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Q9QYC6 (GPR37_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prosaposin receptor GPR37
Alternative name(s):
G-protein coupled receptor 37
G-protein coupled receptor CNS1
Gene names
Name:Gpr37
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

Subunit structure

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highly expressed in the brain. High levels of expression were seen in fiber tracts such as the corpus callosum, anterior commissure, fornix, internal capsule, cerebral peduncles, and stria terminalis. Additionally, moderate levels of expression were seen in the pyramidal tracts and cerebellar peduncles, as well as in the spinal tract of the trigeminal nerve and the spinal fasciculi. Ref.1

Post-translational modification

Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 603577Prosaposin receptor GPR37
PRO_0000012801

Regions

Topological domain27 – 255229Extracellular Potential
Transmembrane256 – 27621Helical; Name=1; Potential
Topological domain277 – 28913Cytoplasmic Potential
Transmembrane290 – 31021Helical; Name=2; Potential
Topological domain311 – 32515Extracellular Potential
Transmembrane326 – 34621Helical; Name=3; Potential
Topological domain347 – 36923Cytoplasmic Potential
Transmembrane370 – 39021Helical; Name=4; Potential
Topological domain391 – 43343Extracellular Potential
Transmembrane434 – 45421Helical; Name=5; Potential
Topological domain455 – 48329Cytoplasmic Potential
Transmembrane484 – 50421Helical; Name=6; Potential
Topological domain505 – 52117Extracellular Potential
Transmembrane522 – 54221Helical; Name=7; Potential
Topological domain543 – 60361Cytoplasmic Potential
Compositional bias541 – 56121Cys-rich
Compositional bias553 – 5586Poly-Cys

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Disulfide bond324 ↔ 409 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYC6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 87F3042B8267CEAD

FASTA60366,961
        10         20         30         40         50         60 
MPAPGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIPR RSRDAGGPRN 

        70         80         90        100        110        120 
SARDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE AAASGPLGPP TKPPGAWRWK 

       130        140        150        160        170        180 
GAQGKEPSGH LGRREPTDSQ LFRQTSERGE MSSKRDEIPQ GSQEHSVKTE PEPRDLFYWP 

       190        200        210        220        230        240 
RKTGQLQGSH YRPSAVHEGR TLAPPGRALP QNGSADDWVP DQGGPRRGNS TNRRVRLKNP 

       250        260        270        280        290        300 
FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI 

       310        320        330        340        350        360 
IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF RAATNVQMYY 

       370        380        390        400        410        420 
EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGQAPAERCV IKISPDLPDT 

       430        440        450        460        470        480 
IYVLALTYDG ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKASTRGN KRQIHLESQM 

       490        500        510        520        530        540 
NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF 

       550        560        570        580        590        600 
CLCRPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG 


THC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system."
Leng N., Gu G., Simerly R.B., Spindel E.R.
Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Hypothalamus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087946 mRNA. Translation: AAD54655.1.
BC087728 mRNA. Translation: AAH87728.1.
RefSeqNP_476549.1. NM_057201.1.
UniGeneRn.28035.

3D structure databases

ProteinModelPortalQ9QYC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000003593.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9QYC6.

Proteomic databases

PaxDbQ9QYC6.
PRIDEQ9QYC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003593; ENSRNOP00000003593; ENSRNOG00000002524.
GeneID117549.
KEGGrno:117549.
UCSCRGD:619848. rat.

Organism-specific databases

CTD2861.
RGD619848. Gpr37.

Phylogenomic databases

eggNOGNOG291459.
GeneTreeENSGT00690000101856.
HOGENOMHOG000252922.
HOVERGENHBG051808.
InParanoidQ9QYC6.
KOK04243.
OMAIQRRSRD.
OrthoDBEOG79SDX9.
PhylomeDBQ9QYC6.
TreeFamTF331292.

Gene expression databases

GenevestigatorQ9QYC6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620383.
PROQ9QYC6.

Entry information

Entry nameGPR37_RAT
AccessionPrimary (citable) accession number: Q9QYC6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries