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Q9QY76

- VAPB_MOUSE

UniProt

Q9QY76 - VAPB_MOUSE

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Protein
Vesicle-associated membrane protein-associated protein B
Gene
Vapb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity By similarity. Involved in cellular calcium homeostasis regulation By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: UniProtKB
  2. cellular calcium ion homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein-associated protein B
Short name:
VAMP-B
Short name:
VAMP-associated protein B
Short name:
VAP-B
Alternative name(s):
VAMP-associated protein 33b
Gene namesi
Name:Vapb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1928744. Vapb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 218217Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 243242Vesicle-associated membrane protein-associated protein B
PRO_0000213474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei156 – 1561Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QY76.
PaxDbiQ9QY76.
PRIDEiQ9QY76.

PTM databases

PhosphoSiteiQ9QY76.

Expressioni

Gene expression databases

GenevestigatoriQ9QY76.

Interactioni

Subunit structurei

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.

Protein-protein interaction databases

IntActiQ9QY76. 2 interactions.
MINTiMINT-1844200.

Structurei

3D structure databases

ProteinModelPortaliQ9QY76.
SMRiQ9QY76. Positions 1-125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 124118MSP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili161 – 19636 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 MSP domain.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5066.
HOGENOMiHOG000293182.
HOVERGENiHBG028551.
InParanoidiQ9QY76.
PhylomeDBiQ9QY76.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
InterProiIPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
PfamiPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiPS50202. MSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QY76-1 [UniParc]FASTAAdd to Basket

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MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTVPR    50
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS 100
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA 150
PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK 200
AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL 243
Length:243
Mass (Da):26,946
Last modified:January 23, 2007 - v3
Checksum:i9D88CBC31701C84E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115504 mRNA. Translation: AAF23077.1.
CCDSiCCDS17146.1.
UniGeneiMm.260456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115504 mRNA. Translation: AAF23077.1 .
CCDSi CCDS17146.1.
UniGenei Mm.260456.

3D structure databases

ProteinModelPortali Q9QY76.
SMRi Q9QY76. Positions 1-125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QY76. 2 interactions.
MINTi MINT-1844200.

PTM databases

PhosphoSitei Q9QY76.

Proteomic databases

MaxQBi Q9QY76.
PaxDbi Q9QY76.
PRIDEi Q9QY76.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1928744. Vapb.

Phylogenomic databases

eggNOGi COG5066.
HOGENOMi HOG000293182.
HOVERGENi HBG028551.
InParanoidi Q9QY76.
PhylomeDBi Q9QY76.

Miscellaneous databases

ChiTaRSi VAPB. mouse.
PROi Q9QY76.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9QY76.

Family and domain databases

Gene3Di 2.60.40.360. 1 hit.
InterProi IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view ]
Pfami PF00635. Motile_Sperm. 1 hit.
[Graphical view ]
PIRSFi PIRSF019693. VAMP-associated. 1 hit.
SUPFAMi SSF49354. SSF49354. 1 hit.
PROSITEi PS50202. MSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two forms of mammalian VAP33."
    Tang B.L., Low D.L.H., Lock M.L., Hong W.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVAPB_MOUSE
AccessioniPrimary (citable) accession number: Q9QY76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi