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Q9QYC5 (ETBR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name=ETBR-LP-2
G-protein coupled receptor 37-like 1
G-protein coupled receptor CNS2
Gene names
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Tissue specificity

Highly expressed in brain. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 481457Prosaposin receptor GPR37L1
PRO_0000012798

Regions

Topological domain25 – 134110Extracellular Potential
Transmembrane135 – 15521Helical; Name=1; Potential
Topological domain156 – 16712Cytoplasmic Potential
Transmembrane168 – 18821Helical; Name=2; Potential
Topological domain189 – 20517Extracellular Potential
Transmembrane206 – 22621Helical; Name=3; Potential
Topological domain227 – 25125Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=4; Potential
Topological domain273 – 31038Extracellular Potential
Transmembrane311 – 33121Helical; Name=5; Potential
Topological domain332 – 36029Cytoplasmic Potential
Transmembrane361 – 38121Helical; Name=6; Potential
Topological domain382 – 39817Extracellular Potential
Transmembrane399 – 41921Helical; Name=7; Potential
Topological domain420 – 48162Cytoplasmic Potential
Compositional bias418 – 43922Cys-rich

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Disulfide bond203 ↔ 286 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYC5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0AD20D1C346FFF68

FASTA48152,860
        10         20         30         40         50         60 
MRWLWPLAVS LAVVLAVGPS EVSGAATLSL GGHRAKVQEQ QSRPRRGTKD EGPKEVQHYV 

        70         80         90        100        110        120 
PEEWAEYPKP IHPAGLQPTK PLVATSPNPD KDGATSESGQ ELRTNLTGTP SQRLQIQNPL 

       130        140        150        160        170        180 
YPVTESSYSA YAVMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL 

       190        200        210        220        230        240 
FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR 

       250        260        270        280        290        300 
PIERCQSILA KLAVIWVGSM MLAVPELLLW QLAQEPTPTM GTVDSCIMKP SADLPESLYS 

       310        320        330        340        350        360 
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH EQCESQLNST 

       370        380        390        400        410        420 
VVGLTVVYAF CTLPENICNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC 

       430        440        450        460        470        480 
RPLGQAFLDC CCCCCCEECG GASDSSATVS ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP 


C 

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References

[1]"Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system."
Leng N., Gu G., Simerly R.B., Spindel E.R.
Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087947 mRNA. Translation: AAD54656.1.
UniGeneRn.144679.

3D structure databases

ProteinModelPortalQ9QYC5.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9QYC5.

Proteomic databases

PRIDEQ9QYC5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:628835. rat.

Organism-specific databases

RGD628835. Gpr37l1.

Phylogenomic databases

eggNOGNOG291459.
HOGENOMHOG000252922.
HOVERGENHBG051808.
InParanoidQ9QYC5.
PhylomeDBQ9QYC5.

Gene expression databases

GenevestigatorQ9QYC5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9QYC5.

Entry information

Entry nameETBR2_RAT
AccessionPrimary (citable) accession number: Q9QYC5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries