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Protein

Dachshund homolog 1

Gene

Dach1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • development of primary female sexual characteristics Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cell proliferation involved in contact inhibition Source: MGI
  • negative regulation of DNA biosynthetic process Source: MGI
  • negative regulation of fibroblast proliferation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by competitive promoter binding Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of nuclear cell cycle DNA replication Source: CACAO
  • regulation of transcription, DNA-templated Source: MGI
  • respiratory gaseous exchange Source: MGI
  • RNA polymerase II transcriptional preinitiation complex assembly Source: GOC
  • suckling behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dachshund homolog 1
Short name:
Dach1
Gene namesi
Name:Dach1
Synonyms:Dach
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1277991. Dach1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Dachshund homolog 1PRO_0000095598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei484 – 4841PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QYB2.
PaxDbiQ9QYB2.
PRIDEiQ9QYB2.

PTM databases

PhosphoSiteiQ9QYB2.

Expressioni

Tissue specificityi

Expressed at higher levels in adult kidney and lung, and at lower levels in brain and testis. Expressed in embryonal kidneys, eyes, cochleae and limb buds.2 Publications

Developmental stagei

Highest expression was found at 11.5 dpc, and expression rapidly declines at later stages of the development. Between 8.0 and 13.5 dpc is found in neural crest cells during their pre-migratory, migratory, and, in some cases post-migratory phase throughout the body axis. Also found in lateral mesenchyme of trunk and head. At 10 and 12 dpc found in mesonephric tubules. At 16 dpc found in epithalial cells of metanephric "comma" and "S"-shaped bodies, in mesenchymal cells of the medulla and the cortex. Colocalized to the nucleus of glomerular podocytes and epithelial cells lining many of the convoluted tubes. At 10.5 dpc found in both the anterior and posterior of the limb bud. At 11.5 dpc expression becomes increasingly peripheral, extending around the entire handplate in the mesenchymal cells underlying the apical ectodermal ridge. At 12.5 dpc expression is entirely peripheral an by 13.5 dpc is localized to the mesenchyme at the distal tips of the digits. At 10 dpc found in cells of the optic cup and in some cells surrounding the eye. At 12 dpc found in developing lens fibers, the ectoderm overlaying the developing eye and less intensely in the retina. At 12 dpc found in cells of the dorsomedial and dorsolateral epithelium of the otic vesicle. At later stages expressed in only a few specialized cell types of the cochlear duct, including the inner and outer hair cells, stria vascularis, and the mesenchymal cells directly underlying the organ of Corti. From 10.5 to 12.5 dpc expressed in the telencephalon including the olfactory bulbs, throughout the length of the neural tube and within the dorsal root ganglia, in cranial ganglia in the trigeminal ganglion and the glossopharyngeal-vagal ganglion complex. At 10.5 and 11.5 dpc expressed in punctate pattern on the ventral side of the embryo between the fore and hind limbs, the rib primordia; this expression disappears by 12.5 dpc. At 11.5 and 12.5 dpc found in genital eminence.4 Publications

Gene expression databases

BgeeiQ9QYB2.
CleanExiMM_DACH1.
GenevisibleiQ9QYB2. MM.

Interactioni

Subunit structurei

Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C-terminus. Interacts with SMAD3 and SMAD4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ncor1Q609742EBI-348961,EBI-349004

Protein-protein interaction databases

BioGridi199044. 1 interaction.
IntActiQ9QYB2. 6 interactions.
MINTiMINT-4092795.
STRINGi10090.ENSMUSP00000071464.

Structurei

3D structure databases

ProteinModelPortaliQ9QYB2.
SMRiQ9QYB2. Positions 177-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 377196Interaction with SIX6 and HDAC3Add
BLAST
Regioni182 – 26887DACHbox-NAdd
BLAST
Regioni609 – 68981DACHbox-CAdd
BLAST
Regioni620 – 69980Interaction with SIN3AAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili623 – 71189Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi76 – 9621Poly-GlyAdd
BLAST
Compositional biasi115 – 1184Poly-Gly
Compositional biasi130 – 15627Poly-SerAdd
BLAST
Compositional biasi318 – 3269Poly-Ala
Compositional biasi460 – 4634Poly-Ala

Domaini

The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.By similarity

Sequence similaritiesi

Belongs to the DACH/dachshund family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3915. Eukaryota.
ENOG4111FAG. LUCA.
GeneTreeiENSGT00390000001134.
HOVERGENiHBG065810.
InParanoidiQ9QYB2.
OMAiHPRMPGA.
OrthoDBiEOG7ZKSCN.
PhylomeDBiQ9QYB2.
TreeFamiTF316697.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR003380. Transform_Ski.
[Graphical view]
PfamiPF02437. Ski_Sno. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QYB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS
60 70 80 90 100
GPTLFRPEPI ASSASSSAAA TVTSPGGGGG GSGGGGGSGG NGGGGGSNCN
110 120 130 140 150
PSLAAGSSGG GVSAGGGGAS STPITASTGS SSSSSSSSSS SSSSSSSSSS
160 170 180 190 200
SSSSSSCGPL PGKPVYSTPS PVENTPQNNE CKMVDLRGAK VASFTVEGCE
210 220 230 240 250
LICLPQAFDL FLKHLVGGLH TVYTKLKRLE ITPVVCNVEQ VRILRGLGAI
260 270 280 290 300
QPGVNRCKLI SRKDFETLYN DCTNASSRPG RPPKRTQSVT SPENSHIMPH
310 320 330 340 350
SVPGLMSPGI IPPTGLTAAA AAAAAATNAA IAEAMKVKKI KLEAMSNYHA
360 370 380 390 400
SNNQHGADSE NGDMNSSVGS SGGSWDKETL HSPPSQGSQA PVAHARMPAA
410 420 430 440 450
FSLPVSHPLN HLQHSHLPPN GLELPFMMMP HPLIPVSLPP ASVTMAMSQM
460 470 480 490 500
NHLSTIANMA AAAQVQSPPS RVETSVIKER VPDSPSPAPS LEEGRRPGSH
510 520 530 540 550
PSSHRSSSVS SSPARTESSS DRIPVHQNGL SMNQMLMGLS PNVLPGPKEG
560 570 580 590 600
DLAGHDMGHE SKRIHIEKDE TPLSTPTARD SIDKLSLTGH GQPLPPGFPS
610 620 630 640 650
PFLFPDGLSS IETLLTNIQG LLKVAIDNAR AQEKQVQLEK TELKMDFLRE
660 670 680 690 700
RELRETLEKQ LAMEQKNRAI VQKRLKKEKK AKRKLQEALE FETKRREQAE
710 720 730 740 750
QTLKQAASAD SLRVLNDSLT PEIEADRSGG RADAERTIQD GRLYLKTTVM

Y
Length:751
Mass (Da):77,972
Last modified:May 1, 2000 - v1
Checksum:i0679337DBA742EC9
GO
Isoform 2 (identifier: Q9QYB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-421: Missing.

Show »
Length:699
Mass (Da):72,534
Checksum:i912197D66E4B829A
GO

Sequence cautioni

The sequence CAA06665.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621S → Y in AAD16097 (PubMed:9915577).Curated
Sequence conflicti62 – 621S → Y in AAD16098 (PubMed:9915577).Curated
Sequence conflicti227 – 2271K → E in BAC33046 (PubMed:16141072).Curated
Sequence conflicti393 – 3931A → T in CAA06665 (PubMed:9915577).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei370 – 42152Missing in isoform 2. 4 PublicationsVSP_009489Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102547 mRNA. Translation: AAF04742.1.
AF090436 mRNA. Translation: AAD16097.1.
AF090437 mRNA. Translation: AAD16098.1.
AF129510 mRNA. Translation: AAF22955.1.
BC141130 mRNA. Translation: AAI41131.1.
AK053594 mRNA. Translation: BAC35441.1.
AK047409 mRNA. Translation: BAC33046.1.
AJ005669 mRNA. Translation: CAA06665.1. Different initiation.
CCDSiCCDS36993.1. [Q9QYB2-2]
CCDS36994.1. [Q9QYB2-1]
RefSeqiNP_001033699.1. NM_001038610.2. [Q9QYB2-2]
NP_031852.1. NM_007826.3. [Q9QYB2-1]
UniGeneiMm.320593.

Genome annotation databases

EnsembliENSMUST00000069334; ENSMUSP00000064970; ENSMUSG00000055639. [Q9QYB2-2]
ENSMUST00000071533; ENSMUSP00000071464; ENSMUSG00000055639. [Q9QYB2-1]
GeneIDi13134.
KEGGimmu:13134.
UCSCiuc007uur.2. mouse. [Q9QYB2-1]
uc007uus.2. mouse. [Q9QYB2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102547 mRNA. Translation: AAF04742.1.
AF090436 mRNA. Translation: AAD16097.1.
AF090437 mRNA. Translation: AAD16098.1.
AF129510 mRNA. Translation: AAF22955.1.
BC141130 mRNA. Translation: AAI41131.1.
AK053594 mRNA. Translation: BAC35441.1.
AK047409 mRNA. Translation: BAC33046.1.
AJ005669 mRNA. Translation: CAA06665.1. Different initiation.
CCDSiCCDS36993.1. [Q9QYB2-2]
CCDS36994.1. [Q9QYB2-1]
RefSeqiNP_001033699.1. NM_001038610.2. [Q9QYB2-2]
NP_031852.1. NM_007826.3. [Q9QYB2-1]
UniGeneiMm.320593.

3D structure databases

ProteinModelPortaliQ9QYB2.
SMRiQ9QYB2. Positions 177-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199044. 1 interaction.
IntActiQ9QYB2. 6 interactions.
MINTiMINT-4092795.
STRINGi10090.ENSMUSP00000071464.

PTM databases

PhosphoSiteiQ9QYB2.

Proteomic databases

MaxQBiQ9QYB2.
PaxDbiQ9QYB2.
PRIDEiQ9QYB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069334; ENSMUSP00000064970; ENSMUSG00000055639. [Q9QYB2-2]
ENSMUST00000071533; ENSMUSP00000071464; ENSMUSG00000055639. [Q9QYB2-1]
GeneIDi13134.
KEGGimmu:13134.
UCSCiuc007uur.2. mouse. [Q9QYB2-1]
uc007uus.2. mouse. [Q9QYB2-2]

Organism-specific databases

CTDi1602.
MGIiMGI:1277991. Dach1.

Phylogenomic databases

eggNOGiKOG3915. Eukaryota.
ENOG4111FAG. LUCA.
GeneTreeiENSGT00390000001134.
HOVERGENiHBG065810.
InParanoidiQ9QYB2.
OMAiHPRMPGA.
OrthoDBiEOG7ZKSCN.
PhylomeDBiQ9QYB2.
TreeFamiTF316697.

Miscellaneous databases

ChiTaRSiDach1. mouse.
NextBioi283192.
PROiQ9QYB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYB2.
CleanExiMM_DACH1.
GenevisibleiQ9QYB2. MM.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR003380. Transform_Ski.
[Graphical view]
PfamiPF02437. Ski_Sno. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene."
    Kozmik Z., Pfeffer P., Kralova J., Paces J., Paces V., Kalousova A., Cvekl A.
    Dev. Genes Evol. 209:537-545(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Mouse Dac, a novel nuclear factor with homology to Drosophila dachshund shows a dynamic expression in the neural crest, the eye, the neocortex, and the limb bud."
    Caubit X., Thangarajah R., Theil T., Wirth J., Nothwang H.-G., Ruether U., Krauss S.
    Dev. Dyn. 214:66-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE.
    Tissue: Limb bud.
  3. "Mouse Dach, a homologue of Drosophila dachshund, is expressed in the developing retina, brain and limbs."
    Davis R.J., Shen W., Heanue T.A., Mardon G.
    Dev. Genes Evol. 209:526-536(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-751 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Eye.
  6. "Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb."
    Hammond K.L., Hanson I.M., Brown A.G., Lettice L.A., Hill R.E.
    Mech. Dev. 74:121-131(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-751 (ISOFORM 1), DEVELOPMENTAL STAGE.
  7. "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
    Ikeda K., Watanabe Y., Ohto H., Kawakami K.
    Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  8. "Tissue-specific regulation of retinal and pituitary precursor cell proliferation."
    Li X., Perissi V., Liu F., Rose D.W., Rosenfeld M.G.
    Science 297:1180-1183(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SIX6; NCOR1; HDAC3 AND SIN3A.
  9. "Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis."
    Li X., Oghi K.A., Zhang J., Krones A., Bush K.T., Glass C.K., Nigam S.K., Aggarwal A.K., Maas R., Rose D.W., Rosenfeld M.G.
    Nature 426:247-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SIX1 AND EYA3.
  10. "Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog."
    Ayres J.A., Shum L., Akarsu A.N., Dashner R., Takahashi K., Ikura T., Slavkin H.C., Nuckolls G.H.
    Genomics 77:18-26(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Lung.

Entry informationi

Entry nameiDACH1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYB2
Secondary accession number(s): B2RUG1
, O88716, Q8BPQ0, Q8C8D7, Q9QY47, Q9R218, Q9Z0Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.