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Protein

Protein NDRG2

Gene

Ndrg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).By similarity

GO - Biological processi

  • brain development Source: GO_Central
  • cell differentiation Source: UniProtKB-KW
  • negative regulation of cytokine production Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: MGI
  • negative regulation of smooth muscle cell proliferation Source: MGI
  • regulation of platelet-derived growth factor production Source: MGI
  • regulation of vascular endothelial growth factor production Source: MGI
  • substantia nigra development Source: Ensembl
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Wnt signaling pathway

Protein family/group databases

ESTHERimouse-ndr2. Ndr_family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG2
Alternative name(s):
N-myc downstream-regulated gene 2 protein
Protein Ndr2
Cleaved into the following chain:
Gene namesi
Name:Ndrg2
Synonyms:Kiaa1248, Ndr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1352498. Ndrg2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004411681 – 371Protein NDRG2Add BLAST371
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00001595762 – 371Protein NDRG2, N-terminally processedAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Protein NDRG2, N-terminally processedBy similarity1
Modified residuei20PhosphothreonineBy similarity1
Modified residuei323PhosphothreonineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei330Phosphothreonine; by SGK1Combined sources1 Publication1
Modified residuei332Phosphoserine; by PKC/PRKCQ or SGK1Combined sources2 Publications1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei348Phosphothreonine; by PKB/AKT1 or SGK1Combined sources2 Publications1
Modified residuei350PhosphoserineCombined sources1 Publication1
Modified residuei352PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei357PhosphothreonineCombined sources1
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QYG0.
PeptideAtlasiQ9QYG0.
PRIDEiQ9QYG0.

PTM databases

iPTMnetiQ9QYG0.
PhosphoSitePlusiQ9QYG0.
SwissPalmiQ9QYG0.

Expressioni

Tissue specificityi

Expressed at highest levels in brain, heart and liver, and at lower levels in kidney, colon, skeletal muscle, adrenal gland, ovary and uterus (at protein level).3 Publications

Developmental stagei

Expression is restricted to the developing heart at the stage of 9.5 dpc, and increases after 11.5 dpc as development of tissues and organs proceeds. Present in many developing tissues including heart, brain, lung, liver, gut, kidney, skeletal muscle, cartilage and epidermis (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000004558.
CleanExiMM_NDRG2.
GenevisibleiQ9QYG0. MM.

Interactioni

Subunit structurei

Interacts with CTNNB1.By similarity

Protein-protein interaction databases

BioGridi205892. 1 interactor.
IntActiQ9QYG0. 3 interactors.
MINTiMINT-1854707.
STRINGi10090.ENSMUSP00000004673.

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 45Combined sources8
Beta strandi48 – 56Combined sources9
Beta strandi64 – 68Combined sources5
Helixi75 – 83Combined sources9
Helixi86 – 92Combined sources7
Beta strandi97 – 101Combined sources5
Turni103 – 105Combined sources3
Helixi121 – 126Combined sources6
Helixi128 – 135Combined sources8
Beta strandi140 – 145Combined sources6
Helixi147 – 158Combined sources12
Helixi160 – 162Combined sources3
Beta strandi163 – 170Combined sources8
Helixi178 – 188Combined sources11
Helixi193 – 201Combined sources9
Helixi204 – 208Combined sources5
Helixi212 – 222Combined sources11
Helixi227 – 238Combined sources12
Beta strandi245 – 247Combined sources3
Beta strandi257 – 262Combined sources6
Helixi268 – 277Combined sources10
Helixi280 – 282Combined sources3
Beta strandi283 – 288Combined sources6
Helixi295 – 298Combined sources4
Helixi300 – 311Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QMQX-ray1.70A40-313[»]
ProteinModelPortaliQ9QYG0.
SMRiQ9QYG0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QYG0.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

eggNOGiKOG2931. Eukaryota.
ENOG410XSPF. LUCA.
GeneTreeiENSGT00390000001874.
HOGENOMiHOG000230891.
HOVERGENiHBG052591.
InParanoidiQ9QYG0.
OMAiHVDAPGM.
OrthoDBiEOG091G09VW.
PhylomeDBiQ9QYG0.
TreeFamiTF313168.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030690. NDRG2.
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF38. PTHR11034:SF38. 1 hit.
PfamiView protein in Pfam
PF03096. Ndr. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QYG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQEVQIT EEKPLLPGQT PETAKEAELA ARILLDQGQT HSVETPYGSV
60 70 80 90 100
TFTVYGTPKP KRPAIFTYHD VGLNYKSCFQ PLFRFGDMQE IIQNFVRVHV
110 120 130 140 150
DAPGMEEGAP VFPLGYQYPS LDQLADMIPC ILQYLNFSTI IGVGVGAGAY
160 170 180 190 200
ILSRYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPDMILGH
210 220 230 240 250
LFSQEELSGN SELIQKYRGI IQHAPNLENI ELYWNSYNNR RDLNFERGGE
260 270 280 290 300
TTLKCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP
310 320 330 340 350
GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASID GSRSRSRTLS
360 370
QSSESGTLPS GPPGHTMEVS C
Length:371
Mass (Da):40,789
Last modified:May 1, 2000 - v1
Checksum:iA5237C04278197B2
GO
Isoform 2 (identifier: Q9QYG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.

Show »
Length:357
Mass (Da):39,281
Checksum:iE6A9E286AD92E7AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253L → P in BAE39998 (PubMed:16141072).Curated1
Sequence conflicti347R → S in BAE39998 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01900926 – 39Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033921 mRNA. Translation: BAA85882.1.
AK076514 mRNA. Translation: BAC36373.1.
AK154597 mRNA. Translation: BAE32700.1.
AK158900 mRNA. Translation: BAE34721.1.
AK168011 mRNA. Translation: BAE39998.1.
BC012963 mRNA. Translation: AAH12963.1.
AK173136 mRNA. Translation: BAD32414.1.
CCDSiCCDS27047.1. [Q9QYG0-1]
CCDS49486.1. [Q9QYG0-2]
RefSeqiNP_001139431.1. NM_001145959.1. [Q9QYG0-2]
NP_038892.1. NM_013864.2. [Q9QYG0-1]
XP_006519161.2. XM_006519098.3. [Q9QYG0-1]
XP_006519162.2. XM_006519099.3. [Q9QYG0-2]
XP_006519166.1. XM_006519103.1. [Q9QYG0-1]
XP_006519167.1. XM_006519104.3. [Q9QYG0-2]
XP_006519168.1. XM_006519105.2. [Q9QYG0-2]
XP_017171534.1. XM_017316045.1. [Q9QYG0-1]
XP_017171535.1. XM_017316046.1. [Q9QYG0-1]
XP_017171536.1. XM_017316047.1. [Q9QYG0-1]
XP_017171538.1. XM_017316049.1. [Q9QYG0-2]
XP_017171539.1. XM_017316050.1. [Q9QYG0-2]
XP_017171540.1. XM_017316051.1. [Q9QYG0-2]
UniGeneiMm.26722.

Genome annotation databases

EnsembliENSMUST00000004673; ENSMUSP00000004673; ENSMUSG00000004558. [Q9QYG0-1]
ENSMUST00000111632; ENSMUSP00000107259; ENSMUSG00000004558. [Q9QYG0-2]
GeneIDi29811.
KEGGimmu:29811.
UCSCiuc007tnk.2. mouse. [Q9QYG0-1]
uc007tnl.2. mouse. [Q9QYG0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNDRG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYG0
Secondary accession number(s): Q3TI48
, Q3TY42, Q3U3T5, Q69ZN2, Q8C661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families