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Q9QYC0

- ADDA_MOUSE

UniProt

Q9QYC0 - ADDA_MOUSE

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Protein

Alpha-adducin

Gene

Add1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. structural molecule activity Source: MGI

GO - Biological processi

  1. actin filament bundle assembly Source: Ensembl
  2. barbed-end actin filament capping Source: Ensembl
  3. cell morphogenesis Source: MGI
  4. cellular response to retinoic acid Source: Ensembl
  5. cell volume homeostasis Source: MGI
  6. erythrocyte differentiation Source: MGI
  7. hemoglobin metabolic process Source: MGI
  8. homeostasis of number of cells within a tissue Source: MGI
  9. in utero embryonic development Source: MGI
  10. multicellular organism growth Source: MGI
  11. positive regulation of angiogenesis Source: Ensembl
  12. positive regulation of endocytosis Source: Ensembl
  13. positive regulation of protein binding Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.
REACT_210562. Caspase-mediated cleavage of cytoskeletal proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-adducin
Alternative name(s):
Erythrocyte adducin subunit alpha
Gene namesi
Name:Add1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:87918. Add1.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: MGI
  2. dendritic spine Source: Ensembl
  3. F-actin capping protein complex Source: Ensembl
  4. intermediate filament cytoskeleton Source: Ensembl
  5. membrane Source: MGI
  6. nucleus Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. plasma membrane Source: UniProtKB-KW
  9. postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Alpha-adducinPRO_0000218531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei59 – 591Phosphoserine; by PKABy similarity
Modified residuei331 – 3311PhosphothreonineBy similarity
Modified residuei334 – 3341PhosphoserineBy similarity
Modified residuei408 – 4081Phosphoserine; by PKABy similarity
Modified residuei431 – 4311PhosphoserineBy similarity
Modified residuei436 – 4361Phosphoserine; by PKABy similarity
Modified residuei445 – 4451Phosphothreonine; by ROCK2By similarity
Modified residuei465 – 4651PhosphoserineBy similarity
Modified residuei480 – 4801Phosphothreonine; by ROCK2By similarity
Modified residuei481 – 4811Phosphoserine; by PKABy similarity
Modified residuei586 – 5861Phosphoserine1 Publication
Modified residuei610 – 6101Phosphothreonine1 Publication
Modified residuei705 – 7051PhosphoserineBy similarity
Modified residuei708 – 7081PhosphoserineBy similarity
Modified residuei712 – 7121PhosphoserineBy similarity
Modified residuei714 – 7141Phosphoserine; by PKCBy similarity
Modified residuei724 – 7241Phosphoserine; by PKA and PKCBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QYC0.
PaxDbiQ9QYC0.
PRIDEiQ9QYC0.

PTM databases

PhosphoSiteiQ9QYC0.

Expressioni

Gene expression databases

BgeeiQ9QYC0.
CleanExiMM_ADD1.
ExpressionAtlasiQ9QYC0. baseline and differential.
GenevestigatoriQ9QYC0.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.

Protein-protein interaction databases

BioGridi197981. 6 interactions.
IntActiQ9QYC0. 4 interactions.
MINTiMINT-4998369.

Structurei

3D structure databases

ProteinModelPortaliQ9QYC0.
SMRiQ9QYC0. Positions 161-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni715 – 73218Interaction with calmodulinSequence AnalysisAdd
BLAST

Domaini

Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
GeneTreeiENSGT00390000016462.
HOGENOMiHOG000116349.
HOVERGENiHBG004180.
InParanoidiQ9QYC0.
OMAiWTKEDGH.
OrthoDBiEOG7HF1HR.
PhylomeDBiQ9QYC0.
TreeFamiTF313003.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR027766. ADD1.
IPR001303. Aldolase_II/adducin_N.
[Graphical view]
PANTHERiPTHR10672:SF4. PTHR10672:SF4. 1 hit.
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9QYC0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDTRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN
60 70 80 90 100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTA
110 120 130 140 150
SVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA
160 170 180 190 200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKV
210 220 230 240 250
NLQGDIVDRG STNLGVNQAG FTLHSAVYAA RPDAKCIVHI HTPAGAAVSA
260 270 280 290 300
MKCGLLPISP EALSLGDVAY HDYHGILVDE EEKILIQKNL GPKSKVLILR
310 320 330 340 350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLDPGKYK
360 370 380 390 400
AKSRSPGTPA GEGSGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL
410 420 430 440 450
RERSKKYSDV EVPASVTGHS FASDGDSGTC SPLRHSFQKQ QREKTRWLHS
460 470 480 490 500
GRGDDASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ
510 520 530 540 550
EMRNKIREQN LQDIKTAGPQ SQVLCGVMMD RSLVQGELVT ASKAIIEKEY
560 570 580 590 600
QPHVIVSTTG PNPFNTLTDR ELEEYRREVE RKQKGSEENL DETREQKEKS
610 620 630 640 650
PPDQSAVPNT PPSTPVKLEE DLPQEPTSRD DSDATTFKPT PPDLSPDEPS
660 670 680 690 700
EALAFPAVEE EAHASPDPTQ PPAEADPEPA SAPTPGAEEV ASPATEEGSP
710 720 730
MDPGSDGSPG KSPSKKKKKF RTPSFLKKSK KKSDS
Length:735
Mass (Da):80,647
Last modified:December 1, 2000 - v2
Checksum:iE6AAA7F6273A33DD
GO
Isoform 2 (identifier: Q9QYC0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-632: DLPQEPTSRDDS → AGDGCAKEYLLP
     633-735: Missing.

Show »
Length:632
Mass (Da):69,887
Checksum:iEA5ED051D13C6B38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341A → T in AAF29504. (PubMed:10845937)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei621 – 63212DLPQE…SRDDS → AGDGCAKEYLLP in isoform 2. CuratedVSP_000177Add
BLAST
Alternative sequencei633 – 735103Missing in isoform 2. CuratedVSP_000178Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096839 mRNA. Translation: AAF24971.1.
AF189771 mRNA. Translation: AAF29504.1.
CCDSiCCDS19216.1. [Q9QYC0-1]
CCDS39069.1. [Q9QYC0-2]
RefSeqiNP_001019629.2. NM_001024458.3. [Q9QYC0-1]
NP_001095914.1. NM_001102444.1.
NP_038485.1. NM_013457.3. [Q9QYC0-2]
UniGeneiMm.289106.

Genome annotation databases

EnsembliENSMUST00000114338; ENSMUSP00000109977; ENSMUSG00000029106. [Q9QYC0-2]
ENSMUST00000114340; ENSMUSP00000109979; ENSMUSG00000029106. [Q9QYC0-1]
GeneIDi11518.
KEGGimmu:11518.
UCSCiuc008xcp.1. mouse. [Q9QYC0-2]
uc008xcr.1. mouse. [Q9QYC0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096839 mRNA. Translation: AAF24971.1 .
AF189771 mRNA. Translation: AAF29504.1 .
CCDSi CCDS19216.1. [Q9QYC0-1 ]
CCDS39069.1. [Q9QYC0-2 ]
RefSeqi NP_001019629.2. NM_001024458.3. [Q9QYC0-1 ]
NP_001095914.1. NM_001102444.1.
NP_038485.1. NM_013457.3. [Q9QYC0-2 ]
UniGenei Mm.289106.

3D structure databases

ProteinModelPortali Q9QYC0.
SMRi Q9QYC0. Positions 161-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197981. 6 interactions.
IntActi Q9QYC0. 4 interactions.
MINTi MINT-4998369.

PTM databases

PhosphoSitei Q9QYC0.

Proteomic databases

MaxQBi Q9QYC0.
PaxDbi Q9QYC0.
PRIDEi Q9QYC0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114338 ; ENSMUSP00000109977 ; ENSMUSG00000029106 . [Q9QYC0-2 ]
ENSMUST00000114340 ; ENSMUSP00000109979 ; ENSMUSG00000029106 . [Q9QYC0-1 ]
GeneIDi 11518.
KEGGi mmu:11518.
UCSCi uc008xcp.1. mouse. [Q9QYC0-2 ]
uc008xcr.1. mouse. [Q9QYC0-1 ]

Organism-specific databases

CTDi 118.
MGIi MGI:87918. Add1.

Phylogenomic databases

eggNOGi COG0235.
GeneTreei ENSGT00390000016462.
HOGENOMi HOG000116349.
HOVERGENi HBG004180.
InParanoidi Q9QYC0.
OMAi WTKEDGH.
OrthoDBi EOG7HF1HR.
PhylomeDBi Q9QYC0.
TreeFami TF313003.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.
REACT_210562. Caspase-mediated cleavage of cytoskeletal proteins.

Miscellaneous databases

ChiTaRSi ADD1. mouse.
NextBioi 278944.
PROi Q9QYC0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QYC0.
CleanExi MM_ADD1.
ExpressionAtlasi Q9QYC0. baseline and differential.
Genevestigatori Q9QYC0.

Family and domain databases

Gene3Di 3.40.225.10. 1 hit.
InterProi IPR027766. ADD1.
IPR001303. Aldolase_II/adducin_N.
[Graphical view ]
PANTHERi PTHR10672:SF4. PTHR10672:SF4. 1 hit.
Pfami PF00596. Aldolase_II. 1 hit.
[Graphical view ]
SMARTi SM01007. Aldolase_II. 1 hit.
[Graphical view ]
SUPFAMi SSF53639. SSF53639. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse adducin gene family: alternative splicing and chromosomal localization."
    Suriyapperuma S.P., Lozovatsky L., Ciciotte S.L., Peters L.L., Gilligan D.M.
    Mamm. Genome 11:16-23(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
  2. "Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice."
    Muro A.F., Marro M.L., Gajovic S., Porro F., Luzzatto L., Baralle F.E.
    Blood 95:3978-3985(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-610, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiADDA_MOUSE
AccessioniPrimary (citable) accession number: Q9QYC0
Secondary accession number(s): Q9JLE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3