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Protein

Vesicle-associated membrane protein-associated protein B

Gene

Vapb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein-associated protein B
Short name:
VAMP-B
Short name:
VAMP-associated protein B
Short name:
VAP-B
Alternative name(s):
VAMP-associated protein 33b
Gene namesi
Name:Vapb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1928744. Vapb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 218CytoplasmicSequence analysisAdd BLAST217
Transmembranei219 – 239Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002134742 – 243Vesicle-associated membrane protein-associated protein BAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei156PhosphoserineBy similarity1
Modified residuei159PhosphoserineCombined sources1
Modified residuei206PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9QY76.
MaxQBiQ9QY76.
PaxDbiQ9QY76.
PRIDEiQ9QY76.

PTM databases

iPTMnetiQ9QY76.
PhosphoSitePlusiQ9QY76.

Interactioni

Subunit structurei

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2 (By similarity). Interacts (via MSP domain) with ZFYVE27 (PubMed:24251978). Interacts with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with STARD3 (via FFAT motif) (By similarity). Interacts with STARD3NL (via FFAT motif) (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QY76. 2 interactors.
MINTiMINT-1844200.
STRINGi10090.ENSMUSP00000064699.

Structurei

3D structure databases

ProteinModelPortaliQ9QY76.
SMRiQ9QY76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 124MSPPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili161 – 196Sequence analysisAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0439. Eukaryota.
COG5066. LUCA.
HOGENOMiHOG000293182.
HOVERGENiHBG028551.
InParanoidiQ9QY76.
PhylomeDBiQ9QY76.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. VAP.
IPR030226. VapB.
PANTHERiPTHR10809. PTHR10809. 1 hit.
PTHR10809:SF86. PTHR10809:SF86. 1 hit.
PfamiView protein in Pfam
PF00635. Motile_Sperm. 1 hit.
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiView protein in PROSITE
PS50202. MSP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QY76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTVPR
60 70 80 90 100
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA
160 170 180 190 200
PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK
210 220 230 240
AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL
Length:243
Mass (Da):26,946
Last modified:January 23, 2007 - v3
Checksum:i9D88CBC31701C84E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115504 mRNA. Translation: AAF23077.1.
CCDSiCCDS17146.1.
UniGeneiMm.260456.

Similar proteinsi

Entry informationi

Entry nameiVAPB_MOUSE
AccessioniPrimary (citable) accession number: Q9QY76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families