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Protein

ATP-binding cassette sub-family D member 2

Gene

Abcd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi512 – 519ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 2
Alternative name(s):
Adrenoleukodystrophy-related protein
Gene namesi
Name:Abcd2
Synonyms:Aldr, Aldrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69244 Abcd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei144 – 164HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei251 – 271HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933081 – 741ATP-binding cassette sub-family D member 2Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QY44
PRIDEiQ9QY44

PTM databases

iPTMnetiQ9QY44
PhosphoSitePlusiQ9QY44

Interactioni

Subunit structurei

Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249916, 1 interactor
STRINGi10116.ENSRNOP00000021064

Structurei

3D structure databases

ProteinModelPortaliQ9QY44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 399ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST293
Domaini479 – 705ABC transporterPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 218Interaction with PEX19By similarityAdd BLAST218

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0064 Eukaryota
COG4178 LUCA
HOGENOMiHOG000206081
HOVERGENiHBG050438
InParanoidiQ9QY44
KOiK05676
PhylomeDBiQ9QY44

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR031239 ABCD2
IPR027417 P-loop_NTPase
PANTHERiPTHR11384:SF24 PTHR11384:SF24, 1 hit
PfamiView protein in Pfam
PF06472 ABC_membrane_2, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QY44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPIL GRRLKQPGHR
60 70 80 90 100
KAKAEDYPPA ENRERLHCTE IICKKPAPGL NADFFKQLLE LRKILFPKLV
110 120 130 140 150
TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLVKW
160 170 180 190 200
LMIAVPATFV NSAIRYLECK LALAFRTRLV DHAYETYFAN QTYYKVINMD
210 220 230 240 250
GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY TLIRTATSRG
260 270 280 290 300
ASPIGPTLLA GLVVYATAKV LKACSPKFGT LVAEEAHRKG YLRYVHSRII
310 320 330 340 350
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY
360 370 380 390 400
VWSGCGLIMV AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS
410 420 430 440 450
GADAIERIMS SYKEITELAG YTARVYNMFW VFDEVKRGIY KRTVTQEPEN
460 470 480 490 500
NSKSGGGLEL PLSDTLAIKG TVIDVDHGIL CENVPIITPA GEVVASSLNF
510 520 530 540 550
KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP PQHMFYIPQR
560 570 580 590 600
PYMSLGSLRD QVIYPDSVDD MHEKGYTDRD LEHILHSVHL YHIVQREGGW
610 620 630 640 650
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ
660 670 680 690 700
AAIGAGISLL SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE
710 720 730 740
KQKLESQLAG IPKMQQRLNE LCKILGEDSV LKTIQTAEDT S
Length:741
Mass (Da):83,369
Last modified:May 1, 2000 - v1
Checksum:iB324988EB13F071B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131294 mRNA Translation: AAF22142.1
RefSeqiNP_203503.1, NM_033352.1
UniGeneiRn.19678

Genome annotation databases

GeneIDi84356
KEGGirno:84356

Similar proteinsi

Entry informationi

Entry nameiABCD2_RAT
AccessioniPrimary (citable) accession number: Q9QY44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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