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Q9QYE5

- JAG2_MOUSE

UniProt

Q9QYE5 - JAG2_MOUSE

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Protein

Protein jagged-2

Gene
Jag2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. growth factor activity Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. auditory receptor cell fate commitment Source: UniProtKB
  2. cell fate determination Source: UniProtKB
  3. epithelial cell apoptotic process involved in palatal shelf morphogenesis Source: MGI
  4. gamma-delta T cell differentiation Source: UniProtKB
  5. in utero embryonic development Source: MGI
  6. morphogenesis of embryonic epithelium Source: MGI
  7. Notch signaling pathway Source: UniProtKB-KW
  8. odontogenesis of dentin-containing tooth Source: MGI
  9. regulation of cell adhesion Source: MGI
  10. regulation of cell proliferation Source: UniProtKB
  11. respiratory system process Source: MGI
  12. sensory perception of sound Source: UniProtKB
  13. skeletal system development Source: MGI
  14. spermatogenesis Source: Ensembl
  15. thymic T cell selection Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Gene namesi
Name:Jag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1098270. Jag2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 10821059Extracellular Reviewed predictionAdd
BLAST
Transmembranei1083 – 110321Helical; Reviewed predictionAdd
BLAST
Topological domaini1104 – 1247144Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane Source: MGI
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 12471224Protein jagged-2PRO_0000007630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi198 ↔ 207 By similarity
Disulfide bondi211 ↔ 223 By similarity
Disulfide bondi231 ↔ 240 By similarity
Disulfide bondi245 ↔ 256 By similarity
Disulfide bondi249 ↔ 262 By similarity
Disulfide bondi264 ↔ 273 By similarity
Disulfide bondi276 ↔ 287 By similarity
Disulfide bondi282 ↔ 293 By similarity
Disulfide bondi295 ↔ 304 By similarity
Disulfide bondi311 ↔ 323 By similarity
Disulfide bondi317 ↔ 333 By similarity
Disulfide bondi335 ↔ 344 By similarity
Disulfide bondi351 ↔ 362 By similarity
Disulfide bondi356 ↔ 371 By similarity
Disulfide bondi373 ↔ 382 By similarity
Disulfide bondi389 ↔ 400 By similarity
Disulfide bondi394 ↔ 409 By similarity
Disulfide bondi411 ↔ 420 By similarity
Disulfide bondi427 ↔ 438 By similarity
Disulfide bondi432 ↔ 447 By similarity
Disulfide bondi449 ↔ 458 By similarity
Disulfide bondi465 ↔ 475 By similarity
Disulfide bondi469 ↔ 484 By similarity
Disulfide bondi486 ↔ 495 By similarity
Disulfide bondi502 ↔ 513 By similarity
Disulfide bondi507 ↔ 522 By similarity
Disulfide bondi524 ↔ 533 By similarity
Disulfide bondi540 ↔ 551 By similarity
Disulfide bondi545 ↔ 560 By similarity
Disulfide bondi562 ↔ 571 By similarity
Glycosylationi570 – 5701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi589 ↔ 612 Reviewed prediction
Disulfide bondi606 ↔ 622 Reviewed prediction
Glycosylationi619 – 6191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi624 ↔ 633 By similarity
Disulfide bondi640 ↔ 651 By similarity
Disulfide bondi645 ↔ 660 By similarity
Disulfide bondi662 ↔ 671 By similarity
Disulfide bondi678 ↔ 689 By similarity
Disulfide bondi683 ↔ 698 By similarity
Disulfide bondi700 ↔ 709 By similarity
Disulfide bondi716 ↔ 727 By similarity
Disulfide bondi721 ↔ 736 By similarity
Disulfide bondi738 ↔ 747 By similarity
Glycosylationi752 – 7521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi755 ↔ 766 By similarity
Disulfide bondi760 ↔ 775 By similarity
Disulfide bondi777 ↔ 786 By similarity
Disulfide bondi793 ↔ 804 By similarity
Disulfide bondi798 ↔ 813 By similarity
Disulfide bondi815 ↔ 824 By similarity
Disulfide bondi831 ↔ 842 By similarity
Disulfide bondi836 ↔ 851 By similarity
Disulfide bondi853 ↔ 862 By similarity
Glycosylationi1060 – 10601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9QYE5.

PTM databases

PhosphoSiteiQ9QYE5.

Expressioni

Tissue specificityi

Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression.1 Publication

Developmental stagei

At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues.

Gene expression databases

CleanExiMM_JAG2.
GenevestigatoriQ9QYE5.

Structurei

3D structure databases

ProteinModelPortaliQ9QYE5.
SMRiQ9QYE5. Positions 28-865, 920-973.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 24045DSLAdd
BLAST
Domaini241 – 27434EGF-like 1Add
BLAST
Domaini275 – 30531EGF-like 2; atypicalAdd
BLAST
Domaini307 – 34539EGF-like 3Add
BLAST
Domaini347 – 38337EGF-like 4Add
BLAST
Domaini385 – 42137EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini423 – 45937EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST
Domaini461 – 49636EGF-like 7; calcium-binding Reviewed predictionAdd
BLAST
Domaini498 – 53437EGF-like 8Add
BLAST
Domaini536 – 57237EGF-like 9Add
BLAST
Domaini574 – 63461EGF-like 10; atypicalAdd
BLAST
Domaini636 – 67237EGF-like 11; calcium-binding Reviewed predictionAdd
BLAST
Domaini674 – 71037EGF-like 12; calcium-binding Reviewed predictionAdd
BLAST
Domaini712 – 74837EGF-like 13Add
BLAST
Domaini751 – 78737EGF-like 14Add
BLAST
Domaini789 – 82537EGF-like 15; calcium-binding Reviewed predictionAdd
BLAST
Domaini827 – 86337EGF-like 16; calcium-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.
Contains 16 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00740000114998.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9QYE5.
KOiK06052.
OMAiECDTYVR.
OrthoDBiEOG7BKCSS.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYE5-1 [UniParc]FASTAAdd to Basket

« Hide

MRARGWGRLP RRLLLLLVLC VQATRPMGYF ELQLSALRNV NGELLSGACC     50
DGDGRTTRAG GCGRDECDTY VRVCLKEYQA KVTPTGPCSY GYGATPVLGG 100
NSFYLPPAGA AGDRARARSR TGGHQDPGLV VIPFQFAWPR SFTLIVEAWD 150
WDNDTTPDEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE 200
NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN 250
LLHGGCTVPG ECRCSYGWQG KFCDECVPYP GCVHGSCVEP WHCDCETNWG 300
GLLCDKDLNY CGSHHPCVNG GTCINAEPDQ YLCACPDGYL GKNCERAEHA 350
CASNPCANGG SCHEVPSGFE CHCPSGWNGP TCALDIDECA SNPCAAGGTC 400
VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCL 450
PGWKGINCQI NINDCHGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELEYD 500
KCASSPCRRG GICEDLVDGF RCHCPRGLSG LHCEVDMDLC EPSPCLNGAR 550
CYNLEGDYYC ACPEDFGGKN CSVPRDTCPG GACRVIDGCG FEAGSRARGV 600
APSGICGPHG HCVSLPGGNF SCICDSGFTG TYCHENIDDC MGQPCRNGGT 650
CIDEVDSFRC FCPSGWEGEL CDINPNDCLP DPCHSRGRCY DLVNDFYCAC 700
DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCTIA 750
KNSSCVPNPC VNGGTCVGSG DSFSCICRDG WEGRTCTHNT NDCNPLPCYN 800
GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR 850
CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD 900
CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ PPCENWGECT 950
AEEPLPPSTP CQPRSSHLDN NCARLTLRFN RDQVPQGTTV GAICSGIRAL 1000
PATRAAAHDR LLLLLCDRAS SGASAVEVAV SFSPARDLPD SSLIQSTAHA 1050
IVAAITQRGN SSLLLAVTEV KVETVVMGGS STGLLVPVLC SVFSVLWLAC 1100
VVICVWWTRK RRKERERSRL PRDESANNQW APLNPIRNPI ERPGGSGLGT 1150
GGHKDILYQC KNFTPPPRRA GEALPGPAGH GAGGEDEEDE ELSRGDGDSP 1200
EAEKFISHKF TKDPSCSLGR PARWAPGPKV DNRAVRSTKD VRRAGRE 1247
Length:1,247
Mass (Da):134,745
Last modified:October 3, 2012 - v2
Checksum:iE1352B1856946EA6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021L → M in AAC14010. 1 Publication
Sequence conflicti378 – 3781N → S in AAF16411. 1 Publication
Sequence conflicti378 – 3781N → S in AAC14010. 1 Publication
Sequence conflicti378 – 3781N → S in CAA74835. 1 Publication
Sequence conflicti461 – 4611N → T in AAC14010. 1 Publication
Sequence conflicti469 – 47810CQHGGTCKDL → VSAWGHLQGP in AAC14010. 1 Publication
Sequence conflicti492 – 4921G → V in AAC14010. 1 Publication
Sequence conflicti546 – 5461L → F in AAC14010. 1 Publication
Sequence conflicti549 – 5491A → V in AAC14010. 1 Publication
Sequence conflicti735 – 7384RCAC → PAR in CAA74835. 1 Publication
Sequence conflicti809 – 8091N → H in AAC14010. 1 Publication
Sequence conflicti812 – 8121R → A in AAC14010. 1 Publication
Sequence conflicti1030 – 10301V → M in AAF16411. 1 Publication
Sequence conflicti1126 – 11261A → T in AAF16411. 1 Publication
Sequence conflicti1223 – 12231R → C in AAF16411. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038572 mRNA. Translation: AAF16411.1.
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1.
Y14495 mRNA. Translation: CAA74835.1.
CCDSiCCDS26200.1.
RefSeqiNP_034718.2. NM_010588.2.
UniGeneiMm.186146.

Genome annotation databases

EnsembliENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799.
GeneIDi16450.
KEGGimmu:16450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038572 mRNA. Translation: AAF16411.1 .
AC160929 Genomic DNA. No translation available.
AF010137 mRNA. Translation: AAC14010.1 .
Y14495 mRNA. Translation: CAA74835.1 .
CCDSi CCDS26200.1.
RefSeqi NP_034718.2. NM_010588.2.
UniGenei Mm.186146.

3D structure databases

ProteinModelPortali Q9QYE5.
SMRi Q9QYE5. Positions 28-865, 920-973.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYE5.

Proteomic databases

PRIDEi Q9QYE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075827 ; ENSMUSP00000075224 ; ENSMUSG00000002799 .
GeneIDi 16450.
KEGGi mmu:16450.

Organism-specific databases

CTDi 3714.
MGIi MGI:1098270. Jag2.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00740000114998.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q9QYE5.
KOi K06052.
OMAi ECDTYVR.
OrthoDBi EOG7BKCSS.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Miscellaneous databases

NextBioi 289709.
PROi Q9QYE5.
SOURCEi Search...

Gene expression databases

CleanExi MM_JAG2.
Genevestigatori Q9QYE5.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tsai S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations."
    Lan Y., Jiang R., Shawber C., Weinmaster G., Gridley T.
    Mamm. Genome 8:875-876(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-819.
    Tissue: Brain.
  4. "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
    Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
    Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 325-759.
    Tissue: Brain.
  5. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
    Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
    Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiJAG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYE5
Secondary accession number(s): F8VPV5, O55139, O70219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi