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Protein

Pecanex-like protein 1

Gene

Pcnx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 1
Alternative name(s):
Pecanex homolog
Gene namesi
Name:Pcnx
Synonyms:Kiaa0805, Pcnxl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1891924. Pcnx.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Transmembranei1010 – 103021HelicalSequence AnalysisAdd
BLAST
Transmembranei1035 – 105521HelicalSequence AnalysisAdd
BLAST
Transmembranei1069 – 108921HelicalSequence AnalysisAdd
BLAST
Transmembranei1119 – 113921HelicalSequence AnalysisAdd
BLAST
Transmembranei1163 – 118321HelicalSequence AnalysisAdd
BLAST
Transmembranei1196 – 121621HelicalSequence AnalysisAdd
BLAST
Transmembranei1269 – 128921HelicalSequence AnalysisAdd
BLAST
Transmembranei1297 – 131721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23442344Pecanex-like protein 1PRO_0000215794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1094 – 10941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1158 – 11581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1582 – 15821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1723 – 17231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1985 – 19851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2075 – 20751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2231 – 22311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2237 – 22371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2263 – 22631N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QYC1.
PRIDEiQ9QYC1.

PTM databases

PhosphoSiteiQ9QYC1.

Expressioni

Gene expression databases

BgeeiQ9QYC1.
CleanExiMM_PCNX.
GenevestigatoriQ9QYC1.

Structurei

3D structure databases

ProteinModelPortaliQ9QYC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi320 – 41798Ser-richAdd
BLAST
Compositional biasi573 – 63866Ser-richAdd
BLAST
Compositional biasi2106 – 220297Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297934.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ9QYC1.
OMAiNYRLHRA.
OrthoDBiEOG72VH54.
PhylomeDBiQ9QYC1.
TreeFamiTF313570.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QYC1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY
60 70 80 90 100
MALPSSMIIV AVYCPVVAAV FIILKMVNYR LHRALDAGEI VDRSAKEFTD
110 120 130 140 150
QRAKAEQGNC STRRKDSNGP SDPGGGIEMS EFIREATPPV GCSSRNSYAG
160 170 180 190 200
LDPSNQIGSG SSRLGTAATI KGDTDTAKTS DDISLSLGQS SSLCKEGSEE
210 220 230 240 250
QDLATDRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV SLPSHSQHHR
260 270 280 290 300
VDQSLCSACD TEVASLVPLH SHSYRKEHRP RGVPRTSSSA VAFPDASLSG
310 320 330 340 350
LPLYQQQQRR GLDPVTELDS SKPHSGTRES SAGKSCPPAQ SQPAADRRKS
360 370 380 390 400
SSQPPTKCGK SRALNAEKSV DSLRSLSTRS SGSTESYCSG TDRDTNSTLS
410 420 430 440 450
SYKSEQTSST HIESILSEHE ESPKVGDKSA RKRECGADSV EERSHRADDR
460 470 480 490 500
RTSSDKTAPE GNTPAGPPEA PDAQASEEMA DQAAPSSSAS EDANKNPHAN
510 520 530 540 550
EFTVPGDRPP EQSAESKEEQ SEKPSLATDS RVCKDDGGKQ KEGDVRPKSS
560 570 580 590 600
SLIHRTTSAH KPGRRRTGKK RASSFDSSRH RDYVSFRGVS GTKPHSAVFG
610 620 630 640 650
HDEDSSDQSD LSRAPSIHSA HQFSSDSSSS ATSHSCQSPE GKYGALKTKH
660 670 680 690 700
GHRDRGTDSD HTHRAHPGPE GTTKKRASRR TSSTSSAKTR ARVLSLDSGT
710 720 730 740 750
VACLNDSNRL LAPDSMKPLT TSKSDLEAKE GEVLDELSLL GRASQLETVT
760 770 780 790 800
RSRNSLPSQV AFPEGEEQDA ATGAAQASEE AVAFRRERST FRRQAVRRRH
810 820 830 840 850
NAGSNPTPPT LLIGSPLSLQ DGQQGQQSTA QVKVQSRPPS QAAVLSASAS
860 870 880 890 900
LLVRKGSVHL EASHDHASAV GGSSLHDELG KFSSTLYETG GCDMSLVNFE
910 920 930 940 950
PAARRASNIC DTDSHVSSST SVRFYPHDML SLPQIRLNRL LTIDTDLLEQ
960 970 980 990 1000
QDIDLSPDLA ATYGPTEEAA QKVKHYYRFW VLPQLWIGIN FDRLTLLALF
1010 1020 1030 1040 1050
DRNREILENI LAVVLAILVA FLGSILLIQG FFRDIWVFQF CLVIASCQYS
1060 1070 1080 1090 1100
LLKSVQPDSS SPRHGHNRII AYSRPVYFCL CCGLIWLLDY GSRNLTTSKF
1110 1120 1130 1140 1150
KLYGVTFTNP LVLLSARDLV IVFTLCFPIV FFIGLLPQVN TFVMYLCEQL
1160 1170 1180 1190 1200
DIHIFGGNAT TSLLAALYSF LCSIVAVALL YGLCYGALRD SWDGQHVPVL
1210 1220 1230 1240 1250
FSVFCGLLVA VSYHLSRQSS DPSVLFSLMQ SKIFPKADEK NPEDPLSEVK
1260 1270 1280 1290 1300
DPLPEKLSNS VSERLQSDLV VCVIIGVLYF AIHVSTVFTA LQPALKYVLY
1310 1320 1330 1340 1350
ALVGVVGLVT HYVLPQVRKQ LPWHCFSRPL LRTAEHSQYE VRNAATMMWF
1360 1370 1380 1390 1400
EKLHVWLLFV EKNIIYPLIV LNELSSSAET IASPKKLDTE LGALMITIAG
1410 1420 1430 1440 1450
LKLLRSSFSS PTYQYITVIF TVLFFKFDYE AFSETMLLDL FFMSILFSKL
1460 1470 1480 1490 1500
WELLYKLQFV YTYVAPWQIT WGSAFHAFAQ PFAVPHSAML FVQAIVSAFF
1510 1520 1530 1540 1550
STPLNPFLGS AIFITSYVRP VKFWERDYNT KRVDHSNTRL ASQLDRNPGS
1560 1570 1580 1590 1600
DDNNLNSIFY EHLTRSLQHS LCGDLLLGRW GNYSTGDCFI LASDYLNALV
1610 1620 1630 1640 1650
HLIEIGNGLV TFQLRGLEFR GTYCQQREVE AITEGVEEDE GFCCCEPGHV
1660 1670 1680 1690 1700
PHVLSFNAAF GQRWLAWEVV VTKYILEGYS ITDNSAASML QVFDLRRVLT
1710 1720 1730 1740 1750
TYYVKGIIYY VTTSSKLEEW LANETMQEGL RLCADRNYVD VDPTFNPNID
1760 1770 1780 1790 1800
EDYDHRLAGI SRESFCVIYL SWIEYCSSRR AKPLDVDKDS SLVTLCYGLC
1810 1820 1830 1840 1850
VLGRRALGTA SHHMSSNLES FLYGLHALFK GDFRISSVRD EWIFADMELL
1860 1870 1880 1890 1900
RKVVVPGIRM SIKLHQDHFT SPDEYDDPTV LYEAIVSHEK NLVIAHEGDP
1910 1920 1930 1940 1950
AWRSAVLANS PSLLALRHVM DDGTNEYKII MLNRRYLSFR VIKVNKECVR
1960 1970 1980 1990 2000
GLWAGQQQEL VFLRNRNPER GSIQNAKQAL RNMINSSCDQ PIGYPIFVSP
2010 2020 2030 2040 2050
LTTSYSDSHD QLKEILGGPI SLGNIRNFIV STWHRLRKGC GAGCNSGGNI
2060 2070 2080 2090 2100
EDSDTGGGTS CPGNSAVTAS DPHNNVSQGS TGHPGQGAGS GLHPPTTSYP
2110 2120 2130 2140 2150
PTLGTSHSAH SVQSSLVRQS PARASMASQS SYCYSSRHSS LRMSTTGFVP
2160 2170 2180 2190 2200
CRRSSTSQIS LRNLPSSIQS RLSMVNQMEA ASQGGMGCVQ HGLPSSSSSS
2210 2220 2230 2240 2250
QSIPACKHHT LVAFLGAEGG QGSATEAQPG NTSSPANISH ARKGEVIYRV
2260 2270 2280 2290 2300
QIVDLSQILE GINVSKRKEL HWPDEGIRLK AGRNSWKDWS PQEGMEGHVV
2310 2320 2330 2340
HRWVPCSRDP STRSHIDKTV LLVQIDDKYV TIIETGVLEL GAEV
Length:2,344
Mass (Da):258,147
Last modified:January 9, 2007 - v3
Checksum:iFF3E3C60D57488CB
GO
Isoform 2 (identifier: Q9QYC1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     854-945: Missing.

Note: No experimental confirmation available.

Show »
Length:2,252
Mass (Da):248,162
Checksum:i970A28422B905E70
GO

Sequence cautioni

The sequence AAF21809.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti930 – 9345Missing in AAF21809. 1 PublicationCurated
Sequence conflicti1220 – 12201S → N in AAF21809. 1 PublicationCurated
Sequence conflicti1457 – 14571L → R in AAF21809. 1 PublicationCurated
Sequence conflicti1806 – 18061A → T in BAB29314. (PubMed:16141072)Curated
Sequence conflicti1874 – 18741E → K in BAB29314. (PubMed:16141072)Curated
Sequence conflicti1899 – 18991D → Y in BAB29314. (PubMed:16141072)Curated
Sequence conflicti2318 – 23181K → N in AAF21809. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei854 – 94592Missing in isoform 2. 1 PublicationVSP_022167Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124484 Genomic DNA. No translation available.
AC124595 Genomic DNA. No translation available.
AK129221 mRNA. Translation: BAC98031.3.
AF096286 mRNA. Translation: AAF21809.1. Different initiation.
AK014387 mRNA. Translation: BAB29314.1.
CCDSiCCDS26025.1. [Q9QYC1-1]
RefSeqiNP_061284.2. NM_018814.3. [Q9QYC1-1]
UniGeneiMm.86584.

Genome annotation databases

EnsembliENSMUST00000021567; ENSMUSP00000021567; ENSMUSG00000021140. [Q9QYC1-1]
GeneIDi54604.
KEGGimmu:54604.
UCSCiuc007ocq.1. mouse. [Q9QYC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124484 Genomic DNA. No translation available.
AC124595 Genomic DNA. No translation available.
AK129221 mRNA. Translation: BAC98031.3.
AF096286 mRNA. Translation: AAF21809.1. Different initiation.
AK014387 mRNA. Translation: BAB29314.1.
CCDSiCCDS26025.1. [Q9QYC1-1]
RefSeqiNP_061284.2. NM_018814.3. [Q9QYC1-1]
UniGeneiMm.86584.

3D structure databases

ProteinModelPortaliQ9QYC1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QYC1.

Proteomic databases

PaxDbiQ9QYC1.
PRIDEiQ9QYC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021567; ENSMUSP00000021567; ENSMUSG00000021140. [Q9QYC1-1]
GeneIDi54604.
KEGGimmu:54604.
UCSCiuc007ocq.1. mouse. [Q9QYC1-1]

Organism-specific databases

CTDi22990.
MGIiMGI:1891924. Pcnx.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG297934.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ9QYC1.
OMAiNYRLHRA.
OrthoDBiEOG72VH54.
PhylomeDBiQ9QYC1.
TreeFamiTF313570.

Miscellaneous databases

NextBioi311396.
PROiQ9QYC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYC1.
CleanExiMM_PCNX.
GenevestigatoriQ9QYC1.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-2344 (ISOFORM 2).
    Tissue: Embryonic tail.
  3. "Cloning of a mouse homolog of the Drosophila pecanex gene."
    Roux A.-F.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 880-2344 (ISOFORM 1).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1658-2344 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiPCX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYC1
Secondary accession number(s): Q6ZQ41, Q9CUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 9, 2007
Last modified: January 7, 2015
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.