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Q9QYC5

- ETBR2_RAT

UniProt

Q9QYC5 - ETBR2_RAT

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Protein

Prosaposin receptor GPR37L1

Gene

Gpr37l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
G-protein coupled receptor CNS2
Gene namesi
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628835. Gpr37l1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 481457Prosaposin receptor GPR37L1PRO_0000012798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9QYC5.

PTM databases

PhosphoSiteiQ9QYC5.

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

GenevestigatoriQ9QYC5.

Structurei

3D structure databases

ProteinModelPortaliQ9QYC5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 134110ExtracellularSequence AnalysisAdd
BLAST
Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
BLAST
Topological domaini332 – 36029CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini382 – 39817ExtracellularSequence AnalysisAdd
BLAST
Topological domaini420 – 48162CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei361 – 38121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 43922Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ9QYC5.
PhylomeDBiQ9QYC5.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYC5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRWLWPLAVS LAVVLAVGPS EVSGAATLSL GGHRAKVQEQ QSRPRRGTKD
60 70 80 90 100
EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK PLVATSPNPD KDGATSESGQ
110 120 130 140 150
ELRTNLTGTP SQRLQIQNPL YPVTESSYSA YAVMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM MLAVPELLLW QLAQEPTPTM GTVDSCIMKP SADLPESLYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENICNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS
460 470 480
ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,860
Last modified:May 1, 2000 - v1
Checksum:i0AD20D1C346FFF68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087947 mRNA. Translation: AAD54656.1.
UniGeneiRn.144679.

Genome annotation databases

UCSCiRGD:628835. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087947 mRNA. Translation: AAD54656.1 .
UniGenei Rn.144679.

3D structure databases

ProteinModelPortali Q9QYC5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QYC5.

Proteomic databases

PRIDEi Q9QYC5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:628835. rat.

Organism-specific databases

RGDi 628835. Gpr37l1.

Phylogenomic databases

eggNOGi NOG291459.
HOGENOMi HOG000252922.
HOVERGENi HBG051808.
InParanoidi Q9QYC5.
PhylomeDBi Q9QYC5.

Miscellaneous databases

PROi Q9QYC5.

Gene expression databases

Genevestigatori Q9QYC5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system."
    Leng N., Gu G., Simerly R.B., Spindel E.R.
    Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiETBR2_RAT
AccessioniPrimary (citable) accession number: Q9QYC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3