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Q9QYC1

- PCX1_MOUSE

UniProt

Q9QYC1 - PCX1_MOUSE

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Protein

Pecanex-like protein 1

Gene
Pcnx, Kiaa0805, Pcnxl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 1
Alternative name(s):
Pecanex homolog
Gene namesi
Name:Pcnx
Synonyms:Kiaa0805, Pcnxl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1891924. Pcnx.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Reviewed predictionAdd
BLAST
Transmembranei57 – 7721Helical; Reviewed predictionAdd
BLAST
Transmembranei1010 – 103021Helical; Reviewed predictionAdd
BLAST
Transmembranei1035 – 105521Helical; Reviewed predictionAdd
BLAST
Transmembranei1069 – 108921Helical; Reviewed predictionAdd
BLAST
Transmembranei1119 – 113921Helical; Reviewed predictionAdd
BLAST
Transmembranei1163 – 118321Helical; Reviewed predictionAdd
BLAST
Transmembranei1196 – 121621Helical; Reviewed predictionAdd
BLAST
Transmembranei1269 – 128921Helical; Reviewed predictionAdd
BLAST
Transmembranei1297 – 131721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23442344Pecanex-like protein 1PRO_0000215794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1094 – 10941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1158 – 11581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1582 – 15821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1723 – 17231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1985 – 19851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2075 – 20751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2231 – 22311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2237 – 22371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2263 – 22631N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QYC1.
PRIDEiQ9QYC1.

PTM databases

PhosphoSiteiQ9QYC1.

Expressioni

Gene expression databases

BgeeiQ9QYC1.
CleanExiMM_PCNX.
GenevestigatoriQ9QYC1.

Structurei

3D structure databases

ProteinModelPortaliQ9QYC1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi320 – 41798Ser-richAdd
BLAST
Compositional biasi573 – 63866Ser-richAdd
BLAST
Compositional biasi2106 – 220297Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the pecanex family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297934.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ9QYC1.
OMAiNYRLHRA.
OrthoDBiEOG72VH54.
PhylomeDBiQ9QYC1.
TreeFamiTF313570.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QYC1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY     50
MALPSSMIIV AVYCPVVAAV FIILKMVNYR LHRALDAGEI VDRSAKEFTD 100
QRAKAEQGNC STRRKDSNGP SDPGGGIEMS EFIREATPPV GCSSRNSYAG 150
LDPSNQIGSG SSRLGTAATI KGDTDTAKTS DDISLSLGQS SSLCKEGSEE 200
QDLATDRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV SLPSHSQHHR 250
VDQSLCSACD TEVASLVPLH SHSYRKEHRP RGVPRTSSSA VAFPDASLSG 300
LPLYQQQQRR GLDPVTELDS SKPHSGTRES SAGKSCPPAQ SQPAADRRKS 350
SSQPPTKCGK SRALNAEKSV DSLRSLSTRS SGSTESYCSG TDRDTNSTLS 400
SYKSEQTSST HIESILSEHE ESPKVGDKSA RKRECGADSV EERSHRADDR 450
RTSSDKTAPE GNTPAGPPEA PDAQASEEMA DQAAPSSSAS EDANKNPHAN 500
EFTVPGDRPP EQSAESKEEQ SEKPSLATDS RVCKDDGGKQ KEGDVRPKSS 550
SLIHRTTSAH KPGRRRTGKK RASSFDSSRH RDYVSFRGVS GTKPHSAVFG 600
HDEDSSDQSD LSRAPSIHSA HQFSSDSSSS ATSHSCQSPE GKYGALKTKH 650
GHRDRGTDSD HTHRAHPGPE GTTKKRASRR TSSTSSAKTR ARVLSLDSGT 700
VACLNDSNRL LAPDSMKPLT TSKSDLEAKE GEVLDELSLL GRASQLETVT 750
RSRNSLPSQV AFPEGEEQDA ATGAAQASEE AVAFRRERST FRRQAVRRRH 800
NAGSNPTPPT LLIGSPLSLQ DGQQGQQSTA QVKVQSRPPS QAAVLSASAS 850
LLVRKGSVHL EASHDHASAV GGSSLHDELG KFSSTLYETG GCDMSLVNFE 900
PAARRASNIC DTDSHVSSST SVRFYPHDML SLPQIRLNRL LTIDTDLLEQ 950
QDIDLSPDLA ATYGPTEEAA QKVKHYYRFW VLPQLWIGIN FDRLTLLALF 1000
DRNREILENI LAVVLAILVA FLGSILLIQG FFRDIWVFQF CLVIASCQYS 1050
LLKSVQPDSS SPRHGHNRII AYSRPVYFCL CCGLIWLLDY GSRNLTTSKF 1100
KLYGVTFTNP LVLLSARDLV IVFTLCFPIV FFIGLLPQVN TFVMYLCEQL 1150
DIHIFGGNAT TSLLAALYSF LCSIVAVALL YGLCYGALRD SWDGQHVPVL 1200
FSVFCGLLVA VSYHLSRQSS DPSVLFSLMQ SKIFPKADEK NPEDPLSEVK 1250
DPLPEKLSNS VSERLQSDLV VCVIIGVLYF AIHVSTVFTA LQPALKYVLY 1300
ALVGVVGLVT HYVLPQVRKQ LPWHCFSRPL LRTAEHSQYE VRNAATMMWF 1350
EKLHVWLLFV EKNIIYPLIV LNELSSSAET IASPKKLDTE LGALMITIAG 1400
LKLLRSSFSS PTYQYITVIF TVLFFKFDYE AFSETMLLDL FFMSILFSKL 1450
WELLYKLQFV YTYVAPWQIT WGSAFHAFAQ PFAVPHSAML FVQAIVSAFF 1500
STPLNPFLGS AIFITSYVRP VKFWERDYNT KRVDHSNTRL ASQLDRNPGS 1550
DDNNLNSIFY EHLTRSLQHS LCGDLLLGRW GNYSTGDCFI LASDYLNALV 1600
HLIEIGNGLV TFQLRGLEFR GTYCQQREVE AITEGVEEDE GFCCCEPGHV 1650
PHVLSFNAAF GQRWLAWEVV VTKYILEGYS ITDNSAASML QVFDLRRVLT 1700
TYYVKGIIYY VTTSSKLEEW LANETMQEGL RLCADRNYVD VDPTFNPNID 1750
EDYDHRLAGI SRESFCVIYL SWIEYCSSRR AKPLDVDKDS SLVTLCYGLC 1800
VLGRRALGTA SHHMSSNLES FLYGLHALFK GDFRISSVRD EWIFADMELL 1850
RKVVVPGIRM SIKLHQDHFT SPDEYDDPTV LYEAIVSHEK NLVIAHEGDP 1900
AWRSAVLANS PSLLALRHVM DDGTNEYKII MLNRRYLSFR VIKVNKECVR 1950
GLWAGQQQEL VFLRNRNPER GSIQNAKQAL RNMINSSCDQ PIGYPIFVSP 2000
LTTSYSDSHD QLKEILGGPI SLGNIRNFIV STWHRLRKGC GAGCNSGGNI 2050
EDSDTGGGTS CPGNSAVTAS DPHNNVSQGS TGHPGQGAGS GLHPPTTSYP 2100
PTLGTSHSAH SVQSSLVRQS PARASMASQS SYCYSSRHSS LRMSTTGFVP 2150
CRRSSTSQIS LRNLPSSIQS RLSMVNQMEA ASQGGMGCVQ HGLPSSSSSS 2200
QSIPACKHHT LVAFLGAEGG QGSATEAQPG NTSSPANISH ARKGEVIYRV 2250
QIVDLSQILE GINVSKRKEL HWPDEGIRLK AGRNSWKDWS PQEGMEGHVV 2300
HRWVPCSRDP STRSHIDKTV LLVQIDDKYV TIIETGVLEL GAEV 2344
Length:2,344
Mass (Da):258,147
Last modified:January 9, 2007 - v3
Checksum:iFF3E3C60D57488CB
GO
Isoform 2 (identifier: Q9QYC1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     854-945: Missing.

Note: No experimental confirmation available.

Show »
Length:2,252
Mass (Da):248,162
Checksum:i970A28422B905E70
GO

Sequence cautioni

The sequence AAF21809.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei854 – 94592Missing in isoform 2. VSP_022167Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti930 – 9345Missing in AAF21809. 1 Publication
Sequence conflicti1220 – 12201S → N in AAF21809. 1 Publication
Sequence conflicti1457 – 14571L → R in AAF21809. 1 Publication
Sequence conflicti1806 – 18061A → T in BAB29314. 1 Publication
Sequence conflicti1874 – 18741E → K in BAB29314. 1 Publication
Sequence conflicti1899 – 18991D → Y in BAB29314. 1 Publication
Sequence conflicti2318 – 23181K → N in AAF21809. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124484 Genomic DNA. No translation available.
AC124595 Genomic DNA. No translation available.
AK129221 mRNA. Translation: BAC98031.3.
AF096286 mRNA. Translation: AAF21809.1. Different initiation.
AK014387 mRNA. Translation: BAB29314.1.
CCDSiCCDS26025.1. [Q9QYC1-1]
RefSeqiNP_061284.2. NM_018814.3. [Q9QYC1-1]
UniGeneiMm.86584.

Genome annotation databases

EnsembliENSMUST00000021567; ENSMUSP00000021567; ENSMUSG00000021140. [Q9QYC1-1]
GeneIDi54604.
KEGGimmu:54604.
UCSCiuc007ocq.1. mouse. [Q9QYC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124484 Genomic DNA. No translation available.
AC124595 Genomic DNA. No translation available.
AK129221 mRNA. Translation: BAC98031.3 .
AF096286 mRNA. Translation: AAF21809.1 . Different initiation.
AK014387 mRNA. Translation: BAB29314.1 .
CCDSi CCDS26025.1. [Q9QYC1-1 ]
RefSeqi NP_061284.2. NM_018814.3. [Q9QYC1-1 ]
UniGenei Mm.86584.

3D structure databases

ProteinModelPortali Q9QYC1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QYC1.

Proteomic databases

PaxDbi Q9QYC1.
PRIDEi Q9QYC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021567 ; ENSMUSP00000021567 ; ENSMUSG00000021140 . [Q9QYC1-1 ]
GeneIDi 54604.
KEGGi mmu:54604.
UCSCi uc007ocq.1. mouse. [Q9QYC1-1 ]

Organism-specific databases

CTDi 22990.
MGIi MGI:1891924. Pcnx.
Rougei Search...

Phylogenomic databases

eggNOGi NOG297934.
GeneTreei ENSGT00390000013164.
HOGENOMi HOG000007773.
HOVERGENi HBG045627.
InParanoidi Q9QYC1.
OMAi NYRLHRA.
OrthoDBi EOG72VH54.
PhylomeDBi Q9QYC1.
TreeFami TF313570.

Miscellaneous databases

NextBioi 311396.
PROi Q9QYC1.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYC1.
CleanExi MM_PCNX.
Genevestigatori Q9QYC1.

Family and domain databases

InterProi IPR007735. Pecanex.
[Graphical view ]
Pfami PF05041. Pecanex_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-2344 (ISOFORM 2).
    Tissue: Embryonic tail.
  3. "Cloning of a mouse homolog of the Drosophila pecanex gene."
    Roux A.-F.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 880-2344 (ISOFORM 1).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1658-2344 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiPCX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYC1
Secondary accession number(s): Q6ZQ41, Q9CUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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