Dlg6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in retinal photoreceptors development By similarity.
Subunit structure	Interacts with MPDZ By similarity. May interact with GRIA2. Forms a complex with CRB1 and MPP5 By similarity.
Subcellular location	Cytoplasm. Note= Localized at photoreceptor synaptic terminals in retina By similarity.
Tissue specificity	Highly expressed in brain and detected in lung, and bone (at protein level). Also expressed in intestine and spleen.
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 1 PDZ (DHR) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil SH3 domain
Gene Ontology (GO)
Molecular function	receptor binding Ref.1 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Efnb1	Q6P7B6	1	EBI-937554,EBI-937609
Gria2	P19491	1	EBI-937554,EBI-77718
Il8rb	P35407	1	EBI-937554,EBI-937591

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9QYH1-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QYH1-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     334-351: Missing.

Isoform 3 (identifier: Q9QYH1-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     181-441: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 441	441	MAGUK p55 subfamily member 4
Regions
	Domain	1 – 84	84	PDZ
	Domain	91 – 161	71	SH3
	Domain	232 – 421	190	Guanylate kinase-like
	Coiled coil	373 – 430	58	Potential
Natural variations
	Alternative sequence	181 – 441	261	Missing in isoform 3.
	Alternative sequence	334 – 351	18	Missing in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified May 1, 2000. Version 1. Checksum: EB5F0711B4AC7CD6	FASTA	441	50,052
	10 20 30 40 50 60 MRTVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERN GLLYAGDKLV EVNGVPVEGL 70 80 90 100 110 120 DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QTTVYVRAMI DYWPQEDPDI PCMDAGLPFL 130 140 150 160 170 180 KGDILQIVDQ SDALWWQARK ISDIAICAGL IPSNHLLKRK QREFWWSQPY QPHTCLKSTR 190 200 210 220 230 240 SKEEFVGDGQ QFFIAGFRQQ HANMRCTCSC YSAVGAPYEE VVRYQRQPAD KHRLIVLVGP 250 260 270 280 290 300 SGVGVNELRR QLIGCNPSCF QSAVPHTTRS PKSYEMDGRE YHYVSRETFE SLMYGHRMLE 310 320 330 340 350 360 FGEYKGHLYG TSVNAVLAVL DEGKICVMDL EPQDIQLART RELKPYVIFI KPPSMSSMRH 370 380 390 400 410 420 SRRNAKIITD YFVDMKFKDE DLQEMEELAQ KMESQFGQFF DHVIVNDNLQ DARAQLLSAI 430 440 QKAEEELQWV PEAWVSPGAE S
	Isoform 2 (Beta) [UniParc]. Checksum: F685CEF1A26A8E28		423	47,867
	10 20 30 40 50 60 MRTVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERN GLLYAGDKLV EVNGVPVEGL 70 80 90 100 110 120 DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QTTVYVRAMI DYWPQEDPDI PCMDAGLPFL 130 140 150 160 170 180 KGDILQIVDQ SDALWWQARK ISDIAICAGL IPSNHLLKRK QREFWWSQPY QPHTCLKSTR 190 200 210 220 230 240 SKEEFVGDGQ QFFIAGFRQQ HANMRCTCSC YSAVGAPYEE VVRYQRQPAD KHRLIVLVGP 250 260 270 280 290 300 SGVGVNELRR QLIGCNPSCF QSAVPHTTRS PKSYEMDGRE YHYVSRETFE SLMYGHRMLE 310 320 330 340 350 360 FGEYKGHLYG TSVNAVLAVL DEGKICVMDL EPQPPSMSSM RHSRRNAKII TDYFVDMKFK 370 380 390 400 410 420 DEDLQEMEEL AQKMESQFGQ FFDHVIVNDN LQDARAQLLS AIQKAEEELQ WVPEAWVSPG AES
	Isoform 3 (Gamma) [UniParc]. Checksum: 9225B4AECAC54C82		180	20,138
	10 20 30 40 50 60 MRTVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERN GLLYAGDKLV EVNGVPVEGL 70 80 90 100 110 120 DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QTTVYVRAMI DYWPQEDPDI PCMDAGLPFL 130 140 150 160 170 180 KGDILQIVDQ SDALWWQARK ISDIAICAGL IPSNHLLKRK QREFWWSQPY QPHTCLKSTR

References

[1]

"rDLG6: a novel homolog of Drosophila DLG expressed in rat brain." Inagaki H., Maeda S., Lin K.H., Shimizu N., Saito T. Biochem. Biophys. Res. Commun. 265:462-468(1999) [PubMed: 10558890] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, INTERACTION WITH GRIA2. Strain: Sprague-Dawley. Tissue: Cerebellum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB030499 mRNA. Translation: BAA88229.1. AB030500 mRNA. Translation: BAA88230.1. AB030501 mRNA. Translation: BAA88231.1.
RefSeq	NP_067088.2.
UniGene	Rn.163075
3D structure databases
HSSP	HSSP built from PDB template 1M3B based on UniProtKB Q64010.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QYH1.
Genome annotation databases
Ensembl	ENSRNOG00000010486. Rattus norvegicus. [Contig view]
GeneID	58808.
KEGG	rno:58808.
Organism-specific databases
RGD	620016. Mpp4.
Phylogenomic databases
HOVERGEN	Q9QYH1.
Gene expression databases
ArrayExpress	Q9QYH1.
GermOnline	ENSRNOG00000010486. Rattus norvegicus.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylt/Ca. IPR001478. PDZ. IPR001452. SH3. IPR011511. SH3_2. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. PF00595. PDZ. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
ProDom	PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00072. GuKc. 1 hit. SM00228. PDZ. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. PS50106. PDZ. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MPP4_RAT

Accession

Primary (citable) accession number: Q9QYH1
Secondary accession number(s): Q9QYG9, Q9QYH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)