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Q9QYC5

- ETBR2_RAT

UniProt

Q9QYC5 - ETBR2_RAT

Protein

Prosaposin receptor GPR37L1

Gene

Gpr37l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37L1
    Alternative name(s):
    Endothelin B receptor-like protein 2
    Short name:
    ETBR-LP-2
    G-protein coupled receptor 37-like 1
    G-protein coupled receptor CNS2
    Gene namesi
    Name:Gpr37l1
    Synonyms:Etbrlp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628835. Gpr37l1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 481457Prosaposin receptor GPR37L1PRO_0000012798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9QYC5.

    PTM databases

    PhosphoSiteiQ9QYC5.

    Expressioni

    Tissue specificityi

    Highly expressed in brain.1 Publication

    Gene expression databases

    GenevestigatoriQ9QYC5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYC5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 134110ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 36029CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini382 – 39817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 48162CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi418 – 43922Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiQ9QYC5.
    PhylomeDBiQ9QYC5.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYC5-1 [UniParc]FASTAAdd to Basket

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    MRWLWPLAVS LAVVLAVGPS EVSGAATLSL GGHRAKVQEQ QSRPRRGTKD    50
    EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK PLVATSPNPD KDGATSESGQ 100
    ELRTNLTGTP SQRLQIQNPL YPVTESSYSA YAVMLLALVV FAVGIVGNLS 150
    VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD 200
    VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA 250
    KLAVIWVGSM MLAVPELLLW QLAQEPTPTM GTVDSCIMKP SADLPESLYS 300
    LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH 350
    EQCESQLNST VVGLTVVYAF CTLPENICNI VVAYLSTELT RQTLDLLGLI 400
    NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS 450
    ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C 481
    Length:481
    Mass (Da):52,860
    Last modified:May 1, 2000 - v1
    Checksum:i0AD20D1C346FFF68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087947 mRNA. Translation: AAD54656.1.
    UniGeneiRn.144679.

    Genome annotation databases

    UCSCiRGD:628835. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087947 mRNA. Translation: AAD54656.1 .
    UniGenei Rn.144679.

    3D structure databases

    ProteinModelPortali Q9QYC5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9QYC5.

    Proteomic databases

    PRIDEi Q9QYC5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:628835. rat.

    Organism-specific databases

    RGDi 628835. Gpr37l1.

    Phylogenomic databases

    eggNOGi NOG291459.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi Q9QYC5.
    PhylomeDBi Q9QYC5.

    Miscellaneous databases

    PROi Q9QYC5.

    Gene expression databases

    Genevestigatori Q9QYC5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system."
      Leng N., Gu G., Simerly R.B., Spindel E.R.
      Brain Res. Mol. Brain Res. 69:73-83(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiETBR2_RAT
    AccessioniPrimary (citable) accession number: Q9QYC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3