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Protein

Retinol dehydrogenase 11

Gene

Rdh11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent all-trans-retinal reductase. Also involved in the metabolism of short-chain aldehydes.

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei174 – 1741SubstrateBy similarity
Active sitei199 – 1991Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 517NADPBy similarity

GO - Molecular functioni

GO - Biological processi

  • adaptation of rhodopsin mediated signaling Source: MGI
  • retinal metabolic process Source: MGI
  • retinol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.300. 3474.
ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-5365859. RA biosynthesis pathway.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 11 (EC:1.1.1.300)
Alternative name(s):
Androgen-regulated short-chain dehydrogenase/reductase 1
Cell line MC/9.IL4-derived protein 1
M42C60
Prostate short-chain dehydrogenase/reductase 1
Retinal reductase 1
Short name:
RalR1
Short-chain aldehyde dehydrogenase
Short name:
SCALD
Gene namesi
Name:Rdh11
Synonyms:Arsdr1, Mdt1, Psdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:102581. Rdh11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini22 – 316295CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Retinol dehydrogenase 11PRO_0000054764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-acetyllysineBy similarity

Post-translational modificationi

Not glycosylated.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QYF1.
MaxQBiQ9QYF1.
PaxDbiQ9QYF1.
PeptideAtlasiQ9QYF1.
PRIDEiQ9QYF1.

PTM databases

iPTMnetiQ9QYF1.
PhosphoSiteiQ9QYF1.

Expressioni

Tissue specificityi

Expressed at higher level in liver and testis. Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the outer segment of rods and cones.

Gene expression databases

BgeeiENSMUSG00000066441.
CleanExiMM_RDH11.
ExpressionAtlasiQ9QYF1. baseline and differential.
GenevisibleiQ9QYF1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9QYF1. 3 interactions.
MINTiMINT-1865554.
STRINGi10090.ENSMUSP00000124066.

Structurei

3D structure databases

ProteinModelPortaliQ9QYF1.
SMRiQ9QYF1. Positions 36-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ9QYF1.
KOiK11152.
OMAiCQLAWVS.
OrthoDBiEOG091G0FGA.
TreeFamiTF105429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: Q9QYF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGFLLLLSL PFILYLVTPK IRKMLSSGVC TSNVQLPGKV AIVTGANTGI
60 70 80 90 100
GKETAKDLAQ RGARVYLACR DVDKGELAAR EIQAVTGNSQ VFVRKLDLAD
110 120 130 140 150
TKSIRAFAKD FLAEEKHLHL LINNAGVMMC PYSKTADGFE MHIGVNHLGH
160 170 180 190 200
FLLTHLLLEK LKESAPSRIV NLSSLGHHLG RIHFHNLQGE KFYSAGLAYC
210 220 230 240 250
HSKLANILFT KELAKRLKGS GVTTYSVHPG TVHSELTRYS SIMRWLWQLF
260 270 280 290 300
FVFIKTPQEG AQTSLYCALT EGLESLSGSH FSDCQLAWVS YQGRNEIIAR
310
RLWDVSCDLL GLPVDW
Length:316
Mass (Da):35,148
Last modified:August 29, 2003 - v2
Checksum:i62FAE25585CC05FE
GO

Sequence cautioni

The sequence BAA88521 differs from that shown. Reason: Frameshift at position 311. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381R → G in BAA88521 (PubMed:8018917).Curated
Sequence conflicti279 – 2791S → R in BAA88521 (PubMed:8018917).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035959 mRNA. Translation: BAA88521.1. Frameshift.
AY039032 mRNA. Translation: AAK91516.1.
AF474027 mRNA. Translation: AAL79910.1.
AK004413 mRNA. Translation: BAB23296.1.
AK135443 mRNA. Translation: BAE22534.1.
BC018261 mRNA. Translation: AAH18261.1.
CCDSiCCDS36480.1. [Q9QYF1-1]
RefSeqiNP_067532.2. NM_021557.5. [Q9QYF1-1]
UniGeneiMm.291799.

Genome annotation databases

EnsembliENSMUST00000161204; ENSMUSP00000124066; ENSMUSG00000066441. [Q9QYF1-1]
GeneIDi17252.
KEGGimmu:17252.
UCSCiuc007oaa.1. mouse. [Q9QYF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035959 mRNA. Translation: BAA88521.1. Frameshift.
AY039032 mRNA. Translation: AAK91516.1.
AF474027 mRNA. Translation: AAL79910.1.
AK004413 mRNA. Translation: BAB23296.1.
AK135443 mRNA. Translation: BAE22534.1.
BC018261 mRNA. Translation: AAH18261.1.
CCDSiCCDS36480.1. [Q9QYF1-1]
RefSeqiNP_067532.2. NM_021557.5. [Q9QYF1-1]
UniGeneiMm.291799.

3D structure databases

ProteinModelPortaliQ9QYF1.
SMRiQ9QYF1. Positions 36-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QYF1. 3 interactions.
MINTiMINT-1865554.
STRINGi10090.ENSMUSP00000124066.

PTM databases

iPTMnetiQ9QYF1.
PhosphoSiteiQ9QYF1.

Proteomic databases

EPDiQ9QYF1.
MaxQBiQ9QYF1.
PaxDbiQ9QYF1.
PeptideAtlasiQ9QYF1.
PRIDEiQ9QYF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161204; ENSMUSP00000124066; ENSMUSG00000066441. [Q9QYF1-1]
GeneIDi17252.
KEGGimmu:17252.
UCSCiuc007oaa.1. mouse. [Q9QYF1-1]

Organism-specific databases

CTDi51109.
MGIiMGI:102581. Rdh11.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ9QYF1.
KOiK11152.
OMAiCQLAWVS.
OrthoDBiEOG091G0FGA.
TreeFamiTF105429.

Enzyme and pathway databases

BRENDAi1.1.1.300. 3474.
ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-5365859. RA biosynthesis pathway.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiQ9QYF1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066441.
CleanExiMM_RDH11.
ExpressionAtlasiQ9QYF1. baseline and differential.
GenevisibleiQ9QYF1. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRDH11_MOUSE
AccessioniPrimary (citable) accession number: Q9QYF1
Secondary accession number(s): Q3UXM9, Q9D0U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.