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Protein

Iroquois-class homeodomain protein IRX-4

Gene

Irx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Likely to be an important mediator of ventricular differentiation during cardiac development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi144 – 205Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • establishment of animal organ orientation Source: Ensembl
  • heart development Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-4
Alternative name(s):
Homeodomain protein IRXA3
Iroquois homeobox protein 4
Gene namesi
Name:Irx4
Synonyms:Irxa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1355275 Irx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491581 – 515Iroquois-class homeodomain protein IRX-4Add BLAST515

Proteomic databases

PaxDbiQ9QY61
PRIDEiQ9QY61

PTM databases

iPTMnetiQ9QY61
PhosphoSitePlusiQ9QY61

Expressioni

Tissue specificityi

Expressed in the developing central nervous system, skin, and vibrissae, but predominantly expressed in the cardiac ventricles of the developing heart. Not expressed in the developing metanephric kidney or adult kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000021604
CleanExiMM_IRX4
GenevisibleiQ9QY61 MM

Interactioni

Subunit structurei

Interacts with the vitamin D receptor VDR but doesn't affect its transactivation activity.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022095

Structurei

3D structure databases

ProteinModelPortaliQ9QY61
SMRiQ9QY61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 122Poly-Ala4
Compositional biasi224 – 229Poly-Glu6
Compositional biasi376 – 383Poly-Ala8

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiQ9QY61
OMAiPYDRYGT
OrthoDBiEOG091G0N9R
PhylomeDBiQ9QY61
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QY61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPQFGYPY SSAPQFLMTT NSLSTCCESG GRTLADSGPA ASAQAPVYCP
60 70 80 90 100
VYESRLLATA RHELNSAAAL GVYGSPYGSS QGYGNYVTYG SEASAFYSLN
110 120 130 140 150
SFESKDGTGS SHAGLPPTAA AAYYPYEPAL SQYPYDRYGT VDSGTRRKNA
160 170 180 190 200
TRETTSTLKA WLQEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR
210 220 230 240 250
LKKENKMTWP PRNKCADEKR PYGEGEEEEA GEEESREEPL KSAKSEGHAG
260 270 280 290 300
KDDKELELSD LEDFDPLDAE TSECELKTPF QSLDSGPERI PASSDGPGTG
310 320 330 340 350
KEASTTLRMP LGTAGGAVMD GDLERARNCL RSTVVVPDSG AEGGPPACEA
360 370 380 390 400
KLTFAQAGAP PNLETKPRIW SLAHTATAAA ATALSQTEFP SCMLKRQGPT
410 420 430 440 450
GVSATTPASS PAVTAPSGAL DRHQDSPVTS LRNWVDGVFH DPILRHSTLN
460 470 480 490 500
QAWATAKGAL LDPGPLGRNL GAGTNVLTTP LACSFPPTVP QDVPPAGASR
510
ELLATPKAGG KPFCT
Length:515
Mass (Da):54,701
Last modified:May 1, 2000 - v1
Checksum:iA3E7C67B7D5334BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215C → Y in BAE21235 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124732 mRNA Translation: AAF23886.1
AK132571 mRNA Translation: BAE21235.1
CH466563 Genomic DNA Translation: EDL37045.1
BC126942 mRNA Translation: AAI26943.1
CCDSiCCDS26629.1
RefSeqiNP_061373.1, NM_018885.2
XP_006517355.1, XM_006517292.2
XP_006517356.1, XM_006517293.2
XP_006517357.1, XM_006517294.3
XP_006517358.1, XM_006517295.1
XP_006517359.1, XM_006517296.1
UniGeneiMm.103784

Genome annotation databases

EnsembliENSMUST00000022095; ENSMUSP00000022095; ENSMUSG00000021604
ENSMUST00000176684; ENSMUSP00000134738; ENSMUSG00000021604
GeneIDi50916
KEGGimmu:50916
UCSCiuc007rdf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIRX4_MOUSE
AccessioniPrimary (citable) accession number: Q9QY61
Secondary accession number(s): A0JNT5, Q3V1B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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