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Q9QYC1

- PCX1_MOUSE

UniProt

Q9QYC1 - PCX1_MOUSE

Protein

Pecanex-like protein 1

Gene

Pcnx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (09 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pecanex-like protein 1
    Alternative name(s):
    Pecanex homolog
    Gene namesi
    Name:Pcnx
    Synonyms:Kiaa0805, Pcnxl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1891924. Pcnx.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23442344Pecanex-like protein 1PRO_0000215794Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi1094 – 10941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1158 – 11581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1582 – 15821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1723 – 17231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1985 – 19851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2075 – 20751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2231 – 22311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2237 – 22371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2263 – 22631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9QYC1.
    PRIDEiQ9QYC1.

    PTM databases

    PhosphoSiteiQ9QYC1.

    Expressioni

    Gene expression databases

    BgeeiQ9QYC1.
    CleanExiMM_PCNX.
    GenevestigatoriQ9QYC1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1010 – 103021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1035 – 105521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1069 – 108921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1119 – 113921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1163 – 118321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1196 – 121621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1269 – 128921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1297 – 131721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi320 – 41798Ser-richAdd
    BLAST
    Compositional biasi573 – 63866Ser-richAdd
    BLAST
    Compositional biasi2106 – 220297Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pecanex family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297934.
    GeneTreeiENSGT00390000013164.
    HOGENOMiHOG000007773.
    HOVERGENiHBG045627.
    InParanoidiQ9QYC1.
    OMAiNYRLHRA.
    OrthoDBiEOG72VH54.
    PhylomeDBiQ9QYC1.
    TreeFamiTF313570.

    Family and domain databases

    InterProiIPR007735. Pecanex.
    [Graphical view]
    PfamiPF05041. Pecanex_C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QYC1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY     50
    MALPSSMIIV AVYCPVVAAV FIILKMVNYR LHRALDAGEI VDRSAKEFTD 100
    QRAKAEQGNC STRRKDSNGP SDPGGGIEMS EFIREATPPV GCSSRNSYAG 150
    LDPSNQIGSG SSRLGTAATI KGDTDTAKTS DDISLSLGQS SSLCKEGSEE 200
    QDLATDRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV SLPSHSQHHR 250
    VDQSLCSACD TEVASLVPLH SHSYRKEHRP RGVPRTSSSA VAFPDASLSG 300
    LPLYQQQQRR GLDPVTELDS SKPHSGTRES SAGKSCPPAQ SQPAADRRKS 350
    SSQPPTKCGK SRALNAEKSV DSLRSLSTRS SGSTESYCSG TDRDTNSTLS 400
    SYKSEQTSST HIESILSEHE ESPKVGDKSA RKRECGADSV EERSHRADDR 450
    RTSSDKTAPE GNTPAGPPEA PDAQASEEMA DQAAPSSSAS EDANKNPHAN 500
    EFTVPGDRPP EQSAESKEEQ SEKPSLATDS RVCKDDGGKQ KEGDVRPKSS 550
    SLIHRTTSAH KPGRRRTGKK RASSFDSSRH RDYVSFRGVS GTKPHSAVFG 600
    HDEDSSDQSD LSRAPSIHSA HQFSSDSSSS ATSHSCQSPE GKYGALKTKH 650
    GHRDRGTDSD HTHRAHPGPE GTTKKRASRR TSSTSSAKTR ARVLSLDSGT 700
    VACLNDSNRL LAPDSMKPLT TSKSDLEAKE GEVLDELSLL GRASQLETVT 750
    RSRNSLPSQV AFPEGEEQDA ATGAAQASEE AVAFRRERST FRRQAVRRRH 800
    NAGSNPTPPT LLIGSPLSLQ DGQQGQQSTA QVKVQSRPPS QAAVLSASAS 850
    LLVRKGSVHL EASHDHASAV GGSSLHDELG KFSSTLYETG GCDMSLVNFE 900
    PAARRASNIC DTDSHVSSST SVRFYPHDML SLPQIRLNRL LTIDTDLLEQ 950
    QDIDLSPDLA ATYGPTEEAA QKVKHYYRFW VLPQLWIGIN FDRLTLLALF 1000
    DRNREILENI LAVVLAILVA FLGSILLIQG FFRDIWVFQF CLVIASCQYS 1050
    LLKSVQPDSS SPRHGHNRII AYSRPVYFCL CCGLIWLLDY GSRNLTTSKF 1100
    KLYGVTFTNP LVLLSARDLV IVFTLCFPIV FFIGLLPQVN TFVMYLCEQL 1150
    DIHIFGGNAT TSLLAALYSF LCSIVAVALL YGLCYGALRD SWDGQHVPVL 1200
    FSVFCGLLVA VSYHLSRQSS DPSVLFSLMQ SKIFPKADEK NPEDPLSEVK 1250
    DPLPEKLSNS VSERLQSDLV VCVIIGVLYF AIHVSTVFTA LQPALKYVLY 1300
    ALVGVVGLVT HYVLPQVRKQ LPWHCFSRPL LRTAEHSQYE VRNAATMMWF 1350
    EKLHVWLLFV EKNIIYPLIV LNELSSSAET IASPKKLDTE LGALMITIAG 1400
    LKLLRSSFSS PTYQYITVIF TVLFFKFDYE AFSETMLLDL FFMSILFSKL 1450
    WELLYKLQFV YTYVAPWQIT WGSAFHAFAQ PFAVPHSAML FVQAIVSAFF 1500
    STPLNPFLGS AIFITSYVRP VKFWERDYNT KRVDHSNTRL ASQLDRNPGS 1550
    DDNNLNSIFY EHLTRSLQHS LCGDLLLGRW GNYSTGDCFI LASDYLNALV 1600
    HLIEIGNGLV TFQLRGLEFR GTYCQQREVE AITEGVEEDE GFCCCEPGHV 1650
    PHVLSFNAAF GQRWLAWEVV VTKYILEGYS ITDNSAASML QVFDLRRVLT 1700
    TYYVKGIIYY VTTSSKLEEW LANETMQEGL RLCADRNYVD VDPTFNPNID 1750
    EDYDHRLAGI SRESFCVIYL SWIEYCSSRR AKPLDVDKDS SLVTLCYGLC 1800
    VLGRRALGTA SHHMSSNLES FLYGLHALFK GDFRISSVRD EWIFADMELL 1850
    RKVVVPGIRM SIKLHQDHFT SPDEYDDPTV LYEAIVSHEK NLVIAHEGDP 1900
    AWRSAVLANS PSLLALRHVM DDGTNEYKII MLNRRYLSFR VIKVNKECVR 1950
    GLWAGQQQEL VFLRNRNPER GSIQNAKQAL RNMINSSCDQ PIGYPIFVSP 2000
    LTTSYSDSHD QLKEILGGPI SLGNIRNFIV STWHRLRKGC GAGCNSGGNI 2050
    EDSDTGGGTS CPGNSAVTAS DPHNNVSQGS TGHPGQGAGS GLHPPTTSYP 2100
    PTLGTSHSAH SVQSSLVRQS PARASMASQS SYCYSSRHSS LRMSTTGFVP 2150
    CRRSSTSQIS LRNLPSSIQS RLSMVNQMEA ASQGGMGCVQ HGLPSSSSSS 2200
    QSIPACKHHT LVAFLGAEGG QGSATEAQPG NTSSPANISH ARKGEVIYRV 2250
    QIVDLSQILE GINVSKRKEL HWPDEGIRLK AGRNSWKDWS PQEGMEGHVV 2300
    HRWVPCSRDP STRSHIDKTV LLVQIDDKYV TIIETGVLEL GAEV 2344
    Length:2,344
    Mass (Da):258,147
    Last modified:January 9, 2007 - v3
    Checksum:iFF3E3C60D57488CB
    GO
    Isoform 2 (identifier: Q9QYC1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         854-945: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,252
    Mass (Da):248,162
    Checksum:i970A28422B905E70
    GO

    Sequence cautioni

    The sequence AAF21809.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti930 – 9345Missing in AAF21809. 1 PublicationCurated
    Sequence conflicti1220 – 12201S → N in AAF21809. 1 PublicationCurated
    Sequence conflicti1457 – 14571L → R in AAF21809. 1 PublicationCurated
    Sequence conflicti1806 – 18061A → T in BAB29314. (PubMed:16141072)Curated
    Sequence conflicti1874 – 18741E → K in BAB29314. (PubMed:16141072)Curated
    Sequence conflicti1899 – 18991D → Y in BAB29314. (PubMed:16141072)Curated
    Sequence conflicti2318 – 23181K → N in AAF21809. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei854 – 94592Missing in isoform 2. 1 PublicationVSP_022167Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124484 Genomic DNA. No translation available.
    AC124595 Genomic DNA. No translation available.
    AK129221 mRNA. Translation: BAC98031.3.
    AF096286 mRNA. Translation: AAF21809.1. Different initiation.
    AK014387 mRNA. Translation: BAB29314.1.
    CCDSiCCDS26025.1. [Q9QYC1-1]
    RefSeqiNP_061284.2. NM_018814.3. [Q9QYC1-1]
    UniGeneiMm.86584.

    Genome annotation databases

    EnsembliENSMUST00000021567; ENSMUSP00000021567; ENSMUSG00000021140. [Q9QYC1-1]
    GeneIDi54604.
    KEGGimmu:54604.
    UCSCiuc007ocq.1. mouse. [Q9QYC1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124484 Genomic DNA. No translation available.
    AC124595 Genomic DNA. No translation available.
    AK129221 mRNA. Translation: BAC98031.3 .
    AF096286 mRNA. Translation: AAF21809.1 . Different initiation.
    AK014387 mRNA. Translation: BAB29314.1 .
    CCDSi CCDS26025.1. [Q9QYC1-1 ]
    RefSeqi NP_061284.2. NM_018814.3. [Q9QYC1-1 ]
    UniGenei Mm.86584.

    3D structure databases

    ProteinModelPortali Q9QYC1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QYC1.

    Proteomic databases

    PaxDbi Q9QYC1.
    PRIDEi Q9QYC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021567 ; ENSMUSP00000021567 ; ENSMUSG00000021140 . [Q9QYC1-1 ]
    GeneIDi 54604.
    KEGGi mmu:54604.
    UCSCi uc007ocq.1. mouse. [Q9QYC1-1 ]

    Organism-specific databases

    CTDi 22990.
    MGIi MGI:1891924. Pcnx.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG297934.
    GeneTreei ENSGT00390000013164.
    HOGENOMi HOG000007773.
    HOVERGENi HBG045627.
    InParanoidi Q9QYC1.
    OMAi NYRLHRA.
    OrthoDBi EOG72VH54.
    PhylomeDBi Q9QYC1.
    TreeFami TF313570.

    Miscellaneous databases

    NextBioi 311396.
    PROi Q9QYC1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QYC1.
    CleanExi MM_PCNX.
    Genevestigatori Q9QYC1.

    Family and domain databases

    InterProi IPR007735. Pecanex.
    [Graphical view ]
    Pfami PF05041. Pecanex_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-2344 (ISOFORM 2).
      Tissue: Embryonic tail.
    3. "Cloning of a mouse homolog of the Drosophila pecanex gene."
      Roux A.-F.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 880-2344 (ISOFORM 1).
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1658-2344 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Brain.

    Entry informationi

    Entry nameiPCX1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYC1
    Secondary accession number(s): Q6ZQ41, Q9CUU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3