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Q9QY96

- CASR_MOUSE

UniProt

Q9QY96 - CASR_MOUSE

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Protein
Extracellular calcium-sensing receptor
Gene
Casr, Gprc2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. calcium ion binding Source: Ensembl
  3. drug binding Source: Ensembl
  4. magnesium ion binding Source: Ensembl
  5. polyamine binding Source: Ensembl

GO - Biological processi

  1. JNK cascade Source: Ensembl
  2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  3. apoptotic process Source: Ensembl
  4. branching morphogenesis of an epithelial tube Source: Ensembl
  5. calcium ion transport Source: Ensembl
  6. cellular calcium ion homeostasis Source: Ensembl
  7. cellular response to glucose stimulus Source: Ensembl
  8. cellular response to hepatocyte growth factor stimulus Source: Ensembl
  9. cellular response to hypoxia Source: Ensembl
  10. cellular response to low-density lipoprotein particle stimulus Source: Ensembl
  11. cellular response to peptide Source: Ensembl
  12. cellular response to vitamin D Source: Ensembl
  13. fat pad development Source: Ensembl
  14. ossification Source: Ensembl
  15. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  16. positive regulation of ATPase activity Source: MGI
  17. positive regulation of calcium ion import Source: Ensembl
  18. positive regulation of cell proliferation Source: Ensembl
  19. positive regulation of gene expression Source: MGI
  20. positive regulation of insulin secretion Source: Ensembl
  21. positive regulation of positive chemotaxis Source: Ensembl
  22. positive regulation of vasoconstriction Source: Ensembl
  23. regulation of calcium ion transport Source: MGI
  24. response to calcium ion Source: Ensembl
  25. response to fibroblast growth factor Source: Ensembl
  26. response to ischemia Source: Ensembl
  27. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular calcium-sensing receptor
Short name:
CaSR
Alternative name(s):
Parathyroid cell calcium-sensing receptor
Short name:
PCaR1
Gene namesi
Name:Casr
Synonyms:Gprc2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1351351. Casr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 612593Extracellular Reviewed prediction
Add
BLAST
Transmembranei613 – 63523Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini636 – 64914Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei650 – 67021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini671 – 68111Extracellular Reviewed prediction
Add
BLAST
Transmembranei682 – 70019Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini701 – 72424Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei725 – 74521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini746 – 76924Extracellular Reviewed prediction
Add
BLAST
Transmembranei770 – 79223Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini793 – 80513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei806 – 82823Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini829 – 8368Extracellular Reviewed prediction
Transmembranei837 – 86226Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini863 – 1079217Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. axon terminus Source: Ensembl
  3. basolateral plasma membrane Source: Ensembl
  4. cell surface Source: Ensembl
  5. cytoplasm Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. neuronal cell body Source: Ensembl
  8. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 10791060Extracellular calcium-sensing receptor
PRO_0000012947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi541 – 5411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi594 – 5941N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.
Ubiquitinated by RNF19A; which induces proteasomal degradation By similarity.

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QY96.
PRIDEiQ9QY96.

PTM databases

PhosphoSiteiQ9QY96.

Expressioni

Tissue specificityi

Epidermis, kidney and cartilage.4 Publications

Gene expression databases

ArrayExpressiQ9QY96.
CleanExiMM_CASR.
GenevestigatoriQ9QY96.

Interactioni

Subunit structurei

Interacts with VCP and RNF19A. Interacts with ARRB1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QY96.
SMRiQ9QY96. Positions 29-531, 603-864.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni880 – 90021Interaction with RNF19A By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00750000117616.
HOVERGENiHBG052876.
InParanoidiQ9QY96.
KOiK04612.
OMAiIILFKPS.
OrthoDBiEOG7DZ8J8.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9QY96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAWFGYCLAL LALTWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD     50
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT 100
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGVS 150
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI 200
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE 250
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA 300
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE 350
FWEETFNCHL QDGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN 400
INSVETPYMD YEHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA 450
DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD ECGDLVGNYS IINWHLSPED 500
GSIVFKEVGY YNVYAKKGER LFINEGKILW SGFSREVPFS NCSRDCQAGT 550
RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA 600
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL 650
SYLLLFSLLC CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN 700
RVLLVFEAKI PTSFHRKWWG LNLQFLLVFL CTFMQIVICI IWLYTAPPSS 750
YRNHELEDEI IFITCHEGSL MALGSLIGYT CLLAAICFFF AFKSRKLPEN 800
FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA ILAASFGLLA 850
CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS 900
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLALTQ QEQQQQPLTL 950
QPQQQQQPQQ PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE 1000
AQKSNDTLNR HQALLPLQCA EADSEMTIQE TGLQGPMVGD HQPEIESPDE 1050
MSPALVMSTS RSFVISGGGS SVTENILHS 1079
Length:1,079
Mass (Da):120,903
Last modified:October 3, 2012 - v2
Checksum:i8AEF586CDCD93CB3
GO
Isoform B (identifier: Q9QY96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-537: Missing.

Show »
Length:1,002
Mass (Da):111,996
Checksum:i94BF8B687C0FD877
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei461 – 53777Missing in isoform B.
VSP_002036Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451A → S in AAD40638. 1 Publication
Sequence conflicti304 – 3041L → P in AAF00193. 1 Publication
Sequence conflicti410 – 4101D → G in AAD28371. 1 Publication
Sequence conflicti410 – 4101D → G in AAD28372. 1 Publication
Sequence conflicti566 – 5661V → A in AAD40638. 1 Publication
Sequence conflicti595 – 5951H → Y in AAD28371. 1 Publication
Sequence conflicti595 – 5951H → Y in AAD28372. 1 Publication
Sequence conflicti610 – 6101E → V in BAA77688. 1 Publication
Sequence conflicti814 – 8141F → L in BAA77688. 1 Publication
Sequence conflicti889 – 8891L → I in AAD40638. 1 Publication
Sequence conflicti906 – 9083TGS → SGW in AAD40638. 1 Publication
Sequence conflicti909 – 9091I → N in AAD28371. 1 Publication
Sequence conflicti909 – 9091I → N in AAD28372. 1 Publication
Sequence conflicti1057 – 10571M → V in AAD28371. 1 Publication
Sequence conflicti1057 – 10571M → V in AAD28372. 1 Publication
Sequence conflicti1064 – 10641V → A in AAD40638. 1 Publication
Sequence conflicti1076 – 10761I → V in AAD40638. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110178 mRNA. Translation: AAD28371.1.
AF110179 mRNA. Translation: AAD28372.1.
AF128842 mRNA. Translation: AAD40638.1.
AC074229 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97924.1.
AF068900 mRNA. Translation: AAC19388.1.
AB027140 mRNA. Translation: BAA77688.1.
AF002015 Genomic DNA. Translation: AAC53252.1.
AF159565 mRNA. Translation: AAF00193.1.
CCDSiCCDS28154.1. [Q9QY96-1]
RefSeqiNP_038831.2. NM_013803.2. [Q9QY96-1]
XP_006521792.1. XM_006521729.1. [Q9QY96-1]
XP_006521793.1. XM_006521730.1. [Q9QY96-1]
XP_006521794.1. XM_006521731.1. [Q9QY96-1]
XP_006521795.1. XM_006521732.1. [Q9QY96-1]
XP_006521796.1. XM_006521733.1. [Q9QY96-1]
XP_006521797.1. XM_006521734.1. [Q9QY96-1]
UniGeneiMm.103619.

Genome annotation databases

EnsembliENSMUST00000063597; ENSMUSP00000069080; ENSMUSG00000051980. [Q9QY96-1]
ENSMUST00000114847; ENSMUSP00000110496; ENSMUSG00000051980. [Q9QY96-2]
ENSMUST00000172826; ENSMUSP00000133500; ENSMUSG00000051980. [Q9QY96-1]
GeneIDi12374.
KEGGimmu:12374.
UCSCiuc007zcp.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110178 mRNA. Translation: AAD28371.1 .
AF110179 mRNA. Translation: AAD28372.1 .
AF128842 mRNA. Translation: AAD40638.1 .
AC074229 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97924.1 .
AF068900 mRNA. Translation: AAC19388.1 .
AB027140 mRNA. Translation: BAA77688.1 .
AF002015 Genomic DNA. Translation: AAC53252.1 .
AF159565 mRNA. Translation: AAF00193.1 .
CCDSi CCDS28154.1. [Q9QY96-1 ]
RefSeqi NP_038831.2. NM_013803.2. [Q9QY96-1 ]
XP_006521792.1. XM_006521729.1. [Q9QY96-1 ]
XP_006521793.1. XM_006521730.1. [Q9QY96-1 ]
XP_006521794.1. XM_006521731.1. [Q9QY96-1 ]
XP_006521795.1. XM_006521732.1. [Q9QY96-1 ]
XP_006521796.1. XM_006521733.1. [Q9QY96-1 ]
XP_006521797.1. XM_006521734.1. [Q9QY96-1 ]
UniGenei Mm.103619.

3D structure databases

ProteinModelPortali Q9QY96.
SMRi Q9QY96. Positions 29-531, 603-864.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 54.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QY96.

Proteomic databases

PaxDbi Q9QY96.
PRIDEi Q9QY96.

Protocols and materials databases

DNASUi 12374.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063597 ; ENSMUSP00000069080 ; ENSMUSG00000051980 . [Q9QY96-1 ]
ENSMUST00000114847 ; ENSMUSP00000110496 ; ENSMUSG00000051980 . [Q9QY96-2 ]
ENSMUST00000172826 ; ENSMUSP00000133500 ; ENSMUSG00000051980 . [Q9QY96-1 ]
GeneIDi 12374.
KEGGi mmu:12374.
UCSCi uc007zcp.1. mouse.

Organism-specific databases

CTDi 846.
MGIi MGI:1351351. Casr.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00750000117616.
HOVERGENi HBG052876.
InParanoidi Q9QY96.
KOi K04612.
OMAi IILFKPS.
OrthoDBi EOG7DZ8J8.
TreeFami TF331269.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 281082.
PROi Q9QY96.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QY96.
CleanExi MM_CASR.
Genevestigatori Q9QY96.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation."
    Oda Y., Tu C.-L., Chang W., Crumrine D., Koemueves L., Mauro T., Elias P.M., Bikle D.D.
    J. Biol. Chem. 275:1183-1190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism."
    Pi M., Garner S.C., Flannery P., Spurney R.F., Quarles L.D.
    J. Biol. Chem. 275:3256-3263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY.
    Strain: Black Swiss X 129/SVJ.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Expression and signal transduction of calcium-sensing receptors in cartilage and bone."
    Chang W., Tu C., Chen T.-H., Komuves L., Oda Y., Pratt S.A., Miller S., Shoback D.
    Endocrinology 140:5883-5893(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 256-600 (ISOFORM A), TISSUE SPECIFICITY.
    Tissue: Epiphyseal cartilage.
  6. Hildenbrand J., Ammon H.P.T., Wahl M.A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 507-582 (ISOFORM A).
    Strain: NMRI.
    Tissue: Brain.
  7. Moawad T.I., Riccardi D.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 562-814.
    Tissue: Kidney.
  8. "A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor."
    Quarles L.D., Hartle J.E. II, Siddhanti S.R., Guo R., Hinson T.K.
    J. Bone Miner. Res. 12:393-402(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 646-799, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASR_MOUSE
AccessioniPrimary (citable) accession number: Q9QY96
Secondary accession number(s): G3UX06
, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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