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Q9QYE5 (JAG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein jagged-2

Short name=Jagged2
Gene names
Name:Jag2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression. Ref.5

Developmental stage

At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues.

Sequence similarities

Contains 1 DSL domain.

Contains 16 EGF-like domains.

Ontologies

Keywords
   Biological processNotch signaling pathway
   Cellular componentMembrane
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

auditory receptor cell fate commitment

Inferred from mutant phenotype PubMed 10080181. Source: UniProtKB

cell fate determination

Non-traceable author statement PubMed 10910909. Source: UniProtKB

epithelial cell apoptotic process involved in palatal shelf morphogenesis

Inferred from mutant phenotype PubMed 16607638. Source: MGI

gamma-delta T cell differentiation

Inferred from mutant phenotype PubMed 10383933. Source: UniProtKB

in utero embryonic development

Inferred from mutant phenotype PubMed 9531541. Source: MGI

morphogenesis of embryonic epithelium

Inferred from mutant phenotype PubMed 16607638. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 15721140. Source: MGI

regulation of cell adhesion

Inferred from mutant phenotype PubMed 16607638. Source: MGI

regulation of cell proliferation

Inferred from sequence or structural similarity PubMed 10383933. Source: UniProtKB

respiratory system process

Inferred from mutant phenotype PubMed 9531541. Source: MGI

sensory perception of sound

Non-traceable author statement PubMed 10080181. Source: UniProtKB

skeletal system development

Inferred from mutant phenotype PubMed 15721140. Source: MGI

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

thymic T cell selection

Inferred from sequence or structural similarity PubMed 10383933. Source: UniProtKB

   Cellular_componentintegral component of plasma membrane

Inferred from direct assay PubMed 10910909. Source: UniProtKB

membrane

Inferred from direct assay PubMed 15886206. Source: MGI

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

growth factor activity

Inferred from sequence or structural similarity PubMed 10383933. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 12496659. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 12471224Protein jagged-2
PRO_0000007630

Regions

Topological domain24 – 10821059Extracellular Potential
Transmembrane1083 – 110321Helical; Potential
Topological domain1104 – 1247144Cytoplasmic Potential
Domain196 – 24045DSL
Domain241 – 27434EGF-like 1
Domain275 – 30531EGF-like 2; atypical
Domain307 – 34539EGF-like 3
Domain347 – 38337EGF-like 4
Domain385 – 42137EGF-like 5; calcium-binding Potential
Domain423 – 45937EGF-like 6; calcium-binding Potential
Domain461 – 49636EGF-like 7; calcium-binding Potential
Domain498 – 53437EGF-like 8
Domain536 – 57237EGF-like 9
Domain574 – 63461EGF-like 10; atypical
Domain636 – 67237EGF-like 11; calcium-binding Potential
Domain674 – 71037EGF-like 12; calcium-binding Potential
Domain712 – 74837EGF-like 13
Domain751 – 78737EGF-like 14
Domain789 – 82537EGF-like 15; calcium-binding Potential
Domain827 – 86337EGF-like 16; calcium-binding Potential

Amino acid modifications

Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation5701N-linked (GlcNAc...) Potential
Glycosylation6191N-linked (GlcNAc...) Potential
Glycosylation7521N-linked (GlcNAc...) Potential
Glycosylation10601N-linked (GlcNAc...) Potential
Disulfide bond198 ↔ 207 By similarity
Disulfide bond211 ↔ 223 By similarity
Disulfide bond231 ↔ 240 By similarity
Disulfide bond245 ↔ 256 By similarity
Disulfide bond249 ↔ 262 By similarity
Disulfide bond264 ↔ 273 By similarity
Disulfide bond276 ↔ 287 By similarity
Disulfide bond282 ↔ 293 By similarity
Disulfide bond295 ↔ 304 By similarity
Disulfide bond311 ↔ 323 By similarity
Disulfide bond317 ↔ 333 By similarity
Disulfide bond335 ↔ 344 By similarity
Disulfide bond351 ↔ 362 By similarity
Disulfide bond356 ↔ 371 By similarity
Disulfide bond373 ↔ 382 By similarity
Disulfide bond389 ↔ 400 By similarity
Disulfide bond394 ↔ 409 By similarity
Disulfide bond411 ↔ 420 By similarity
Disulfide bond427 ↔ 438 By similarity
Disulfide bond432 ↔ 447 By similarity
Disulfide bond449 ↔ 458 By similarity
Disulfide bond465 ↔ 475 By similarity
Disulfide bond469 ↔ 484 By similarity
Disulfide bond486 ↔ 495 By similarity
Disulfide bond502 ↔ 513 By similarity
Disulfide bond507 ↔ 522 By similarity
Disulfide bond524 ↔ 533 By similarity
Disulfide bond540 ↔ 551 By similarity
Disulfide bond545 ↔ 560 By similarity
Disulfide bond562 ↔ 571 By similarity
Disulfide bond589 ↔ 612 Potential
Disulfide bond606 ↔ 622 Potential
Disulfide bond624 ↔ 633 By similarity
Disulfide bond640 ↔ 651 By similarity
Disulfide bond645 ↔ 660 By similarity
Disulfide bond662 ↔ 671 By similarity
Disulfide bond678 ↔ 689 By similarity
Disulfide bond683 ↔ 698 By similarity
Disulfide bond700 ↔ 709 By similarity
Disulfide bond716 ↔ 727 By similarity
Disulfide bond721 ↔ 736 By similarity
Disulfide bond738 ↔ 747 By similarity
Disulfide bond755 ↔ 766 By similarity
Disulfide bond760 ↔ 775 By similarity
Disulfide bond777 ↔ 786 By similarity
Disulfide bond793 ↔ 804 By similarity
Disulfide bond798 ↔ 813 By similarity
Disulfide bond815 ↔ 824 By similarity
Disulfide bond831 ↔ 842 By similarity
Disulfide bond836 ↔ 851 By similarity
Disulfide bond853 ↔ 862 By similarity

Experimental info

Sequence conflict3021L → M in AAC14010. Ref.3
Sequence conflict3781N → S in AAF16411. Ref.1
Sequence conflict3781N → S in AAC14010. Ref.3
Sequence conflict3781N → S in CAA74835. Ref.4
Sequence conflict4611N → T in AAC14010. Ref.3
Sequence conflict469 – 47810CQHGGTCKDL → VSAWGHLQGP in AAC14010. Ref.3
Sequence conflict4921G → V in AAC14010. Ref.3
Sequence conflict5461L → F in AAC14010. Ref.3
Sequence conflict5491A → V in AAC14010. Ref.3
Sequence conflict735 – 7384RCAC → PAR in CAA74835. Ref.4
Sequence conflict8091N → H in AAC14010. Ref.3
Sequence conflict8121R → A in AAC14010. Ref.3
Sequence conflict10301V → M in AAF16411. Ref.1
Sequence conflict11261A → T in AAF16411. Ref.1
Sequence conflict12231R → C in AAF16411. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9QYE5 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: E1352B1856946EA6

FASTA1,247134,745
        10         20         30         40         50         60 
MRARGWGRLP RRLLLLLVLC VQATRPMGYF ELQLSALRNV NGELLSGACC DGDGRTTRAG 

        70         80         90        100        110        120 
GCGRDECDTY VRVCLKEYQA KVTPTGPCSY GYGATPVLGG NSFYLPPAGA AGDRARARSR 

       130        140        150        160        170        180 
TGGHQDPGLV VIPFQFAWPR SFTLIVEAWD WDNDTTPDEE LLIERVSHAG MINPEDRWKS 

       190        200        210        220        230        240 
LHFSGHVAHL ELQIRVRCDE NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC 

       250        260        270        280        290        300 
KEAVCKQGCN LLHGGCTVPG ECRCSYGWQG KFCDECVPYP GCVHGSCVEP WHCDCETNWG 

       310        320        330        340        350        360 
GLLCDKDLNY CGSHHPCVNG GTCINAEPDQ YLCACPDGYL GKNCERAEHA CASNPCANGG 

       370        380        390        400        410        420 
SCHEVPSGFE CHCPSGWNGP TCALDIDECA SNPCAAGGTC VDQVDGFECI CPEQWVGATC 

       430        440        450        460        470        480 
QLDANECEGK PCLNAFSCKN LIGGYYCDCL PGWKGINCQI NINDCHGQCQ HGGTCKDLVN 

       490        500        510        520        530        540 
GYQCVCPRGF GGRHCELEYD KCASSPCRRG GICEDLVDGF RCHCPRGLSG LHCEVDMDLC 

       550        560        570        580        590        600 
EPSPCLNGAR CYNLEGDYYC ACPEDFGGKN CSVPRDTCPG GACRVIDGCG FEAGSRARGV 

       610        620        630        640        650        660 
APSGICGPHG HCVSLPGGNF SCICDSGFTG TYCHENIDDC MGQPCRNGGT CIDEVDSFRC 

       670        680        690        700        710        720 
FCPSGWEGEL CDINPNDCLP DPCHSRGRCY DLVNDFYCAC DDGWKGKTCH SREFQCDAYT 

       730        740        750        760        770        780 
CSNGGTCYDS GDTFRCACPP GWKGSTCTIA KNSSCVPNPC VNGGTCVGSG DSFSCICRDG 

       790        800        810        820        830        840 
WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA 

       850        860        870        880        890        900 
TCVDEINGYR CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD 

       910        920        930        940        950        960 
CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ PPCENWGECT AEEPLPPSTP 

       970        980        990       1000       1010       1020 
CQPRSSHLDN NCARLTLRFN RDQVPQGTTV GAICSGIRAL PATRAAAHDR LLLLLCDRAS 

      1030       1040       1050       1060       1070       1080 
SGASAVEVAV SFSPARDLPD SSLIQSTAHA IVAAITQRGN SSLLLAVTEV KVETVVMGGS 

      1090       1100       1110       1120       1130       1140 
STGLLVPVLC SVFSVLWLAC VVICVWWTRK RRKERERSRL PRDESANNQW APLNPIRNPI 

      1150       1160       1170       1180       1190       1200 
ERPGGSGLGT GGHKDILYQC KNFTPPPRRA GEALPGPAGH GAGGEDEEDE ELSRGDGDSP 

      1210       1220       1230       1240 
EAEKFISHKF TKDPSCSLGR PARWAPGPKV DNRAVRSTKD VRRAGRE 

« Hide

References

« Hide 'large scale' references
[1]Tsai S.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster / NIH.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations."
Lan Y., Jiang R., Shawber C., Weinmaster G., Gridley T.
Mamm. Genome 8:875-876(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-819.
Tissue: Brain.
[4]"JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 325-759.
Tissue: Brain.
[5]"Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038572 mRNA. Translation: AAF16411.1.
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1.
Y14495 mRNA. Translation: CAA74835.1.
CCDSCCDS26200.1.
RefSeqNP_034718.2. NM_010588.2.
UniGeneMm.186146.

3D structure databases

ProteinModelPortalQ9QYE5.
SMRQ9QYE5. Positions 28-865, 920-973.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QYE5.

Proteomic databases

PRIDEQ9QYE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799.
GeneID16450.
KEGGmmu:16450.

Organism-specific databases

CTD3714.
MGIMGI:1098270. Jag2.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00740000114998.
HOGENOMHOG000113124.
HOVERGENHBG031645.
InParanoidQ9QYE5.
KOK06052.
OMAECDTYVR.
OrthoDBEOG7BKCSS.
TreeFamTF351835.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

CleanExMM_JAG2.
GenevestigatorQ9QYE5.

Family and domain databases

InterProIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSPR02059. JAGGEDFAMILY.
SMARTSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio289709.
PROQ9QYE5.
SOURCESearch...

Entry information

Entry nameJAG2_MOUSE
AccessionPrimary (citable) accession number: Q9QYE5
Secondary accession number(s): F8VPV5, O55139, O70219
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot