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Q9QYE5

- JAG2_MOUSE

UniProt

Q9QYE5 - JAG2_MOUSE

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Protein

Protein jagged-2

Gene

Jag2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. growth factor activity Source: UniProtKB

GO - Biological processi

  1. auditory receptor cell fate commitment Source: UniProtKB
  2. cell fate determination Source: UniProtKB
  3. epithelial cell apoptotic process involved in palatal shelf morphogenesis Source: MGI
  4. gamma-delta T cell differentiation Source: UniProtKB
  5. in utero embryonic development Source: MGI
  6. morphogenesis of embryonic epithelium Source: MGI
  7. Notch signaling pathway Source: UniProtKB-KW
  8. odontogenesis of dentin-containing tooth Source: MGI
  9. regulation of cell adhesion Source: MGI
  10. regulation of cell proliferation Source: UniProtKB
  11. respiratory system process Source: MGI
  12. sensory perception of sound Source: UniProtKB
  13. skeletal system development Source: MGI
  14. spermatogenesis Source: Ensembl
  15. thymic T cell selection Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Gene namesi
Name:Jag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1098270. Jag2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 10821059ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1083 – 110321HelicalSequence AnalysisAdd
BLAST
Topological domaini1104 – 1247144CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane Source: MGI
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 12471224Protein jagged-2PRO_0000007630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi198 ↔ 207By similarity
Disulfide bondi211 ↔ 223By similarity
Disulfide bondi231 ↔ 240By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi276 ↔ 287By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi295 ↔ 304By similarity
Disulfide bondi311 ↔ 323By similarity
Disulfide bondi317 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi351 ↔ 362By similarity
Disulfide bondi356 ↔ 371By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi389 ↔ 400By similarity
Disulfide bondi394 ↔ 409By similarity
Disulfide bondi411 ↔ 420By similarity
Disulfide bondi427 ↔ 438By similarity
Disulfide bondi432 ↔ 447By similarity
Disulfide bondi449 ↔ 458By similarity
Disulfide bondi465 ↔ 475By similarity
Disulfide bondi469 ↔ 484By similarity
Disulfide bondi486 ↔ 495By similarity
Disulfide bondi502 ↔ 513By similarity
Disulfide bondi507 ↔ 522By similarity
Disulfide bondi524 ↔ 533By similarity
Disulfide bondi540 ↔ 551By similarity
Disulfide bondi545 ↔ 560By similarity
Disulfide bondi562 ↔ 571By similarity
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi589 ↔ 612Sequence Analysis
Disulfide bondi606 ↔ 622Sequence Analysis
Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi640 ↔ 651By similarity
Disulfide bondi645 ↔ 660By similarity
Disulfide bondi662 ↔ 671By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi683 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity
Disulfide bondi716 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 747By similarity
Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi755 ↔ 766By similarity
Disulfide bondi760 ↔ 775By similarity
Disulfide bondi777 ↔ 786By similarity
Disulfide bondi793 ↔ 804By similarity
Disulfide bondi798 ↔ 813By similarity
Disulfide bondi815 ↔ 824By similarity
Disulfide bondi831 ↔ 842By similarity
Disulfide bondi836 ↔ 851By similarity
Disulfide bondi853 ↔ 862By similarity
Glycosylationi1060 – 10601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9QYE5.

PTM databases

PhosphoSiteiQ9QYE5.

Expressioni

Tissue specificityi

Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression.1 Publication

Developmental stagei

At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues.

Gene expression databases

CleanExiMM_JAG2.
GenevestigatoriQ9QYE5.

Structurei

3D structure databases

ProteinModelPortaliQ9QYE5.
SMRiQ9QYE5. Positions 28-865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 24045DSLPROSITE-ProRule annotationAdd
BLAST
Domaini241 – 27434EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 30531EGF-like 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini307 – 34539EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini347 – 38337EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 42137EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini423 – 45937EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini461 – 49636EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini498 – 53437EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini536 – 57237EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini574 – 63461EGF-like 10; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini636 – 67237EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini674 – 71037EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini712 – 74837EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 78737EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini789 – 82537EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini827 – 86337EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 16 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9QYE5.
KOiK06052.
OMAiECDTYVR.
OrthoDBiEOG7BKCSS.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRARGWGRLP RRLLLLLVLC VQATRPMGYF ELQLSALRNV NGELLSGACC
60 70 80 90 100
DGDGRTTRAG GCGRDECDTY VRVCLKEYQA KVTPTGPCSY GYGATPVLGG
110 120 130 140 150
NSFYLPPAGA AGDRARARSR TGGHQDPGLV VIPFQFAWPR SFTLIVEAWD
160 170 180 190 200
WDNDTTPDEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE
210 220 230 240 250
NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN
260 270 280 290 300
LLHGGCTVPG ECRCSYGWQG KFCDECVPYP GCVHGSCVEP WHCDCETNWG
310 320 330 340 350
GLLCDKDLNY CGSHHPCVNG GTCINAEPDQ YLCACPDGYL GKNCERAEHA
360 370 380 390 400
CASNPCANGG SCHEVPSGFE CHCPSGWNGP TCALDIDECA SNPCAAGGTC
410 420 430 440 450
VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCL
460 470 480 490 500
PGWKGINCQI NINDCHGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELEYD
510 520 530 540 550
KCASSPCRRG GICEDLVDGF RCHCPRGLSG LHCEVDMDLC EPSPCLNGAR
560 570 580 590 600
CYNLEGDYYC ACPEDFGGKN CSVPRDTCPG GACRVIDGCG FEAGSRARGV
610 620 630 640 650
APSGICGPHG HCVSLPGGNF SCICDSGFTG TYCHENIDDC MGQPCRNGGT
660 670 680 690 700
CIDEVDSFRC FCPSGWEGEL CDINPNDCLP DPCHSRGRCY DLVNDFYCAC
710 720 730 740 750
DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCTIA
760 770 780 790 800
KNSSCVPNPC VNGGTCVGSG DSFSCICRDG WEGRTCTHNT NDCNPLPCYN
810 820 830 840 850
GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR
860 870 880 890 900
CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD
910 920 930 940 950
CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ PPCENWGECT
960 970 980 990 1000
AEEPLPPSTP CQPRSSHLDN NCARLTLRFN RDQVPQGTTV GAICSGIRAL
1010 1020 1030 1040 1050
PATRAAAHDR LLLLLCDRAS SGASAVEVAV SFSPARDLPD SSLIQSTAHA
1060 1070 1080 1090 1100
IVAAITQRGN SSLLLAVTEV KVETVVMGGS STGLLVPVLC SVFSVLWLAC
1110 1120 1130 1140 1150
VVICVWWTRK RRKERERSRL PRDESANNQW APLNPIRNPI ERPGGSGLGT
1160 1170 1180 1190 1200
GGHKDILYQC KNFTPPPRRA GEALPGPAGH GAGGEDEEDE ELSRGDGDSP
1210 1220 1230 1240
EAEKFISHKF TKDPSCSLGR PARWAPGPKV DNRAVRSTKD VRRAGRE
Length:1,247
Mass (Da):134,745
Last modified:October 3, 2012 - v2
Checksum:iE1352B1856946EA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021L → M in AAC14010. (PubMed:9341252)Curated
Sequence conflicti378 – 3781N → S in AAF16411. 1 PublicationCurated
Sequence conflicti378 – 3781N → S in AAC14010. (PubMed:9341252)Curated
Sequence conflicti378 – 3781N → S in CAA74835. (PubMed:9486542)Curated
Sequence conflicti461 – 4611N → T in AAC14010. (PubMed:9341252)Curated
Sequence conflicti469 – 47810CQHGGTCKDL → VSAWGHLQGP in AAC14010. (PubMed:9341252)Curated
Sequence conflicti492 – 4921G → V in AAC14010. (PubMed:9341252)Curated
Sequence conflicti546 – 5461L → F in AAC14010. (PubMed:9341252)Curated
Sequence conflicti549 – 5491A → V in AAC14010. (PubMed:9341252)Curated
Sequence conflicti735 – 7384RCAC → PAR in CAA74835. (PubMed:9486542)Curated
Sequence conflicti809 – 8091N → H in AAC14010. (PubMed:9341252)Curated
Sequence conflicti812 – 8121R → A in AAC14010. (PubMed:9341252)Curated
Sequence conflicti1030 – 10301V → M in AAF16411. 1 PublicationCurated
Sequence conflicti1126 – 11261A → T in AAF16411. 1 PublicationCurated
Sequence conflicti1223 – 12231R → C in AAF16411. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038572 mRNA. Translation: AAF16411.1.
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1.
Y14495 mRNA. Translation: CAA74835.1.
CCDSiCCDS26200.1.
RefSeqiNP_034718.2. NM_010588.2.
UniGeneiMm.186146.

Genome annotation databases

EnsembliENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799.
GeneIDi16450.
KEGGimmu:16450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038572 mRNA. Translation: AAF16411.1 .
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1 .
Y14495 mRNA. Translation: CAA74835.1 .
CCDSi CCDS26200.1.
RefSeqi NP_034718.2. NM_010588.2.
UniGenei Mm.186146.

3D structure databases

ProteinModelPortali Q9QYE5.
SMRi Q9QYE5. Positions 28-865.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYE5.

Proteomic databases

PRIDEi Q9QYE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075827 ; ENSMUSP00000075224 ; ENSMUSG00000002799 .
GeneIDi 16450.
KEGGi mmu:16450.

Organism-specific databases

CTDi 3714.
MGIi MGI:1098270. Jag2.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q9QYE5.
KOi K06052.
OMAi ECDTYVR.
OrthoDBi EOG7BKCSS.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Miscellaneous databases

NextBioi 289709.
PROi Q9QYE5.
SOURCEi Search...

Gene expression databases

CleanExi MM_JAG2.
Genevestigatori Q9QYE5.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tsai S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations."
    Lan Y., Jiang R., Shawber C., Weinmaster G., Gridley T.
    Mamm. Genome 8:875-876(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-819.
    Tissue: Brain.
  4. "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
    Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
    Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 325-759.
    Tissue: Brain.
  5. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
    Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
    Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiJAG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYE5
Secondary accession number(s): F8VPV5, O55139, O70219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3