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Protein

Actin-like protein 7B

Gene

Actl7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 7B
Alternative name(s):
Actin-like-7-beta
Testis-specific actin-1
Short name:
T-actin-1
Gene namesi
Name:Actl7b
Synonyms:Tact1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1343053. Actl7b.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Actin-like protein 7BPRO_0000089141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QY83.
PeptideAtlasiQ9QY83.
PRIDEiQ9QY83.

2D gel databases

REPRODUCTION-2DPAGEQ9QY83.

PTM databases

iPTMnetiQ9QY83.
PhosphoSiteiQ9QY83.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9QY83.
CleanExiMM_ACTL7B.
GenevisibleiQ9QY83. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092693.

Structurei

3D structure databases

ProteinModelPortaliQ9QY83.
SMRiQ9QY83. Positions 53-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9QY83.
OMAiYVGHELL.
OrthoDBiEOG7VHSX3.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR027680. ACTL7B.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF59. PTHR11937:SF59. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKNSPSPK PMGTAQGDPG EAGTLPAPEA AGIRDTGSTQ LKTKPKKIRK
60 70 80 90 100
IKALVIDLGS QYCKCGYAGE PRPTYFISST VGKRSAEMAA DAGDNFKETY
110 120 130 140 150
VGHELLNMEA SLKLVNPLKH GVVVDWDCIQ NIWEYIFHTA MKIMPEEHAV
160 170 180 190 200
LVSDPPLSPT SNREKYAELL FETFGIPAMH VTSQALLSIY SYGKTSGLVV
210 220 230 240 250
ESGHGVSHVV PISEGDLLPG LPSRVDYAGC DLTNYLMQLL NEAGHKFSDD
260 270 280 290 300
HLHIIEHIKK KCCYAALLPE EEMSLGLDEL HVDYELPDGK IITIGQERFR
310 320 330 340 350
CSEMLFKPSL VGCTQPGLPE LTATCLARCQ GTGFKEEMAA NVLLCGGCTM
360 370 380 390 400
LDGFPERFQR ELSLLCPGDS PTVAAAPERK TSVWTGGSIL ASLQAFQQLW
410
VSKEEFEERG CAAIYSKC
Length:418
Mass (Da):45,565
Last modified:July 27, 2011 - v2
Checksum:i81ED555E1D2B5088
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 862SA → RP in AAF18299 (PubMed:10373328).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113520 mRNA. Translation: AAF18299.1.
AB023062 mRNA. Translation: BAA90821.1.
AB079643 Genomic DNA. Translation: BAC07296.1.
AL807762 Genomic DNA. Translation: CAM25710.1.
CH466565 Genomic DNA. Translation: EDL02259.1.
BC116815 mRNA. Translation: AAI16816.1.
BC116817 mRNA. Translation: AAI16818.1.
CCDSiCCDS18196.1.
RefSeqiNP_079547.2. NM_025271.2.
UniGeneiMm.251434.

Genome annotation databases

EnsembliENSMUST00000095080; ENSMUSP00000092693; ENSMUSG00000070980.
GeneIDi11471.
KEGGimmu:11471.
UCSCiuc008sxn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113520 mRNA. Translation: AAF18299.1.
AB023062 mRNA. Translation: BAA90821.1.
AB079643 Genomic DNA. Translation: BAC07296.1.
AL807762 Genomic DNA. Translation: CAM25710.1.
CH466565 Genomic DNA. Translation: EDL02259.1.
BC116815 mRNA. Translation: AAI16816.1.
BC116817 mRNA. Translation: AAI16818.1.
CCDSiCCDS18196.1.
RefSeqiNP_079547.2. NM_025271.2.
UniGeneiMm.251434.

3D structure databases

ProteinModelPortaliQ9QY83.
SMRiQ9QY83. Positions 53-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092693.

PTM databases

iPTMnetiQ9QY83.
PhosphoSiteiQ9QY83.

2D gel databases

REPRODUCTION-2DPAGEQ9QY83.

Proteomic databases

PaxDbiQ9QY83.
PeptideAtlasiQ9QY83.
PRIDEiQ9QY83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095080; ENSMUSP00000092693; ENSMUSG00000070980.
GeneIDi11471.
KEGGimmu:11471.
UCSCiuc008sxn.1. mouse.

Organism-specific databases

CTDi10880.
MGIiMGI:1343053. Actl7b.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9QY83.
OMAiYVGHELL.
OrthoDBiEOG7VHSX3.
TreeFamiTF354237.

Miscellaneous databases

PROiQ9QY83.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QY83.
CleanExiMM_ACTL7B.
GenevisibleiQ9QY83. MM.

Family and domain databases

InterProiIPR004000. Actin.
IPR027680. ACTL7B.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF59. PTHR11937:SF59. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31."
    Chadwick B.P., Mull J., Helbling L.A., Gill S., Leyne M., Robbins C.M., Pinkett H.W., Makalowska I., Maayan C., Blumenfeld A., Axelrod F.B., Brownstein M., Gusella J.F., Slaugenhaupt S.A.
    Genomics 58:302-309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Testis.
  2. "Testis specific actin."
    Tanaka H., Iguchi N., Carvalho C.E., Nozaki M., Nishimune Y.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Genomic structure and promoter activity of the testis haploid germ cell-specific intronless genes, Tact1 and Tact2."
    Hisano M., Yamada S., Tanaka H., Nishimune Y., Nozaki M.
    Mol. Reprod. Dev. 65:148-156(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiACL7B_MOUSE
AccessioniPrimary (citable) accession number: Q9QY83
Secondary accession number(s): Q14AJ4, Q9JMI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.