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Protein

Golgin subfamily A member 5

Gene

Golga5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 5
Alternative name(s):
Golgin-84
Protein Ret-II
Protein Sumiko
Gene namesi
Name:Golga5
Synonyms:Retii
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1351475. Golga5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 696695CytoplasmicSequence analysisAdd
BLAST
Transmembranei697 – 71721Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini718 – 72912LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 729728Golgin subfamily A member 5PRO_0000190062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei27 – 271Dimethylated arginine; alternateBy similarity
Modified residuei27 – 271Omega-N-methylated arginine; alternateBy similarity
Modified residuei89 – 891Dimethylated arginine; alternateBy similarity
Modified residuei89 – 891Omega-N-methylated arginine; alternateBy similarity
Modified residuei116 – 1161PhosphoserineCombined sources

Post-translational modificationi

Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9QYE6.
MaxQBiQ9QYE6.
PaxDbiQ9QYE6.
PRIDEiQ9QYE6.

PTM databases

iPTMnetiQ9QYE6.
PhosphoSiteiQ9QYE6.

Expressioni

Gene expression databases

BgeeiQ9QYE6.
CleanExiMM_GOLGA5.
GenevisibleiQ9QYE6. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with RAB1A that has been activated by GTP-binding. Interacts with isoform CASP of CUX1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mcf2Q99N723EBI-644242,EBI-641874

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QYE6. 1 interaction.
MINTiMINT-1762194.
STRINGi10090.ENSMUSP00000021609.

Structurei

3D structure databases

ProteinModelPortaliQ9QYE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili215 – 629415Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi150 – 22374Ser-richAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4677. Eukaryota.
ENOG410XR4F. LUCA.
GeneTreeiENSGT00390000018470.
HOGENOMiHOG000273871.
HOVERGENiHBG051755.
InParanoidiQ9QYE6.
OMAiNRVDQGA.
OrthoDBiEOG74BJRQ.
PhylomeDBiQ9QYE6.
TreeFamiTF319468.

Family and domain databases

InterProiIPR019177. Golgin_subfamily_A_member_5.
[Graphical view]
PfamiPF09787. Golgin_A5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWFADLAGR AEDLLNRVDQ GAATALRKEN TSNIFYSKNT DYPELQQQNT
60 70 80 90 100
DSNYQTGQKA NYISSAADNI RHQKATILAG TANVKVGSRT VGDATHPTEH
110 120 130 140 150
ASAPRPSSQF VRRKKSEPDD ELLFDFLNSS QKEPTGRVEV KKEKGRAPVS
160 170 180 190 200
PSSPSGVSSV NTSVTTTKAM GGNAGSQSPG VNSSDSVPEV HKEPSEESTA
210 220 230 240 250
PSATSEEHSS TPSDGSSRSQ ELSNLRLENQ LLRNEVQSLN QEMASLLQRS
260 270 280 290 300
KETQEELNKA RVRVEKWNVD NSKSDRITRE LRAQVDDLTE AVAAKDSQLA
310 320 330 340 350
VLKVRLQEAD QVLSSRTEAL EALRSEKSRI MQDHKEGSSL QNQALQTLQE
360 370 380 390 400
RLHEADATLK REQESYKQMQ SEFAARLNKM EVDRQNLAEA VTLAERKYSE
410 420 430 440 450
EKKKVDELQQ QVKLHRASLE SAKQELVDYK QKATRILQSK EKLINSLKEG
460 470 480 490 500
SSFEGLESST ASSMELEELR HEKEMQKEEI QKLMGQMHQL RSELQDMEAQ
510 520 530 540 550
QVSEAESARE QLQDLQDQIA KQRTSKQELE TELERMKQEF RYMEEDLHRT
560 570 580 590 600
KNTLQSRIKD REEEIQKLRN QLTNKTLSNS SQSELESRLH QLTETLIQKQ
610 620 630 640 650
TMLESLSTEK NSLVFQLERL EQQVHSASSG PNSGSAINMS GVDSGEGTRL
660 670 680 690 700
RNVPVLFNDT ETNLAGMYGK VRKAASSIDQ FSIRLGIFLR RYPIARVFVI
710 720
IYMALLHLWV MIVLLTYSPE MHHDQPYGK
Length:729
Mass (Da):82,368
Last modified:July 3, 2003 - v2
Checksum:i8418BE8E6E4865E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931D → N in AAF21628 (Ref. 1) Curated
Sequence conflicti145 – 1451G → D in AAF21628 (Ref. 1) Curated
Sequence conflicti224 – 2241N → D in BAE31649 (PubMed:16141072).Curated
Sequence conflicti224 – 2241N → D in BAE31289 (PubMed:16141072).Curated
Sequence conflicti312 – 3121V → M in BAE23668 (PubMed:16141072).Curated
Sequence conflicti417 – 4171A → S in AAF21628 (Ref. 1) Curated
Sequence conflicti463 – 4631S → R in BAE40601 (PubMed:16141072).Curated
Sequence conflicti640 – 6401S → P in AAF21628 (Ref. 1) Curated
Sequence conflicti669 – 6691G → R in BAE31649 (PubMed:16141072).Curated
Sequence conflicti669 – 6691G → R in BAE31289 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026274 mRNA. Translation: AAF21628.1.
AB016784 mRNA. Translation: BAA33010.1.
AK138455 mRNA. Translation: BAE23668.1.
AK152533 mRNA. Translation: BAE31289.1.
AK153010 mRNA. Translation: BAE31649.1.
AK168765 mRNA. Translation: BAE40601.1.
BC016883 mRNA. Translation: AAH16883.1.
BC086782 mRNA. Translation: AAH86782.1.
CCDSiCCDS36526.1.
RefSeqiNP_001185933.1. NM_001199004.1.
NP_038775.1. NM_013747.4.
XP_006515998.1. XM_006515935.2.
UniGeneiMm.273370.

Genome annotation databases

EnsembliENSMUST00000021609; ENSMUSP00000021609; ENSMUSG00000021192.
ENSMUST00000179218; ENSMUSP00000137305; ENSMUSG00000021192.
GeneIDi27277.
KEGGimmu:27277.
UCSCiuc007oug.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026274 mRNA. Translation: AAF21628.1.
AB016784 mRNA. Translation: BAA33010.1.
AK138455 mRNA. Translation: BAE23668.1.
AK152533 mRNA. Translation: BAE31289.1.
AK153010 mRNA. Translation: BAE31649.1.
AK168765 mRNA. Translation: BAE40601.1.
BC016883 mRNA. Translation: AAH16883.1.
BC086782 mRNA. Translation: AAH86782.1.
CCDSiCCDS36526.1.
RefSeqiNP_001185933.1. NM_001199004.1.
NP_038775.1. NM_013747.4.
XP_006515998.1. XM_006515935.2.
UniGeneiMm.273370.

3D structure databases

ProteinModelPortaliQ9QYE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QYE6. 1 interaction.
MINTiMINT-1762194.
STRINGi10090.ENSMUSP00000021609.

PTM databases

iPTMnetiQ9QYE6.
PhosphoSiteiQ9QYE6.

Proteomic databases

EPDiQ9QYE6.
MaxQBiQ9QYE6.
PaxDbiQ9QYE6.
PRIDEiQ9QYE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021609; ENSMUSP00000021609; ENSMUSG00000021192.
ENSMUST00000179218; ENSMUSP00000137305; ENSMUSG00000021192.
GeneIDi27277.
KEGGimmu:27277.
UCSCiuc007oug.2. mouse.

Organism-specific databases

CTDi9950.
MGIiMGI:1351475. Golga5.

Phylogenomic databases

eggNOGiKOG4677. Eukaryota.
ENOG410XR4F. LUCA.
GeneTreeiENSGT00390000018470.
HOGENOMiHOG000273871.
HOVERGENiHBG051755.
InParanoidiQ9QYE6.
OMAiNRVDQGA.
OrthoDBiEOG74BJRQ.
PhylomeDBiQ9QYE6.
TreeFamiTF319468.

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.

Miscellaneous databases

ChiTaRSiGolga5. mouse.
PROiQ9QYE6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYE6.
CleanExiMM_GOLGA5.
GenevisibleiQ9QYE6. MM.

Family and domain databases

InterProiIPR019177. Golgin_subfamily_A_member_5.
[Graphical view]
PfamiPF09787. Golgin_A5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression of anti-immunoglobulin-induced apoptosis in B lymphoma cells by a novel nuclear protein."
    Ku P.T., You M.J., Cottam M.K., Bose H.R. Jr.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: B-cell lymphoma.
  2. "Unknown, 5' similar to RET-II mRNA."
    Snider J., Sano H., Ohta M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Kidney and Spinal cord.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Kidney.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiGOGA5_MOUSE
AccessioniPrimary (citable) accession number: Q9QYE6
Secondary accession number(s): O88317
, Q3TGE7, Q3U6S5, Q3UUF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.