Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QYA2

- TOM40_MOUSE

UniProt

Q9QYA2 - TOM40_MOUSE

Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene

Tomm40

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (04 Dec 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Channel-forming protein essential for import of protein precursors into mitochondria.By similarity

    GO - Molecular functioni

    1. porin activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW
    2. protein targeting to mitochondrion Source: UniProtKB

    Keywords - Molecular functioni

    Porin

    Keywords - Biological processi

    Ion transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199101. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import receptor subunit TOM40 homolog
    Alternative name(s):
    Mitochondrial outer membrane protein of 35 kDa
    Short name:
    MOM35
    Protein Haymaker
    Translocase of outer membrane 40 kDa subunit homolog
    Gene namesi
    Name:Tomm40
    Synonyms:Mom35, Tom40
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1858259. Tomm40.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial membrane Source: MGI
    2. mitochondrial outer membrane translocase complex Source: Ensembl
    3. mitochondrion Source: MGI
    4. pore complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Mitochondrial import receptor subunit TOM40 homologPRO_0000051524Add
    BLAST

    Proteomic databases

    MaxQBiQ9QYA2.
    PaxDbiQ9QYA2.
    PRIDEiQ9QYA2.

    PTM databases

    PhosphoSiteiQ9QYA2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QYA2.
    BgeeiQ9QYA2.
    GenevestigatoriQ9QYA2.

    Interactioni

    Subunit structurei

    Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences By similarity.By similarity

    Protein-protein interaction databases

    BioGridi207293. 2 interactions.
    IntActiQ9QYA2. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 3930Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Tom40 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiNOG275568.
    GeneTreeiENSGT00390000003308.
    HOGENOMiHOG000007440.
    HOVERGENiHBG054707.
    InParanoidiQ9QYA2.
    KOiK11518.
    OMAiTRMQDTT.
    OrthoDBiEOG7GQXVZ.
    PhylomeDBiQ9QYA2.
    TreeFamiTF106204.

    Family and domain databases

    Gene3Di2.40.160.10. 1 hit.
    InterProiIPR023614. Porin_dom.
    IPR027246. Porin_Euk/Tom40.
    [Graphical view]
    PfamiPF01459. Porin_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QYA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNVLAASSP PAGPPPPPTP SLVGLPPPPP SPPGFTLPPL GGGLGTGSST    50
    GRGSERTPGA AASGAAAASE DGSCGCLPNP GTFEECHRKC KELFPVQMEG 100
    VKLTVNKGLS NRFQVTHTVA LGTIGESNYH FGVTYVGTKQ LSPTEAFPVL 150
    VGDMDNSGSL NAQVIHQLSP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT 200
    AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL 250
    AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSAS 300
    FGYQLDLPKA NFLFKGSVNS NWIVGATLEK KLPPLPLTLS LCAFLNHRKN 350
    KFLCGFGLTI G 361
    Length:361
    Mass (Da):37,895
    Last modified:December 4, 2007 - v3
    Checksum:i8415114963EBAB9B
    GO

    Sequence cautioni

    The sequence AAC82341.1 differs from that shown. Reason: Frameshift at positions 34 and 43.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 7878MGNVL…CGCLP → MMKSGDWVKHWPWFGTDSRG CGQRRCGGLGRWELRMPA in AAF21906. (PubMed:11768756)CuratedAdd
    BLAST
    Sequence conflicti13 – 142GP → R in AAC82341. 1 PublicationCurated
    Sequence conflicti70 – 701E → D in BAE42165. (PubMed:16141072)Curated
    Sequence conflicti126 – 1261E → G in AAL46628. 1 PublicationCurated
    Sequence conflicti185 – 23450Missing in AAC82341. 1 PublicationCuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109918 mRNA. Translation: AAF21906.1.
    AF316403 mRNA. Translation: AAL46628.1.
    AF316404 mRNA. Translation: AAL46629.1.
    AF043249 mRNA. Translation: AAC82341.1. Frameshift.
    AK150019 mRNA. Translation: BAE29244.1.
    AK163759 mRNA. Translation: BAE37483.1.
    AK164570 mRNA. Translation: BAE37837.1.
    AK165173 mRNA. Translation: BAE38058.1.
    AK170991 mRNA. Translation: BAE42165.1.
    BC100452 mRNA. Translation: AAI00453.1.
    CCDSiCCDS52062.1.
    RefSeqiNP_001103218.1. NM_001109748.1.
    NP_058567.2. NM_016871.2.
    UniGeneiMm.416870.
    Mm.440173.

    Genome annotation databases

    EnsembliENSMUST00000032555; ENSMUSP00000032555; ENSMUSG00000002984.
    ENSMUST00000093552; ENSMUSP00000104090; ENSMUSG00000002984.
    GeneIDi53333.
    KEGGimmu:53333.
    UCSCiuc009fna.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109918 mRNA. Translation: AAF21906.1 .
    AF316403 mRNA. Translation: AAL46628.1 .
    AF316404 mRNA. Translation: AAL46629.1 .
    AF043249 mRNA. Translation: AAC82341.1 . Frameshift.
    AK150019 mRNA. Translation: BAE29244.1 .
    AK163759 mRNA. Translation: BAE37483.1 .
    AK164570 mRNA. Translation: BAE37837.1 .
    AK165173 mRNA. Translation: BAE38058.1 .
    AK170991 mRNA. Translation: BAE42165.1 .
    BC100452 mRNA. Translation: AAI00453.1 .
    CCDSi CCDS52062.1.
    RefSeqi NP_001103218.1. NM_001109748.1.
    NP_058567.2. NM_016871.2.
    UniGenei Mm.416870.
    Mm.440173.

    3D structure databases

    ProteinModelPortali Q9QYA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207293. 2 interactions.
    IntActi Q9QYA2. 1 interaction.

    PTM databases

    PhosphoSitei Q9QYA2.

    Proteomic databases

    MaxQBi Q9QYA2.
    PaxDbi Q9QYA2.
    PRIDEi Q9QYA2.

    Protocols and materials databases

    DNASUi 53333.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032555 ; ENSMUSP00000032555 ; ENSMUSG00000002984 .
    ENSMUST00000093552 ; ENSMUSP00000104090 ; ENSMUSG00000002984 .
    GeneIDi 53333.
    KEGGi mmu:53333.
    UCSCi uc009fna.2. mouse.

    Organism-specific databases

    CTDi 10452.
    MGIi MGI:1858259. Tomm40.

    Phylogenomic databases

    eggNOGi NOG275568.
    GeneTreei ENSGT00390000003308.
    HOGENOMi HOG000007440.
    HOVERGENi HBG054707.
    InParanoidi Q9QYA2.
    KOi K11518.
    OMAi TRMQDTT.
    OrthoDBi EOG7GQXVZ.
    PhylomeDBi Q9QYA2.
    TreeFami TF106204.

    Enzyme and pathway databases

    Reactomei REACT_199101. Mitochondrial protein import.

    Miscellaneous databases

    ChiTaRSi TOMM40. mouse.
    NextBioi 310161.
    PROi Q9QYA2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYA2.
    Bgeei Q9QYA2.
    Genevestigatori Q9QYA2.

    Family and domain databases

    Gene3Di 2.40.160.10. 1 hit.
    InterProi IPR023614. Porin_dom.
    IPR027246. Porin_Euk/Tom40.
    [Graphical view ]
    Pfami PF01459. Porin_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40."
      Lee Rivera I., Shore G.C., Schleiff E.
      J. Bioenerg. Biomembr. 32:111-121(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and non-malignant cells."
      Das B., Tao S.-Z., Mushnitsky R., Norin A.J.
      Int. J. Cancer 94:800-806(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mastocytoma.
    3. "A transcriptional map in the region of 19q13 derived using direct sequencing and exon trapping."
      Yoshiura K., Murray J.C.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Corpus striatum, Dendritic cell, Lung and Macrophage.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 185-195; 316-330 AND 352-361, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiTOM40_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYA2
    Secondary accession number(s): Q3TBZ2
    , Q3TQA1, Q8VI26, Q8VI27, Q9Z2N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3