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Protein

Prosaposin receptor GPR37

Gene

Gpr37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
G-protein coupled receptor 37
G-protein coupled receptor CNS1
Gene namesi
Name:Gpr37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi619848 Gpr37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 255ExtracellularSequence analysisAdd BLAST229
Transmembranei256 – 276Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini277 – 289CytoplasmicSequence analysisAdd BLAST13
Transmembranei290 – 310Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini311 – 325ExtracellularSequence analysisAdd BLAST15
Transmembranei326 – 346Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini347 – 369CytoplasmicSequence analysisAdd BLAST23
Transmembranei370 – 390Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini391 – 433ExtracellularSequence analysisAdd BLAST43
Transmembranei434 – 454Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini455 – 483CytoplasmicSequence analysisAdd BLAST29
Transmembranei484 – 504Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini505 – 521ExtracellularSequence analysisAdd BLAST17
Transmembranei522 – 542Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini543 – 603CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001280127 – 603Prosaposin receptor GPR37Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 409PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated by PRKN in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QYC6
PRIDEiQ9QYC6

PTM databases

PhosphoSitePlusiQ9QYC6

Expressioni

Tissue specificityi

Highly expressed in the brain. High levels of expression were seen in fiber tracts such as the corpus callosum, anterior commissure, fornix, internal capsule, cerebral peduncles, and stria terminalis. Additionally, moderate levels of expression were seen in the pyramidal tracts and cerebellar peduncles, as well as in the spinal tract of the trigeminal nerve and the spinal fasciculi.1 Publication

Gene expression databases

BgeeiENSRNOG00000002524
GenevisibleiQ9QYC6 RN

Interactioni

Subunit structurei

Forms a complex with PRKN, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN, thus facilitating PRKN-mediated GPR37 ubiquitination. Interacts with PACRG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003593

Structurei

3D structure databases

ProteinModelPortaliQ9QYC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi541 – 561Cys-richAdd BLAST21
Compositional biasi553 – 558Poly-Cys6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiQ9QYC6
KOiK04243
OMAiAERCVIK
OrthoDBiEOG091G04SU
PhylomeDBiQ9QYC6
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIPR
60 70 80 90 100
RSRDAGGPRN SARDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE
110 120 130 140 150
AAASGPLGPP TKPPGAWRWK GAQGKEPSGH LGRREPTDSQ LFRQTSERGE
160 170 180 190 200
MSSKRDEIPQ GSQEHSVKTE PEPRDLFYWP RKTGQLQGSH YRPSAVHEGR
210 220 230 240 250
TLAPPGRALP QNGSADDWVP DQGGPRRGNS TNRRVRLKNP FYPLTQESYG
260 270 280 290 300
AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI
310 320 330 340 350
IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF
360 370 380 390 400
RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF
410 420 430 440 450
SGQAPAERCV IKISPDLPDT IYVLALTYDG ARLWWYFGCY FCLPTLFTIT
460 470 480 490 500
CSLVTARKIR KAEKASTRGN KRQIHLESQM NCTVVALTIL YGFCIIPENI
510 520 530 540 550
CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF CLCRPFSRAF
560 570 580 590 600
MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG

THC
Length:603
Mass (Da):66,961
Last modified:May 1, 2000 - v1
Checksum:i87F3042B8267CEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087946 mRNA Translation: AAD54655.1
BC087728 mRNA Translation: AAH87728.1
RefSeqiNP_476549.1, NM_057201.1
UniGeneiRn.28035

Genome annotation databases

EnsembliENSRNOT00000003593; ENSRNOP00000003593; ENSRNOG00000002524
GeneIDi117549
KEGGirno:117549
UCSCiRGD:619848 rat

Similar proteinsi

Entry informationi

Entry nameiGPR37_RAT
AccessioniPrimary (citable) accession number: Q9QYC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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