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Q9QYC7

- VKGC_MOUSE

UniProt

Q9QYC7 - VKGC_MOUSE

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Protein
Vitamin K-dependent gamma-carboxylase
Gene
Ggcx
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Catalytic activityi

[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = [peptidyl]-glutamate + CO2 + O2 + phylloquinone.

GO - Molecular functioni

  1. gamma-glutamyl carboxylase activity Source: MGI

GO - Biological processi

  1. peptidyl-glutamic acid carboxylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K-dependent gamma-carboxylase (EC:4.1.1.90)
Alternative name(s):
Gamma-glutamyl carboxylase
Peptidyl-glutamate 4-carboxylase
Vitamin K gamma glutamyl carboxylase
Gene namesi
Name:Ggcx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1927655. Ggcx.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6059Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei61 – 8121Helical; Reviewed prediction
Add
BLAST
Topological domaini82 – 11332Lumenal Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Topological domaini135 – 1362Cytoplasmic Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 292135Lumenal Reviewed prediction
Add
BLAST
Transmembranei293 – 31321Helical; Reviewed prediction
Add
BLAST
Topological domaini314 – 36148Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Topological domaini383 – 757375Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 757756Vitamin K-dependent gamma-carboxylase
PRO_0000191824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Disulfide bondi99 ↔ 450 By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ9QYC7.
PRIDEiQ9QYC7.

PTM databases

PhosphoSiteiQ9QYC7.

Expressioni

Gene expression databases

ArrayExpressiQ9QYC7.
BgeeiQ9QYC7.
CleanExiMM_GGCX.
GenevestigatoriQ9QYC7.

Interactioni

Subunit structurei

Monomer By similarity. May interact with CALU By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83578.
GeneTreeiENSGT00390000014909.
HOGENOMiHOG000007593.
HOVERGENiHBG012798.
InParanoidiQ9QYC7.
KOiK10106.
OMAiSPSCYMY.
OrthoDBiEOG7B5WV9.
PhylomeDBiQ9QYC7.
TreeFamiTF323879.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR011020. HTTM.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR007782. VKG_COase.
[Graphical view]
PANTHERiPTHR12639. PTHR12639. 1 hit.
PfamiPF05090. VKG_Carbox. 1 hit.
[Graphical view]
SMARTiSM00752. HTTM. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYC7-1 [UniParc]FASTAAdd to Basket

« Hide

MAVHRGSALV APASDKVQKN KSAQTSGLKQ GSRMEKILGF EWTDLSSWQS    50
VVTLLNKPTD PANLAVFRFL FAFLMLLDIP QERGLSSLDR KYLDGLDVCR 100
FPLLDALRPL PLDWMYLVYT IMFLGALGMM LGLCYRLSCV LFLLPYWYVF 150
LLDKTSWNNH SYLYGLLAFQ LTFMDANHYW SVDGLLNARK KNAHVPLWNY 200
TVLRGQIFIV YFIAGVKKLD ADWVGGYSME HLSRHWLFSP FKLVLSEELT 250
SLLVVHWCGL LLDLSAGFLL FFDASRPVGL FFVSYFHCMN SQLFSIGMFP 300
YVMLASSPLF CSAEWPRKLV ARCPKRLQEL LPTKAAPRPS ASCVYKRSRG 350
KAGPKPGLRH QLGAIFTLLY LLEQLFLPYS HFLTQGYNNW TNGLYGYSWD 400
MMVHSRSHQH VKITYRDGLT GELGYLNPGV FTQSRRWKDH ADMLKQYATC 450
LSLLLPKYNV TEPQIYFDIW VSINDRFQQR LFDPRVDIVQ AVWSPFQRTP 500
WVQPLLMDLS PWRTKLQDIK SSLDNHTEVV FIADFPGLHL ENFVSEDLGN 550
TSIQLLQGEV TVELVAEQKN QTLQEGEKMQ LPAGEYHKVY TVSSSPSCYM 600
YVYVNTTEVA LEQDLAYLQE LKEKVENGSE TGPLPPELQP LLEGEVKGGP 650
EPTPLVQTFL RRQRKLQEIE RRRNSPFHER FLRFVLRKLY VFRRSFLMTR 700
ISLRNLLLGR PSLEQLAQEV TYANLRPFEP VDESSASNTD SSNHPSEPDS 750
EHVHSEF 757
Length:757
Mass (Da):87,195
Last modified:May 1, 2000 - v1
Checksum:i178CDDCEE5CFBA34
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti525 – 5251N → K in BAC28319. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087938 mRNA. Translation: AAF21291.1.
AK033496 mRNA. Translation: BAC28319.1.
AK036577 mRNA. Translation: BAC29487.1.
AK135425 mRNA. Translation: BAE22528.1.
CCDSiCCDS20242.1.
RefSeqiNP_062776.1. NM_019802.5.
UniGeneiMm.19937.

Genome annotation databases

EnsembliENSMUST00000065906; ENSMUSP00000070109; ENSMUSG00000053460.
GeneIDi56316.
KEGGimmu:56316.
UCSCiuc009cio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087938 mRNA. Translation: AAF21291.1 .
AK033496 mRNA. Translation: BAC28319.1 .
AK036577 mRNA. Translation: BAC29487.1 .
AK135425 mRNA. Translation: BAE22528.1 .
CCDSi CCDS20242.1.
RefSeqi NP_062776.1. NM_019802.5.
UniGenei Mm.19937.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYC7.

Proteomic databases

PaxDbi Q9QYC7.
PRIDEi Q9QYC7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065906 ; ENSMUSP00000070109 ; ENSMUSG00000053460 .
GeneIDi 56316.
KEGGi mmu:56316.
UCSCi uc009cio.1. mouse.

Organism-specific databases

CTDi 2677.
MGIi MGI:1927655. Ggcx.

Phylogenomic databases

eggNOGi NOG83578.
GeneTreei ENSGT00390000014909.
HOGENOMi HOG000007593.
HOVERGENi HBG012798.
InParanoidi Q9QYC7.
KOi K10106.
OMAi SPSCYMY.
OrthoDBi EOG7B5WV9.
PhylomeDBi Q9QYC7.
TreeFami TF323879.

Miscellaneous databases

NextBioi 312268.
PROi Q9QYC7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QYC7.
Bgeei Q9QYC7.
CleanExi MM_GGCX.
Genevestigatori Q9QYC7.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR011020. HTTM.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR007782. VKG_COase.
[Graphical view ]
PANTHERi PTHR12639. PTHR12639. 1 hit.
Pfami PF05090. VKG_Carbox. 1 hit.
[Graphical view ]
SMARTi SM00752. HTTM. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mouse gamma-carboxylase genomic locus and its promoter."
    Zhu A., Zheng X., Ginsburg D.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone, Colon and Muellerian duct.

Entry informationi

Entry nameiVKGC_MOUSE
AccessioniPrimary (citable) accession number: Q9QYC7
Secondary accession number(s): Q3UXN5, Q8CCB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO2, O2 and reduced vitamin K are cosubstrates.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi