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Q9QYC1 (PCX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pecanex-like protein 1
Alternative name(s):
Pecanex homolog
Gene names
Name:Pcnx
Synonyms:Kiaa0805, Pcnxl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the pecanex family.

Sequence caution

The sequence AAF21809.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QYC1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QYC1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     854-945: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23442344Pecanex-like protein 1
PRO_0000215794

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane1010 – 103021Helical; Potential
Transmembrane1035 – 105521Helical; Potential
Transmembrane1069 – 108921Helical; Potential
Transmembrane1119 – 113921Helical; Potential
Transmembrane1163 – 118321Helical; Potential
Transmembrane1196 – 121621Helical; Potential
Transmembrane1269 – 128921Helical; Potential
Transmembrane1297 – 131721Helical; Potential
Compositional bias320 – 41798Ser-rich
Compositional bias573 – 63866Ser-rich
Compositional bias2106 – 220297Ser-rich

Amino acid modifications

Glycosylation10941N-linked (GlcNAc...) Potential
Glycosylation11581N-linked (GlcNAc...) Potential
Glycosylation15821N-linked (GlcNAc...) Potential
Glycosylation17231N-linked (GlcNAc...) Potential
Glycosylation19851N-linked (GlcNAc...) Potential
Glycosylation20751N-linked (GlcNAc...) Potential
Glycosylation22311N-linked (GlcNAc...) Potential
Glycosylation22371N-linked (GlcNAc...) Potential
Glycosylation22631N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence854 – 94592Missing in isoform 2.
VSP_022167

Experimental info

Sequence conflict930 – 9345Missing in AAF21809. Ref.3
Sequence conflict12201S → N in AAF21809. Ref.3
Sequence conflict14571L → R in AAF21809. Ref.3
Sequence conflict18061A → T in BAB29314. Ref.4
Sequence conflict18741E → K in BAB29314. Ref.4
Sequence conflict18991D → Y in BAB29314. Ref.4
Sequence conflict23181K → N in AAF21809. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2007. Version 3.
Checksum: FF3E3C60D57488CB

FASTA2,344258,147
        10         20         30         40         50         60 
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSSMIIV 

        70         80         90        100        110        120 
AVYCPVVAAV FIILKMVNYR LHRALDAGEI VDRSAKEFTD QRAKAEQGNC STRRKDSNGP 

       130        140        150        160        170        180 
SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS 

       190        200        210        220        230        240 
DDISLSLGQS SSLCKEGSEE QDLATDRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV 

       250        260        270        280        290        300 
SLPSHSQHHR VDQSLCSACD TEVASLVPLH SHSYRKEHRP RGVPRTSSSA VAFPDASLSG 

       310        320        330        340        350        360 
LPLYQQQQRR GLDPVTELDS SKPHSGTRES SAGKSCPPAQ SQPAADRRKS SSQPPTKCGK 

       370        380        390        400        410        420 
SRALNAEKSV DSLRSLSTRS SGSTESYCSG TDRDTNSTLS SYKSEQTSST HIESILSEHE 

       430        440        450        460        470        480 
ESPKVGDKSA RKRECGADSV EERSHRADDR RTSSDKTAPE GNTPAGPPEA PDAQASEEMA 

       490        500        510        520        530        540 
DQAAPSSSAS EDANKNPHAN EFTVPGDRPP EQSAESKEEQ SEKPSLATDS RVCKDDGGKQ 

       550        560        570        580        590        600 
KEGDVRPKSS SLIHRTTSAH KPGRRRTGKK RASSFDSSRH RDYVSFRGVS GTKPHSAVFG 

       610        620        630        640        650        660 
HDEDSSDQSD LSRAPSIHSA HQFSSDSSSS ATSHSCQSPE GKYGALKTKH GHRDRGTDSD 

       670        680        690        700        710        720 
HTHRAHPGPE GTTKKRASRR TSSTSSAKTR ARVLSLDSGT VACLNDSNRL LAPDSMKPLT 

       730        740        750        760        770        780 
TSKSDLEAKE GEVLDELSLL GRASQLETVT RSRNSLPSQV AFPEGEEQDA ATGAAQASEE 

       790        800        810        820        830        840 
AVAFRRERST FRRQAVRRRH NAGSNPTPPT LLIGSPLSLQ DGQQGQQSTA QVKVQSRPPS 

       850        860        870        880        890        900 
QAAVLSASAS LLVRKGSVHL EASHDHASAV GGSSLHDELG KFSSTLYETG GCDMSLVNFE 

       910        920        930        940        950        960 
PAARRASNIC DTDSHVSSST SVRFYPHDML SLPQIRLNRL LTIDTDLLEQ QDIDLSPDLA 

       970        980        990       1000       1010       1020 
ATYGPTEEAA QKVKHYYRFW VLPQLWIGIN FDRLTLLALF DRNREILENI LAVVLAILVA 

      1030       1040       1050       1060       1070       1080 
FLGSILLIQG FFRDIWVFQF CLVIASCQYS LLKSVQPDSS SPRHGHNRII AYSRPVYFCL 

      1090       1100       1110       1120       1130       1140 
CCGLIWLLDY GSRNLTTSKF KLYGVTFTNP LVLLSARDLV IVFTLCFPIV FFIGLLPQVN 

      1150       1160       1170       1180       1190       1200 
TFVMYLCEQL DIHIFGGNAT TSLLAALYSF LCSIVAVALL YGLCYGALRD SWDGQHVPVL 

      1210       1220       1230       1240       1250       1260 
FSVFCGLLVA VSYHLSRQSS DPSVLFSLMQ SKIFPKADEK NPEDPLSEVK DPLPEKLSNS 

      1270       1280       1290       1300       1310       1320 
VSERLQSDLV VCVIIGVLYF AIHVSTVFTA LQPALKYVLY ALVGVVGLVT HYVLPQVRKQ 

      1330       1340       1350       1360       1370       1380 
LPWHCFSRPL LRTAEHSQYE VRNAATMMWF EKLHVWLLFV EKNIIYPLIV LNELSSSAET 

      1390       1400       1410       1420       1430       1440 
IASPKKLDTE LGALMITIAG LKLLRSSFSS PTYQYITVIF TVLFFKFDYE AFSETMLLDL 

      1450       1460       1470       1480       1490       1500 
FFMSILFSKL WELLYKLQFV YTYVAPWQIT WGSAFHAFAQ PFAVPHSAML FVQAIVSAFF 

      1510       1520       1530       1540       1550       1560 
STPLNPFLGS AIFITSYVRP VKFWERDYNT KRVDHSNTRL ASQLDRNPGS DDNNLNSIFY 

      1570       1580       1590       1600       1610       1620 
EHLTRSLQHS LCGDLLLGRW GNYSTGDCFI LASDYLNALV HLIEIGNGLV TFQLRGLEFR 

      1630       1640       1650       1660       1670       1680 
GTYCQQREVE AITEGVEEDE GFCCCEPGHV PHVLSFNAAF GQRWLAWEVV VTKYILEGYS 

      1690       1700       1710       1720       1730       1740 
ITDNSAASML QVFDLRRVLT TYYVKGIIYY VTTSSKLEEW LANETMQEGL RLCADRNYVD 

      1750       1760       1770       1780       1790       1800 
VDPTFNPNID EDYDHRLAGI SRESFCVIYL SWIEYCSSRR AKPLDVDKDS SLVTLCYGLC 

      1810       1820       1830       1840       1850       1860 
VLGRRALGTA SHHMSSNLES FLYGLHALFK GDFRISSVRD EWIFADMELL RKVVVPGIRM 

      1870       1880       1890       1900       1910       1920 
SIKLHQDHFT SPDEYDDPTV LYEAIVSHEK NLVIAHEGDP AWRSAVLANS PSLLALRHVM 

      1930       1940       1950       1960       1970       1980 
DDGTNEYKII MLNRRYLSFR VIKVNKECVR GLWAGQQQEL VFLRNRNPER GSIQNAKQAL 

      1990       2000       2010       2020       2030       2040 
RNMINSSCDQ PIGYPIFVSP LTTSYSDSHD QLKEILGGPI SLGNIRNFIV STWHRLRKGC 

      2050       2060       2070       2080       2090       2100 
GAGCNSGGNI EDSDTGGGTS CPGNSAVTAS DPHNNVSQGS TGHPGQGAGS GLHPPTTSYP 

      2110       2120       2130       2140       2150       2160 
PTLGTSHSAH SVQSSLVRQS PARASMASQS SYCYSSRHSS LRMSTTGFVP CRRSSTSQIS 

      2170       2180       2190       2200       2210       2220 
LRNLPSSIQS RLSMVNQMEA ASQGGMGCVQ HGLPSSSSSS QSIPACKHHT LVAFLGAEGG 

      2230       2240       2250       2260       2270       2280 
QGSATEAQPG NTSSPANISH ARKGEVIYRV QIVDLSQILE GINVSKRKEL HWPDEGIRLK 

      2290       2300       2310       2320       2330       2340 
AGRNSWKDWS PQEGMEGHVV HRWVPCSRDP STRSHIDKTV LLVQIDDKYV TIIETGVLEL 


GAEV 

« Hide

Isoform 2 [UniParc].

Checksum: 970A28422B905E70
Show »

FASTA2,252248,162

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-2344 (ISOFORM 2).
Tissue: Embryonic tail.
[3]"Cloning of a mouse homolog of the Drosophila pecanex gene."
Roux A.-F.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 880-2344 (ISOFORM 1).
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1658-2344 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC124484 Genomic DNA. No translation available.
AC124595 Genomic DNA. No translation available.
AK129221 mRNA. Translation: BAC98031.3.
AF096286 mRNA. Translation: AAF21809.1. Different initiation.
AK014387 mRNA. Translation: BAB29314.1.
CCDSCCDS26025.1. [Q9QYC1-1]
RefSeqNP_061284.2. NM_018814.3. [Q9QYC1-1]
UniGeneMm.86584.

3D structure databases

ProteinModelPortalQ9QYC1.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QYC1.

Proteomic databases

PaxDbQ9QYC1.
PRIDEQ9QYC1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021567; ENSMUSP00000021567; ENSMUSG00000021140. [Q9QYC1-1]
GeneID54604.
KEGGmmu:54604.
UCSCuc007ocq.1. mouse. [Q9QYC1-1]

Organism-specific databases

CTD22990.
MGIMGI:1891924. Pcnx.
RougeSearch...

Phylogenomic databases

eggNOGNOG297934.
GeneTreeENSGT00390000013164.
HOGENOMHOG000007773.
HOVERGENHBG045627.
InParanoidQ9QYC1.
OMANYRLHRA.
OrthoDBEOG72VH54.
PhylomeDBQ9QYC1.
TreeFamTF313570.

Gene expression databases

BgeeQ9QYC1.
CleanExMM_PCNX.
GenevestigatorQ9QYC1.

Family and domain databases

InterProIPR007735. Pecanex.
[Graphical view]
PfamPF05041. Pecanex_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311396.
PROQ9QYC1.
SOURCESearch...

Entry information

Entry namePCX1_MOUSE
AccessionPrimary (citable) accession number: Q9QYC1
Secondary accession number(s): Q6ZQ41, Q9CUU7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot