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Protein

Prosaposin receptor GPR37

Gene

Gpr37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
G-protein coupled receptor 37
G-protein coupled receptor CNS1
Gene namesi
Name:Gpr37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619848. Gpr37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 255229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini277 – 28913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini311 – 32515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei326 – 34621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini347 – 36923CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei370 – 39021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini391 – 43343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei434 – 45421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini455 – 48329CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei484 – 50421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini505 – 52117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei522 – 54221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini543 – 60361CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 603577Prosaposin receptor GPR37PRO_0000012801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 409PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QYC6.
PRIDEiQ9QYC6.

PTM databases

PhosphoSiteiQ9QYC6.

Expressioni

Tissue specificityi

Highly expressed in the brain. High levels of expression were seen in fiber tracts such as the corpus callosum, anterior commissure, fornix, internal capsule, cerebral peduncles, and stria terminalis. Additionally, moderate levels of expression were seen in the pyramidal tracts and cerebellar peduncles, as well as in the spinal tract of the trigeminal nerve and the spinal fasciculi.1 Publication

Gene expression databases

GenevisibleiQ9QYC6. RN.

Interactioni

Subunit structurei

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003593.

Structurei

3D structure databases

ProteinModelPortaliQ9QYC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi541 – 56121Cys-richAdd
BLAST
Compositional biasi553 – 5586Poly-Cys

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ9QYC6.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG79SDX9.
PhylomeDBiQ9QYC6.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIPR
60 70 80 90 100
RSRDAGGPRN SARDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE
110 120 130 140 150
AAASGPLGPP TKPPGAWRWK GAQGKEPSGH LGRREPTDSQ LFRQTSERGE
160 170 180 190 200
MSSKRDEIPQ GSQEHSVKTE PEPRDLFYWP RKTGQLQGSH YRPSAVHEGR
210 220 230 240 250
TLAPPGRALP QNGSADDWVP DQGGPRRGNS TNRRVRLKNP FYPLTQESYG
260 270 280 290 300
AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI
310 320 330 340 350
IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF
360 370 380 390 400
RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF
410 420 430 440 450
SGQAPAERCV IKISPDLPDT IYVLALTYDG ARLWWYFGCY FCLPTLFTIT
460 470 480 490 500
CSLVTARKIR KAEKASTRGN KRQIHLESQM NCTVVALTIL YGFCIIPENI
510 520 530 540 550
CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF CLCRPFSRAF
560 570 580 590 600
MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG

THC
Length:603
Mass (Da):66,961
Last modified:May 1, 2000 - v1
Checksum:i87F3042B8267CEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087946 mRNA. Translation: AAD54655.1.
BC087728 mRNA. Translation: AAH87728.1.
RefSeqiNP_476549.1. NM_057201.1.
UniGeneiRn.28035.

Genome annotation databases

EnsembliENSRNOT00000003593; ENSRNOP00000003593; ENSRNOG00000002524.
GeneIDi117549.
KEGGirno:117549.
UCSCiRGD:619848. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087946 mRNA. Translation: AAD54655.1.
BC087728 mRNA. Translation: AAH87728.1.
RefSeqiNP_476549.1. NM_057201.1.
UniGeneiRn.28035.

3D structure databases

ProteinModelPortaliQ9QYC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003593.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9QYC6.

Proteomic databases

PaxDbiQ9QYC6.
PRIDEiQ9QYC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003593; ENSRNOP00000003593; ENSRNOG00000002524.
GeneIDi117549.
KEGGirno:117549.
UCSCiRGD:619848. rat.

Organism-specific databases

CTDi2861.
RGDi619848. Gpr37.

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ9QYC6.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG79SDX9.
PhylomeDBiQ9QYC6.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi620383.
PROiQ9QYC6.

Gene expression databases

GenevisibleiQ9QYC6. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system."
    Leng N., Gu G., Simerly R.B., Spindel E.R.
    Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hypothalamus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGPR37_RAT
AccessioniPrimary (citable) accession number: Q9QYC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.