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Q9QY61 (IRX4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iroquois-class homeodomain protein IRX-4
Alternative name(s):
Homeodomain protein IRXA3
Iroquois homeobox protein 4
Gene names
Name:Irx4
Synonyms:Irxa3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Likely to be an important mediator of ventricular differentiation during cardiac development. Ref.1

Subunit structure

Interacts with the vitamin D receptor VDR but doesn't affect its transactivation activity By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in the developing central nervous system, skin, and vibrissae, but predominantly expressed in the cardiac ventricles of the developing heart. Not expressed in the developing metanephric kidney or adult kidney. Ref.1 Ref.2

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Iroquois-class homeodomain protein IRX-4
PRO_0000049158

Regions

DNA binding144 – 20562Homeobox; TALE-type
Compositional bias119 – 1224Poly-Ala
Compositional bias224 – 2296Poly-Glu
Compositional bias376 – 3838Poly-Ala

Experimental info

Sequence conflict2151C → Y in BAE21235. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9QY61 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: A3E7C67B7D5334BE

FASTA51554,701
        10         20         30         40         50         60 
MSYPQFGYPY SSAPQFLMTT NSLSTCCESG GRTLADSGPA ASAQAPVYCP VYESRLLATA 

        70         80         90        100        110        120 
RHELNSAAAL GVYGSPYGSS QGYGNYVTYG SEASAFYSLN SFESKDGTGS SHAGLPPTAA 

       130        140        150        160        170        180 
AAYYPYEPAL SQYPYDRYGT VDSGTRRKNA TRETTSTLKA WLQEHRKNPY PTKGEKIMLA 

       190        200        210        220        230        240 
IITKMTLTQV STWFANARRR LKKENKMTWP PRNKCADEKR PYGEGEEEEA GEEESREEPL 

       250        260        270        280        290        300 
KSAKSEGHAG KDDKELELSD LEDFDPLDAE TSECELKTPF QSLDSGPERI PASSDGPGTG 

       310        320        330        340        350        360 
KEASTTLRMP LGTAGGAVMD GDLERARNCL RSTVVVPDSG AEGGPPACEA KLTFAQAGAP 

       370        380        390        400        410        420 
PNLETKPRIW SLAHTATAAA ATALSQTEFP SCMLKRQGPT GVSATTPASS PAVTAPSGAL 

       430        440        450        460        470        480 
DRHQDSPVTS LRNWVDGVFH DPILRHSTLN QAWATAKGAL LDPGPLGRNL GAGTNVLTTP 

       490        500        510 
LACSFPPTVP QDVPPAGASR ELLATPKAGG KPFCT 

« Hide

References

« Hide 'large scale' references
[1]"Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand."
Bruneau B.G., Bao Z.-Z., Tanaka M., Schott J.-J., Izumo S., Cepko C.L., Seidman J.G., Seidman C.E.
Dev. Biol. 217:266-277(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION, TISSUE SPECIFICITY.
Tissue: Embryonic heart.
[2]"Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart."
Christoffels V.M., Keijser A.G.M., Houweling A.C., Clout D.E.W., Moorman A.F.M.
Dev. Biol. 224:263-274(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: FVB/N.
Tissue: Embryonic heart.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The prepattern transcription factor Irx3 directs nephron segment identity."
Reggiani L., Raciti D., Airik R., Kispert A., Braendli A.W.
Genes Dev. 21:2358-2370(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF RENAL EXPRESSION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF124732 mRNA. Translation: AAF23886.1.
AK132571 mRNA. Translation: BAE21235.1.
CH466563 Genomic DNA. Translation: EDL37045.1.
BC126942 mRNA. Translation: AAI26943.1.
CCDSCCDS26629.1.
RefSeqNP_061373.1. NM_018885.2.
XP_006517355.1. XM_006517292.1.
XP_006517356.1. XM_006517293.1.
XP_006517357.1. XM_006517294.1.
XP_006517358.1. XM_006517295.1.
XP_006517359.1. XM_006517296.1.
UniGeneMm.103784.

3D structure databases

ProteinModelPortalQ9QY61.
SMRQ9QY61. Positions 152-201.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QY61.

Proteomic databases

PRIDEQ9QY61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022095; ENSMUSP00000022095; ENSMUSG00000021604.
ENSMUST00000176684; ENSMUSP00000134738; ENSMUSG00000021604.
GeneID50916.
KEGGmmu:50916.
UCSCuc007rdf.2. mouse.

Organism-specific databases

CTD50805.
MGIMGI:1355275. Irx4.

Phylogenomic databases

eggNOGNOG310996.
GeneTreeENSGT00750000117365.
HOGENOMHOG000234546.
HOVERGENHBG006180.
InParanoidA0JNT5.
OMACELKPPF.
OrthoDBEOG7J1802.
PhylomeDBQ9QY61.
TreeFamTF319371.

Gene expression databases

BgeeQ9QY61.
CleanExMM_IRX4.
GenevestigatorQ9QY61.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307915.
PROQ9QY61.
SOURCESearch...

Entry information

Entry nameIRX4_MOUSE
AccessionPrimary (citable) accession number: Q9QY61
Secondary accession number(s): A0JNT5, Q3V1B6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot