Q9QYC6 (GPR37_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 37

Alternative name(s):
G-protein coupled receptor CNS1

Gene names

Name:

Gpr37

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subunit structure	Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed in the brain. High levels of expression were seen in fiber tracts such as the corpus callosum, anterior commissure, fornix, internal capsule, cerebral peduncles, and stria terminalis. Additionally, moderate levels of expression were seen in the pyramidal tracts and cerebellar peduncles, as well as in the spinal tract of the trigeminal nerve and the spinal fasciculi. Ref.1
Post-translational modification	Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Endoplasmic reticulum Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 603	577	Probable G-protein coupled receptor 37		PRO_0000012801
Regions
	Topological domain	27 – 255	229	Extracellular Potential
	Transmembrane	256 – 276	21	Helical; Name=1; Potential
	Topological domain	277 – 289	13	Cytoplasmic Potential
	Transmembrane	290 – 310	21	Helical; Name=2; Potential
	Topological domain	311 – 325	15	Extracellular Potential
	Transmembrane	326 – 346	21	Helical; Name=3; Potential
	Topological domain	347 – 369	23	Cytoplasmic Potential
	Transmembrane	370 – 390	21	Helical; Name=4; Potential
	Topological domain	391 – 433	43	Extracellular Potential
	Transmembrane	434 – 454	21	Helical; Name=5; Potential
	Topological domain	455 – 483	29	Cytoplasmic Potential
	Transmembrane	484 – 504	21	Helical; Name=6; Potential
	Topological domain	505 – 521	17	Extracellular Potential
	Transmembrane	522 – 542	21	Helical; Name=7; Potential
	Topological domain	543 – 603	61	Cytoplasmic Potential
	Compositional bias	541 – 561	21	Cys-rich
	Compositional bias	553 – 558	6	Poly-Cys
Amino acid modifications
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Disulfide bond	324 ↔ 409		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QYC6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 87F3042B8267CEAD	FASTA	603	66,961
	10 20 30 40 50 60 MPAPGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIPR RSRDAGGPRN 70 80 90 100 110 120 SARDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE AAASGPLGPP TKPPGAWRWK 130 140 150 160 170 180 GAQGKEPSGH LGRREPTDSQ LFRQTSERGE MSSKRDEIPQ GSQEHSVKTE PEPRDLFYWP 190 200 210 220 230 240 RKTGQLQGSH YRPSAVHEGR TLAPPGRALP QNGSADDWVP DQGGPRRGNS TNRRVRLKNP 250 260 270 280 290 300 FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI 310 320 330 340 350 360 IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF RAATNVQMYY 370 380 390 400 410 420 EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGQAPAERCV IKISPDLPDT 430 440 450 460 470 480 IYVLALTYDG ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKASTRGN KRQIHLESQM 490 500 510 520 530 540 NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF 550 560 570 580 590 600 CLCRPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG THC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system." Leng N., Gu G., Simerly R.B., Spindel E.R. Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Hypothalamus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087946 mRNA. Translation: AAD54655.1. BC087728 mRNA. Translation: AAH87728.1.
IPI	IPI00213932.
RefSeq	NP_476549.1. NM_057201.1.
UniGene	Rn.28035.
3D structure databases
ProteinModelPortal	Q9QYC6.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000003593.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9QYC6.
Proteomic databases
PaxDb	Q9QYC6.
PRIDE	Q9QYC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000003593; ENSRNOP00000003593; ENSRNOG00000002524.
GeneID	117549.
KEGG	rno:117549.
UCSC	RGD:619848. rat.
Organism-specific databases
CTD	2861.
RGD	619848. Gpr37.
Phylogenomic databases
eggNOG	NOG291459.
GeneTree	ENSGT00690000101856.
HOGENOM	HOG000252922.
HOVERGEN	HBG051808.
InParanoid	Q9QYC6.
KO	K04243.
OMA	IQRRSRD.
OrthoDB	EOG4B5P5H.
Gene expression databases
Genevestigator	Q9QYC6.
GermOnline	ENSRNOG00000002524. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003909. GPR37_orph. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01421. GPR37ORPHANR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	620383.

Entry information

Entry name

GPR37_RAT

Accession

Primary (citable) accession number: Q9QYC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program