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Protein

Extracellular calcium-sensing receptor

Gene

Casr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular calcium-sensing receptor
Short name:
CaSR
Alternative name(s):
Parathyroid cell calcium-sensing receptor
Short name:
PCaR1
Gene namesi
Name:Casr
Synonyms:Gprc2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1351351. Casr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 612ExtracellularSequence analysisAdd BLAST593
Transmembranei613 – 635Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini636 – 649CytoplasmicSequence analysisAdd BLAST14
Transmembranei650 – 670Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini671 – 681ExtracellularSequence analysisAdd BLAST11
Transmembranei682 – 700Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini701 – 724CytoplasmicSequence analysisAdd BLAST24
Transmembranei725 – 745Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini746 – 769ExtracellularSequence analysisAdd BLAST24
Transmembranei770 – 792Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini793 – 805CytoplasmicSequence analysisAdd BLAST13
Transmembranei806 – 828Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini829 – 836ExtracellularSequence analysis8
Transmembranei837 – 862Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini863 – 1079CytoplasmicSequence analysisAdd BLAST217

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi54.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001294720 – 1079Extracellular calcium-sensing receptorAdd BLAST1060

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Glycosylationi541N-linked (GlcNAc...)Sequence analysis1
Glycosylationi594N-linked (GlcNAc...)Sequence analysis1
Modified residuei920PhosphoserineCombined sources1
Modified residuei1062PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.By similarity
Ubiquitinated by RNF19A; which induces proteasomal degradation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QY96.
PRIDEiQ9QY96.

PTM databases

iPTMnetiQ9QY96.
PhosphoSitePlusiQ9QY96.

Expressioni

Tissue specificityi

Epidermis, kidney and cartilage.4 Publications

Gene expression databases

BgeeiENSMUSG00000051980.
CleanExiMM_CASR.
GenevisibleiQ9QY96. MM.

Interactioni

Subunit structurei

Interacts with VCP and RNF19A. Interacts with ARRB1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069080.

Structurei

3D structure databases

ProteinModelPortaliQ9QY96.
SMRiQ9QY96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni880 – 900Interaction with RNF19ABy similarityAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
HOVERGENiHBG052876.
InParanoidiQ9QY96.
KOiK04612.
OMAiMGEQVTF.
OrthoDBiEOG091G01NA.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9QY96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWFGYCLAL LALTWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD
60 70 80 90 100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT
110 120 130 140 150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGVS
160 170 180 190 200
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI
210 220 230 240 250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE
260 270 280 290 300
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA
310 320 330 340 350
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE
360 370 380 390 400
FWEETFNCHL QDGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN
410 420 430 440 450
INSVETPYMD YEHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA
460 470 480 490 500
DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD ECGDLVGNYS IINWHLSPED
510 520 530 540 550
GSIVFKEVGY YNVYAKKGER LFINEGKILW SGFSREVPFS NCSRDCQAGT
560 570 580 590 600
RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA
610 620 630 640 650
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL
660 670 680 690 700
SYLLLFSLLC CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN
710 720 730 740 750
RVLLVFEAKI PTSFHRKWWG LNLQFLLVFL CTFMQIVICI IWLYTAPPSS
760 770 780 790 800
YRNHELEDEI IFITCHEGSL MALGSLIGYT CLLAAICFFF AFKSRKLPEN
810 820 830 840 850
FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA ILAASFGLLA
860 870 880 890 900
CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS
910 920 930 940 950
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLALTQ QEQQQQPLTL
960 970 980 990 1000
QPQQQQQPQQ PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE
1010 1020 1030 1040 1050
AQKSNDTLNR HQALLPLQCA EADSEMTIQE TGLQGPMVGD HQPEIESPDE
1060 1070
MSPALVMSTS RSFVISGGGS SVTENILHS
Length:1,079
Mass (Da):120,903
Last modified:October 3, 2012 - v2
Checksum:i8AEF586CDCD93CB3
GO
Isoform B (identifier: Q9QY96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-537: Missing.

Show »
Length:1,002
Mass (Da):111,996
Checksum:i94BF8B687C0FD877
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → S in AAD40638 (PubMed:10652312).Curated1
Sequence conflicti304L → P in AAF00193 (PubMed:10579354).Curated1
Sequence conflicti410D → G in AAD28371 (PubMed:10625662).Curated1
Sequence conflicti410D → G in AAD28372 (PubMed:10625662).Curated1
Sequence conflicti566V → A in AAD40638 (PubMed:10652312).Curated1
Sequence conflicti595H → Y in AAD28371 (PubMed:10625662).Curated1
Sequence conflicti595H → Y in AAD28372 (PubMed:10625662).Curated1
Sequence conflicti610E → V in BAA77688 (Ref. 7) Curated1
Sequence conflicti814F → L in BAA77688 (Ref. 7) Curated1
Sequence conflicti889L → I in AAD40638 (PubMed:10652312).Curated1
Sequence conflicti906 – 908TGS → SGW in AAD40638 (PubMed:10652312).Curated3
Sequence conflicti909I → N in AAD28371 (PubMed:10625662).Curated1
Sequence conflicti909I → N in AAD28372 (PubMed:10625662).Curated1
Sequence conflicti1057M → V in AAD28371 (PubMed:10625662).Curated1
Sequence conflicti1057M → V in AAD28372 (PubMed:10625662).Curated1
Sequence conflicti1064V → A in AAD40638 (PubMed:10652312).Curated1
Sequence conflicti1076I → V in AAD40638 (PubMed:10652312).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002036461 – 537Missing in isoform B. CuratedAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110178 mRNA. Translation: AAD28371.1.
AF110179 mRNA. Translation: AAD28372.1.
AF128842 mRNA. Translation: AAD40638.1.
AC074229 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97924.1.
AF068900 mRNA. Translation: AAC19388.1.
AB027140 mRNA. Translation: BAA77688.1.
AF002015 Genomic DNA. Translation: AAC53252.1.
AF159565 mRNA. Translation: AAF00193.1.
CCDSiCCDS28154.1. [Q9QY96-1]
RefSeqiNP_038831.2. NM_013803.3. [Q9QY96-1]
XP_006521792.1. XM_006521729.2. [Q9QY96-1]
XP_006521793.1. XM_006521730.2. [Q9QY96-1]
XP_006521794.1. XM_006521731.3. [Q9QY96-1]
XP_006521795.1. XM_006521732.2. [Q9QY96-1]
UniGeneiMm.103619.
Mm.393142.

Genome annotation databases

EnsembliENSMUST00000063597; ENSMUSP00000069080; ENSMUSG00000051980. [Q9QY96-1]
ENSMUST00000114847; ENSMUSP00000110496; ENSMUSG00000051980. [Q9QY96-2]
ENSMUST00000172826; ENSMUSP00000133500; ENSMUSG00000051980. [Q9QY96-1]
GeneIDi12374.
KEGGimmu:12374.
UCSCiuc007zcp.1. mouse. [Q9QY96-1]
uc012afg.1. mouse. [Q9QY96-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110178 mRNA. Translation: AAD28371.1.
AF110179 mRNA. Translation: AAD28372.1.
AF128842 mRNA. Translation: AAD40638.1.
AC074229 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97924.1.
AF068900 mRNA. Translation: AAC19388.1.
AB027140 mRNA. Translation: BAA77688.1.
AF002015 Genomic DNA. Translation: AAC53252.1.
AF159565 mRNA. Translation: AAF00193.1.
CCDSiCCDS28154.1. [Q9QY96-1]
RefSeqiNP_038831.2. NM_013803.3. [Q9QY96-1]
XP_006521792.1. XM_006521729.2. [Q9QY96-1]
XP_006521793.1. XM_006521730.2. [Q9QY96-1]
XP_006521794.1. XM_006521731.3. [Q9QY96-1]
XP_006521795.1. XM_006521732.2. [Q9QY96-1]
UniGeneiMm.103619.
Mm.393142.

3D structure databases

ProteinModelPortaliQ9QY96.
SMRiQ9QY96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069080.

Chemistry databases

GuidetoPHARMACOLOGYi54.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9QY96.
PhosphoSitePlusiQ9QY96.

Proteomic databases

PaxDbiQ9QY96.
PRIDEiQ9QY96.

Protocols and materials databases

DNASUi12374.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063597; ENSMUSP00000069080; ENSMUSG00000051980. [Q9QY96-1]
ENSMUST00000114847; ENSMUSP00000110496; ENSMUSG00000051980. [Q9QY96-2]
ENSMUST00000172826; ENSMUSP00000133500; ENSMUSG00000051980. [Q9QY96-1]
GeneIDi12374.
KEGGimmu:12374.
UCSCiuc007zcp.1. mouse. [Q9QY96-1]
uc012afg.1. mouse. [Q9QY96-2]

Organism-specific databases

CTDi846.
MGIiMGI:1351351. Casr.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
HOVERGENiHBG052876.
InParanoidiQ9QY96.
KOiK04612.
OMAiMGEQVTF.
OrthoDBiEOG091G01NA.
TreeFamiTF331269.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

PROiQ9QY96.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051980.
CleanExiMM_CASR.
GenevisibleiQ9QY96. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASR_MOUSE
AccessioniPrimary (citable) accession number: Q9QY96
Secondary accession number(s): G3UX06
, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.