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Protein

Integrin alpha-D

Gene

Itgad

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi467 – 475Sequence analysis9
Calcium bindingi531 – 539Sequence analysis9
Calcium bindingi594 – 602Sequence analysis9

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-D
Alternative name(s):
CD_antigen: CD11d
Gene namesi
Name:Itgad
Synonyms:Itgax
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71075. Itgad.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1100ExtracellularSequence analysisAdd BLAST1081
Transmembranei1101 – 1121HelicalSequence analysisAdd BLAST21
Topological domaini1122 – 1161CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001629720 – 1161Integrin alpha-DAdd BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi69 ↔ 76By similarity
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 126By similarity
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi656 ↔ 711By similarity
Glycosylationi696N-linked (GlcNAc...)Sequence analysis1
Glycosylationi734N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi769 ↔ 775By similarity
Glycosylationi784N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi845 ↔ 860By similarity
Glycosylationi907N-linked (GlcNAc...)Sequence analysis1
Glycosylationi936N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi993 ↔ 1017By similarity
Disulfide bondi1022 ↔ 1027By similarity
Glycosylationi1045N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QYE7.
PRIDEiQ9QYE7.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2 (By similarity).By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026855.

Structurei

3D structure databases

ProteinModelPortaliQ9QYE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 78FG-GAP 1PROSITE-ProRule annotationAdd BLAST58
Repeati79 – 138FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini152 – 334VWFAPROSITE-ProRule annotationAdd BLAST183
Repeati341 – 392FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati393 – 444FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati445 – 505FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati508 – 566FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati571 – 631FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1126 – 1130GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ9QYE7.
KOiK06594.
PhylomeDBiQ9QYE7.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGVVILLC GWVLASCHGS NLDVEEPIVF REDAASFGQT VVQFGGSRLV
60 70 80 90 100
VGAPLEAVAV NQTGRLYDCA PATGMCQPIV LRSPLEAVNM SLGLSLVTAT
110 120 130 140 150
NNAQLLACGP TAQRACVKNM YAKGSCLLLG SSLQFIQAVP ASMPECPRQE
160 170 180 190 200
MDIAFLIDGS GSINQRDFAQ MKDFVKALMG EFASTSTLFS LMQYSNILKT
210 220 230 240 250
HFTFTEFKNI LDPQSLVDPI VQLQGLTYTA TGIRTVMEEL FHSKNGSRKS
260 270 280 290 300
AKKILLVITD GQKYRDPLEY SDVIPAADKA GIIRYAIGVG DAFQEPTALK
310 320 330 340 350
ELNTIGSAPP QDHVFKVGNF AALRSIQRQL QEKIFAIEGT QSRSSSSFQH
360 370 380 390 400
EMSQEGFSSA LTSDGPVLGA VGSFSWSGGA FLYPPNTRPT FINMSQENVD
410 420 430 440 450
MRDSYLGYST AVAFWKGVHS LILGAPRHQH TGKVVIFTQE ARHWRPKSEV
460 470 480 490 500
RGTQIGSYFG ASLCSVDVDR DGSTDLVLIG APHYYEQTRG GQVSVFPVPG
510 520 530 540 550
VRGRWQCEAT LHGEQGHPWG RFGVALTVLG DVNGDNLADV AIGAPGEEES
560 570 580 590 600
RGAVYIFHGA SRLEIMPSPS QRVTGSQLSL RLQYFGQSLS GGQDLTQDGL
610 620 630 640 650
VDLAVGAQGH VLLLRSLPLL KVELSIRFAP MEVAKAVYQC WERTPTVLEA
660 670 680 690 700
GEATVCLTVH KGSPDLLGNV QGSVRYDLAL DPGRLISRAI FDETKNCTLT
710 720 730 740 750
GRKTLGLGDH CETVKLLLPD CVEDAVSPII LRLNFSLVRD SASPRNLHPV
760 770 780 790 800
LAVGSQDHIT ASLPFEKNCK QELLCEGDLG ISFNFSGLQV LVVGGSPELT
810 820 830 840 850
VTVTVWNEGE DSYGTLVKFY YPAGLSYRRV TGTQQPHQYP LRLACEAEPA
860 870 880 890 900
AQEDLRSSSC SINHPIFREG AKTTFMITFD VSYKAFLGDR LLLRAKASSE
910 920 930 940 950
NNKPDTNKTA FQLELPVKYT VYTLISRQED STNHVNFSSS HGGRRQEAAH
960 970 980 990 1000
RYRVNNLSPL KLAVRVNFWV PVLLNGVAVW DVTLSSPAQG VSCVSQMKPP
1010 1020 1030 1040 1050
QNPDFLTQIQ RRSVLDCSIA DCLHFRCDIP SLDIQDELDF ILRGNLSFGW
1060 1070 1080 1090 1100
VSQTLQEKVL LVSEAEITFD TSVYSQLPGQ EAFLRAQVET TLEEYVVYEP
1110 1120 1130 1140 1150
IFLVAGSSVG GLLLLALITV VLYKLGFFKR QYKEMLDGKA ADPVTAGQAD
1160
FGCETPPYLV S
Length:1,161
Mass (Da):126,600
Last modified:May 1, 2000 - v1
Checksum:i2258491A984A705E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021334 mRNA. Translation: AAF21241.1.
RefSeqiNP_113879.1. NM_031691.1.
UniGeneiRn.34728.

Genome annotation databases

GeneIDi64350.
KEGGirno:64350.
UCSCiRGD:71075. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021334 mRNA. Translation: AAF21241.1.
RefSeqiNP_113879.1. NM_031691.1.
UniGeneiRn.34728.

3D structure databases

ProteinModelPortaliQ9QYE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026855.

Proteomic databases

PaxDbiQ9QYE7.
PRIDEiQ9QYE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64350.
KEGGirno:64350.
UCSCiRGD:71075. rat.

Organism-specific databases

CTDi3681.
RGDi71075. Itgad.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ9QYE7.
KOiK06594.
PhylomeDBiQ9QYE7.

Miscellaneous databases

PROiQ9QYE7.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITAD_RAT
AccessioniPrimary (citable) accession number: Q9QYE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.