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Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene

Tomm40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Channel-forming protein essential for import of protein precursors into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5205685 Pink/Parkin Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40 homolog
Alternative name(s):
Mitochondrial outer membrane protein of 35 kDa
Short name:
MOM35
Protein Haymaker
Translocase of outer membrane 40 kDa subunit homolog
Gene namesi
Name:Tomm40
Synonyms:Mom35, Tom40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858259 Tomm40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515241 – 361Mitochondrial import receptor subunit TOM40 homologAdd BLAST361

Proteomic databases

EPDiQ9QYA2
MaxQBiQ9QYA2
PaxDbiQ9QYA2
PeptideAtlasiQ9QYA2
PRIDEiQ9QYA2

PTM databases

iPTMnetiQ9QYA2
PhosphoSitePlusiQ9QYA2
SwissPalmiQ9QYA2

Expressioni

Gene expression databases

BgeeiENSMUSG00000002984
ExpressionAtlasiQ9QYA2 baseline and differential
GenevisibleiQ9QYA2 MM

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences. Interacts with TIMM29; linking the TIM22 complex to the TOM complex.By similarity

Protein-protein interaction databases

BioGridi207293, 2 interactors
IntActiQ9QYA2, 2 interactors
STRINGi10090.ENSMUSP00000032555

Structurei

3D structure databases

ProteinModelPortaliQ9QYA2
SMRiQ9QYA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 39Pro-richAdd BLAST30

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiQ9QYA2
KOiK11518
OMAiDFRMSTF
OrthoDBiEOG091G0MNA
PhylomeDBiQ9QYA2
TreeFamiTF106204

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QYA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNVLAASSP PAGPPPPPTP SLVGLPPPPP SPPGFTLPPL GGGLGTGSST
60 70 80 90 100
GRGSERTPGA AASGAAAASE DGSCGCLPNP GTFEECHRKC KELFPVQMEG
110 120 130 140 150
VKLTVNKGLS NRFQVTHTVA LGTIGESNYH FGVTYVGTKQ LSPTEAFPVL
160 170 180 190 200
VGDMDNSGSL NAQVIHQLSP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT
210 220 230 240 250
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL
260 270 280 290 300
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSAS
310 320 330 340 350
FGYQLDLPKA NFLFKGSVNS NWIVGATLEK KLPPLPLTLS LCAFLNHRKN
360
KFLCGFGLTI G
Length:361
Mass (Da):37,895
Last modified:December 4, 2007 - v3
Checksum:i8415114963EBAB9B
GO

Sequence cautioni

The sequence AAC82341 differs from that shown. Reason: Frameshift at positions 34 and 43.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 78MGNVL…CGCLP → MMKSGDWVKHWPWFGTDSRG CGQRRCGGLGRWELRMPA in AAF21906 (PubMed:11768756).CuratedAdd BLAST78
Sequence conflicti13 – 14GP → R in AAC82341 (Ref. 3) Curated2
Sequence conflicti70E → D in BAE42165 (PubMed:16141072).Curated1
Sequence conflicti126E → G in AAL46628 (Ref. 3) Curated1
Sequence conflicti185 – 234Missing in AAC82341 (Ref. 3) CuratedAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109918 mRNA Translation: AAF21906.1
AF316403 mRNA Translation: AAL46628.1
AF316404 mRNA Translation: AAL46629.1
AF043249 mRNA Translation: AAC82341.1 Frameshift.
AK150019 mRNA Translation: BAE29244.1
AK163759 mRNA Translation: BAE37483.1
AK164570 mRNA Translation: BAE37837.1
AK165173 mRNA Translation: BAE38058.1
AK170991 mRNA Translation: BAE42165.1
BC100452 mRNA Translation: AAI00453.1
CCDSiCCDS52062.1
RefSeqiNP_001103218.1, NM_001109748.1
NP_058567.2, NM_016871.2
UniGeneiMm.416870
Mm.440173
Mm.61682

Genome annotation databases

EnsembliENSMUST00000032555; ENSMUSP00000032555; ENSMUSG00000002984
ENSMUST00000093552; ENSMUSP00000104090; ENSMUSG00000002984
GeneIDi53333
KEGGimmu:53333
UCSCiuc009fna.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTOM40_MOUSE
AccessioniPrimary (citable) accession number: Q9QYA2
Secondary accession number(s): Q3TBZ2
, Q3TQA1, Q8VI26, Q8VI27, Q9Z2N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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