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Q9QY44 (ABCD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family D member 2
Alternative name(s):
Adrenoleukodystrophy-related protein
Gene names
Name:Abcd2
Synonyms:Aldr, Aldrp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transporter By similarity.

Subunit structure

Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 By similarity.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
Peroxisome
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Inferred from electronic annotation. Source: GOC

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

peroxisomal membrane

Inferred from direct assay PubMed 14561759. Source: HGNC

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 741741ATP-binding cassette sub-family D member 2
PRO_0000093308

Regions

Transmembrane107 – 12721Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane351 – 37121Helical; Potential
Domain107 – 399293ABC transmembrane type-1
Domain479 – 705227ABC transporter
Nucleotide binding512 – 5198ATP Potential
Region1 – 218218Interaction with PEX19 By similarity

Amino acid modifications

Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9QY44 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B324988EB13F071B

FASTA74183,369
        10         20         30         40         50         60 
MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPIL GRRLKQPGHR KAKAEDYPPA 

        70         80         90        100        110        120 
ENRERLHCTE IICKKPAPGL NADFFKQLLE LRKILFPKLV TTETGWLCLH SVALISRTFL 

       130        140        150        160        170        180 
SIYVAGLDGK IVKSIVEKKP RTFIIKLVKW LMIAVPATFV NSAIRYLECK LALAFRTRLV 

       190        200        210        220        230        240 
DHAYETYFAN QTYYKVINMD GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY 

       250        260        270        280        290        300 
TLIRTATSRG ASPIGPTLLA GLVVYATAKV LKACSPKFGT LVAEEAHRKG YLRYVHSRII 

       310        320        330        340        350        360 
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY VWSGCGLIMV 

       370        380        390        400        410        420 
AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS GADAIERIMS SYKEITELAG 

       430        440        450        460        470        480 
YTARVYNMFW VFDEVKRGIY KRTVTQEPEN NSKSGGGLEL PLSDTLAIKG TVIDVDHGIL 

       490        500        510        520        530        540 
CENVPIITPA GEVVASSLNF KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP 

       550        560        570        580        590        600 
PQHMFYIPQR PYMSLGSLRD QVIYPDSVDD MHEKGYTDRD LEHILHSVHL YHIVQREGGW 

       610        620        630        640        650        660 
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ AAIGAGISLL 

       670        680        690        700        710        720 
SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE KQKLESQLAG IPKMQQRLNE 

       730        740 
LCKILGEDSV LKTIQTAEDT S

« Hide

References

[1]"Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA sequence and new insight in expression."
Albet S., Bentejac M., Savary S., Gondcaille C., Netik A., Berger J., Szpirer C., Troffer-Charlier N., Bugaut M.
Biochim. Biophys. Acta 1517:257-269(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF131294 mRNA. Translation: AAF22142.1.
IPIIPI00213550.
RefSeqNP_203503.1. NM_033352.1.
UniGeneRn.19678.

3D structure databases

ProteinModelPortalQ9QY44.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021064.

PTM databases

PhosphoSiteQ9QY44.

Proteomic databases

PaxDbQ9QY44.
PRIDEQ9QY44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID84356.
KEGGrno:84356.

Organism-specific databases

CTD225.
RGD69244. Abcd2.

Phylogenomic databases

eggNOGCOG4178.
HOGENOMHOG000206081.
HOVERGENHBG050438.
InParanoidQ9QY44.
KOK05676.
OrthoDBEOG4DFPMX.

Gene expression databases

GenevestigatorQ9QY44.
GermOnlineENSRNOG00000015538. Rattus norvegicus.

Family and domain databases

InterProIPR003593. AAA+_ATPase.
IPR010509. ABC_Ald_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
[Graphical view]
PfamPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616679.

Entry information

Entry nameABCD2_RAT
AccessionPrimary (citable) accession number: Q9QY44
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 1, 2000
Last modified: April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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