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Q9QY76

- VAPB_MOUSE

UniProt

Q9QY76 - VAPB_MOUSE

Protein

Vesicle-associated membrane protein-associated protein B

Gene

Vapb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: UniProtKB
    2. cellular calcium ion homeostasis Source: UniProtKB

    Keywords - Biological processi

    Unfolded protein response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-associated membrane protein-associated protein B
    Short name:
    VAMP-B
    Short name:
    VAMP-associated protein B
    Short name:
    VAP-B
    Alternative name(s):
    VAMP-associated protein 33b
    Gene namesi
    Name:Vapb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1928744. Vapb.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 243242Vesicle-associated membrane protein-associated protein BPRO_0000213474Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei156 – 1561PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QY76.
    PaxDbiQ9QY76.
    PRIDEiQ9QY76.

    PTM databases

    PhosphoSiteiQ9QY76.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QY76.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9QY76. 2 interactions.
    MINTiMINT-1844200.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QY76.
    SMRiQ9QY76. Positions 1-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 218217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei219 – 23921Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 124118MSPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili161 – 19636Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MSP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5066.
    HOGENOMiHOG000293182.
    HOVERGENiHBG028551.
    InParanoidiQ9QY76.
    PhylomeDBiQ9QY76.

    Family and domain databases

    Gene3Di2.60.40.360. 1 hit.
    InterProiIPR000535. MSP_dom.
    IPR008962. PapD-like.
    IPR016763. Vesicle-associated_membrane.
    [Graphical view]
    PfamiPF00635. Motile_Sperm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019693. VAMP-associated. 1 hit.
    SUPFAMiSSF49354. SSF49354. 1 hit.
    PROSITEiPS50202. MSP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QY76-1 [UniParc]FASTAAdd to Basket

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    MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTVPR    50
    RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS 100
    DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA 150
    PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK 200
    AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL 243
    Length:243
    Mass (Da):26,946
    Last modified:January 23, 2007 - v3
    Checksum:i9D88CBC31701C84E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115504 mRNA. Translation: AAF23077.1.
    CCDSiCCDS17146.1.
    UniGeneiMm.260456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115504 mRNA. Translation: AAF23077.1 .
    CCDSi CCDS17146.1.
    UniGenei Mm.260456.

    3D structure databases

    ProteinModelPortali Q9QY76.
    SMRi Q9QY76. Positions 1-125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QY76. 2 interactions.
    MINTi MINT-1844200.

    PTM databases

    PhosphoSitei Q9QY76.

    Proteomic databases

    MaxQBi Q9QY76.
    PaxDbi Q9QY76.
    PRIDEi Q9QY76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1928744. Vapb.

    Phylogenomic databases

    eggNOGi COG5066.
    HOGENOMi HOG000293182.
    HOVERGENi HBG028551.
    InParanoidi Q9QY76.
    PhylomeDBi Q9QY76.

    Miscellaneous databases

    ChiTaRSi VAPB. mouse.
    PROi Q9QY76.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9QY76.

    Family and domain databases

    Gene3Di 2.60.40.360. 1 hit.
    InterProi IPR000535. MSP_dom.
    IPR008962. PapD-like.
    IPR016763. Vesicle-associated_membrane.
    [Graphical view ]
    Pfami PF00635. Motile_Sperm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019693. VAMP-associated. 1 hit.
    SUPFAMi SSF49354. SSF49354. 1 hit.
    PROSITEi PS50202. MSP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two forms of mammalian VAP33."
      Tang B.L., Low D.L.H., Lock M.L., Hong W.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiVAPB_MOUSE
    AccessioniPrimary (citable) accession number: Q9QY76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3