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Protein

Actin-like protein 7A

Gene

Actl7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 7A
Alternative name(s):
Actin-like-7-alpha
Testis-specific actin-2
Short name:
T-actin-2
Gene namesi
Name:Actl7a
Synonyms:Tact2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1343051. Actl7a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • male germ cell nucleus Source: MGI
  • motile cilium Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000891381 – 440Actin-like protein 7AAdd BLAST440

Proteomic databases

PaxDbiQ9QY84.
PRIDEiQ9QY84.

PTM databases

iPTMnetiQ9QY84.
PhosphoSitePlusiQ9QY84.

Expressioni

Tissue specificityi

Detected in testis. Detected at the acrosome of round spermatids (at protein level). Detected in adult and embryonic testis. Detected in developing male germ cells.3 Publications

Gene expression databases

BgeeiENSMUSG00000070979.
CleanExiMM_ACTL7A.
GenevisibleiQ9QY84. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092692.

Structurei

3D structure databases

ProteinModelPortaliQ9QY84.
SMRiQ9QY84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 56Required for interaction with TESBy similarityAdd BLAST21

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9QY84.
OMAiIWEYLFH.
OrthoDBiEOG091G07GC.
PhylomeDBiQ9QY84.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR027679. ACTL7A.
IPR031769. ACTL7A_N.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF167. PTHR11937:SF167. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF16840. ACTL7A_N. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDGVWAPQ TANIGDGPAK KASDQASMQT QVLQTASLKD GPAKRAVWVR
60 70 80 90 100
RDNAETEDPV KSTMSKDRPR LEVTKAVVVD LGTGFCKCGF AGLPKPTHKI
110 120 130 140 150
STTVGKPYME TAKTGDNRKE TFVGHELFNP DIHLKLVNPL RHGIIVDWDT
160 170 180 190 200
VQDIWEYLFR QEMKIAPEEH AVLVSDPPLS PHTNREKYAE MLFETFNTPA
210 220 230 240 250
MHIAYQSRLS MYSYGRTSGL VVEVGHGVSY VVPIYEGYPL PSITGRLDYA
260 270 280 290 300
GSDLTTYLMN LMNNSGKHFS EDHLGIVEDI KTRCCFVALD PIEEKKIPAP
310 320 330 340 350
EHEIHYTLPD GKEIRLGQER FLCSEMFFKP SLIKSMQLGL HTQTVSCLNK
360 370 380 390 400
CDIALKRDLM GNILLCGGST MLRGFPNRLQ KELSSMCPND TPQVNVLPER
410 420 430 440
DTAVWTGGSI LASLQGFQPL WVHRLEYEEH GPFFLYRRCF
Length:440
Mass (Da):49,451
Last modified:May 1, 2000 - v1
Checksum:i1909838FB9D8DEC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176 – 181DPPLSP → VTPREC in BAB24681 (PubMed:16141072).Curated6
Sequence conflicti224V → D in BAB24681 (PubMed:16141072).Curated1
Sequence conflicti290D → T in BAB24681 (PubMed:16141072).Curated1
Sequence conflicti328F → S in BAA90822 (Ref. 2) Curated1
Sequence conflicti373R → G in BAB24681 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113519 mRNA. Translation: AAF18298.1.
AB023063 mRNA. Translation: BAA90822.1.
AB079643 Genomic DNA. Translation: BAC07297.1.
AL807762 Genomic DNA. Translation: CAM25709.1.
CH466565 Genomic DNA. Translation: EDL02258.1.
AK006631 mRNA. Translation: BAB24681.1.
BC049610 mRNA. Translation: AAH49610.1.
CCDSiCCDS18197.1.
RefSeqiNP_033741.1. NM_009611.3.
UniGeneiMm.30959.

Genome annotation databases

EnsembliENSMUST00000095079; ENSMUSP00000092692; ENSMUSG00000070979.
GeneIDi11470.
KEGGimmu:11470.
UCSCiuc008sxo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113519 mRNA. Translation: AAF18298.1.
AB023063 mRNA. Translation: BAA90822.1.
AB079643 Genomic DNA. Translation: BAC07297.1.
AL807762 Genomic DNA. Translation: CAM25709.1.
CH466565 Genomic DNA. Translation: EDL02258.1.
AK006631 mRNA. Translation: BAB24681.1.
BC049610 mRNA. Translation: AAH49610.1.
CCDSiCCDS18197.1.
RefSeqiNP_033741.1. NM_009611.3.
UniGeneiMm.30959.

3D structure databases

ProteinModelPortaliQ9QY84.
SMRiQ9QY84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092692.

PTM databases

iPTMnetiQ9QY84.
PhosphoSitePlusiQ9QY84.

Proteomic databases

PaxDbiQ9QY84.
PRIDEiQ9QY84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095079; ENSMUSP00000092692; ENSMUSG00000070979.
GeneIDi11470.
KEGGimmu:11470.
UCSCiuc008sxo.2. mouse.

Organism-specific databases

CTDi10881.
MGIiMGI:1343051. Actl7a.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9QY84.
OMAiIWEYLFH.
OrthoDBiEOG091G07GC.
PhylomeDBiQ9QY84.
TreeFamiTF354237.

Miscellaneous databases

PROiQ9QY84.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070979.
CleanExiMM_ACTL7A.
GenevisibleiQ9QY84. MM.

Family and domain databases

InterProiIPR004000. Actin.
IPR027679. ACTL7A.
IPR031769. ACTL7A_N.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF167. PTHR11937:SF167. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF16840. ACTL7A_N. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACL7A_MOUSE
AccessioniPrimary (citable) accession number: Q9QY84
Secondary accession number(s): A2AMK4, Q9D9P4, Q9JMI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.