Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QYE5

- JAG2_MOUSE

UniProt

Q9QYE5 - JAG2_MOUSE

Protein

Protein jagged-2

Gene

Jag2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. growth factor activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. auditory receptor cell fate commitment Source: UniProtKB
    2. cell fate determination Source: UniProtKB
    3. epithelial cell apoptotic process involved in palatal shelf morphogenesis Source: MGI
    4. gamma-delta T cell differentiation Source: UniProtKB
    5. in utero embryonic development Source: MGI
    6. morphogenesis of embryonic epithelium Source: MGI
    7. Notch signaling pathway Source: UniProtKB-KW
    8. odontogenesis of dentin-containing tooth Source: MGI
    9. regulation of cell adhesion Source: MGI
    10. regulation of cell proliferation Source: UniProtKB
    11. respiratory system process Source: MGI
    12. sensory perception of sound Source: UniProtKB
    13. skeletal system development Source: MGI
    14. spermatogenesis Source: Ensembl
    15. thymic T cell selection Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Notch signaling pathway

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein jagged-2
    Short name:
    Jagged2
    Gene namesi
    Name:Jag2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1098270. Jag2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. membrane Source: MGI
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 12471224Protein jagged-2PRO_0000007630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi198 ↔ 207By similarity
    Disulfide bondi211 ↔ 223By similarity
    Disulfide bondi231 ↔ 240By similarity
    Disulfide bondi245 ↔ 256By similarity
    Disulfide bondi249 ↔ 262By similarity
    Disulfide bondi264 ↔ 273By similarity
    Disulfide bondi276 ↔ 287By similarity
    Disulfide bondi282 ↔ 293By similarity
    Disulfide bondi295 ↔ 304By similarity
    Disulfide bondi311 ↔ 323By similarity
    Disulfide bondi317 ↔ 333By similarity
    Disulfide bondi335 ↔ 344By similarity
    Disulfide bondi351 ↔ 362By similarity
    Disulfide bondi356 ↔ 371By similarity
    Disulfide bondi373 ↔ 382By similarity
    Disulfide bondi389 ↔ 400By similarity
    Disulfide bondi394 ↔ 409By similarity
    Disulfide bondi411 ↔ 420By similarity
    Disulfide bondi427 ↔ 438By similarity
    Disulfide bondi432 ↔ 447By similarity
    Disulfide bondi449 ↔ 458By similarity
    Disulfide bondi465 ↔ 475By similarity
    Disulfide bondi469 ↔ 484By similarity
    Disulfide bondi486 ↔ 495By similarity
    Disulfide bondi502 ↔ 513By similarity
    Disulfide bondi507 ↔ 522By similarity
    Disulfide bondi524 ↔ 533By similarity
    Disulfide bondi540 ↔ 551By similarity
    Disulfide bondi545 ↔ 560By similarity
    Disulfide bondi562 ↔ 571By similarity
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi589 ↔ 612Sequence Analysis
    Disulfide bondi606 ↔ 622Sequence Analysis
    Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi624 ↔ 633By similarity
    Disulfide bondi640 ↔ 651By similarity
    Disulfide bondi645 ↔ 660By similarity
    Disulfide bondi662 ↔ 671By similarity
    Disulfide bondi678 ↔ 689By similarity
    Disulfide bondi683 ↔ 698By similarity
    Disulfide bondi700 ↔ 709By similarity
    Disulfide bondi716 ↔ 727By similarity
    Disulfide bondi721 ↔ 736By similarity
    Disulfide bondi738 ↔ 747By similarity
    Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi755 ↔ 766By similarity
    Disulfide bondi760 ↔ 775By similarity
    Disulfide bondi777 ↔ 786By similarity
    Disulfide bondi793 ↔ 804By similarity
    Disulfide bondi798 ↔ 813By similarity
    Disulfide bondi815 ↔ 824By similarity
    Disulfide bondi831 ↔ 842By similarity
    Disulfide bondi836 ↔ 851By similarity
    Disulfide bondi853 ↔ 862By similarity
    Glycosylationi1060 – 10601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9QYE5.

    PTM databases

    PhosphoSiteiQ9QYE5.

    Expressioni

    Tissue specificityi

    Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression.1 Publication

    Developmental stagei

    At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues.

    Gene expression databases

    CleanExiMM_JAG2.
    GenevestigatoriQ9QYE5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYE5.
    SMRiQ9QYE5. Positions 28-865, 920-973.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 10821059ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1104 – 1247144CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1083 – 110321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini196 – 24045DSLPROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 27434EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 30531EGF-like 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini307 – 34539EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini347 – 38337EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 42137EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 45937EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini461 – 49636EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini498 – 53437EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini536 – 57237EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini574 – 63461EGF-like 10; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini636 – 67237EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini674 – 71037EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini712 – 74837EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini751 – 78737EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini789 – 82537EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini827 – 86337EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DSL domain.PROSITE-ProRule annotation
    Contains 16 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00740000114998.
    HOGENOMiHOG000113124.
    HOVERGENiHBG031645.
    InParanoidiQ9QYE5.
    KOiK06052.
    OMAiECDTYVR.
    OrthoDBiEOG7BKCSS.
    TreeFamiTF351835.

    Family and domain databases

    InterProiIPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF01414. DSL. 1 hit.
    PF00008. EGF. 9 hits.
    PF07645. EGF_CA. 1 hit.
    PF07657. MNNL. 1 hit.
    [Graphical view]
    PRINTSiPR02059. JAGGEDFAMILY.
    SMARTiSM00051. DSL. 1 hit.
    SM00181. EGF. 6 hits.
    SM00179. EGF_CA. 9 hits.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 11 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRARGWGRLP RRLLLLLVLC VQATRPMGYF ELQLSALRNV NGELLSGACC     50
    DGDGRTTRAG GCGRDECDTY VRVCLKEYQA KVTPTGPCSY GYGATPVLGG 100
    NSFYLPPAGA AGDRARARSR TGGHQDPGLV VIPFQFAWPR SFTLIVEAWD 150
    WDNDTTPDEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE 200
    NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN 250
    LLHGGCTVPG ECRCSYGWQG KFCDECVPYP GCVHGSCVEP WHCDCETNWG 300
    GLLCDKDLNY CGSHHPCVNG GTCINAEPDQ YLCACPDGYL GKNCERAEHA 350
    CASNPCANGG SCHEVPSGFE CHCPSGWNGP TCALDIDECA SNPCAAGGTC 400
    VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCL 450
    PGWKGINCQI NINDCHGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELEYD 500
    KCASSPCRRG GICEDLVDGF RCHCPRGLSG LHCEVDMDLC EPSPCLNGAR 550
    CYNLEGDYYC ACPEDFGGKN CSVPRDTCPG GACRVIDGCG FEAGSRARGV 600
    APSGICGPHG HCVSLPGGNF SCICDSGFTG TYCHENIDDC MGQPCRNGGT 650
    CIDEVDSFRC FCPSGWEGEL CDINPNDCLP DPCHSRGRCY DLVNDFYCAC 700
    DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCTIA 750
    KNSSCVPNPC VNGGTCVGSG DSFSCICRDG WEGRTCTHNT NDCNPLPCYN 800
    GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR 850
    CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD 900
    CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ PPCENWGECT 950
    AEEPLPPSTP CQPRSSHLDN NCARLTLRFN RDQVPQGTTV GAICSGIRAL 1000
    PATRAAAHDR LLLLLCDRAS SGASAVEVAV SFSPARDLPD SSLIQSTAHA 1050
    IVAAITQRGN SSLLLAVTEV KVETVVMGGS STGLLVPVLC SVFSVLWLAC 1100
    VVICVWWTRK RRKERERSRL PRDESANNQW APLNPIRNPI ERPGGSGLGT 1150
    GGHKDILYQC KNFTPPPRRA GEALPGPAGH GAGGEDEEDE ELSRGDGDSP 1200
    EAEKFISHKF TKDPSCSLGR PARWAPGPKV DNRAVRSTKD VRRAGRE 1247
    Length:1,247
    Mass (Da):134,745
    Last modified:October 3, 2012 - v2
    Checksum:iE1352B1856946EA6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti302 – 3021L → M in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti378 – 3781N → S in AAF16411. 1 PublicationCurated
    Sequence conflicti378 – 3781N → S in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti378 – 3781N → S in CAA74835. (PubMed:9486542)Curated
    Sequence conflicti461 – 4611N → T in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti469 – 47810CQHGGTCKDL → VSAWGHLQGP in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti492 – 4921G → V in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti546 – 5461L → F in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti549 – 5491A → V in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti735 – 7384RCAC → PAR in CAA74835. (PubMed:9486542)Curated
    Sequence conflicti809 – 8091N → H in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti812 – 8121R → A in AAC14010. (PubMed:9341252)Curated
    Sequence conflicti1030 – 10301V → M in AAF16411. 1 PublicationCurated
    Sequence conflicti1126 – 11261A → T in AAF16411. 1 PublicationCurated
    Sequence conflicti1223 – 12231R → C in AAF16411. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038572 mRNA. Translation: AAF16411.1.
    AC160929 Genomic DNA. No translation available.
    AF010137 mRNA. Translation: AAC14010.1.
    Y14495 mRNA. Translation: CAA74835.1.
    CCDSiCCDS26200.1.
    RefSeqiNP_034718.2. NM_010588.2.
    UniGeneiMm.186146.

    Genome annotation databases

    EnsembliENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799.
    GeneIDi16450.
    KEGGimmu:16450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038572 mRNA. Translation: AAF16411.1 .
    AC160929 Genomic DNA. No translation available.
    AF010137 mRNA. Translation: AAC14010.1 .
    Y14495 mRNA. Translation: CAA74835.1 .
    CCDSi CCDS26200.1.
    RefSeqi NP_034718.2. NM_010588.2.
    UniGenei Mm.186146.

    3D structure databases

    ProteinModelPortali Q9QYE5.
    SMRi Q9QYE5. Positions 28-865, 920-973.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QYE5.

    Proteomic databases

    PRIDEi Q9QYE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075827 ; ENSMUSP00000075224 ; ENSMUSG00000002799 .
    GeneIDi 16450.
    KEGGi mmu:16450.

    Organism-specific databases

    CTDi 3714.
    MGIi MGI:1098270. Jag2.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00740000114998.
    HOGENOMi HOG000113124.
    HOVERGENi HBG031645.
    InParanoidi Q9QYE5.
    KOi K06052.
    OMAi ECDTYVR.
    OrthoDBi EOG7BKCSS.
    TreeFami TF351835.

    Enzyme and pathway databases

    Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.

    Miscellaneous databases

    NextBioi 289709.
    PROi Q9QYE5.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_JAG2.
    Genevestigatori Q9QYE5.

    Family and domain databases

    InterProi IPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF01414. DSL. 1 hit.
    PF00008. EGF. 9 hits.
    PF07645. EGF_CA. 1 hit.
    PF07657. MNNL. 1 hit.
    [Graphical view ]
    PRINTSi PR02059. JAGGEDFAMILY.
    SMARTi SM00051. DSL. 1 hit.
    SM00181. EGF. 6 hits.
    SM00179. EGF_CA. 9 hits.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 11 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tsai S.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster / NIH.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations."
      Lan Y., Jiang R., Shawber C., Weinmaster G., Gridley T.
      Mamm. Genome 8:875-876(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-819.
      Tissue: Brain.
    4. "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
      Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
      Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 325-759.
      Tissue: Brain.
    5. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
      Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
      Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiJAG2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYE5
    Secondary accession number(s): F8VPV5, O55139, O70219
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3