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Q9QYF9

- NDRG3_MOUSE

UniProt

Q9QYF9 - NDRG3_MOUSE

Protein

Protein NDRG3

Gene

Ndrg3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NDRG3
    Alternative name(s):
    N-myc downstream-regulated gene 3 protein
    Protein Ndr3
    Gene namesi
    Name:Ndrg3
    Synonyms:Ndr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1352499. Ndrg3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Protein NDRG3PRO_0000159578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei322 – 3221PhosphothreonineBy similarity
    Modified residuei331 – 3311Phosphoserine1 Publication
    Modified residuei334 – 3341Phosphoserine1 Publication
    Modified residuei335 – 3351Phosphoserine1 Publication
    Modified residuei352 – 3521PhosphoserineBy similarity
    Modified residuei374 – 3741PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QYF9.
    PaxDbiQ9QYF9.
    PRIDEiQ9QYF9.

    PTM databases

    PhosphoSiteiQ9QYF9.

    Expressioni

    Tissue specificityi

    Expressed at high levels in brain, followed by small intestine and kidney (at protein level). Also expressed in thymus.1 Publication

    Developmental stagei

    Its expression is already significant at 9.5 dpc, covering the entire embryo except the heart, and it shows only a slight increase in later developmental stages.

    Gene expression databases

    ArrayExpressiQ9QYF9.
    BgeeiQ9QYF9.
    CleanExiMM_NDRG3.
    GenevestigatoriQ9QYF9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9QYF9. 1 interaction.
    MINTiMINT-4103233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYF9.
    SMRiQ9QYF9. Positions 33-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDRG family.Curated

    Phylogenomic databases

    eggNOGiNOG310435.
    GeneTreeiENSGT00390000001874.
    HOGENOMiHOG000230891.
    HOVERGENiHBG052591.
    PhylomeDBiQ9QYF9.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR004142. NDRG.
    [Graphical view]
    PANTHERiPTHR11034. PTHR11034. 1 hit.
    PfamiPF03096. Ndr. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QYF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETPHG MVHVTIRGLP    50
    KGNRPVILTY HDIGLNHKSC FNTFFNFEDM QEITQHFAVC HVDAPGQQEA 100
    APSFPTGYQY PTMDELAEML PPVLTHLSMK SIIGIGVGAG AYILSRFALN 150
    HPELVEGLVL INIDPCAKGW IDWAASKLSG FTTNIVDIIL AHHFGQEELQ 200
    ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLEIERP ILGQNDNRLK 250
    TLKCSTLLVV GDNSPAVEAV VECNSRLDPI NTTLLKMADC GGLPQVVQPG 300
    KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSIGSGE SPFSRSVTSN 350
    QSDGTQESCE SPDVLDRHQT MEVSC 375
    Length:375
    Mass (Da):41,555
    Last modified:May 1, 2000 - v1
    Checksum:iB33D3CC3E816AEA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033922 mRNA. Translation: BAA85883.1.
    CCDSiCCDS16971.1.
    RefSeqiNP_038893.1. NM_013865.2.
    UniGeneiMm.279256.

    Genome annotation databases

    EnsembliENSMUST00000072298; ENSMUSP00000072144; ENSMUSG00000027634.
    GeneIDi29812.
    KEGGimmu:29812.
    UCSCiuc008nof.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033922 mRNA. Translation: BAA85883.1 .
    CCDSi CCDS16971.1.
    RefSeqi NP_038893.1. NM_013865.2.
    UniGenei Mm.279256.

    3D structure databases

    ProteinModelPortali Q9QYF9.
    SMRi Q9QYF9. Positions 33-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QYF9. 1 interaction.
    MINTi MINT-4103233.

    PTM databases

    PhosphoSitei Q9QYF9.

    Proteomic databases

    MaxQBi Q9QYF9.
    PaxDbi Q9QYF9.
    PRIDEi Q9QYF9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072298 ; ENSMUSP00000072144 ; ENSMUSG00000027634 .
    GeneIDi 29812.
    KEGGi mmu:29812.
    UCSCi uc008nof.2. mouse.

    Organism-specific databases

    CTDi 57446.
    MGIi MGI:1352499. Ndrg3.

    Phylogenomic databases

    eggNOGi NOG310435.
    GeneTreei ENSGT00390000001874.
    HOGENOMi HOG000230891.
    HOVERGENi HBG052591.
    PhylomeDBi Q9QYF9.

    Miscellaneous databases

    ChiTaRSi NDRG3. mouse.
    NextBioi 306966.
    PROi Q9QYF9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYF9.
    Bgeei Q9QYF9.
    CleanExi MM_NDRG3.
    Genevestigatori Q9QYF9.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR004142. NDRG.
    [Graphical view ]
    PANTHERi PTHR11034. PTHR11034. 1 hit.
    Pfami PF03096. Ndr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc."
      Okuda T., Kondoh H.
      Biochem. Biophys. Res. Commun. 266:208-215(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-334 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    3. "NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia."
      Yamamoto H., Kokame K., Okuda T., Nakajo Y., Yanamoto H., Miyata T.
      J. Biol. Chem. 286:26158-26165(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNDRG3_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3