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Protein

Protein jagged-2

Gene

Jag2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • growth factor activity Source: UniProtKB
  • Notch binding Source: UniProtKB

GO - Biological processi

  • auditory receptor cell fate commitment Source: UniProtKB
  • cell differentiation Source: MGI
  • cell fate determination Source: UniProtKB
  • epithelial cell apoptotic process involved in palatal shelf morphogenesis Source: MGI
  • gamma-delta T cell differentiation Source: UniProtKB
  • in utero embryonic development Source: MGI
  • morphogenesis of embryonic epithelium Source: MGI
  • Notch signaling pathway Source: Reactome
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • regulation of cell adhesion Source: MGI
  • regulation of cell proliferation Source: UniProtKB
  • respiratory system process Source: MGI
  • sensory perception of sound Source: UniProtKB
  • skeletal system development Source: MGI
  • spermatogenesis Source: Ensembl
  • T cell differentiation Source: MGI
  • thymic T cell selection Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-1980148. Signaling by NOTCH3.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-MMU-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Gene namesi
Name:Jag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1098270. Jag2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 1082ExtracellularSequence analysisAdd BLAST1059
Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Topological domaini1104 – 1247CytoplasmicSequence analysisAdd BLAST144

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000763024 – 1247Protein jagged-2Add BLAST1224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi198 ↔ 207By similarity
Disulfide bondi211 ↔ 223By similarity
Disulfide bondi231 ↔ 240By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi276 ↔ 287By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi295 ↔ 304By similarity
Disulfide bondi311 ↔ 323By similarity
Disulfide bondi317 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi351 ↔ 362By similarity
Disulfide bondi356 ↔ 371By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi389 ↔ 400By similarity
Disulfide bondi394 ↔ 409By similarity
Disulfide bondi411 ↔ 420By similarity
Disulfide bondi427 ↔ 438By similarity
Disulfide bondi432 ↔ 447By similarity
Disulfide bondi449 ↔ 458By similarity
Disulfide bondi465 ↔ 475By similarity
Disulfide bondi469 ↔ 484By similarity
Disulfide bondi486 ↔ 495By similarity
Disulfide bondi502 ↔ 513By similarity
Disulfide bondi507 ↔ 522By similarity
Disulfide bondi524 ↔ 533By similarity
Disulfide bondi540 ↔ 551By similarity
Disulfide bondi545 ↔ 560By similarity
Disulfide bondi562 ↔ 571By similarity
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi589 ↔ 612Sequence analysis
Disulfide bondi606 ↔ 622Sequence analysis
Glycosylationi619N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi640 ↔ 651By similarity
Disulfide bondi645 ↔ 660By similarity
Disulfide bondi662 ↔ 671By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi683 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity
Disulfide bondi716 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 747By similarity
Glycosylationi752N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi755 ↔ 766By similarity
Disulfide bondi760 ↔ 775By similarity
Disulfide bondi777 ↔ 786By similarity
Disulfide bondi793 ↔ 804By similarity
Disulfide bondi798 ↔ 813By similarity
Disulfide bondi815 ↔ 824By similarity
Disulfide bondi831 ↔ 842By similarity
Disulfide bondi836 ↔ 851By similarity
Disulfide bondi853 ↔ 862By similarity
Glycosylationi1060N-linked (GlcNAc...)Sequence analysis1
Modified residuei1125PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QYE5.
PeptideAtlasiQ9QYE5.
PRIDEiQ9QYE5.

PTM databases

PhosphoSitePlusiQ9QYE5.

Expressioni

Tissue specificityi

Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression.1 Publication

Developmental stagei

At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues.

Gene expression databases

BgeeiENSMUSG00000002799.
CleanExiMM_JAG2.
GenevisibleiQ9QYE5. MM.

Interactioni

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • Notch binding Source: UniProtKB

Protein-protein interaction databases

BioGridi200855. 1 interactor.
STRINGi10090.ENSMUSP00000075224.

Structurei

3D structure databases

ProteinModelPortaliQ9QYE5.
SMRiQ9QYE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 240DSLPROSITE-ProRule annotationAdd BLAST45
Domaini241 – 274EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini275 – 305EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini307 – 345EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini347 – 383EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini385 – 421EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini423 – 459EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini461 – 496EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini498 – 534EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini536 – 572EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini574 – 634EGF-like 10; atypicalPROSITE-ProRule annotationAdd BLAST61
Domaini636 – 672EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini674 – 710EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini712 – 748EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini751 – 787EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini789 – 825EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini827 – 863EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 16 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9QYE5.
KOiK06052.
OMAiHHPCTNG.
OrthoDBiEOG091G0A88.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR033108. Jag2.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR24044:SF316. PTHR24044:SF316. 1 hit.
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 3 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARGWGRLP RRLLLLLVLC VQATRPMGYF ELQLSALRNV NGELLSGACC
60 70 80 90 100
DGDGRTTRAG GCGRDECDTY VRVCLKEYQA KVTPTGPCSY GYGATPVLGG
110 120 130 140 150
NSFYLPPAGA AGDRARARSR TGGHQDPGLV VIPFQFAWPR SFTLIVEAWD
160 170 180 190 200
WDNDTTPDEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE
210 220 230 240 250
NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN
260 270 280 290 300
LLHGGCTVPG ECRCSYGWQG KFCDECVPYP GCVHGSCVEP WHCDCETNWG
310 320 330 340 350
GLLCDKDLNY CGSHHPCVNG GTCINAEPDQ YLCACPDGYL GKNCERAEHA
360 370 380 390 400
CASNPCANGG SCHEVPSGFE CHCPSGWNGP TCALDIDECA SNPCAAGGTC
410 420 430 440 450
VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCL
460 470 480 490 500
PGWKGINCQI NINDCHGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELEYD
510 520 530 540 550
KCASSPCRRG GICEDLVDGF RCHCPRGLSG LHCEVDMDLC EPSPCLNGAR
560 570 580 590 600
CYNLEGDYYC ACPEDFGGKN CSVPRDTCPG GACRVIDGCG FEAGSRARGV
610 620 630 640 650
APSGICGPHG HCVSLPGGNF SCICDSGFTG TYCHENIDDC MGQPCRNGGT
660 670 680 690 700
CIDEVDSFRC FCPSGWEGEL CDINPNDCLP DPCHSRGRCY DLVNDFYCAC
710 720 730 740 750
DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCTIA
760 770 780 790 800
KNSSCVPNPC VNGGTCVGSG DSFSCICRDG WEGRTCTHNT NDCNPLPCYN
810 820 830 840 850
GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR
860 870 880 890 900
CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD
910 920 930 940 950
CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ PPCENWGECT
960 970 980 990 1000
AEEPLPPSTP CQPRSSHLDN NCARLTLRFN RDQVPQGTTV GAICSGIRAL
1010 1020 1030 1040 1050
PATRAAAHDR LLLLLCDRAS SGASAVEVAV SFSPARDLPD SSLIQSTAHA
1060 1070 1080 1090 1100
IVAAITQRGN SSLLLAVTEV KVETVVMGGS STGLLVPVLC SVFSVLWLAC
1110 1120 1130 1140 1150
VVICVWWTRK RRKERERSRL PRDESANNQW APLNPIRNPI ERPGGSGLGT
1160 1170 1180 1190 1200
GGHKDILYQC KNFTPPPRRA GEALPGPAGH GAGGEDEEDE ELSRGDGDSP
1210 1220 1230 1240
EAEKFISHKF TKDPSCSLGR PARWAPGPKV DNRAVRSTKD VRRAGRE
Length:1,247
Mass (Da):134,745
Last modified:October 3, 2012 - v2
Checksum:iE1352B1856946EA6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302L → M in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti378N → S in AAF16411 (Ref. 1) Curated1
Sequence conflicti378N → S in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti378N → S in CAA74835 (PubMed:9486542).Curated1
Sequence conflicti461N → T in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti469 – 478CQHGGTCKDL → VSAWGHLQGP in AAC14010 (PubMed:9341252).Curated10
Sequence conflicti492G → V in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti546L → F in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti549A → V in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti735 – 738RCAC → PAR in CAA74835 (PubMed:9486542).Curated4
Sequence conflicti809N → H in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti812R → A in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti1030V → M in AAF16411 (Ref. 1) Curated1
Sequence conflicti1126A → T in AAF16411 (Ref. 1) Curated1
Sequence conflicti1223R → C in AAF16411 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038572 mRNA. Translation: AAF16411.1.
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1.
Y14495 mRNA. Translation: CAA74835.1.
CCDSiCCDS26200.1.
RefSeqiNP_034718.2. NM_010588.2.
UniGeneiMm.186146.

Genome annotation databases

EnsembliENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799.
GeneIDi16450.
KEGGimmu:16450.
UCSCiuc007pfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038572 mRNA. Translation: AAF16411.1.
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1.
Y14495 mRNA. Translation: CAA74835.1.
CCDSiCCDS26200.1.
RefSeqiNP_034718.2. NM_010588.2.
UniGeneiMm.186146.

3D structure databases

ProteinModelPortaliQ9QYE5.
SMRiQ9QYE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200855. 1 interactor.
STRINGi10090.ENSMUSP00000075224.

PTM databases

PhosphoSitePlusiQ9QYE5.

Proteomic databases

PaxDbiQ9QYE5.
PeptideAtlasiQ9QYE5.
PRIDEiQ9QYE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799.
GeneIDi16450.
KEGGimmu:16450.
UCSCiuc007pfl.1. mouse.

Organism-specific databases

CTDi3714.
MGIiMGI:1098270. Jag2.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9QYE5.
KOiK06052.
OMAiHHPCTNG.
OrthoDBiEOG091G0A88.
TreeFamiTF351835.

Enzyme and pathway databases

ReactomeiR-MMU-1980148. Signaling by NOTCH3.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-MMU-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Miscellaneous databases

PROiQ9QYE5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002799.
CleanExiMM_JAG2.
GenevisibleiQ9QYE5. MM.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR033108. Jag2.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR24044:SF316. PTHR24044:SF316. 1 hit.
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 3 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJAG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYE5
Secondary accession number(s): F8VPV5, O55139, O70219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.