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Protein

Retinol dehydrogenase 11

Gene

Rdh11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent all-trans-retinal reductase. Also involved in the metabolism of short-chain aldehydes.

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei174SubstrateBy similarity1
Active sitei199Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 51NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • adaptation of rhodopsin mediated signaling Source: MGI
  • retinal metabolic process Source: MGI
  • retinol metabolic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.300 3474
ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-5365859 RA biosynthesis pathway
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 11 (EC:1.1.1.300)
Alternative name(s):
Androgen-regulated short-chain dehydrogenase/reductase 1
Cell line MC/9.IL4-derived protein 1
M42C60
Prostate short-chain dehydrogenase/reductase 1
Retinal reductase 1
Short name:
RalR1
Short-chain aldehyde dehydrogenase
Short name:
SCALD
Gene namesi
Name:Rdh11
Synonyms:Arsdr1, Mdt1, Psdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:102581 Rdh11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini22 – 316CytoplasmicSequence analysisAdd BLAST295

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547641 – 316Retinol dehydrogenase 11Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109N6-acetyllysineBy similarity1

Post-translational modificationi

Not glycosylated.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QYF1
MaxQBiQ9QYF1
PaxDbiQ9QYF1
PeptideAtlasiQ9QYF1
PRIDEiQ9QYF1

PTM databases

iPTMnetiQ9QYF1
PhosphoSitePlusiQ9QYF1
SwissPalmiQ9QYF1

Expressioni

Tissue specificityi

Expressed at higher level in liver and testis. Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the outer segment of rods and cones.

Gene expression databases

BgeeiENSMUSG00000066441
CleanExiMM_RDH11
ExpressionAtlasiQ9QYF1 baseline and differential
GenevisibleiQ9QYF1 MM

Interactioni

Protein-protein interaction databases

IntActiQ9QYF1, 3 interactors
MINTiQ9QYF1
STRINGi10090.ENSMUSP00000124066

Structurei

3D structure databases

ProteinModelPortaliQ9QYF1
SMRiQ9QYF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ9QYF1
KOiK11152
OMAiMWWLFSF
OrthoDBiEOG091G0FGA
TreeFamiTF105429

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: Q9QYF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGFLLLLSL PFILYLVTPK IRKMLSSGVC TSNVQLPGKV AIVTGANTGI
60 70 80 90 100
GKETAKDLAQ RGARVYLACR DVDKGELAAR EIQAVTGNSQ VFVRKLDLAD
110 120 130 140 150
TKSIRAFAKD FLAEEKHLHL LINNAGVMMC PYSKTADGFE MHIGVNHLGH
160 170 180 190 200
FLLTHLLLEK LKESAPSRIV NLSSLGHHLG RIHFHNLQGE KFYSAGLAYC
210 220 230 240 250
HSKLANILFT KELAKRLKGS GVTTYSVHPG TVHSELTRYS SIMRWLWQLF
260 270 280 290 300
FVFIKTPQEG AQTSLYCALT EGLESLSGSH FSDCQLAWVS YQGRNEIIAR
310
RLWDVSCDLL GLPVDW
Length:316
Mass (Da):35,148
Last modified:August 29, 2003 - v2
Checksum:i62FAE25585CC05FE
GO

Sequence cautioni

The sequence BAA88521 differs from that shown. Reason: Frameshift at position 311.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238R → G in BAA88521 (PubMed:8018917).Curated1
Sequence conflicti279S → R in BAA88521 (PubMed:8018917).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035959 mRNA Translation: BAA88521.1 Frameshift.
AY039032 mRNA Translation: AAK91516.1
AF474027 mRNA Translation: AAL79910.1
AK004413 mRNA Translation: BAB23296.1
AK135443 mRNA Translation: BAE22534.1
BC018261 mRNA Translation: AAH18261.1
CCDSiCCDS36480.1 [Q9QYF1-1]
RefSeqiNP_067532.2, NM_021557.5 [Q9QYF1-1]
UniGeneiMm.291799

Genome annotation databases

EnsembliENSMUST00000161204; ENSMUSP00000124066; ENSMUSG00000066441 [Q9QYF1-1]
GeneIDi17252
KEGGimmu:17252
UCSCiuc007oaa.1 mouse [Q9QYF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRDH11_MOUSE
AccessioniPrimary (citable) accession number: Q9QYF1
Secondary accession number(s): Q3UXM9, Q9D0U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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