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Q9QY96

- CASR_MOUSE

UniProt

Q9QY96 - CASR_MOUSE

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Protein

Extracellular calcium-sensing receptor

Gene

Casr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. drug binding Source: Ensembl
  3. G-protein coupled receptor activity Source: UniProtKB-KW
  4. magnesium ion binding Source: Ensembl
  5. polyamine binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. apoptotic process Source: Ensembl
  3. branching morphogenesis of an epithelial tube Source: Ensembl
  4. calcium ion transport Source: Ensembl
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular response to glucose stimulus Source: Ensembl
  7. cellular response to hepatocyte growth factor stimulus Source: Ensembl
  8. cellular response to hypoxia Source: Ensembl
  9. cellular response to low-density lipoprotein particle stimulus Source: Ensembl
  10. cellular response to peptide Source: Ensembl
  11. cellular response to vitamin D Source: Ensembl
  12. fat pad development Source: Ensembl
  13. JNK cascade Source: Ensembl
  14. ossification Source: Ensembl
  15. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  16. positive regulation of ATPase activity Source: MGI
  17. positive regulation of calcium ion import Source: Ensembl
  18. positive regulation of cell proliferation Source: Ensembl
  19. positive regulation of gene expression Source: MGI
  20. positive regulation of insulin secretion Source: Ensembl
  21. positive regulation of positive chemotaxis Source: Ensembl
  22. positive regulation of vasoconstriction Source: Ensembl
  23. regulation of calcium ion transport Source: MGI
  24. response to calcium ion Source: Ensembl
  25. response to fibroblast growth factor Source: Ensembl
  26. response to ischemia Source: Ensembl
  27. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular calcium-sensing receptor
Short name:
CaSR
Alternative name(s):
Parathyroid cell calcium-sensing receptor
Short name:
PCaR1
Gene namesi
Name:Casr
Synonyms:Gprc2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1351351. Casr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 612593ExtracellularSequence AnalysisAdd
BLAST
Transmembranei613 – 63523Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini636 – 64914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei650 – 67021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini671 – 68111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei682 – 70019Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini701 – 72424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei725 – 74521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini746 – 76924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei770 – 79223Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini793 – 80513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei806 – 82823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini829 – 8368ExtracellularSequence Analysis
Transmembranei837 – 86226Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini863 – 1079217CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. axon terminus Source: Ensembl
  3. basolateral plasma membrane Source: Ensembl
  4. cell surface Source: Ensembl
  5. cytoplasm Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. neuronal cell body Source: Ensembl
  8. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 10791060Extracellular calcium-sensing receptorPRO_0000012947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity
Ubiquitinated by RNF19A; which induces proteasomal degradation.By similarity

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QY96.
PRIDEiQ9QY96.

PTM databases

PhosphoSiteiQ9QY96.

Expressioni

Tissue specificityi

Epidermis, kidney and cartilage.4 Publications

Gene expression databases

CleanExiMM_CASR.
ExpressionAtlasiQ9QY96. baseline.
GenevestigatoriQ9QY96.

Interactioni

Subunit structurei

Interacts with VCP and RNF19A. Interacts with ARRB1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QY96.
SMRiQ9QY96. Positions 29-531, 603-867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni880 – 90021Interaction with RNF19ABy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118974.
HOVERGENiHBG052876.
InParanoidiQ9QY96.
KOiK04612.
OMAiIILFKPS.
OrthoDBiEOG7DZ8J8.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9QY96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWFGYCLAL LALTWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD
60 70 80 90 100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT
110 120 130 140 150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGVS
160 170 180 190 200
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI
210 220 230 240 250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE
260 270 280 290 300
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA
310 320 330 340 350
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE
360 370 380 390 400
FWEETFNCHL QDGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN
410 420 430 440 450
INSVETPYMD YEHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA
460 470 480 490 500
DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD ECGDLVGNYS IINWHLSPED
510 520 530 540 550
GSIVFKEVGY YNVYAKKGER LFINEGKILW SGFSREVPFS NCSRDCQAGT
560 570 580 590 600
RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA
610 620 630 640 650
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL
660 670 680 690 700
SYLLLFSLLC CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN
710 720 730 740 750
RVLLVFEAKI PTSFHRKWWG LNLQFLLVFL CTFMQIVICI IWLYTAPPSS
760 770 780 790 800
YRNHELEDEI IFITCHEGSL MALGSLIGYT CLLAAICFFF AFKSRKLPEN
810 820 830 840 850
FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA ILAASFGLLA
860 870 880 890 900
CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS
910 920 930 940 950
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLALTQ QEQQQQPLTL
960 970 980 990 1000
QPQQQQQPQQ PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE
1010 1020 1030 1040 1050
AQKSNDTLNR HQALLPLQCA EADSEMTIQE TGLQGPMVGD HQPEIESPDE
1060 1070
MSPALVMSTS RSFVISGGGS SVTENILHS
Length:1,079
Mass (Da):120,903
Last modified:October 3, 2012 - v2
Checksum:i8AEF586CDCD93CB3
GO
Isoform B (identifier: Q9QY96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-537: Missing.

Show »
Length:1,002
Mass (Da):111,996
Checksum:i94BF8B687C0FD877
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451A → S in AAD40638. (PubMed:10652312)Curated
Sequence conflicti304 – 3041L → P in AAF00193. (PubMed:10579354)Curated
Sequence conflicti410 – 4101D → G in AAD28371. (PubMed:10625662)Curated
Sequence conflicti410 – 4101D → G in AAD28372. (PubMed:10625662)Curated
Sequence conflicti566 – 5661V → A in AAD40638. (PubMed:10652312)Curated
Sequence conflicti595 – 5951H → Y in AAD28371. (PubMed:10625662)Curated
Sequence conflicti595 – 5951H → Y in AAD28372. (PubMed:10625662)Curated
Sequence conflicti610 – 6101E → V in BAA77688. 1 PublicationCurated
Sequence conflicti814 – 8141F → L in BAA77688. 1 PublicationCurated
Sequence conflicti889 – 8891L → I in AAD40638. (PubMed:10652312)Curated
Sequence conflicti906 – 9083TGS → SGW in AAD40638. (PubMed:10652312)Curated
Sequence conflicti909 – 9091I → N in AAD28371. (PubMed:10625662)Curated
Sequence conflicti909 – 9091I → N in AAD28372. (PubMed:10625662)Curated
Sequence conflicti1057 – 10571M → V in AAD28371. (PubMed:10625662)Curated
Sequence conflicti1057 – 10571M → V in AAD28372. (PubMed:10625662)Curated
Sequence conflicti1064 – 10641V → A in AAD40638. (PubMed:10652312)Curated
Sequence conflicti1076 – 10761I → V in AAD40638. (PubMed:10652312)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei461 – 53777Missing in isoform B. CuratedVSP_002036Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110178 mRNA. Translation: AAD28371.1.
AF110179 mRNA. Translation: AAD28372.1.
AF128842 mRNA. Translation: AAD40638.1.
AC074229 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97924.1.
AF068900 mRNA. Translation: AAC19388.1.
AB027140 mRNA. Translation: BAA77688.1.
AF002015 Genomic DNA. Translation: AAC53252.1.
AF159565 mRNA. Translation: AAF00193.1.
CCDSiCCDS28154.1. [Q9QY96-1]
RefSeqiNP_038831.2. NM_013803.2. [Q9QY96-1]
XP_006521792.1. XM_006521729.1. [Q9QY96-1]
XP_006521793.1. XM_006521730.1. [Q9QY96-1]
XP_006521794.1. XM_006521731.1. [Q9QY96-1]
XP_006521795.1. XM_006521732.1. [Q9QY96-1]
XP_006521796.1. XM_006521733.1. [Q9QY96-1]
XP_006521797.1. XM_006521734.1. [Q9QY96-1]
UniGeneiMm.103619.

Genome annotation databases

EnsembliENSMUST00000063597; ENSMUSP00000069080; ENSMUSG00000051980. [Q9QY96-1]
ENSMUST00000114847; ENSMUSP00000110496; ENSMUSG00000051980. [Q9QY96-2]
ENSMUST00000172826; ENSMUSP00000133500; ENSMUSG00000051980. [Q9QY96-1]
GeneIDi12374.
KEGGimmu:12374.
UCSCiuc007zcp.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110178 mRNA. Translation: AAD28371.1 .
AF110179 mRNA. Translation: AAD28372.1 .
AF128842 mRNA. Translation: AAD40638.1 .
AC074229 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97924.1 .
AF068900 mRNA. Translation: AAC19388.1 .
AB027140 mRNA. Translation: BAA77688.1 .
AF002015 Genomic DNA. Translation: AAC53252.1 .
AF159565 mRNA. Translation: AAF00193.1 .
CCDSi CCDS28154.1. [Q9QY96-1 ]
RefSeqi NP_038831.2. NM_013803.2. [Q9QY96-1 ]
XP_006521792.1. XM_006521729.1. [Q9QY96-1 ]
XP_006521793.1. XM_006521730.1. [Q9QY96-1 ]
XP_006521794.1. XM_006521731.1. [Q9QY96-1 ]
XP_006521795.1. XM_006521732.1. [Q9QY96-1 ]
XP_006521796.1. XM_006521733.1. [Q9QY96-1 ]
XP_006521797.1. XM_006521734.1. [Q9QY96-1 ]
UniGenei Mm.103619.

3D structure databases

ProteinModelPortali Q9QY96.
SMRi Q9QY96. Positions 29-531, 603-867.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 54.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QY96.

Proteomic databases

PaxDbi Q9QY96.
PRIDEi Q9QY96.

Protocols and materials databases

DNASUi 12374.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063597 ; ENSMUSP00000069080 ; ENSMUSG00000051980 . [Q9QY96-1 ]
ENSMUST00000114847 ; ENSMUSP00000110496 ; ENSMUSG00000051980 . [Q9QY96-2 ]
ENSMUST00000172826 ; ENSMUSP00000133500 ; ENSMUSG00000051980 . [Q9QY96-1 ]
GeneIDi 12374.
KEGGi mmu:12374.
UCSCi uc007zcp.1. mouse.

Organism-specific databases

CTDi 846.
MGIi MGI:1351351. Casr.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00760000118974.
HOVERGENi HBG052876.
InParanoidi Q9QY96.
KOi K04612.
OMAi IILFKPS.
OrthoDBi EOG7DZ8J8.
TreeFami TF331269.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi 281082.
PROi Q9QY96.
SOURCEi Search...

Gene expression databases

CleanExi MM_CASR.
ExpressionAtlasi Q9QY96. baseline.
Genevestigatori Q9QY96.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation."
    Oda Y., Tu C.-L., Chang W., Crumrine D., Koemueves L., Mauro T., Elias P.M., Bikle D.D.
    J. Biol. Chem. 275:1183-1190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism."
    Pi M., Garner S.C., Flannery P., Spurney R.F., Quarles L.D.
    J. Biol. Chem. 275:3256-3263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY.
    Strain: Black Swiss X 129/SVJ.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Expression and signal transduction of calcium-sensing receptors in cartilage and bone."
    Chang W., Tu C., Chen T.-H., Komuves L., Oda Y., Pratt S.A., Miller S., Shoback D.
    Endocrinology 140:5883-5893(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 256-600 (ISOFORM A), TISSUE SPECIFICITY.
    Tissue: Epiphyseal cartilage.
  6. Hildenbrand J., Ammon H.P.T., Wahl M.A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 507-582 (ISOFORM A).
    Strain: NMRI.
    Tissue: Brain.
  7. Moawad T.I., Riccardi D.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 562-814.
    Tissue: Kidney.
  8. "A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor."
    Quarles L.D., Hartle J.E. II, Siddhanti S.R., Guo R., Hinson T.K.
    J. Bone Miner. Res. 12:393-402(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 646-799, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASR_MOUSE
AccessioniPrimary (citable) accession number: Q9QY96
Secondary accession number(s): G3UX06
, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3