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Protein

ATP-binding cassette sub-family D member 2

Gene

Abcd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi512 – 5198ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 2
Alternative name(s):
Adrenoleukodystrophy-related protein
Gene namesi
Name:Abcd2
Synonyms:Aldr, Aldrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69244. Abcd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei107 – 12721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei144 – 16421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei351 – 37121HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • peroxisomal membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741ATP-binding cassette sub-family D member 2PRO_0000093308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QY44.
PRIDEiQ9QY44.

PTM databases

iPTMnetiQ9QY44.
PhosphoSiteiQ9QY44.

Interactioni

Subunit structurei

Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249916. 1 interaction.
STRINGi10116.ENSRNOP00000021064.

Structurei

3D structure databases

ProteinModelPortaliQ9QY44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 399293ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini479 – 705227ABC transporterPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 218218Interaction with PEX19By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0064. Eukaryota.
COG4178. LUCA.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiQ9QY44.
KOiK05676.
PhylomeDBiQ9QY44.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR031239. ABCD2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11384:SF24. PTHR11384:SF24. 1 hit.
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPIL GRRLKQPGHR
60 70 80 90 100
KAKAEDYPPA ENRERLHCTE IICKKPAPGL NADFFKQLLE LRKILFPKLV
110 120 130 140 150
TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLVKW
160 170 180 190 200
LMIAVPATFV NSAIRYLECK LALAFRTRLV DHAYETYFAN QTYYKVINMD
210 220 230 240 250
GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY TLIRTATSRG
260 270 280 290 300
ASPIGPTLLA GLVVYATAKV LKACSPKFGT LVAEEAHRKG YLRYVHSRII
310 320 330 340 350
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY
360 370 380 390 400
VWSGCGLIMV AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS
410 420 430 440 450
GADAIERIMS SYKEITELAG YTARVYNMFW VFDEVKRGIY KRTVTQEPEN
460 470 480 490 500
NSKSGGGLEL PLSDTLAIKG TVIDVDHGIL CENVPIITPA GEVVASSLNF
510 520 530 540 550
KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP PQHMFYIPQR
560 570 580 590 600
PYMSLGSLRD QVIYPDSVDD MHEKGYTDRD LEHILHSVHL YHIVQREGGW
610 620 630 640 650
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ
660 670 680 690 700
AAIGAGISLL SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE
710 720 730 740
KQKLESQLAG IPKMQQRLNE LCKILGEDSV LKTIQTAEDT S
Length:741
Mass (Da):83,369
Last modified:May 1, 2000 - v1
Checksum:iB324988EB13F071B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131294 mRNA. Translation: AAF22142.1.
RefSeqiNP_203503.1. NM_033352.1.
UniGeneiRn.19678.

Genome annotation databases

GeneIDi84356.
KEGGirno:84356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131294 mRNA. Translation: AAF22142.1.
RefSeqiNP_203503.1. NM_033352.1.
UniGeneiRn.19678.

3D structure databases

ProteinModelPortaliQ9QY44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249916. 1 interaction.
STRINGi10116.ENSRNOP00000021064.

PTM databases

iPTMnetiQ9QY44.
PhosphoSiteiQ9QY44.

Proteomic databases

PaxDbiQ9QY44.
PRIDEiQ9QY44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84356.
KEGGirno:84356.

Organism-specific databases

CTDi225.
RGDi69244. Abcd2.

Phylogenomic databases

eggNOGiKOG0064. Eukaryota.
COG4178. LUCA.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiQ9QY44.
KOiK05676.
PhylomeDBiQ9QY44.

Miscellaneous databases

PROiQ9QY44.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR031239. ABCD2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11384:SF24. PTHR11384:SF24. 1 hit.
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCD2_RAT
AccessioniPrimary (citable) accession number: Q9QY44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.