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Q9QY61

- IRX4_MOUSE

UniProt

Q9QY61 - IRX4_MOUSE

Protein

Iroquois-class homeodomain protein IRX-4

Gene

Irx4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Likely to be an important mediator of ventricular differentiation during cardiac development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi144 – 20562Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. establishment of organ orientation Source: Ensembl
    3. heart development Source: MGI
    4. regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iroquois-class homeodomain protein IRX-4
    Alternative name(s):
    Homeodomain protein IRXA3
    Iroquois homeobox protein 4
    Gene namesi
    Name:Irx4
    Synonyms:Irxa3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1355275. Irx4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Iroquois-class homeodomain protein IRX-4PRO_0000049158Add
    BLAST

    Proteomic databases

    PRIDEiQ9QY61.

    PTM databases

    PhosphoSiteiQ9QY61.

    Expressioni

    Tissue specificityi

    Expressed in the developing central nervous system, skin, and vibrissae, but predominantly expressed in the cardiac ventricles of the developing heart. Not expressed in the developing metanephric kidney or adult kidney.2 Publications

    Gene expression databases

    BgeeiQ9QY61.
    CleanExiMM_IRX4.
    GenevestigatoriQ9QY61.

    Interactioni

    Subunit structurei

    Interacts with the vitamin D receptor VDR but doesn't affect its transactivation activity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QY61.
    SMRiQ9QY61. Positions 152-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi119 – 1224Poly-Ala
    Compositional biasi224 – 2296Poly-Glu
    Compositional biasi376 – 3838Poly-Ala

    Sequence similaritiesi

    Belongs to the TALE/IRO homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG310996.
    GeneTreeiENSGT00750000117365.
    HOGENOMiHOG000234546.
    HOVERGENiHBG006180.
    InParanoidiA0JNT5.
    OMAiCELKPPF.
    OrthoDBiEOG7J1802.
    PhylomeDBiQ9QY61.
    TreeFamiTF319371.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QY61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYPQFGYPY SSAPQFLMTT NSLSTCCESG GRTLADSGPA ASAQAPVYCP    50
    VYESRLLATA RHELNSAAAL GVYGSPYGSS QGYGNYVTYG SEASAFYSLN 100
    SFESKDGTGS SHAGLPPTAA AAYYPYEPAL SQYPYDRYGT VDSGTRRKNA 150
    TRETTSTLKA WLQEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR 200
    LKKENKMTWP PRNKCADEKR PYGEGEEEEA GEEESREEPL KSAKSEGHAG 250
    KDDKELELSD LEDFDPLDAE TSECELKTPF QSLDSGPERI PASSDGPGTG 300
    KEASTTLRMP LGTAGGAVMD GDLERARNCL RSTVVVPDSG AEGGPPACEA 350
    KLTFAQAGAP PNLETKPRIW SLAHTATAAA ATALSQTEFP SCMLKRQGPT 400
    GVSATTPASS PAVTAPSGAL DRHQDSPVTS LRNWVDGVFH DPILRHSTLN 450
    QAWATAKGAL LDPGPLGRNL GAGTNVLTTP LACSFPPTVP QDVPPAGASR 500
    ELLATPKAGG KPFCT 515
    Length:515
    Mass (Da):54,701
    Last modified:May 1, 2000 - v1
    Checksum:iA3E7C67B7D5334BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti215 – 2151C → Y in BAE21235. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124732 mRNA. Translation: AAF23886.1.
    AK132571 mRNA. Translation: BAE21235.1.
    CH466563 Genomic DNA. Translation: EDL37045.1.
    BC126942 mRNA. Translation: AAI26943.1.
    CCDSiCCDS26629.1.
    RefSeqiNP_061373.1. NM_018885.2.
    XP_006517355.1. XM_006517292.1.
    XP_006517356.1. XM_006517293.1.
    XP_006517357.1. XM_006517294.1.
    XP_006517358.1. XM_006517295.1.
    XP_006517359.1. XM_006517296.1.
    UniGeneiMm.103784.

    Genome annotation databases

    EnsembliENSMUST00000022095; ENSMUSP00000022095; ENSMUSG00000021604.
    ENSMUST00000176684; ENSMUSP00000134738; ENSMUSG00000021604.
    GeneIDi50916.
    KEGGimmu:50916.
    UCSCiuc007rdf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124732 mRNA. Translation: AAF23886.1 .
    AK132571 mRNA. Translation: BAE21235.1 .
    CH466563 Genomic DNA. Translation: EDL37045.1 .
    BC126942 mRNA. Translation: AAI26943.1 .
    CCDSi CCDS26629.1.
    RefSeqi NP_061373.1. NM_018885.2.
    XP_006517355.1. XM_006517292.1.
    XP_006517356.1. XM_006517293.1.
    XP_006517357.1. XM_006517294.1.
    XP_006517358.1. XM_006517295.1.
    XP_006517359.1. XM_006517296.1.
    UniGenei Mm.103784.

    3D structure databases

    ProteinModelPortali Q9QY61.
    SMRi Q9QY61. Positions 152-201.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QY61.

    Proteomic databases

    PRIDEi Q9QY61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022095 ; ENSMUSP00000022095 ; ENSMUSG00000021604 .
    ENSMUST00000176684 ; ENSMUSP00000134738 ; ENSMUSG00000021604 .
    GeneIDi 50916.
    KEGGi mmu:50916.
    UCSCi uc007rdf.2. mouse.

    Organism-specific databases

    CTDi 50805.
    MGIi MGI:1355275. Irx4.

    Phylogenomic databases

    eggNOGi NOG310996.
    GeneTreei ENSGT00750000117365.
    HOGENOMi HOG000234546.
    HOVERGENi HBG006180.
    InParanoidi A0JNT5.
    OMAi CELKPPF.
    OrthoDBi EOG7J1802.
    PhylomeDBi Q9QY61.
    TreeFami TF319371.

    Miscellaneous databases

    NextBioi 307915.
    PROi Q9QY61.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QY61.
    CleanExi MM_IRX4.
    Genevestigatori Q9QY61.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand."
      Bruneau B.G., Bao Z.-Z., Tanaka M., Schott J.-J., Izumo S., Cepko C.L., Seidman J.G., Seidman C.E.
      Dev. Biol. 217:266-277(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION, TISSUE SPECIFICITY.
      Tissue: Embryonic heart.
    2. "Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart."
      Christoffels V.M., Keijser A.G.M., Houweling A.C., Clout D.E.W., Moorman A.F.M.
      Dev. Biol. 224:263-274(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: FVB/N.
      Tissue: Embryonic heart.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The prepattern transcription factor Irx3 directs nephron segment identity."
      Reggiani L., Raciti D., Airik R., Kispert A., Braendli A.W.
      Genes Dev. 21:2358-2370(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF RENAL EXPRESSION.

    Entry informationi

    Entry nameiIRX4_MOUSE
    AccessioniPrimary (citable) accession number: Q9QY61
    Secondary accession number(s): A0JNT5, Q3V1B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3