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Q9QYA2

- TOM40_MOUSE

UniProt

Q9QYA2 - TOM40_MOUSE

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Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene
Tomm40, Mom35, Tom40
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Channel-forming protein essential for import of protein precursors into mitochondria By similarity.

GO - Molecular functioni

  1. porin activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
  2. protein targeting to mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40 homolog
Alternative name(s):
Mitochondrial outer membrane protein of 35 kDa
Short name:
MOM35
Protein Haymaker
Translocase of outer membrane 40 kDa subunit homolog
Gene namesi
Name:Tomm40
Synonyms:Mom35, Tom40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1858259. Tomm40.

Subcellular locationi

GO - Cellular componenti

  1. integral component of mitochondrial membrane Source: MGI
  2. mitochondrial outer membrane translocase complex Source: Ensembl
  3. mitochondrion Source: MGI
  4. pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Mitochondrial import receptor subunit TOM40 homologPRO_0000051524Add
BLAST

Proteomic databases

MaxQBiQ9QYA2.
PaxDbiQ9QYA2.
PRIDEiQ9QYA2.

PTM databases

PhosphoSiteiQ9QYA2.

Expressioni

Gene expression databases

ArrayExpressiQ9QYA2.
BgeeiQ9QYA2.
GenevestigatoriQ9QYA2.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences By similarity.

Protein-protein interaction databases

BioGridi207293. 2 interactions.
IntActiQ9QYA2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QYA2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 3930Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Tom40 family.

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG275568.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiQ9QYA2.
KOiK11518.
OMAiTRMQDTT.
OrthoDBiEOG7GQXVZ.
PhylomeDBiQ9QYA2.
TreeFamiTF106204.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYA2-1 [UniParc]FASTAAdd to Basket

« Hide

MGNVLAASSP PAGPPPPPTP SLVGLPPPPP SPPGFTLPPL GGGLGTGSST    50
GRGSERTPGA AASGAAAASE DGSCGCLPNP GTFEECHRKC KELFPVQMEG 100
VKLTVNKGLS NRFQVTHTVA LGTIGESNYH FGVTYVGTKQ LSPTEAFPVL 150
VGDMDNSGSL NAQVIHQLSP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT 200
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL 250
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSAS 300
FGYQLDLPKA NFLFKGSVNS NWIVGATLEK KLPPLPLTLS LCAFLNHRKN 350
KFLCGFGLTI G 361
Length:361
Mass (Da):37,895
Last modified:December 4, 2007 - v3
Checksum:i8415114963EBAB9B
GO

Sequence cautioni

The sequence AAC82341.1 differs from that shown. Reason: Frameshift at positions 34 and 43.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 7878MGNVL…CGCLP → MMKSGDWVKHWPWFGTDSRG CGQRRCGGLGRWELRMPA in AAF21906. 1 PublicationAdd
BLAST
Sequence conflicti13 – 142GP → R in AAC82341. 1 Publication
Sequence conflicti70 – 701E → D in BAE42165. 1 Publication
Sequence conflicti126 – 1261E → G in AAL46628. 1 Publication
Sequence conflicti185 – 23450Missing in AAC82341. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109918 mRNA. Translation: AAF21906.1.
AF316403 mRNA. Translation: AAL46628.1.
AF316404 mRNA. Translation: AAL46629.1.
AF043249 mRNA. Translation: AAC82341.1. Frameshift.
AK150019 mRNA. Translation: BAE29244.1.
AK163759 mRNA. Translation: BAE37483.1.
AK164570 mRNA. Translation: BAE37837.1.
AK165173 mRNA. Translation: BAE38058.1.
AK170991 mRNA. Translation: BAE42165.1.
BC100452 mRNA. Translation: AAI00453.1.
CCDSiCCDS52062.1.
RefSeqiNP_001103218.1. NM_001109748.1.
NP_058567.2. NM_016871.2.
UniGeneiMm.416870.
Mm.440173.

Genome annotation databases

EnsembliENSMUST00000032555; ENSMUSP00000032555; ENSMUSG00000002984.
ENSMUST00000093552; ENSMUSP00000104090; ENSMUSG00000002984.
GeneIDi53333.
KEGGimmu:53333.
UCSCiuc009fna.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109918 mRNA. Translation: AAF21906.1 .
AF316403 mRNA. Translation: AAL46628.1 .
AF316404 mRNA. Translation: AAL46629.1 .
AF043249 mRNA. Translation: AAC82341.1 . Frameshift.
AK150019 mRNA. Translation: BAE29244.1 .
AK163759 mRNA. Translation: BAE37483.1 .
AK164570 mRNA. Translation: BAE37837.1 .
AK165173 mRNA. Translation: BAE38058.1 .
AK170991 mRNA. Translation: BAE42165.1 .
BC100452 mRNA. Translation: AAI00453.1 .
CCDSi CCDS52062.1.
RefSeqi NP_001103218.1. NM_001109748.1.
NP_058567.2. NM_016871.2.
UniGenei Mm.416870.
Mm.440173.

3D structure databases

ProteinModelPortali Q9QYA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207293. 2 interactions.
IntActi Q9QYA2. 1 interaction.

PTM databases

PhosphoSitei Q9QYA2.

Proteomic databases

MaxQBi Q9QYA2.
PaxDbi Q9QYA2.
PRIDEi Q9QYA2.

Protocols and materials databases

DNASUi 53333.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032555 ; ENSMUSP00000032555 ; ENSMUSG00000002984 .
ENSMUST00000093552 ; ENSMUSP00000104090 ; ENSMUSG00000002984 .
GeneIDi 53333.
KEGGi mmu:53333.
UCSCi uc009fna.2. mouse.

Organism-specific databases

CTDi 10452.
MGIi MGI:1858259. Tomm40.

Phylogenomic databases

eggNOGi NOG275568.
GeneTreei ENSGT00390000003308.
HOGENOMi HOG000007440.
HOVERGENi HBG054707.
InParanoidi Q9QYA2.
KOi K11518.
OMAi TRMQDTT.
OrthoDBi EOG7GQXVZ.
PhylomeDBi Q9QYA2.
TreeFami TF106204.

Enzyme and pathway databases

Reactomei REACT_199101. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSi TOMM40. mouse.
NextBioi 310161.
PROi Q9QYA2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QYA2.
Bgeei Q9QYA2.
Genevestigatori Q9QYA2.

Family and domain databases

Gene3Di 2.40.160.10. 1 hit.
InterProi IPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view ]
Pfami PF01459. Porin_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40."
    Lee Rivera I., Shore G.C., Schleiff E.
    J. Bioenerg. Biomembr. 32:111-121(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and non-malignant cells."
    Das B., Tao S.-Z., Mushnitsky R., Norin A.J.
    Int. J. Cancer 94:800-806(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mastocytoma.
  3. "A transcriptional map in the region of 19q13 derived using direct sequencing and exon trapping."
    Yoshiura K., Murray J.C.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Corpus striatum, Dendritic cell, Lung and Macrophage.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 185-195; 316-330 AND 352-361, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiTOM40_MOUSE
AccessioniPrimary (citable) accession number: Q9QYA2
Secondary accession number(s): Q3TBZ2
, Q3TQA1, Q8VI26, Q8VI27, Q9Z2N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi