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Q9QYA2 (TOM40_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import receptor subunit TOM40 homolog
Alternative name(s):
Mitochondrial outer membrane protein of 35 kDa
Short name=MOM35
Protein Haymaker
Translocase of outer membrane 40 kDa subunit homolog
Gene names
Name:Tomm40
Synonyms:Mom35, Tom40
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Channel-forming protein essential for import of protein precursors into mitochondria By similarity.

Subunit structure

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences By similarity.

Subcellular location

Mitochondrion outer membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Tom40 family.

Sequence caution

The sequence AAC82341.1 differs from that shown. Reason: Frameshift at positions 34 and 43.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Mitochondrial import receptor subunit TOM40 homolog
PRO_0000051524

Regions

Compositional bias10 – 3930Pro-rich

Experimental info

Sequence conflict1 – 7878MGNVL…CGCLP → MMKSGDWVKHWPWFGTDSRG CGQRRCGGLGRWELRMPA in AAF21906. Ref.1
Sequence conflict13 – 142GP → R in AAC82341. Ref.3
Sequence conflict701E → D in BAE42165. Ref.4
Sequence conflict1261E → G in AAL46628. Ref.3
Sequence conflict185 – 23450Missing in AAC82341. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9QYA2 [UniParc].

Last modified December 4, 2007. Version 3.
Checksum: 8415114963EBAB9B

FASTA36137,895
        10         20         30         40         50         60 
MGNVLAASSP PAGPPPPPTP SLVGLPPPPP SPPGFTLPPL GGGLGTGSST GRGSERTPGA 

        70         80         90        100        110        120 
AASGAAAASE DGSCGCLPNP GTFEECHRKC KELFPVQMEG VKLTVNKGLS NRFQVTHTVA 

       130        140        150        160        170        180 
LGTIGESNYH FGVTYVGTKQ LSPTEAFPVL VGDMDNSGSL NAQVIHQLSP GLRSKMAIQT 

       190        200        210        220        230        240 
QQSKFVNWQV DGEYRGSDFT AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR 

       250        260        270        280        290        300 
PGEEGTVMSL AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSAS 

       310        320        330        340        350        360 
FGYQLDLPKA NFLFKGSVNS NWIVGATLEK KLPPLPLTLS LCAFLNHRKN KFLCGFGLTI 


G 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40."
Lee Rivera I., Shore G.C., Schleiff E.
J. Bioenerg. Biomembr. 32:111-121(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and non-malignant cells."
Das B., Tao S.-Z., Mushnitsky R., Norin A.J.
Int. J. Cancer 94:800-806(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mastocytoma.
[3]"A transcriptional map in the region of 19q13 derived using direct sequencing and exon trapping."
Yoshiura K., Murray J.C.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Corpus striatum, Dendritic cell, Lung and Macrophage.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 185-195; 316-330 AND 352-361, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF109918 mRNA. Translation: AAF21906.1.
AF316403 mRNA. Translation: AAL46628.1.
AF316404 mRNA. Translation: AAL46629.1.
AF043249 mRNA. Translation: AAC82341.1. Frameshift.
AK150019 mRNA. Translation: BAE29244.1.
AK163759 mRNA. Translation: BAE37483.1.
AK164570 mRNA. Translation: BAE37837.1.
AK165173 mRNA. Translation: BAE38058.1.
AK170991 mRNA. Translation: BAE42165.1.
BC100452 mRNA. Translation: AAI00453.1.
CCDSCCDS52062.1.
RefSeqNP_001103218.1. NM_001109748.1.
NP_058567.2. NM_016871.2.
UniGeneMm.416870.
Mm.440173.

3D structure databases

ProteinModelPortalQ9QYA2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207293. 2 interactions.
IntActQ9QYA2. 1 interaction.

PTM databases

PhosphoSiteQ9QYA2.

Proteomic databases

MaxQBQ9QYA2.
PaxDbQ9QYA2.
PRIDEQ9QYA2.

Protocols and materials databases

DNASU53333.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032555; ENSMUSP00000032555; ENSMUSG00000002984.
ENSMUST00000093552; ENSMUSP00000104090; ENSMUSG00000002984.
GeneID53333.
KEGGmmu:53333.
UCSCuc009fna.2. mouse.

Organism-specific databases

CTD10452.
MGIMGI:1858259. Tomm40.

Phylogenomic databases

eggNOGNOG275568.
GeneTreeENSGT00390000003308.
HOGENOMHOG000007440.
HOVERGENHBG054707.
InParanoidQ9QYA2.
KOK11518.
OMATRMQDTT.
OrthoDBEOG7GQXVZ.
PhylomeDBQ9QYA2.
TreeFamTF106204.

Gene expression databases

ArrayExpressQ9QYA2.
BgeeQ9QYA2.
GenevestigatorQ9QYA2.

Family and domain databases

Gene3D2.40.160.10. 1 hit.
InterProIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTOMM40. mouse.
NextBio310161.
PROQ9QYA2.
SOURCESearch...

Entry information

Entry nameTOM40_MOUSE
AccessionPrimary (citable) accession number: Q9QYA2
Secondary accession number(s): Q3TBZ2 expand/collapse secondary AC list , Q3TQA1, Q8VI26, Q8VI27, Q9Z2N1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot