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Q9QYF9 (NDRG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NDRG3
Alternative name(s):
N-myc downstream-regulated gene 3 protein
Protein Ndr3
Gene names
Name:Ndrg3
Synonyms:Ndr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed at high levels in brain, followed by small intestine and kidney (at protein level). Also expressed in thymus. Ref.3

Developmental stage

Its expression is already significant at 9.5 dpc, covering the entire embryo except the heart, and it shows only a slight increase in later developmental stages.

Sequence similarities

Belongs to the NDRG family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Protein NDRG3
PRO_0000159578

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue3221Phosphothreonine By similarity
Modified residue3311Phosphoserine Ref.2
Modified residue3341Phosphoserine Ref.2
Modified residue3351Phosphoserine Ref.2
Modified residue3521Phosphoserine By similarity
Modified residue3741Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYF9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B33D3CC3E816AEA1

FASTA37541,555
        10         20         30         40         50         60 
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETPHG MVHVTIRGLP KGNRPVILTY 

        70         80         90        100        110        120 
HDIGLNHKSC FNTFFNFEDM QEITQHFAVC HVDAPGQQEA APSFPTGYQY PTMDELAEML 

       130        140        150        160        170        180 
PPVLTHLSMK SIIGIGVGAG AYILSRFALN HPELVEGLVL INIDPCAKGW IDWAASKLSG 

       190        200        210        220        230        240 
FTTNIVDIIL AHHFGQEELQ ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLEIERP 

       250        260        270        280        290        300 
ILGQNDNRLK TLKCSTLLVV GDNSPAVEAV VECNSRLDPI NTTLLKMADC GGLPQVVQPG 

       310        320        330        340        350        360 
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSIGSGE SPFSRSVTSN QSDGTQESCE 

       370 
SPDVLDRHQT MEVSC 

« Hide

References

« Hide 'large scale' references
[1]"Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc."
Okuda T., Kondoh H.
Biochem. Biophys. Res. Commun. 266:208-215(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-334 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[3]"NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia."
Yamamoto H., Kokame K., Okuda T., Nakajo Y., Yanamoto H., Miyata T.
J. Biol. Chem. 286:26158-26165(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033922 mRNA. Translation: BAA85883.1.
CCDSCCDS16971.1.
RefSeqNP_038893.1. NM_013865.2.
UniGeneMm.279256.

3D structure databases

ProteinModelPortalQ9QYF9.
SMRQ9QYF9. Positions 33-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QYF9. 1 interaction.
MINTMINT-4103233.

PTM databases

PhosphoSiteQ9QYF9.

Proteomic databases

MaxQBQ9QYF9.
PaxDbQ9QYF9.
PRIDEQ9QYF9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072298; ENSMUSP00000072144; ENSMUSG00000027634.
GeneID29812.
KEGGmmu:29812.
UCSCuc008nof.2. mouse.

Organism-specific databases

CTD57446.
MGIMGI:1352499. Ndrg3.

Phylogenomic databases

eggNOGNOG310435.
GeneTreeENSGT00390000001874.
HOGENOMHOG000230891.
HOVERGENHBG052591.
PhylomeDBQ9QYF9.

Gene expression databases

ArrayExpressQ9QYF9.
BgeeQ9QYF9.
CleanExMM_NDRG3.
GenevestigatorQ9QYF9.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR004142. NDRG.
[Graphical view]
PANTHERPTHR11034. PTHR11034. 1 hit.
PfamPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNDRG3. mouse.
NextBio306966.
PROQ9QYF9.
SOURCESearch...

Entry information

Entry nameNDRG3_MOUSE
AccessionPrimary (citable) accession number: Q9QYF9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot