Q9QYF9 (NDRG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NDRG3

Alternative name(s):
N-myc downstream-regulated gene 3 protein
Protein Ndr3

Gene names

Name:	Ndrg3
Synonyms:	Ndr3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed at high levels in brain, followed by small intestine and kidney (at protein level). Also expressed in thymus. Ref.4
Developmental stage	Its expression is already significant at 9.5 dpc, covering the entire embryo except the heart, and it shows only a slight increase in later developmental stages.
Sequence similarities	Belongs to the NDRG family.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from sequence or structural similarity PubMed 11936845. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Protein NDRG3		PRO_0000159578
Amino acid modifications
	Modified residue	322	1	Phosphothreonine By similarity
	Modified residue	331	1	Phosphoserine Ref.2 Ref.3
	Modified residue	334	1	Phosphoserine Ref.2
	Modified residue	335	1	Phosphoserine Ref.2
	Modified residue	352	1	Phosphoserine By similarity
	Modified residue	374	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QYF9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B33D3CC3E816AEA1	FASTA	375	41,555
	10 20 30 40 50 60 MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETPHG MVHVTIRGLP KGNRPVILTY 70 80 90 100 110 120 HDIGLNHKSC FNTFFNFEDM QEITQHFAVC HVDAPGQQEA APSFPTGYQY PTMDELAEML 130 140 150 160 170 180 PPVLTHLSMK SIIGIGVGAG AYILSRFALN HPELVEGLVL INIDPCAKGW IDWAASKLSG 190 200 210 220 230 240 FTTNIVDIIL AHHFGQEELQ ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLEIERP 250 260 270 280 290 300 ILGQNDNRLK TLKCSTLLVV GDNSPAVEAV VECNSRLDPI NTTLLKMADC GGLPQVVQPG 310 320 330 340 350 360 KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSIGSGE SPFSRSVTSN QSDGTQESCE 370 SPDVLDRHQT MEVSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc." Okuda T., Kondoh H. Biochem. Biophys. Res. Commun. 266:208-215(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-334 AND SER-335, MASS SPECTROMETRY. Tissue: Liver.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, MASS SPECTROMETRY. Tissue: Melanoma.
[4]	"NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia." Yamamoto H., Kokame K., Okuda T., Nakajo Y., Yanamoto H., Miyata T. J. Biol. Chem. 286:26158-26165(2011) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033922 mRNA. Translation: BAA85883.1.
IPI	IPI00136107.
RefSeq	NP_038893.1. NM_013865.2.
UniGene	Mm.279256.
3D structure databases
ProteinModelPortal	Q9QYF9.
SMR	Q9QYF9. Positions 33-312.
ModBase	Search...
PTM databases
PhosphoSite	Q9QYF9.
Proteomic databases
PaxDb	Q9QYF9.
PRIDE	Q9QYF9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000072298; ENSMUSP00000072144; ENSMUSG00000027634.
GeneID	29812.
KEGG	mmu:29812.
Organism-specific databases
CTD	57446.
MGI	MGI:1352499. Ndrg3.
Phylogenomic databases
eggNOG	NOG310435.
GeneTree	ENSGT00390000001874.
HOGENOM	HOG000230891.
HOVERGEN	HBG052591.
OrthoDB	EOG4GMTXB.
Gene expression databases
ArrayExpress	Q9QYF9.
Bgee	Q9QYF9.
CleanEx	MM_NDRG3.
Genevestigator	Q9QYF9.
GermOnline	ENSMUSG00000027634. Mus musculus.
Family and domain databases
InterPro	IPR004142. Ndr. [Graphical view]
PANTHER	PTHR11034. PTHR11034. 1 hit.
Pfam	PF03096. Ndr. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NDRG3. mouse.
NextBio	306966.
SOURCE	Search...

Entry information

Entry name

NDRG3_MOUSE

Accession

Primary (citable) accession number: Q9QYF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program