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Protein
Submitted name:

Nuclear factor I-C

Gene

Nfic

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. core promoter proximal region DNA binding Source: RGD
  2. DNA binding Source: RGD
  3. double-stranded DNA binding Source: RGD
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. DNA replication Source: InterPro
  2. negative regulation of transcription, DNA-templated Source: RGD
  3. negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  4. positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  5. sensory perception of smell Source: RGD
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor I-CImported
Gene namesi
Name:NficImported
Synonyms:NFICImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi62016. Nfic.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ9QY87.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000013028.
HOVERGENiHBG006561.
PhylomeDBiQ9QY87.

Family and domain databases

InterProiIPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
[Graphical view]
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
PROSITEiPS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9QY87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD ELLGEKAEVK
60 70 80 90 100
QKWASRLLAK LRKDIRPECR EDFVLAVTGK KAPGCVLSNP DQKGKMRRID
110 120 130 140
CLRQADKVWR LDLVMVILFK GIPLESTDGE RLVKAAASAH PVLC
Length:144
Mass (Da):16,672
Last modified:April 30, 2000 - v1
Checksum:iD23D544A692A70AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei144 – 1441Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112458 mRNA. Translation: AAF23587.1.
UniGeneiRn.86582.

Genome annotation databases

UCSCiRGD:62016. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112458 mRNA. Translation: AAF23587.1.
UniGeneiRn.86582.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:62016. rat.

Organism-specific databases

RGDi62016. Nfic.

Phylogenomic databases

HOGENOMiHOG000013028.
HOVERGENiHBG006561.
PhylomeDBiQ9QY87.

Gene expression databases

GenevestigatoriQ9QY87.

Family and domain databases

InterProiIPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
[Graphical view]
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
PROSITEiPS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a regulatory role for NFI transcription factors in olfactory neuron gene expression."
    Baumeister H., Gronostajski R.M., Lyons G.E., Margolis F.L.
    Brain Res. Mol. Brain Res. 72:65-79(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Olfactory epitheliumImported.

Entry informationi

Entry nameiQ9QY87_RAT
AccessioniPrimary (citable) accession number: Q9QY87
Entry historyi
Integrated into UniProtKB/TrEMBL: April 30, 2000
Last sequence update: April 30, 2000
Last modified: February 3, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.