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Protein

Protein NDRG3

Gene

Ndrg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERimouse-ndr3. Ndr_family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG3
Alternative name(s):
N-myc downstream-regulated gene 3 protein
Protein Ndr3
Gene namesi
Name:Ndrg3
Synonyms:Ndr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1352499. Ndrg3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Protein NDRG3PRO_0000159578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei322 – 3221PhosphothreonineBy similarity
Modified residuei331 – 3311Phosphoserine1 Publication
Modified residuei334 – 3341Phosphoserine1 Publication
Modified residuei335 – 3351Phosphoserine1 Publication
Modified residuei352 – 3521PhosphoserineBy similarity
Modified residuei374 – 3741PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QYF9.
PaxDbiQ9QYF9.
PRIDEiQ9QYF9.

PTM databases

PhosphoSiteiQ9QYF9.

Expressioni

Tissue specificityi

Expressed at high levels in brain, followed by small intestine and kidney (at protein level). Also expressed in thymus.1 Publication

Developmental stagei

Its expression is already significant at 9.5 dpc, covering the entire embryo except the heart, and it shows only a slight increase in later developmental stages.

Gene expression databases

BgeeiQ9QYF9.
CleanExiMM_NDRG3.
ExpressionAtlasiQ9QYF9. baseline and differential.
GenevisibleiQ9QYF9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9QYF9. 1 interaction.
MINTiMINT-4103233.
STRINGi10090.ENSMUSP00000070052.

Structurei

3D structure databases

ProteinModelPortaliQ9QYF9.
SMRiQ9QYF9. Positions 33-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

eggNOGiNOG310435.
GeneTreeiENSGT00390000001874.
HOGENOMiHOG000230891.
HOVERGENiHBG052591.
InParanoidiQ9QYF9.
PhylomeDBiQ9QYF9.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030692. NDRG3.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF20. PTHR11034:SF20. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETPHG MVHVTIRGLP
60 70 80 90 100
KGNRPVILTY HDIGLNHKSC FNTFFNFEDM QEITQHFAVC HVDAPGQQEA
110 120 130 140 150
APSFPTGYQY PTMDELAEML PPVLTHLSMK SIIGIGVGAG AYILSRFALN
160 170 180 190 200
HPELVEGLVL INIDPCAKGW IDWAASKLSG FTTNIVDIIL AHHFGQEELQ
210 220 230 240 250
ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLEIERP ILGQNDNRLK
260 270 280 290 300
TLKCSTLLVV GDNSPAVEAV VECNSRLDPI NTTLLKMADC GGLPQVVQPG
310 320 330 340 350
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSIGSGE SPFSRSVTSN
360 370
QSDGTQESCE SPDVLDRHQT MEVSC
Length:375
Mass (Da):41,555
Last modified:May 1, 2000 - v1
Checksum:iB33D3CC3E816AEA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033922 mRNA. Translation: BAA85883.1.
CCDSiCCDS16971.1.
RefSeqiNP_038893.1. NM_013865.2.
UniGeneiMm.279256.

Genome annotation databases

EnsembliENSMUST00000072298; ENSMUSP00000072144; ENSMUSG00000027634.
GeneIDi29812.
KEGGimmu:29812.
UCSCiuc008nof.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033922 mRNA. Translation: BAA85883.1.
CCDSiCCDS16971.1.
RefSeqiNP_038893.1. NM_013865.2.
UniGeneiMm.279256.

3D structure databases

ProteinModelPortaliQ9QYF9.
SMRiQ9QYF9. Positions 33-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QYF9. 1 interaction.
MINTiMINT-4103233.
STRINGi10090.ENSMUSP00000070052.

Protein family/group databases

ESTHERimouse-ndr3. Ndr_family.

PTM databases

PhosphoSiteiQ9QYF9.

Proteomic databases

MaxQBiQ9QYF9.
PaxDbiQ9QYF9.
PRIDEiQ9QYF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072298; ENSMUSP00000072144; ENSMUSG00000027634.
GeneIDi29812.
KEGGimmu:29812.
UCSCiuc008nof.2. mouse.

Organism-specific databases

CTDi57446.
MGIiMGI:1352499. Ndrg3.

Phylogenomic databases

eggNOGiNOG310435.
GeneTreeiENSGT00390000001874.
HOGENOMiHOG000230891.
HOVERGENiHBG052591.
InParanoidiQ9QYF9.
PhylomeDBiQ9QYF9.

Miscellaneous databases

ChiTaRSiNdrg3. mouse.
NextBioi306966.
PROiQ9QYF9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYF9.
CleanExiMM_NDRG3.
ExpressionAtlasiQ9QYF9. baseline and differential.
GenevisibleiQ9QYF9. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030692. NDRG3.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF20. PTHR11034:SF20. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc."
    Okuda T., Kondoh H.
    Biochem. Biophys. Res. Commun. 266:208-215(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-334 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. "NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia."
    Yamamoto H., Kokame K., Okuda T., Nakajo Y., Yanamoto H., Miyata T.
    J. Biol. Chem. 286:26158-26165(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNDRG3_MOUSE
AccessioniPrimary (citable) accession number: Q9QYF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.