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Q9QYC6

- GPR37_RAT

UniProt

Q9QYC6 - GPR37_RAT

Protein

Prosaposin receptor GPR37

Gene

Gpr37

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37
    Alternative name(s):
    G-protein coupled receptor 37
    G-protein coupled receptor CNS1
    Gene namesi
    Name:Gpr37
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi619848. Gpr37.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 603577Prosaposin receptor GPR37PRO_0000012801Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 409PROSITE-ProRule annotation

    Post-translational modificationi

    Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9QYC6.
    PRIDEiQ9QYC6.

    PTM databases

    PhosphoSiteiQ9QYC6.

    Expressioni

    Tissue specificityi

    Highly expressed in the brain. High levels of expression were seen in fiber tracts such as the corpus callosum, anterior commissure, fornix, internal capsule, cerebral peduncles, and stria terminalis. Additionally, moderate levels of expression were seen in the pyramidal tracts and cerebellar peduncles, as well as in the spinal tract of the trigeminal nerve and the spinal fasciculi.1 Publication

    Gene expression databases

    GenevestigatoriQ9QYC6.

    Interactioni

    Subunit structurei

    Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 255229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini277 – 28913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini311 – 32515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini347 – 36923CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini391 – 43343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini455 – 48329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini505 – 52117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini543 – 60361CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei256 – 27621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi541 – 56121Cys-richAdd
    BLAST
    Compositional biasi553 – 5586Poly-Cys

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiQ9QYC6.
    KOiK04243.
    OMAiIQRRSRD.
    OrthoDBiEOG79SDX9.
    PhylomeDBiQ9QYC6.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYC6-1 [UniParc]FASTAAdd to Basket

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    MPAPGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIPR    50
    RSRDAGGPRN SARDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE 100
    AAASGPLGPP TKPPGAWRWK GAQGKEPSGH LGRREPTDSQ LFRQTSERGE 150
    MSSKRDEIPQ GSQEHSVKTE PEPRDLFYWP RKTGQLQGSH YRPSAVHEGR 200
    TLAPPGRALP QNGSADDWVP DQGGPRRGNS TNRRVRLKNP FYPLTQESYG 250
    AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI 300
    IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF 350
    RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF 400
    SGQAPAERCV IKISPDLPDT IYVLALTYDG ARLWWYFGCY FCLPTLFTIT 450
    CSLVTARKIR KAEKASTRGN KRQIHLESQM NCTVVALTIL YGFCIIPENI 500
    CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF CLCRPFSRAF 550
    MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG 600
    THC 603
    Length:603
    Mass (Da):66,961
    Last modified:May 1, 2000 - v1
    Checksum:i87F3042B8267CEAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087946 mRNA. Translation: AAD54655.1.
    BC087728 mRNA. Translation: AAH87728.1.
    RefSeqiNP_476549.1. NM_057201.1.
    UniGeneiRn.28035.

    Genome annotation databases

    EnsembliENSRNOT00000003593; ENSRNOP00000003593; ENSRNOG00000002524.
    GeneIDi117549.
    KEGGirno:117549.
    UCSCiRGD:619848. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087946 mRNA. Translation: AAD54655.1 .
    BC087728 mRNA. Translation: AAH87728.1 .
    RefSeqi NP_476549.1. NM_057201.1.
    UniGenei Rn.28035.

    3D structure databases

    ProteinModelPortali Q9QYC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003593.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9QYC6.

    Proteomic databases

    PaxDbi Q9QYC6.
    PRIDEi Q9QYC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003593 ; ENSRNOP00000003593 ; ENSRNOG00000002524 .
    GeneIDi 117549.
    KEGGi rno:117549.
    UCSCi RGD:619848. rat.

    Organism-specific databases

    CTDi 2861.
    RGDi 619848. Gpr37.

    Phylogenomic databases

    eggNOGi NOG291459.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi Q9QYC6.
    KOi K04243.
    OMAi IQRRSRD.
    OrthoDBi EOG79SDX9.
    PhylomeDBi Q9QYC6.
    TreeFami TF331292.

    Miscellaneous databases

    NextBioi 620383.
    PROi Q9QYC6.

    Gene expression databases

    Genevestigatori Q9QYC6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system."
      Leng N., Gu G., Simerly R.B., Spindel E.R.
      Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hypothalamus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGPR37_RAT
    AccessioniPrimary (citable) accession number: Q9QYC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3