Q9QY76 (VAPB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vesicle-associated membrane protein-associated protein B
Short name=VAMP-B
Short name=VAMP-associated protein B
Short name=VAP-B

Alternative name(s):
VAMP-associated protein 33b

Gene names

Name:

Vapb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in vesicle trafficking.
Subunit structure	Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity.
Sequence similarities	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. [View classification] Contains 1 MSP domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane fraction Inferred from direct assay. Source: HGNC
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 243	242	Vesicle-associated membrane protein-associated protein B		PRO_0000213474
Regions
	Topological domain	2 – 218	217	Cytoplasmic Potential
	Transmembrane	219 – 239	21	Helical; Anchor for type IV membrane protein; Potential
	Domain	7 – 124	118	MSP
	Coiled coil	161 – 196	36	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	3	1	N6-acetyllysine By similarity
	Modified residue	156	1	Phosphoserine By similarity
	Modified residue	159	1	Phosphoserine By similarity
	Modified residue	206	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QY76 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9D88CBC31701C84E	FASTA	243	26,946
	10 20 30 40 50 60 MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTVPR RYCVRPNSGV 70 80 90 100 110 120 IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS DMEAVWKEAK PEDLMDSKLR 130 140 150 160 170 180 CVFELPAENA KPHDVEINKI IPTSASKTEA PAAAKSLTSP LDDTEVKKVM EECRRLQGEV 190 200 210 220 230 240 QRLREESRQL KEEDGLRVRK AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL

References

[1]	"Two forms of mammalian VAP33." Tang B.L., Low D.L.H., Lock M.L., Hong W. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF115504 mRNA. Translation: AAF23077.1.
IPI	IPI00135655.
UniGene	Mm.260456.
3D structure databases
ProteinModelPortal	Q9QY76.
SMR	Q9QY76. Positions 1-125.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QY76. 2 interactions.
STRING	Q9QY76.
PTM databases
PhosphoSite	Q9QY76.
Proteomic databases
PRIDE	Q9QY76.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1928744. Vapb.
Phylogenomic databases
GeneTree	ENSGT00390000006947.
HOGENOM	HBG446464.
HOVERGEN	HBG028551.
InParanoid	Q9QY76.
OrthoDB	EOG4DNF5D.
PhylomeDB	Q9QY76.
Gene expression databases
ArrayExpress	Q9QY76.
Bgee	Q9QY76.
Genevestigator	Q9QY76.
GermOnline	ENSMUSG00000054455. Mus musculus.
Family and domain databases
InterPro	IPR000535. Major_sperm. IPR008962. PapD-like. IPR016763. Vesicle-associated_membrane. [Graphical view]
Gene3D	G3DSA:2.60.40.360. MSP. 1 hit.
Pfam	PF00635. Motile_Sperm. 1 hit. [Graphical view]
PIRSF	PIRSF019693. VAMP-associated. 1 hit.
SUPFAM	SSF49354. PapD-like. 1 hit.
PROSITE	PS50202. MSP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

VAPB_MOUSE

Accession

Primary (citable) accession number: Q9QY76

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	January 23, 2007
Last modified:	September 21, 2011
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program