ID   Q9QY87_RAT              Unreviewed;       144 AA.
AC   Q9QY87;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=CCAAT-box-binding transcription factor {ECO:0000256|ARBA:ARBA00031941};
DE   AltName: Full=TGGCA-binding protein {ECO:0000256|ARBA:ARBA00030530};
DE   Flags: Fragment;
GN   Name=Nfic {ECO:0000313|RGD:62016};
GN   Synonyms=NFIC {ECO:0000313|EMBL:AAF23587.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAF23587.1};
RN   [1] {ECO:0000313|EMBL:AAF23587.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAF23587.1};
RX   PubMed=10521600; DOI=10.1016/S0169-328X(99)00210-7;
RA   Baumeister H., Gronostajski R.M., Lyons G.E., Margolis F.L.;
RT   "Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a
RT   regulatory role for NFI transcription factors in olfactory neuron gene
RT   expression.";
RL   Brain Res. Mol. Brain Res. 72:65-79(1999).
CC   -!- FUNCTION: Recognizes and binds the palindromic sequence 5'-
CC       TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the
CC       origin of replication of adenovirus type 2. These proteins are
CC       individually capable of activating transcription and replication.
CC       {ECO:0000256|ARBA:ARBA00037633}.
CC   -!- SUBUNIT: Binds DNA as a homodimer. {ECO:0000256|ARBA:ARBA00011432}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AF112458; AAF23587.1; -; mRNA.
DR   AlphaFoldDB; Q9QY87; -.
DR   UCSC; RGD:62016; rat.
DR   AGR; RGD:62016; -.
DR   RGD; 62016; Nfic.
DR   PhylomeDB; Q9QY87; -.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:RGD.
DR   GO; GO:0003677; F:DNA binding; IDA:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IDA:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR000647; CTF/NFI.
DR   InterPro; IPR020604; CTF/NFI_DNA-bd-dom.
DR   InterPro; IPR019739; CTF/NFI_DNA-bd_CS.
DR   InterPro; IPR019548; CTF/NFI_DNA-bd_N.
DR   InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR   PANTHER; PTHR11492:SF2; NUCLEAR FACTOR 1 C-TYPE; 1.
DR   PANTHER; PTHR11492; NUCLEAR FACTOR I; 1.
DR   Pfam; PF03165; MH1; 1.
DR   Pfam; PF10524; NfI_DNAbd_pre-N; 1.
DR   SMART; SM00523; DWA; 1.
DR   PROSITE; PS00349; CTF_NFI_1; 1.
DR   PROSITE; PS51080; CTF_NFI_2; 1.
PE   2: Evidence at transcript level;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          1..144
FT                   /note="CTF/NF-I"
FT                   /evidence="ECO:0000259|PROSITE:PS51080"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF23587.1"
FT   NON_TER         144
FT                   /evidence="ECO:0000313|EMBL:AAF23587.1"
SQ   SEQUENCE   144 AA;  16672 MW;  D23D544A692A70AC CRC64;
     LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD ELLGEKAEVK QKWASRLLAK
     LRKDIRPECR EDFVLAVTGK KAPGCVLSNP DQKGKMRRID CLRQADKVWR LDLVMVILFK
     GIPLESTDGE RLVKAAASAH PVLC
//